Details for: DMBT1

Gene ID: 1755

Symbol: DMBT1

Ensembl ID: ENSG00000187908

Description: deleted in malignant brain tumors 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: precursor cell (CL0011115)
    Fold Change: 40.1179
    Cell Significance Index: 304.2200
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 6.7247
    Cell Significance Index: 37.4300
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 5.2251
    Cell Significance Index: 52.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 4.4270
    Cell Significance Index: 95.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.1630
    Cell Significance Index: 194.1000
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 3.9901
    Cell Significance Index: 39.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.6657
    Cell Significance Index: 105.6200
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 2.9586
    Cell Significance Index: 20.8200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.4708
    Cell Significance Index: 268.7500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.1780
    Cell Significance Index: 32.6400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.1153
    Cell Significance Index: 1910.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.1146
    Cell Significance Index: 209.1800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.9318
    Cell Significance Index: 48.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.3424
    Cell Significance Index: 92.8400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.0349
    Cell Significance Index: 22.0400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9612
    Cell Significance Index: 182.9300
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.9336
    Cell Significance Index: 19.4700
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 0.8379
    Cell Significance Index: 6.0300
  • Cell Name: airway submucosal gland collecting duct epithelial cell (CL4033023)
    Fold Change: 0.7004
    Cell Significance Index: 4.9200
  • Cell Name: serous cell of epithelium of trachea (CL1000330)
    Fold Change: 0.6362
    Cell Significance Index: 4.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5213
    Cell Significance Index: 27.0800
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.4285
    Cell Significance Index: 4.4200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.4074
    Cell Significance Index: 308.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.3994
    Cell Significance Index: 84.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3350
    Cell Significance Index: 4.5700
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 0.2920
    Cell Significance Index: 1.9500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1584
    Cell Significance Index: 1.6400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0636
    Cell Significance Index: 39.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0391
    Cell Significance Index: 1.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0340
    Cell Significance Index: 1.5400
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.0294
    Cell Significance Index: 0.3800
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0289
    Cell Significance Index: 0.2100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0270
    Cell Significance Index: 14.7600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0141
    Cell Significance Index: 0.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0123
    Cell Significance Index: 2.2100
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.0113
    Cell Significance Index: 0.0700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0080
    Cell Significance Index: 0.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0049
    Cell Significance Index: 0.8300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0034
    Cell Significance Index: 0.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0028
    Cell Significance Index: 0.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0001
    Cell Significance Index: 0.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0010
    Cell Significance Index: -0.5900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0036
    Cell Significance Index: -6.8500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0045
    Cell Significance Index: -8.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0054
    Cell Significance Index: -8.3700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0058
    Cell Significance Index: -0.2900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0062
    Cell Significance Index: -8.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0080
    Cell Significance Index: -3.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0120
    Cell Significance Index: -1.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0129
    Cell Significance Index: -0.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0151
    Cell Significance Index: -5.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0160
    Cell Significance Index: -0.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0165
    Cell Significance Index: -10.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0202
    Cell Significance Index: -9.1700
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0218
    Cell Significance Index: -0.1800
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0226
    Cell Significance Index: -0.1200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0231
    Cell Significance Index: -2.6400
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.0275
    Cell Significance Index: -0.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0318
    Cell Significance Index: -6.3200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0331
    Cell Significance Index: -3.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0365
    Cell Significance Index: -7.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0372
    Cell Significance Index: -10.7000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0387
    Cell Significance Index: -0.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0403
    Cell Significance Index: -5.2100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0456
    Cell Significance Index: -0.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0470
    Cell Significance Index: -6.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0532
    Cell Significance Index: -3.2600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0597
    Cell Significance Index: -0.9000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0612
    Cell Significance Index: -4.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0681
    Cell Significance Index: -7.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0713
    Cell Significance Index: -10.3700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0872
    Cell Significance Index: -0.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0951
    Cell Significance Index: -7.0900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0964
    Cell Significance Index: -1.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0989
    Cell Significance Index: -6.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1052
    Cell Significance Index: -10.7500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1239
    Cell Significance Index: -4.5500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1306
    Cell Significance Index: -2.0200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1413
    Cell Significance Index: -3.6100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1558
    Cell Significance Index: -1.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1661
    Cell Significance Index: -9.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1672
    Cell Significance Index: -8.7100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1741
    Cell Significance Index: -6.1000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1763
    Cell Significance Index: -3.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1918
    Cell Significance Index: -9.0200
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1938
    Cell Significance Index: -2.6800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1948
    Cell Significance Index: -4.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1960
    Cell Significance Index: -8.6700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2153
    Cell Significance Index: -5.6600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2229
    Cell Significance Index: -4.3500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2236
    Cell Significance Index: -7.3200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2264
    Cell Significance Index: -7.2100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2270
    Cell Significance Index: -3.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2295
    Cell Significance Index: -8.6900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2311
    Cell Significance Index: -7.3100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2321
    Cell Significance Index: -6.2200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2372
    Cell Significance Index: -6.7700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2467
    Cell Significance Index: -4.1500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2515
    Cell Significance Index: -7.2100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2526
    Cell Significance Index: -6.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DMBT1 is a gene that codes for a protein with a scavenger receptor activity, which is involved in the recognition and binding to various ligands, including proteins and lipids. This receptor activity is crucial for the regulation of immune responses, particularly in the context of bacterial and viral infections. DMBT1 is also involved in the endocytosis of proteins and lipids, which is essential for the regulation of cellular differentiation and survival. **Pathways and Functions:** DMBT1 is involved in various cellular pathways, including: 1. **Calcium-dependent protein binding:** DMBT1 regulates the binding of proteins to calcium ions, which is essential for the regulation of immune responses and cellular differentiation. 2. **Defense response:** DMBT1 plays a crucial role in the defense response against bacterial and viral infections, particularly in the context of pattern recognition receptor activity. 3. **Endocytosis:** DMBT1 is involved in the endocytosis of proteins and lipids, which is essential for the regulation of cellular differentiation and survival. 4. **Extracellular exosome:** DMBT1 regulates the formation and function of extracellular exosomes, which are involved in intercellular communication and immune responses. 5. **Metabolism of proteins:** DMBT1 is involved in the regulation of protein metabolism, particularly in the context of protein degradation and recycling. **Significantly Expressed Cells:** DMBT1 is significantly expressed in various cell types, including: 1. **Lung secretory cell:** DMBT1 is expressed in lung secretory cells, which are involved in the production of surfactant and other secretory proteins. 2. **Serous secreting cell:** DMBT1 is expressed in serous secreting cells, which are involved in the production of secretory proteins and antibodies. 3. **Tracheobronchial serous cell:** DMBT1 is expressed in tracheobronchial serous cells, which are involved in the production of secretory proteins and antibodies. 4. **Pneumocyte:** DMBT1 is expressed in pneumocytes, which are involved in the production of surfactant and other secretory proteins. 5. **Cardiac endothelial cell:** DMBT1 is expressed in cardiac endothelial cells, which are involved in the regulation of blood flow and immune responses. 6. **Precursor cell:** DMBT1 is expressed in precursor cells, which are involved in the regulation of cellular differentiation and survival. 7. **Enterocyte:** DMBT1 is expressed in enterocytes, which are involved in the absorption of nutrients and regulation of immune responses. 8. **Stem cell:** DMBT1 is expressed in stem cells, which are involved in the regulation of cellular differentiation and survival. **Clinical Significance:** DMBT1 has been implicated in various clinical disorders, including cancer and immune disorders. Specifically: 1. **Cancer:** DMBT1 is deleted in malignant brain tumors, particularly in glioblastoma and medulloblastoma. 2. **Immune disorders:** DMBT1 is involved in the regulation of immune responses, particularly in the context of autoimmune disorders and immunodeficiency diseases. 3. **Infectious diseases:** DMBT1 plays a crucial role in the defense response against bacterial and viral infections, particularly in the context of pattern recognition receptor activity. In conclusion, DMBT1 is a gene with multiple roles in the immune system and cellular differentiation. Its involvement in various biological processes, including endocytosis, protein binding, and pattern recognition receptor activity, makes it a crucial regulator of immune responses and cellular survival. Further research is needed to fully understand the clinical significance of DMBT1 in cancer and immune disorders.

Genular Protein ID: 2469427301

Symbol: DMBT1_HUMAN

Name: Deleted in malignant brain tumors 1 protein

UniProtKB Accession Codes:

Q9UGM3 A6NDG4 A6NDJ5 A8E4R5 B1ARE7 B1ARE8 B1ARE9 B1ARF0 B7Z8Y2 F8WEF7 Q59EX0 Q5JR26 Q6MZN4 Q96DU4 Q9UGM2 Q9UJ57 Q9UKJ4 Q9Y211 Q9Y4V9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 11 ExpressionAtlas 1 GO 19 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 9 Pumba 1 RNAct 1 Reactome 1 RefSeq 7 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9288095

Title: DMBT1, a new member of the SRCR superfamily on chromosome 10q25.3-q26.1 is deleted in malignant brain tumours.

PubMed ID: 9288095

DOI: 10.1038/ng0997-32

PubMed ID: 10485905

Title: Cloning of gp-340, a putative opsonin receptor for lung surfactant protein D.

PubMed ID: 10485905

DOI: 10.1073/pnas.96.19.10794

PubMed ID: 10597221

Title: The genomic structure of the DMBT1 gene: evidence for a region with susceptibility to genomic instability.

PubMed ID: 10597221

DOI: 10.1038/sj.onc.1203071

PubMed ID: 10551316

Title: Expression of the DMBT1 gene is frequently suppressed in human lung cancer.

PubMed ID: 10551316

DOI: 10.1111/j.1349-7006.1999.tb00833.x

PubMed ID: 11751412

Title: Deleted in malignant brain tumors 1 is a versatile mucin-like molecule likely to play a differential role in digestive tract cancer.

PubMed ID: 11751412

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 25946035

Title: Human basal tear peptidome characterization by CID, HCD, and ETD followed by in silico and in vitro analyses for antimicrobial peptide identification.

PubMed ID: 25946035

DOI: 10.1021/acs.jproteome.5b00179

PubMed ID: 9153228

Title: Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule.

PubMed ID: 9153228

DOI: 10.1074/jbc.272.21.13743

PubMed ID: 10101009

Title: Glycoprotein-340 binds surfactant protein-A (SP-A) and stimulates alveolar macrophage migration in an SP-A-independent manner.

PubMed ID: 10101009

DOI: 10.1165/ajrcmb.20.4.3439

PubMed ID: 9888459

Title: Lack of DMBT1 expression in oesophageal, gastric and colon cancers.

PubMed ID: 9888459

DOI: 10.1038/sj.bjc.6690035

PubMed ID: 10749143

Title: DMBT1 encodes a protein involved in the immune defense and in epithelial differentiation and is highly unstable in cancer.

PubMed ID: 10749143

PubMed ID: 11007786

Title: Salivary agglutinin, which binds Streptococcus mutans and Helicobacter pylori, is the lung scavenger receptor cysteine-rich protein gp-340.

PubMed ID: 11007786

DOI: 10.1074/jbc.m006928200

PubMed ID: 15355985

Title: Bacteria binding by DMBT1/SAG/gp-340 is confined to the VEVLXXXXW motif in its scavenger receptor cysteine-rich domains.

PubMed ID: 15355985

DOI: 10.1074/jbc.m406095200

PubMed ID: 16796526

Title: The N-terminal SRCR-SID domain of gp-340 interacts with HIV type 1 gp120 sequences and inhibits viral infection.

PubMed ID: 16796526

DOI: 10.1089/aid.2006.22.508

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 17983803

Title: DMBT1 confers mucosal protection in vivo and a deletion variant is associated with Crohn's disease.

PubMed ID: 17983803

DOI: 10.1053/j.gastro.2007.08.007

PubMed ID: 17548659

Title: Regulation of DMBT1 via NOD2 and TLR4 in intestinal epithelial cells modulates bacterial recognition and invasion.

PubMed ID: 17548659

DOI: 10.4049/jimmunol.178.12.8203

PubMed ID: 17709527

Title: gp340 expressed on human genital epithelia binds HIV-1 envelope protein and facilitates viral transmission.

PubMed ID: 17709527

DOI: 10.4049/jimmunol.179.5.3126

PubMed ID: 18713006

Title: A common binding motif for various bacteria of the bacteria-binding peptide SRCRP2 of DMBT1/gp-340/salivary agglutinin.

PubMed ID: 18713006

DOI: 10.1515/bc.2008.135

PubMed ID: 19189310

Title: DMBT1 functions as pattern-recognition molecule for poly-sulfated and poly-phosphorylated ligands.

PubMed ID: 19189310

DOI: 10.1002/eji.200838689

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23439307

Title: Staphylococcus aureus SasA is responsible for binding to the salivary agglutinin gp340, derived from human saliva.

PubMed ID: 23439307

DOI: 10.1128/iai.00011-13

PubMed ID: 12353266

Title: The SRCR/SID region of DMBT1 defines a complex multi-allele system representing the major basis for its variability in cancer.

PubMed ID: 12353266

DOI: 10.1002/gcc.10115

PubMed ID: 12185598

Title: Rare mutations of the DMBT1 gene in human astrocytic gliomas.

PubMed ID: 12185598

DOI: 10.1038/sj.onc.1205733

PubMed ID: 28397838

Title: Mapping autosomal recessive intellectual disability: combined microarray and exome sequencing identifies 26 novel candidate genes in 192 consanguineous families.

PubMed ID: 28397838

DOI: 10.1038/mp.2017.60

Sequence Information:

  • Length: 2413
  • Mass: 260735
  • Checksum: 25363E6263234F15
  • Sequence:
    • MGISTVILEM CLLWGQVLST GGWIPRTTDY ASLIPSEVPL DPTVAEGSPF PSESTLESTV 
AEGSPISLES TLESTVAEGS LIPSESTLES TVAEGSDSGL ALRLVNGDGR CQGRVEILYR 
GSWGTVCDDS WDTNDANVVC RQLGCGWAMS APGNAWFGQG SGPIALDDVR CSGHESYLWS 
CPHNGWLSHN CGHGEDAGVI CSAAQPQSTL RPESWPVRIS PPVPTEGSES SLALRLVNGG 
DRCRGRVEVL YRGSWGTVCD DYWDTNDANV VCRQLGCGWA MSAPGNAQFG QGSGPIVLDD 
VRCSGHESYL WSCPHNGWLT HNCGHSEDAG VICSAPQSRP TPSPDTWPTS HASTAGPESS 
LALRLVNGGD RCQGRVEVLY RGSWGTVCDD SWDTSDANVV CRQLGCGWAT SAPGNARFGQ 
GSGPIVLDDV RCSGYESYLW SCPHNGWLSH NCQHSEDAGV ICSAAHSWST PSPDTLPTIT 
LPASTVGSES SLALRLVNGG DRCQGRVEVL YRGSWGTVCD DSWDTNDANV VCRQLGCGWA 
MLAPGNARFG QGSGPIVLDD VRCSGNESYL WSCPHNGWLS HNCGHSEDAG VICSGPESSL 
ALRLVNGGDR CQGRVEVLYR GSWGTVCDDS WDTNDANVVC RQLGCGWATS APGNARFGQG 
SGPIVLDDVR CSGHESYLWS CPNNGWLSHN CGHHEDAGVI CSAAQSRSTP RPDTLSTITL 
PPSTVGSESS LTLRLVNGSD RCQGRVEVLY RGSWGTVCDD SWDTNDANVV CRQLGCGWAT 
SAPGNARFGQ GSGPIVLDDV RCSGHESYLW SCPHNGWLSH NCGHHEDAGV ICSVSQSRPT 
PSPDTWPTSH ASTAGPESSL ALRLVNGGDR CQGRVEVLYR GSWGTVCDDS WDTSDANVVC 
RQLGCGWATS APGNARFGQG SGPIVLDDVR CSGYESYLWS CPHNGWLSHN CQHSEDAGVI 
CSAAHSWSTP SPDTLPTITL PASTVGSESS LALRLVNGGD RCQGRVEVLY QGSWGTVCDD 
SWDTNDANVV CRQLGCGWAM SAPGNARFGQ GSGPIVLDDV RCSGHESYLW SCPHNGWLSH 
NCGHSEDAGV ICSASQSRPT PSPDTWPTSH ASTAGSESSL ALRLVNGGDR CQGRVEVLYR 
GSWGTVCDDY WDTNDANVVC RQLGCGWAMS APGNARFGQG SGPIVLDDVR CSGHESYLWS 
CPHNGWLSHN CGHHEDAGVI CSASQSQPTP SPDTWPTSHA STAGSESSLA LRLVNGGDRC 
QGRVEVLYRG SWGTVCDDYW DTNDANVVCR QLGCGWATSA PGNARFGQGS GPIVLDDVRC 
SGHESYLWSC PHNGWLSHNC GHHEDAGVIC SASQSQPTPS PDTWPTSHAS TAGSESSLAL 
RLVNGGDRCQ GRVEVLYRGS WGTVCDDYWD TNDANVVCRQ LGCGWATSAP GNARFGQGSG 
PIVLDDVRCS GHESYLWSCP HNGWLSHNCG HHEDAGVICS ASQSQPTPSP DTWPTSRAST 
AGSESTLALR LVNGGDRCRG RVEVLYQGSW GTVCDDYWDT NDANVVCRQL GCGWAMSAPG 
NAQFGQGSGP IVLDDVRCSG HESYLWSCPH NGWLSHNCGH HEDAGVICSA AQSQSTPRPD 
TWLTTNLPAL TVGSESSLAL RLVNGGDRCR GRVEVLYRGS WGTVCDDSWD TNDANVVCRQ 
LGCGWAMSAP GNARFGQGSG PIVLDDVRCS GNESYLWSCP HKGWLTHNCG HHEDAGVICS 
ATQINSTTTD WWHPTTTTTA RPSSNCGGFL FYASGTFSSP SYPAYYPNNA KCVWEIEVNS 
GYRINLGFSN LKLEAHHNCS FDYVEIFDGS LNSSLLLGKI CNDTRQIFTS SYNRMTIHFR 
SDISFQNTGF LAWYNSFPSD ATLRLVNLNS SYGLCAGRVE IYHGGTWGTV CDDSWTIQEA 
EVVCRQLGCG RAVSALGNAY FGSGSGPITL DDVECSGTES TLWQCRNRGW FSHNCNHRED 
AGVICSGNHL STPAPFLNIT RPNTDYSCGG FLSQPSGDFS SPFYPGNYPN NAKCVWDIEV 
QNNYRVTVIF RDVQLEGGCN YDYIEVFDGP YRSSPLIARV CDGARGSFTS SSNFMSIRFI 
SDHSITRRGF RAEYYSSPSN DSTNLLCLPN HMQASVSRSY LQSLGFSASD LVISTWNGYY 
ECRPQITPNL VIFTIPYSGC GTFKQADNDT IDYSNFLTAA VSGGIIKRRT DLRIHVSCRM 
LQNTWVDTMY IANDTIHVAN NTIQVEEVQY GNFDVNISFY TSSSFLYPVT SRPYYVDLNQ 
DLYVQAEILH SDAVLTLFVD TCVASPYSND FTSLTYDLIR SGCVRDDTYG PYSSPSLRIA 
RFRFRAFHFL NRFPSVYLRC KMVVCRAYDP SSRCYRGCVL RSKRDVGSYQ EKVDVVLGPI 
QLQTPPRREE EPR

Genular Protein ID: 3276539820

Symbol: A0A590UJ76_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A590UJ76

Database IDs:

ARBA 10 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 4 GeneTree 1 HGNC 1 InterPro 9 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 8 PROSITE-ProRule 2 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SMART 3 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 2412
  • Mass: 260633
  • Checksum: BED99F08A4979027
  • Sequence:
    • MGISTVILEM CLLWGQVLST GGWIPRTTDY ASLIPSEVPL DPTVAEGSPF PSESTLESTV 
AEGSPISLES TLESTVAEGS LIPSESTLES TVAEGSDSGL ALRLVNGDGR CQGRVEILYR 
GSWGTVCDDS WDTNDANVVC RQLGCGWAMS APGNAWFGQG SGPIALDDVR CSGHESYLWS 
CPHNGWLSHN CGHGEDAGVI CSAAQPQSTL RPESWPVRIS PPVPTEGSES SLALRLVNGG 
DRCRGRVEVL YRGSWGTVCD DYWDTNDANV VCRQLGCGWA MSAPGNAQFG QGSGPIVLDD 
VRCSGHESYL WSCPHNGWLT HNCGHSEDAG VICSAPQSRP TPSPDTWPTS HASTAGPESS 
LALRLVNGGD RCQGRVEVLY RGSWGTVCDD SWDTSDANVV CRQLGCGWAT SAPGNARFGQ 
GSGPIVLDDV RCSGYESYLW SCPHNGWLSH NCQHSEDAGV ICSAAHSWST PSPDTLPTIT 
LPASTVGSES SLALRLVNGG DRCQGRVEVL YRGSWGTVCD DSWDTNDANV VCRQLGCGWA 
MLAPGNARFG QGSGPIVLDD VRCSGNESYL WSCPHNGWLS HNCGHSEDAG VICSGPESSL 
ALRLVNGGDR CQGRVEVLYR GSWGTVCDDS WDTNDANVVC RQLGCGWATS APGNARFGQG 
SGPIVLDDVR CSGHESYLWS CPNNGWLSHN CGHHEDAGVI CSAAQSRSTP RPDTLSTITL 
PPSTVGSESS LTLRLVNGSD RCQGRVEVLY RGSWGTVCDD SWDTNDANVV CRQLGCGWAT 
SAPGNARFGQ GSGPIVLDDV RCSGHESYLW SCPHNGWLSH NCGHHEDAGV ICSVSQSRPT 
PSPDTWPTSH ASTAGPESSL ALRLVNGGDR CQGRVEVLYR GSWGTVCDDS WDTSDANVVC 
RQLGCGWATS APGNARFGQG SGPIVLDDVR CSGYESYLWS CPHNGWLSHN CQHSEDAGVI 
CSAAHSWSTP SPDTLPTITL PASTVGSESS LALRLVNGGD RCQGRVEVLY QGSWGTVCDD 
SWDTNDANVV CRQLGCGWAM SAPGNARFGQ GSGPIVLDDV RCSGHESYLW SCPHNGWLSH 
NCGHSEDAGV ICSASQSRPT PSPDTWPTSH ASTAGSESSL ALRLVNGGDR CQGRVEVLYR 
GSWGTVCDDY WDTNDANVVC RQLGCGWAMS APGNARFGQG SGPIVLDDVR CSGHESYLWS 
CPHNGWLSHN CGHHEDAGVI CSASQSQPTP SPDTWPTSHA STAGSESSLA LRLVNGGDRC 
QGRVEVLYRG SWGTVCDDYW DTNDANVVCR QLGCGWATSA PGNARFGQGS GPIVLDDVRC 
SGHESYLWSC PHNGWLSHNC GHHEDAGVIC SASQSQPTPS PDTWPTSHAS TAGSESSLAL 
RLVNGGDRCQ GRVEVLYRGS WGTVCDDYWD TNDANVVCRQ LGCGWATSAP GNARFGQGSG 
PIVLDDVRCS GHESYLWSCP HNGWLSHNCG HHEDAGVICS ASQSQPTPSP DTWPTSRAST 
AGSESTLALR LVNGGDRCRG RVEVLYQGSW GTVCDDYWDT NDANVVCRQL GCGWAMSAPG 
NAQFGQGSGP IVLDDVRCSG HESYLWSCPH NGWLSHNCGH HEDAGVICSA AQSQSTPRPD 
TWLTTNLPAL TVGSESSLAL RLVNGGDRCR GRVEVLYRGS WGTVCDDSWD TNDANVVCRQ 
LGCGWAMSAP GNARFGQGSG PIVLDDVRCS GNESYLWSCP HKGWLTHNCG HHEDAGVICS 
ATQINSTTTD WWHPTTTTTA RPSSNCGGFL FYASGTFSSP SYPAYYPNNA KCVWEIEVNS 
GYRINLGFSN LKLEAHHNCS FDYVEIFDGS LNSSLLLGKI CNDTRQIFTS SYNRMTIHFR 
SDISFQNTGF LAWYNSFPSD ATLRLVNLNS SYGLCAGRVE IYHGGTWGTV CDDSWTIQEA 
EVVCRQLGCG RAVSALGNAY FGSGSGPITL DDVECSGTES TLWQCRNRGW FSHNCNHRED 
AGVICSGNHL STPAPFLNIT RPNNYSCGGF LSQPSGDFSS PFYPGNYPNN AKCVWDIEVQ 
NNYRVTVIFR DVQLEGGCNY DYIEVFDGPY RSSPLIARVC DGARGSFTSS SNFMSIRFIS 
DHSITRRGFR AEYYSSPSND STNLLCLPNH MQASVSRSYL QSLGFSASDL VISTWNGYYE 
CRPQITPNLV IFTIPYSGCG TFKQADNDTI DYSNFLTAAV SGGIIKRRTD LRIHVSCRML 
QNTWVDTMYI ANDTIHVANN TIQVEEVQYG NFDVNISFYT SSSFLYPVTS RPYYVDLNQD 
LYVQAEILHS DAVLTLFVDT CVASPYSNDF TSLTYDLIRS GCVRDDTYGP YSSPSLRIAR 
FRFRAFHFLN RFPSVYLRCK MVVCRAYDPS SRCYRGCVLR SKRDVGSYQE KVDVVLGPIQ 
LQTPPRREEE PR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.