Details for: CCL25

Gene ID: 6370

Symbol: CCL25

Ensembl ID: ENSG00000131142

Description: C-C motif chemokine ligand 25

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: precursor cell (CL0011115)
    Fold Change: 35.2617
    Cell Significance Index: 267.3900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 12.2939
    Cell Significance Index: 354.2100
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 9.8000
    Cell Significance Index: 81.0500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 9.5725
    Cell Significance Index: 143.4400
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 7.5447
    Cell Significance Index: 76.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 6.1753
    Cell Significance Index: 279.9100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 5.7955
    Cell Significance Index: -1.4700
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 4.7434
    Cell Significance Index: 33.3800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 4.2718
    Cell Significance Index: 136.8200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 3.7808
    Cell Significance Index: -1.7900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 3.6866
    Cell Significance Index: 221.3300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.8227
    Cell Significance Index: 307.0200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 2.6527
    Cell Significance Index: -1.7800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.4831
    Cell Significance Index: 2242.0900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.3654
    Cell Significance Index: 233.9900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 2.3074
    Cell Significance Index: 49.1400
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 1.8344
    Cell Significance Index: 14.1100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.7374
    Cell Significance Index: 37.6400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.3304
    Cell Significance Index: 32.2300
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.6528
    Cell Significance Index: 7.1400
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.5588
    Cell Significance Index: 1.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5048
    Cell Significance Index: 96.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4670
    Cell Significance Index: 16.4100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.4509
    Cell Significance Index: 11.5200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1871
    Cell Significance Index: 4.0000
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 0.1007
    Cell Significance Index: 0.5500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0593
    Cell Significance Index: 0.9000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0496
    Cell Significance Index: 0.8500
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.0296
    Cell Significance Index: 0.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0257
    Cell Significance Index: 5.1000
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0248
    Cell Significance Index: 0.1800
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: 0.0057
    Cell Significance Index: 0.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0052
    Cell Significance Index: 1.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0045
    Cell Significance Index: 0.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0026
    Cell Significance Index: 1.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0011
    Cell Significance Index: 0.0600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0010
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0003
    Cell Significance Index: -0.5700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0004
    Cell Significance Index: -0.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0012
    Cell Significance Index: -0.4300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0020
    Cell Significance Index: -1.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0022
    Cell Significance Index: -1.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0022
    Cell Significance Index: -0.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0027
    Cell Significance Index: -1.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0029
    Cell Significance Index: -0.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0035
    Cell Significance Index: -1.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0037
    Cell Significance Index: -2.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0048
    Cell Significance Index: -0.1200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0049
    Cell Significance Index: -0.0700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0060
    Cell Significance Index: -0.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0060
    Cell Significance Index: -0.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0073
    Cell Significance Index: -1.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0104
    Cell Significance Index: -1.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0104
    Cell Significance Index: -1.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0117
    Cell Significance Index: -1.3600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0123
    Cell Significance Index: -0.3300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0125
    Cell Significance Index: -0.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0132
    Cell Significance Index: -1.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0139
    Cell Significance Index: -1.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0142
    Cell Significance Index: -1.4800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0167
    Cell Significance Index: -0.2800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0176
    Cell Significance Index: -2.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0180
    Cell Significance Index: -0.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0186
    Cell Significance Index: -1.1400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0207
    Cell Significance Index: -1.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0223
    Cell Significance Index: -1.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0231
    Cell Significance Index: -1.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0233
    Cell Significance Index: -0.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0234
    Cell Significance Index: -1.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0248
    Cell Significance Index: -2.5400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0248
    Cell Significance Index: -0.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0258
    Cell Significance Index: -1.4500
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0282
    Cell Significance Index: -0.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0283
    Cell Significance Index: -0.7900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0284
    Cell Significance Index: -0.7600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0307
    Cell Significance Index: -0.4100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0308
    Cell Significance Index: -1.0800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0317
    Cell Significance Index: -1.0100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0318
    Cell Significance Index: -0.6200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0327
    Cell Significance Index: -1.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0341
    Cell Significance Index: -1.5100
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0343
    Cell Significance Index: -0.3100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0359
    Cell Significance Index: -0.5300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0389
    Cell Significance Index: -0.4100
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.0389
    Cell Significance Index: -0.3400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0390
    Cell Significance Index: -0.8600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0394
    Cell Significance Index: -1.1300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0395
    Cell Significance Index: -0.8200
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.0396
    Cell Significance Index: -0.2500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0396
    Cell Significance Index: -0.5000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0401
    Cell Significance Index: -1.5200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0402
    Cell Significance Index: -0.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0408
    Cell Significance Index: -2.1200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0420
    Cell Significance Index: -0.5600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0421
    Cell Significance Index: -1.3300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0428
    Cell Significance Index: -0.8700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0429
    Cell Significance Index: -0.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0430
    Cell Significance Index: -2.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CCL25 is a small, four-cysteine-rich chemokine that belongs to the C-C chemokine family. Its expression is tightly regulated in various tissues, including the colon, thymus, and brain. CCL25 is known to interact with its specific receptor, CCR10, which is expressed on the surface of immune cells. This interaction triggers a signaling cascade that modulates the migration and adhesion of immune cells, thereby influencing the inflammatory response. **Pathways and Functions:** The CCL25-CCR10 axis is involved in several key biological processes, including: 1. **Cell chemotaxis**: CCL25 induces the migration of immune cells, such as eosinophils and lymphocytes, towards sites of inflammation. 2. **Cell surface receptor signaling pathway**: The interaction between CCL25 and CCR10 activates a signaling cascade that regulates the expression of genes involved in inflammation and immune response. 3. **Cellular response to cytokines**: CCL25 modulates the response of immune cells to cytokines, such as IL-1β and TNF-α, which are key players in the inflammatory response. 4. **Immune response**: CCL25 plays a crucial role in the regulation of the immune response, particularly in the context of allergic inflammation and autoimmune diseases. **Clinical Significance:** CCL25 has been implicated in various diseases, including: 1. **Atopic dermatitis**: CCL25 is overexpressed in the skin of patients with atopic dermatitis, suggesting its role in the pathogenesis of this disease. 2. **Asthma**: CCL25 has been shown to promote eosinophilic inflammation in the airways, contributing to the pathogenesis of asthma. 3. **Multiple sclerosis**: CCL25 has been implicated in the regulation of immune cell migration and inflammation in the central nervous system, suggesting its role in the pathogenesis of multiple sclerosis. 4. **Cancer**: CCL25 has been shown to promote tumor progression and metastasis in certain types of cancer, highlighting its potential as a therapeutic target. In conclusion, CCL25 is a critical regulator of the immune response and inflammation, and its dysregulation has been implicated in various diseases. Further research into the mechanisms of CCL25 and its interactions with other molecules will provide valuable insights into the development of novel therapeutic strategies for the treatment of these diseases.

Genular Protein ID: 2375826894

Symbol: CCL25_HUMAN

Name: C-C motif chemokine 25

UniProtKB Accession Codes:

O15444 A1L4J4 A6NI52 A8K9E7 B5MCA5 Q96KJ7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 7 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9285413

Title: TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development.

PubMed ID: 9285413

DOI: 10.1016/s1074-7613(00)80531-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10229797

Title: Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK.

PubMed ID: 10229797

PubMed ID: 23341447

Title: Beta-arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR.

PubMed ID: 23341447

DOI: 10.1074/jbc.m112.406108

Sequence Information:

  • Length: 150
  • Mass: 16609
  • Checksum: 91D0810F137FBC7B
  • Sequence:
    • MNLWLLACLV AGFLGAWAPA VHTQGVFEDC CLAYHYPIGW AVLRRAWTYR IQEVSGSCNL 
PAAIFYLPKR HRKVCGNPKS REVQRAMKLL DARNKVFAKL HHNTQTFQAG PHAVKKLSSG 
NSKLSSSKFS NPISSSKRNV SLLISANSGL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.