Details for: PTPRH

Gene ID: 5794

Symbol: PTPRH

Ensembl ID: ENSG00000080031

Description: protein tyrosine phosphatase receptor type H

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 30.2806
    Cell Significance Index: -4.7100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 18.3723
    Cell Significance Index: -4.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 5.9413
    Cell Significance Index: 171.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 4.8847
    Cell Significance Index: 105.8300
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 4.6947
    Cell Significance Index: 35.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.5187
    Cell Significance Index: 121.0800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.1963
    Cell Significance Index: 32.9100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.8179
    Cell Significance Index: -4.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.5730
    Cell Significance Index: 183.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5201
    Cell Significance Index: 68.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1325
    Cell Significance Index: 58.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9138
    Cell Significance Index: 32.1100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6803
    Cell Significance Index: 74.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6738
    Cell Significance Index: 14.3500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.6683
    Cell Significance Index: 11.2400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.6580
    Cell Significance Index: -1.4400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.5736
    Cell Significance Index: 8.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5524
    Cell Significance Index: 109.6200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4280
    Cell Significance Index: 5.8400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4223
    Cell Significance Index: 29.2100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.4212
    Cell Significance Index: 6.1200
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.4011
    Cell Significance Index: 2.6200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3605
    Cell Significance Index: 58.6400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.3186
    Cell Significance Index: 4.4200
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.2897
    Cell Significance Index: 3.1400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2214
    Cell Significance Index: 3.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2144
    Cell Significance Index: 5.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2013
    Cell Significance Index: 19.9100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1268
    Cell Significance Index: 1.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0969
    Cell Significance Index: 6.1100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0963
    Cell Significance Index: 2.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0783
    Cell Significance Index: 14.9100
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.0740
    Cell Significance Index: 0.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0597
    Cell Significance Index: 1.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0496
    Cell Significance Index: 1.5900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0253
    Cell Significance Index: 13.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0214
    Cell Significance Index: 4.2900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.0178
    Cell Significance Index: 0.1800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0136
    Cell Significance Index: 0.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0119
    Cell Significance Index: 2.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0095
    Cell Significance Index: 0.7300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0068
    Cell Significance Index: 0.0700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0047
    Cell Significance Index: 0.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0041
    Cell Significance Index: 0.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0020
    Cell Significance Index: 0.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0019
    Cell Significance Index: 0.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0010
    Cell Significance Index: -1.9000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0015
    Cell Significance Index: -2.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0015
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0021
    Cell Significance Index: -1.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0023
    Cell Significance Index: -3.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0032
    Cell Significance Index: -4.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0033
    Cell Significance Index: -1.2000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0042
    Cell Significance Index: -0.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0056
    Cell Significance Index: -3.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0061
    Cell Significance Index: -4.6200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0062
    Cell Significance Index: -0.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0067
    Cell Significance Index: -4.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0068
    Cell Significance Index: -4.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0079
    Cell Significance Index: -3.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0098
    Cell Significance Index: -1.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0100
    Cell Significance Index: -4.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0105
    Cell Significance Index: -3.0200
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0145
    Cell Significance Index: -0.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0167
    Cell Significance Index: -2.3000
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.0189
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0220
    Cell Significance Index: -4.6300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0244
    Cell Significance Index: -0.3600
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0268
    Cell Significance Index: -0.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0270
    Cell Significance Index: -3.9200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0308
    Cell Significance Index: -1.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0370
    Cell Significance Index: -4.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0384
    Cell Significance Index: -3.9200
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.0388
    Cell Significance Index: -0.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0403
    Cell Significance Index: -1.1300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0426
    Cell Significance Index: -0.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0427
    Cell Significance Index: -4.4500
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0436
    Cell Significance Index: -0.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0441
    Cell Significance Index: -1.2000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0449
    Cell Significance Index: -0.7200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0451
    Cell Significance Index: -0.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0495
    Cell Significance Index: -3.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0561
    Cell Significance Index: -4.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0599
    Cell Significance Index: -4.0300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0690
    Cell Significance Index: -1.0400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0774
    Cell Significance Index: -1.9300
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0776
    Cell Significance Index: -0.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0795
    Cell Significance Index: -5.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0799
    Cell Significance Index: -4.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0818
    Cell Significance Index: -4.5900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0843
    Cell Significance Index: -3.4500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0899
    Cell Significance Index: -3.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0904
    Cell Significance Index: -4.2500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0914
    Cell Significance Index: -2.4500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0950
    Cell Significance Index: -4.9900
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.0956
    Cell Significance Index: -0.3600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0999
    Cell Significance Index: -4.4200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1034
    Cell Significance Index: -1.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1038
    Cell Significance Index: -3.3100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1115
    Cell Significance Index: -3.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane Localization**: PTPRH is a transmembrane receptor tyrosine phosphatase, with its extracellular domain interacting with ligands and its intracellular domain possessing phosphatase activity. 2. **Phosphatase Activity**: PTPRH's phosphatase activity is essential for dephosphorylating tyrosine residues on its ligands, thereby regulating their activity and modulating downstream signaling pathways. 3. **Ligand Binding**: PTPRH binds to various ligands, including proteins and growth factors, which triggers its phosphatase activity and subsequent signaling cascades. 4. **Cellular Expression**: PTPRH is expressed in a wide range of cell types, including immune cells, epithelial cells, neurons, and progenitor cells, highlighting its broad functional significance. **Pathways and Functions:** 1. **Apoptotic Process**: PTPRH's phosphatase activity regulates the activity of pro-apoptotic proteins, thereby influencing cell survival and apoptosis. 2. **Cytoskeleton Reorganization**: PTPRH's signaling pathways are involved in cytoskeleton reorganization, which is crucial for cellular migration, adhesion, and differentiation. 3. **Cell Signaling**: PTPRH's phosphatase activity modulates the activity of various signaling molecules, including growth factors, cytokines, and receptors, thereby influencing cellular responses to stimuli. 4. **Immune Regulation**: PTPRH's expression in immune cells and its involvement in immune-related signaling pathways highlight its role in regulating immune responses and maintaining immune homeostasis. **Clinical Significance:** 1. **Cancer Association**: Alterations in PTPRH expression and function have been linked to various cancers, including colorectal, breast, and prostate cancer, underscoring its potential as a therapeutic target. 2. **Neurological Disorders**: PTPRH's involvement in neuronal signaling and synaptic plasticity suggests its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Immune-Mediated Diseases**: PTPRH's expression in immune cells and its involvement in immune-related signaling pathways highlight its potential role in immune-mediated diseases, such as autoimmune disorders and inflammatory conditions. In conclusion, PTPRH is a multifunctional enzyme that plays a critical role in regulating various cellular processes, including immune responses, cell signaling, and cellular differentiation. Its widespread expression and involvement in multiple signaling pathways underscore its importance in maintaining tissue homeostasis and overall health. Further research is warranted to fully elucidate the mechanisms by which PTPRH regulates cellular processes and to explore its potential as a therapeutic target in various diseases.

Genular Protein ID: 465090527

Symbol: PTPRH_HUMAN

Name: Receptor-type tyrosine-protein phosphatase H

UniProtKB Accession Codes:

Q9HD43 C9JCH2 Q15426 Q2NKN9 Q2NKP0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 4 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 24 Ensembl 2 GO 10 Gene3D 3 GeneCards 1 GeneTree 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 2 Rhea 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8294459

Title: Molecular cloning of a human transmembrane-type protein tyrosine phosphatase and its expression in gastrointestinal cancers.

PubMed ID: 8294459

DOI: 10.1016/s0021-9258(17)42137-5

PubMed ID: 11435690

Title: Gene for the human transmembrane-type protein tyrosine phosphatase H (PTPRH): genomic structure, fine-mapping and its exclusion as a candidate for Peutz-Jeghers syndrome.

PubMed ID: 11435690

DOI: 10.1159/000056905

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11278335

Title: Inhibition of cell growth and spreading by stomach cancer-associated protein-tyrosine phosphatase-1 (SAP-1) through dephosphorylation of p130cas.

PubMed ID: 11278335

DOI: 10.1074/jbc.m007208200

PubMed ID: 12101188

Title: Induction of apoptosis by stomach cancer-associated protein-tyrosine phosphatase-1.

PubMed ID: 12101188

DOI: 10.1074/jbc.m206541200

PubMed ID: 12837766

Title: Interaction of SAP-1, a transmembrane-type protein-tyrosine phosphatase, with the tyrosine kinase Lck. Roles in regulation of T cell function.

PubMed ID: 12837766

DOI: 10.1074/jbc.m300648200

PubMed ID: 12879010

Title: Downregulation of stomach cancer-associated protein tyrosine phosphatase-1 (SAP-1) in advanced human hepatocellular carcinoma.

PubMed ID: 12879010

DOI: 10.1038/sj.onc.1206588

PubMed ID: 15850787

Title: Sap-1/PTPRH activity is regulated by reversible dimerization.

PubMed ID: 15850787

DOI: 10.1016/j.bbrc.2005.03.196

Sequence Information:

  • Length: 1115
  • Mass: 122353
  • Checksum: 4E6C1DF86DCFB26C
  • Sequence:
    • MAGAGGGLGV WGNLVLLGLC SWTGARAPAP NPGRNLTVET QTTSSISLSW EVPDGLDSQN 
SNYWVQCTGD GGTTETRNTT ATNVTVDGLG PGSLYTCSVW VEKDGVNSSV GTVTTATAPN 
PVRNLRVEAQ TNSSIALTWE VPDGPDPQNS TYGVEYTGDG GRAGTRSTAH TNITVDGLEP 
GCLYAFSMWV GKNGINSSRE TRNATTAHNP VRNLRVEAQT TSSISLSWEV PDGTDPQNST 
YCVQCTGDGG RTETRNTTDT RVTVDGLGPG SLYTCSVWVE KDGVNSSVEI VTSATAPNPV 
RNLTVEAQTN SSIALTWEVP DGPDPQNSTY GVEYTGDGGR AGTRSTAHTN ITVDRLEPGC 
LYVFSVWVGK NGINSSRETR NATTAPNPVR NLHMETQTNS SIALCWEVPD GPYPQDYTYW 
VEYTGDGGGT ETRNTTNTSV TAERLEPGTL YTFSVWAEKN GARGSRQNVS ISTVPNAVTS 
LSKQDWTNST IALRWTAPQG PGQSSYSYWV SWVREGMTDP RTQSTSGTDI TLKELEAGSL 
YHLTVWAERN EVRGYNSTLT AATAPNEVTD LQNETQTKNS VMLWWKAPGD PHSQLYVYWV 
QWASKGHPRR GQDPQANWVN QTSRTNETWY KVEALEPGTL YNFTVWAERN DVASSTQSLC 
ASTYPDTVTI TSCVSTSAGY GVNLIWSCPQ GGYEAFELEV GGQRGSQDRS SCGEAVSVLG 
LGPARSYPAT ITTIWDGMKV VSHSVVCHTE SAGVIAGAFV GILLFLILVG LLIFFLKRRN 
KKKQQKPELR DLVFSSPGDI PAEDFADHVR KNERDSNCGF ADEYQQLSLV GHSQSQMVAS 
ASENNAKNRY RNVLPYDWSR VPLKPIHEEP GSDYINASFM PGLWSPQEFI ATQGPLPQTV 
GDFWRLVWEQ QSHTLVMLTN CMEAGRVKCE HYWPLDSQPC THGHLRVTLV GEEVMENWTV 
RELLLLQVEE QKTLSVRQFH YQAWPDHGVP SSPDTLLAFW RMLRQWLDQT MEGGPPIVHC 
SAGVGRTGTL IALDVLLRQL QSEGLLGPFS FVRKMRESRP LMVQTEAQYV FLHQCILRFL 
QQSAQAPAEK EVPYEDVENL IYENVAAIQA HKLEV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.