Details for: GCNT3

Gene ID: 9245

Symbol: GCNT3

Ensembl ID: ENSG00000140297

Description: glucosaminyl (N-acetyl) transferase 3, mucin type

Associated with

  • Metabolism of proteins
    (R-HSA-392499)
  • O-linked glycosylation
    (R-HSA-5173105)
  • O-linked glycosylation of mucins
    (R-HSA-913709)
  • Post-translational protein modification
    (R-HSA-597592)
  • Acetylgalactosaminyl-o-glycosyl-seryl-glycoprotein beta-1,6-n-acetylglucosaminyltransferase activity
    (GO:0106325)
  • Acetylgalactosaminyl-o-glycosyl-threonyl-glycoprotein beta-1,6-n-acetylglucosaminyltransferase activity
    (GO:0106326)
  • Acetylglucosaminyltransferase activity
    (GO:0008375)
  • Beta-1,3-galactosyl-o-glycosyl-glycoprotein beta-1,6-n-acetylglucosaminyltransferase activity
    (GO:0003829)
  • Carbohydrate metabolic process
    (GO:0005975)
  • Extracellular exosome
    (GO:0070062)
  • Golgi membrane
    (GO:0000139)
  • Intestinal absorption
    (GO:0050892)
  • Kidney morphogenesis
    (GO:0060993)
  • Membrane
    (GO:0016020)
  • N-acetyllactosaminide beta-1,6-n-acetylglucosaminyltransferase activity
    (GO:0008109)
  • O-glycan processing
    (GO:0016266)
  • Protein o-linked glycosylation
    (GO:0006493)
  • Tissue morphogenesis
    (GO:0048729)

Other Information

Genular Protein ID: 2129151345

Symbol: GCNT3_HUMAN

Name: Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3

UniProtKB Accession Codes:

O95395

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CTD 1 ChEBI 25 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 5 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 14 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 13 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9915862

Title: Molecular cloning and expression of a novel beta-1, 6-N-acetylglucosaminyltransferase that forms core 2, core 4, and I branches.

PubMed ID: 9915862

DOI: 10.1074/jbc.274.5.3215

PubMed ID: 9988682

Title: Control of O-glycan branch formation. Molecular cloning of human cDNA encoding a novel beta1,6-N-acetylglucosaminyltransferase forming core 2 and core 4.

PubMed ID: 9988682

DOI: 10.1074/jbc.274.8.4504

PubMed ID: 17303715

Title: Mucin biosynthesis: identification of the cis-regulatory elements of human C2GnT-M gene.

PubMed ID: 17303715

DOI: 10.1165/rcmb.2006-0334oc

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15864435

Title: Regulation of sialyl-Lewis x epitope expression by TNF-alpha and EGF in an airway carcinoma cell line.

PubMed ID: 15864435

DOI: 10.1007/s10719-005-0292-7

PubMed ID: 16418723

Title: C2GnT-M is downregulated in colorectal cancer and its re-expression causes growth inhibition of colon cancer cells.

PubMed ID: 16418723

DOI: 10.1038/sj.onc.1209350

Sequence Information:

  • Length: 438
  • Mass: 50864
  • Checksum: 1FF0A7B451C88407
  • Sequence:
    • MVQWKRLCQL HYLWALGCYM LLATVALKLS FRLKCDSDHL GLESRESQSQ YCRNILYNFL 
KLPAKRSINC SGVTRGDQEA VLQAILNNLE VKKKREPFTD THYLSLTRDC EHFKAERKFI 
QFPLSKEEVE FPIAYSMVIH EKIENFERLL RAVYAPQNIY CVHVDEKSPE TFKEAVKAII 
SCFPNVFIAS KLVRVVYASW SRVQADLNCM EDLLQSSVPW KYFLNTCGTD FPIKSNAEMV 
QALKMLNGRN SMESEVPPKH KETRWKYHFE VVRDTLHLTN KKKDPPPYNL TMFTGNAYIV 
ASRDFVQHVL KNPKSQQLIE WVKDTYSPDE HLWATLQRAR WMPGSVPNHP KYDISDMTSI 
ARLVKWQGHE GDIDKGAPYA PCSGIHQRAI CVYGAGDLNW MLQNHHLLAN KFDPKVDDNA 
LQCLEEYLRY KAIYGTEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.