Details for: RBP2

Gene ID: 5948

Symbol: RBP2

Ensembl ID: ENSG00000114113

Description: retinol binding protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: precursor cell (CL0011115)
    Fold Change: 62.0808
    Cell Significance Index: 470.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 14.3295
    Cell Significance Index: 412.8600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 11.5436
    Cell Significance Index: -5.4500
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 6.1965
    Cell Significance Index: 62.5100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 4.9010
    Cell Significance Index: 73.4400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.4483
    Cell Significance Index: 307.6300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.6133
    Cell Significance Index: 156.8900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 2.2308
    Cell Significance Index: 47.5100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.1024
    Cell Significance Index: 207.9700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.9799
    Cell Significance Index: 215.3600
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.8142
    Cell Significance Index: 4.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.7798
    Cell Significance Index: 38.5600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.6218
    Cell Significance Index: 1464.3400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.6750
    Cell Significance Index: 21.3500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5587
    Cell Significance Index: 110.8700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4661
    Cell Significance Index: 75.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3740
    Cell Significance Index: 71.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3157
    Cell Significance Index: 11.1000
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: 0.2667
    Cell Significance Index: 1.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1599
    Cell Significance Index: 9.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1354
    Cell Significance Index: 7.6000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1204
    Cell Significance Index: 1.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1058
    Cell Significance Index: 4.6800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0996
    Cell Significance Index: 3.7700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0798
    Cell Significance Index: 16.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0739
    Cell Significance Index: 113.7000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0667
    Cell Significance Index: 0.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0639
    Cell Significance Index: 117.8100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0542
    Cell Significance Index: 1.3000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0496
    Cell Significance Index: 67.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0462
    Cell Significance Index: 3.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0278
    Cell Significance Index: 52.2500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0241
    Cell Significance Index: 0.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0216
    Cell Significance Index: 7.7400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0178
    Cell Significance Index: 0.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0136
    Cell Significance Index: 1.3900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0128
    Cell Significance Index: 0.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0113
    Cell Significance Index: 1.6400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0113
    Cell Significance Index: 4.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0008
    Cell Significance Index: -0.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0022
    Cell Significance Index: -0.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0044
    Cell Significance Index: -1.9900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0057
    Cell Significance Index: -4.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0074
    Cell Significance Index: -5.6200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0084
    Cell Significance Index: -0.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0087
    Cell Significance Index: -4.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0102
    Cell Significance Index: -5.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0106
    Cell Significance Index: -7.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0131
    Cell Significance Index: -3.7600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0146
    Cell Significance Index: -0.3700
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0161
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0190
    Cell Significance Index: -3.2400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0246
    Cell Significance Index: -0.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0261
    Cell Significance Index: -5.5000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0292
    Cell Significance Index: -3.3400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0293
    Cell Significance Index: -0.7100
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0358
    Cell Significance Index: -0.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0360
    Cell Significance Index: -4.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0368
    Cell Significance Index: -5.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0411
    Cell Significance Index: -2.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0416
    Cell Significance Index: -2.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0431
    Cell Significance Index: -4.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0455
    Cell Significance Index: -5.5900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0556
    Cell Significance Index: -2.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0566
    Cell Significance Index: -3.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0637
    Cell Significance Index: -8.2400
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.0647
    Cell Significance Index: -0.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0697
    Cell Significance Index: -3.2500
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0698
    Cell Significance Index: -0.5700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0717
    Cell Significance Index: -1.0200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0846
    Cell Significance Index: -1.4500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0854
    Cell Significance Index: -1.6700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0863
    Cell Significance Index: -1.4500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0881
    Cell Significance Index: -1.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0964
    Cell Significance Index: -2.7000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0979
    Cell Significance Index: -7.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1067
    Cell Significance Index: -7.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1081
    Cell Significance Index: -5.0800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1142
    Cell Significance Index: -1.6400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1199
    Cell Significance Index: -1.7700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1206
    Cell Significance Index: -3.9500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1327
    Cell Significance Index: -1.8200
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.1335
    Cell Significance Index: -1.1500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1349
    Cell Significance Index: -1.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1353
    Cell Significance Index: -4.3100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1404
    Cell Significance Index: -5.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1415
    Cell Significance Index: -1.9300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1416
    Cell Significance Index: -4.9600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1431
    Cell Significance Index: -3.8400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1444
    Cell Significance Index: -3.0700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1483
    Cell Significance Index: -1.8400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1547
    Cell Significance Index: -3.2100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1562
    Cell Significance Index: -3.2700
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: -0.1608
    Cell Significance Index: -1.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1614
    Cell Significance Index: -4.3100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1627
    Cell Significance Index: -3.9700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1636
    Cell Significance Index: -2.0400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1687
    Cell Significance Index: -2.4900
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.1733
    Cell Significance Index: -1.2600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1794
    Cell Significance Index: -5.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RBP2 is a small, secreted protein primarily expressed in the liver, retina, and enterocytes. Its primary function is to bind and transport retinoids, including retinal, retinyl esters, and retinoids, facilitating their metabolism and distribution to target tissues. RBP2 is structurally distinct from its well-known homolog, RBP1, and exhibits a unique binding specificity for retinoids. The protein is synthesized as a precursor, which undergoes post-translational modifications, including glycosylation and phosphorylation, to form the mature RBP2 protein. **Pathways and Functions:** RBP2 plays a pivotal role in the retinoid metabolism and transport pathways, which are critical for maintaining retinoid homeostasis. The protein is involved in the following key pathways: 1. **Retinoid metabolism and transport:** RBP2 facilitates the transport of retinoids from the liver to peripheral tissues, where they are metabolized by specific enzymes, such as retinaldehyde dehydrogenase (RALDH). 2. **Visual phototransduction:** RBP2 is expressed in the retina, where it plays a crucial role in the visual cycle, facilitating the transport of retinoids from photoreceptors to the retinal pigment epithelium (RPE). 3. **Fatty acid binding and transport:** RBP2 has been shown to interact with fatty acid-binding proteins (FABPs), facilitating the transport of fatty acids across cell membranes. 4. **Metabolism of fat-soluble vitamins:** RBP2 is involved in the metabolism of fat-soluble vitamins, including vitamins A, D, E, and K. **Clinical Significance:** Dysregulation of RBP2 has been implicated in various human diseases, including: 1. **Retinal disorders:** Abnormalities in RBP2 expression have been linked to retinal disorders, such as retinitis pigmentosa and age-related macular degeneration. 2. **Visual impairment:** Impaired RBP2 function has been associated with visual impairment, including reduced visual acuity and increased risk of age-related macular degeneration. 3. **Metabolic disorders:** RBP2 has been implicated in the regulation of lipid metabolism, and dysregulation of the protein has been linked to metabolic disorders, such as obesity and type 2 diabetes. 4. **Cancer:** RBP2 has been shown to play a role in cancer development and progression, particularly in the context of vitamin A metabolism and retinoid signaling. In conclusion, RBP2 is a vital protein involved in the regulation of retinoid metabolism and transport, with significant implications for visual function and human health. Further research is necessary to fully elucidate the mechanisms of RBP2 function and its role in disease pathogenesis, with the ultimate goal of developing novel therapeutic strategies for the treatment of retinoid-related disorders.

Genular Protein ID: 2579544032

Symbol: RET2_HUMAN

Name: Retinol-binding protein 2

UniProtKB Accession Codes:

P50120 A8K7G3 Q6ISQ9 Q6ISS7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 2 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 10 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 85 PDBsum 85 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7657783

Title: Variation in the expression of cellular retinoid binding proteins in human endometrium throughout the menstrual cycle.

PubMed ID: 7657783

DOI: 10.1093/oxfordjournals.humrep.a136137

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11274389

Title: Identification, retinoid binding and X-ray analysis of a human retinol-binding protein.

PubMed ID: 11274389

DOI: 10.1073/pnas.061455898

PubMed ID: 18076076

Title: Crystal structure of human cellular retinol-binding protein II to 1.2 A resolution.

PubMed ID: 18076076

DOI: 10.1002/prot.21848

Sequence Information:

  • Length: 134
  • Mass: 15707
  • Checksum: A4A7FB157B099A7D
  • Sequence:
    • MTRDQNGTWE MESNENFEGY MKALDIDFAT RKIAVRLTQT KVIDQDGDNF KTKTTSTFRN 
YDVDFTVGVE FDEYTKSLDN RHVKALVTWE GDVLVCVQKG EKENRGWKQW IEGDKLYLEL 
TCGDQVCRQV FKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.