Details for: LCT

Gene ID: 3938

Symbol: LCT

Ensembl ID: ENSG00000115850

Description: lactase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 6.7417
    Cell Significance Index: -1.7100
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 4.8286
    Cell Significance Index: 36.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.4672
    Cell Significance Index: 71.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.2813
    Cell Significance Index: 434.1400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.2567
    Cell Significance Index: 40.2500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2531
    Cell Significance Index: 123.9600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0669
    Cell Significance Index: 963.3600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.9148
    Cell Significance Index: 13.1000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7578
    Cell Significance Index: 82.4300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7091
    Cell Significance Index: 42.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6453
    Cell Significance Index: 13.9800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5104
    Cell Significance Index: 10.8700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5078
    Cell Significance Index: 35.1200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.3856
    Cell Significance Index: 9.8500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3360
    Cell Significance Index: 6.9700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2570
    Cell Significance Index: 2.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1699
    Cell Significance Index: 27.6400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1473
    Cell Significance Index: 2.2200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1176
    Cell Significance Index: 2.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0783
    Cell Significance Index: 2.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0308
    Cell Significance Index: 0.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0242
    Cell Significance Index: 4.3600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0232
    Cell Significance Index: 16.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0196
    Cell Significance Index: 0.8900
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.0129
    Cell Significance Index: 0.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0128
    Cell Significance Index: 2.5600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0101
    Cell Significance Index: 1.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0089
    Cell Significance Index: 1.7700
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.0085
    Cell Significance Index: 0.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0004
    Cell Significance Index: 0.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0004
    Cell Significance Index: -0.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0004
    Cell Significance Index: -0.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0007
    Cell Significance Index: -1.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0009
    Cell Significance Index: -1.2300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0029
    Cell Significance Index: -0.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0031
    Cell Significance Index: -0.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0033
    Cell Significance Index: -0.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0034
    Cell Significance Index: -2.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0034
    Cell Significance Index: -2.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0034
    Cell Significance Index: -1.8700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0035
    Cell Significance Index: -2.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0037
    Cell Significance Index: -0.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0041
    Cell Significance Index: -1.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0042
    Cell Significance Index: -2.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0046
    Cell Significance Index: -2.1000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0081
    Cell Significance Index: -0.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0121
    Cell Significance Index: -2.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0126
    Cell Significance Index: -1.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0141
    Cell Significance Index: -1.9300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0148
    Cell Significance Index: -0.7000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0156
    Cell Significance Index: -0.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0168
    Cell Significance Index: -2.0600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0176
    Cell Significance Index: -2.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0179
    Cell Significance Index: -0.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0199
    Cell Significance Index: -2.0700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0213
    Cell Significance Index: -0.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0268
    Cell Significance Index: -1.3900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0268
    Cell Significance Index: -0.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0272
    Cell Significance Index: -2.0900
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0274
    Cell Significance Index: -0.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0284
    Cell Significance Index: -1.9100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0285
    Cell Significance Index: -2.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0301
    Cell Significance Index: -2.2400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0309
    Cell Significance Index: -0.5200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0310
    Cell Significance Index: -0.7500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0317
    Cell Significance Index: -1.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0333
    Cell Significance Index: -1.8700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0357
    Cell Significance Index: -1.1700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0377
    Cell Significance Index: -1.2000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0410
    Cell Significance Index: -0.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0416
    Cell Significance Index: -2.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0423
    Cell Significance Index: -1.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0459
    Cell Significance Index: -1.7400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0477
    Cell Significance Index: -3.0800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0481
    Cell Significance Index: -1.5200
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0484
    Cell Significance Index: -0.3000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0485
    Cell Significance Index: -0.7100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0495
    Cell Significance Index: -2.5800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0497
    Cell Significance Index: -1.2400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0497
    Cell Significance Index: -1.0400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0505
    Cell Significance Index: -0.8700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0518
    Cell Significance Index: -1.4500
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0543
    Cell Significance Index: -0.6400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0557
    Cell Significance Index: -1.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0558
    Cell Significance Index: -1.5000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0593
    Cell Significance Index: -0.8000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0622
    Cell Significance Index: -1.6600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0625
    Cell Significance Index: -1.3500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0625
    Cell Significance Index: -1.5300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0631
    Cell Significance Index: -1.3400
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0658
    Cell Significance Index: -0.8100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0673
    Cell Significance Index: -1.3700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0713
    Cell Significance Index: -1.4100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0726
    Cell Significance Index: -0.9200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0727
    Cell Significance Index: -1.0600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0730
    Cell Significance Index: -3.6900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0744
    Cell Significance Index: -0.9400
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0744
    Cell Significance Index: -0.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0771
    Cell Significance Index: -2.2100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0772
    Cell Significance Index: -1.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Lactase enzyme**: The LCT gene encodes for the lactase enzyme, a beta-galactosidase that hydrolyzes lactose into glucose and galactose. 2. **Expression in small intestine**: The LCT gene is highly expressed in enterocytes of the small intestine, where it plays a crucial role in lactose digestion and absorption. 3. **Variability in expression**: The LCT gene exhibits variability in expression, leading to lactase non-persistence in some individuals. 4. **Evolutionary significance**: The LCT gene has evolved to allow for the digestion of lactose in humans, a trait that is unique among mammals. **Pathways and Functions:** 1. **Beta-glucosidase activity**: The LCT gene is involved in beta-glucosidase activity, which is essential for the hydrolysis of lactose. 2. **Cellobiose catabolic process**: The LCT gene is also involved in the catabolic process of cellobiose, a disaccharide sugar found in plant cell walls. 3. **Glycosylceramidase activity**: The LCT gene exhibits glycosylceramidase activity, which is involved in the hydrolysis of glycosylceramides. 4. **Digestion of dietary carbohydrate**: The LCT gene plays a crucial role in the digestion of dietary carbohydrate, particularly lactose. **Clinical Significance:** 1. **Lactase non-persistence**: Variations in the LCT gene have been associated with lactase non-persistence, a condition where individuals lose the ability to digest lactose after weaning. 2. **Gastrointestinal disorders**: Abnormalities in the LCT gene have been linked to gastrointestinal disorders, such as lactose intolerance and irritable bowel syndrome. 3. **Nutritional implications**: The LCT gene has significant implications for nutritional health, particularly for individuals who consume dairy products. 4. **Evolutionary medicine**: The LCT gene provides insights into the evolutionary history of humans and our ability to digest lactose. In conclusion, the LCT gene plays a crucial role in the digestion and metabolism of lactose, and its variability in expression has significant implications for human health and nutrition. Further research on the LCT gene will provide valuable insights into the complex relationships between carbohydrate digestion, metabolism, and disease.

Genular Protein ID: 3402442830

Symbol: LPH_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2460343

Title: Complete primary structure of human and rabbit lactase-phlorizin hydrolase: implications for biosynthesis, membrane anchoring and evolution of the enzyme.

PubMed ID: 2460343

DOI: 10.1002/j.1460-2075.1988.tb03124.x

PubMed ID: 1902057

Title: Structure of the chromosomal gene and cDNAs coding for lactase-phlorizin hydrolase in humans with adult-type hypolactasia or persistence of lactase.

PubMed ID: 1902057

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 3929764

Title: Human lactase and the molecular basis of lactase persistence.

PubMed ID: 3929764

DOI: 10.1007/bf00499084

PubMed ID: 9762914

Title: Intestinal lactase-phlorizin hydrolase (LPH): the two catalytic sites; the role of the pancreas in pro-LPH maturation.

PubMed ID: 9762914

DOI: 10.1016/s0014-5793(98)01076-x

PubMed ID: 9593732

Title: Protein domains implicated in intracellular transport and sorting of lactase-phlorizin hydrolase.

PubMed ID: 9593732

DOI: 10.1074/jbc.273.22.13861

PubMed ID: 11788828

Title: Identification of a variant associated with adult-type hypolactasia.

PubMed ID: 11788828

DOI: 10.1038/ng826

PubMed ID: 12594539

Title: Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans.

PubMed ID: 12594539

DOI: 10.1007/s00394-003-0397-3

PubMed ID: 16400612

Title: Mutations in the translated region of the lactase gene (LCT) underlie congenital lactase deficiency.

PubMed ID: 16400612

DOI: 10.1086/500053

Sequence Information:

  • Length: 1927
  • Mass: 218587
  • Checksum: 2FCD55CB47BBA35A
  • Sequence:
  • MELSWHVVFI ALLSFSCWGS DWESDRNFIS TAGPLTNDLL HNLSGLLGDQ SSNFVAGDKD 
    MYVCHQPLPT FLPEYFSSLH ASQITHYKVF LSWAQLLPAG STQNPDEKTV QCYRRLLKAL 
    KTARLQPMVI LHHQTLPAST LRRTEAFADL FADYATFAFH SFGDLVGIWF TFSDLEEVIK 
    ELPHQESRAS QLQTLSDAHR KAYEIYHESY AFQGGKLSVV LRAEDIPELL LEPPISALAQ 
    DTVDFLSLDL SYECQNEASL RQKLSKLQTI EPKVKVFIFN LKLPDCPSTM KNPASLLFSL 
    FEAINKDQVL TIGFDINEFL SCSSSSKKSM SCSLTGSLAL QPDQQQDHET TDSSPASAYQ 
    RIWEAFANQS RAERDAFLQD TFPEGFLWGA STGAFNVEGG WAEGGRGVSI WDPRRPLNTT 
    EGQATLEVAS DSYHKVASDV ALLCGLRAQV YKFSISWSRI FPMGHGSSPS LPGVAYYNKL 
    IDRLQDAGIE PMATLFHWDL PQALQDHGGW QNESVVDAFL DYAAFCFSTF GDRVKLWVTF 
    HEPWVMSYAG YGTGQHPPGI SDPGVASFKV AHLVLKAHAR TWHHYNSHHR PQQQGHVGIV 
    LNSDWAEPLS PERPEDLRAS ERFLHFMLGW FAHPVFVDGD YPATLRTQIQ QMNRQCSHPV 
    AQLPEFTEAE KQLLKGSADF LGLSHYTSRL ISNAPQNTCI PSYDTIGGFS QHVNHVWPQT 
    SSSWIRVVPW GIRRLLQFVS LEYTRGKVPI YLAGNGMPIG ESENLFDDSL RVDYFNQYIN 
    EVLKAIKEDS VDVRSYIARS LIDGFEGPSG YSQRFGLHHV NFSDSSKSRT PRKSAYFFTS 
    IIEKNGFLTK GAKRLLPPNT VNLPSKVRAF TFPSEVPSKA KVVWEKFSSQ PKFERDLFYH 
    GTFRDDFLWG VSSSAYQIEG AWDADGKGPS IWDNFTHTPG SNVKDNATGD IACDSYHQLD 
    ADLNMLRALK VKAYRFSISW SRIFPTGRNS SINSHGVDYY NRLINGLVAS NIFPMVTLFH 
    WDLPQALQDI GGWENPALID LFDSYADFCF QTFGDRVKFW MTFNEPMYLA WLGYGSGEFP 
    PGVKDPGWAP YRIAHAVIKA HARVYHTYDE KYRQEQKGVI SLSLSTHWAE PKSPGVPRDV 
    EAADRMLQFS LGWFAHPIFR NGDYPDTMKW KVGNRSELQH LATSRLPSFT EEEKRFIRAT 
    ADVFCLNTYY SRIVQHKTPR LNPPSYEDDQ EMAEEEDPSW PSTAMNRAAP WGTRRLLNWI 
    KEEYGDIPIY ITENGVGLTN PNTEDTDRIF YHKTYINEAL KAYRLDGIDL RGYVAWSLMD 
    NFEWLNGYTV KFGLYHVDFN NTNRPRTARA SARYYTEVIT NNGMPLARED EFLYGRFPEG 
    FIWSAASAAY QIEGAWRADG KGLSIWDTFS HTPLRVENDA IGDVACDSYH KIAEDLVTLQ 
    NLGVSHYRFS ISWSRILPDG TTRYINEAGL NYYVRLIDTL LAASIQPQVT IYHWDLPQTL 
    QDVGGWENET IVQRFKEYAD VLFQRLGDKV KFWITLNEPF VIAYQGYGYG TAAPGVSNRP 
    GTAPYIVGHN LIKAHAEAWH LYNDVYRASQ GGVISITISS DWAEPRDPSN QEDVEAARRY 
    VQFMGGWFAH PIFKNGDYNE VMKTRIRDRS LAAGLNKSRL PEFTESEKRR INGTYDFFGF 
    NHYTTVLAYN LNYATAISSF DADRGVASIA DRSWPDSGSF WLKMTPFGFR RILNWLKEEY 
    NDPPIYVTEN GVSQREETDL NDTARIYYLR TYINEALKAV QDKVDLRGYT VWSAMDNFEW 
    ATGFSERFGL HFVNYSDPSL PRIPKASAKF YASVVRCNGF PDPATGPHAC LHQPDAGPTI 
    SPVRQEEVQF LGLMLGTTEA QTALYVLFSL VLLGVCGLAF LSYKYCKRSK QGKTQRSQQE 
    LSPVSSF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.