Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 6.7417
Cell Significance Index: -1.7100 - Cell Name: precursor cell (CL0011115)
Fold Change: 4.8286
Cell Significance Index: 36.6200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 2.4672
Cell Significance Index: 71.0900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 2.2813
Cell Significance Index: 434.1400 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.2567
Cell Significance Index: 40.2500 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.2531
Cell Significance Index: 123.9600 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.0669
Cell Significance Index: 963.3600 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.9148
Cell Significance Index: 13.1000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7578
Cell Significance Index: 82.4300 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.7091
Cell Significance Index: 42.5700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.6453
Cell Significance Index: 13.9800 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.5104
Cell Significance Index: 10.8700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.5078
Cell Significance Index: 35.1200 - Cell Name: pro-T cell (CL0000827)
Fold Change: 0.3856
Cell Significance Index: 9.8500 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.3360
Cell Significance Index: 6.9700 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.2570
Cell Significance Index: 2.6600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1699
Cell Significance Index: 27.6400 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.1473
Cell Significance Index: 2.2200 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.1176
Cell Significance Index: 2.0200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0783
Cell Significance Index: 2.7500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0308
Cell Significance Index: 0.7700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0242
Cell Significance Index: 4.3600 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0232
Cell Significance Index: 16.0700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0196
Cell Significance Index: 0.8900 - Cell Name: colonocyte (CL1000347)
Fold Change: 0.0129
Cell Significance Index: 0.0800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0128
Cell Significance Index: 2.5600 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.0101
Cell Significance Index: 1.3000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0089
Cell Significance Index: 1.7700 - Cell Name: tendon cell (CL0000388)
Fold Change: 0.0085
Cell Significance Index: 0.1200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0004
Cell Significance Index: 0.8000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0004
Cell Significance Index: -0.1400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0004
Cell Significance Index: -0.7300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0007
Cell Significance Index: -1.0900 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0009
Cell Significance Index: -1.2300 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.0029
Cell Significance Index: -0.0400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0031
Cell Significance Index: -0.4600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0033
Cell Significance Index: -0.2000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0034
Cell Significance Index: -2.1900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0034
Cell Significance Index: -2.5000 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0034
Cell Significance Index: -1.8700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0035
Cell Significance Index: -2.6400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0037
Cell Significance Index: -0.6300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0041
Cell Significance Index: -1.1800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0042
Cell Significance Index: -2.3700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0046
Cell Significance Index: -2.1000 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.0081
Cell Significance Index: -0.1200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0121
Cell Significance Index: -2.5500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0126
Cell Significance Index: -1.4400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0141
Cell Significance Index: -1.9300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0148
Cell Significance Index: -0.7000 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.0156
Cell Significance Index: -0.1900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0168
Cell Significance Index: -2.0600 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0176
Cell Significance Index: -2.0800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0179
Cell Significance Index: -0.8400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0199
Cell Significance Index: -2.0700 - Cell Name: proerythroblast (CL0000547)
Fold Change: -0.0213
Cell Significance Index: -0.3100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0268
Cell Significance Index: -1.3900 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0268
Cell Significance Index: -0.6900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0272
Cell Significance Index: -2.0900 - Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.0274
Cell Significance Index: -0.3100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0284
Cell Significance Index: -1.9100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0285
Cell Significance Index: -2.9100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0301
Cell Significance Index: -2.2400 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.0309
Cell Significance Index: -0.5200 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0310
Cell Significance Index: -0.7500 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0317
Cell Significance Index: -1.1100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0333
Cell Significance Index: -1.8700 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0357
Cell Significance Index: -1.1700 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0377
Cell Significance Index: -1.2000 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0410
Cell Significance Index: -0.8000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0416
Cell Significance Index: -2.5600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0423
Cell Significance Index: -1.8700 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0459
Cell Significance Index: -1.7400 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0477
Cell Significance Index: -3.0800 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.0481
Cell Significance Index: -1.5200 - Cell Name: enterocyte (CL0000584)
Fold Change: -0.0484
Cell Significance Index: -0.3000 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.0485
Cell Significance Index: -0.7100 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0495
Cell Significance Index: -2.5800 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0497
Cell Significance Index: -1.2400 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0497
Cell Significance Index: -1.0400 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0505
Cell Significance Index: -0.8700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0518
Cell Significance Index: -1.4500 - Cell Name: ependymal cell (CL0000065)
Fold Change: -0.0543
Cell Significance Index: -0.6400 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0557
Cell Significance Index: -1.5900 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0558
Cell Significance Index: -1.5000 - Cell Name: medium spiny neuron (CL1001474)
Fold Change: -0.0593
Cell Significance Index: -0.8000 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0622
Cell Significance Index: -1.6600 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0625
Cell Significance Index: -1.3500 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.0625
Cell Significance Index: -1.5300 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0631
Cell Significance Index: -1.3400 - Cell Name: neuroplacodal cell (CL0000032)
Fold Change: -0.0658
Cell Significance Index: -0.8100 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.0673
Cell Significance Index: -1.3700 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0713
Cell Significance Index: -1.4100 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.0726
Cell Significance Index: -0.9200 - Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.0727
Cell Significance Index: -1.0600 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0730
Cell Significance Index: -3.6900 - Cell Name: thymocyte (CL0000893)
Fold Change: -0.0744
Cell Significance Index: -0.9400 - Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: -0.0744
Cell Significance Index: -0.6400 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0771
Cell Significance Index: -2.2100 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0772
Cell Significance Index: -1.5500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3402442830
Symbol: LPH_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2460343
Title: Complete primary structure of human and rabbit lactase-phlorizin hydrolase: implications for biosynthesis, membrane anchoring and evolution of the enzyme.
PubMed ID: 2460343
PubMed ID: 1902057
Title: Structure of the chromosomal gene and cDNAs coding for lactase-phlorizin hydrolase in humans with adult-type hypolactasia or persistence of lactase.
PubMed ID: 1902057
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 3929764
Title: Human lactase and the molecular basis of lactase persistence.
PubMed ID: 3929764
DOI: 10.1007/bf00499084
PubMed ID: 9762914
Title: Intestinal lactase-phlorizin hydrolase (LPH): the two catalytic sites; the role of the pancreas in pro-LPH maturation.
PubMed ID: 9762914
PubMed ID: 9593732
Title: Protein domains implicated in intracellular transport and sorting of lactase-phlorizin hydrolase.
PubMed ID: 9593732
PubMed ID: 11788828
Title: Identification of a variant associated with adult-type hypolactasia.
PubMed ID: 11788828
DOI: 10.1038/ng826
PubMed ID: 12594539
Title: Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans.
PubMed ID: 12594539
PubMed ID: 16400612
Title: Mutations in the translated region of the lactase gene (LCT) underlie congenital lactase deficiency.
PubMed ID: 16400612
DOI: 10.1086/500053
Sequence Information:
- Length: 1927
- Mass: 218587
- Checksum: 2FCD55CB47BBA35A
- Sequence:
MELSWHVVFI ALLSFSCWGS DWESDRNFIS TAGPLTNDLL HNLSGLLGDQ SSNFVAGDKD MYVCHQPLPT FLPEYFSSLH ASQITHYKVF LSWAQLLPAG STQNPDEKTV QCYRRLLKAL KTARLQPMVI LHHQTLPAST LRRTEAFADL FADYATFAFH SFGDLVGIWF TFSDLEEVIK ELPHQESRAS QLQTLSDAHR KAYEIYHESY AFQGGKLSVV LRAEDIPELL LEPPISALAQ DTVDFLSLDL SYECQNEASL RQKLSKLQTI EPKVKVFIFN LKLPDCPSTM KNPASLLFSL FEAINKDQVL TIGFDINEFL SCSSSSKKSM SCSLTGSLAL QPDQQQDHET TDSSPASAYQ RIWEAFANQS RAERDAFLQD TFPEGFLWGA STGAFNVEGG WAEGGRGVSI WDPRRPLNTT EGQATLEVAS DSYHKVASDV ALLCGLRAQV YKFSISWSRI FPMGHGSSPS LPGVAYYNKL IDRLQDAGIE PMATLFHWDL PQALQDHGGW QNESVVDAFL DYAAFCFSTF GDRVKLWVTF HEPWVMSYAG YGTGQHPPGI SDPGVASFKV AHLVLKAHAR TWHHYNSHHR PQQQGHVGIV LNSDWAEPLS PERPEDLRAS ERFLHFMLGW FAHPVFVDGD YPATLRTQIQ QMNRQCSHPV AQLPEFTEAE KQLLKGSADF LGLSHYTSRL ISNAPQNTCI PSYDTIGGFS QHVNHVWPQT SSSWIRVVPW GIRRLLQFVS LEYTRGKVPI YLAGNGMPIG ESENLFDDSL RVDYFNQYIN EVLKAIKEDS VDVRSYIARS LIDGFEGPSG YSQRFGLHHV NFSDSSKSRT PRKSAYFFTS IIEKNGFLTK GAKRLLPPNT VNLPSKVRAF TFPSEVPSKA KVVWEKFSSQ PKFERDLFYH GTFRDDFLWG VSSSAYQIEG AWDADGKGPS IWDNFTHTPG SNVKDNATGD IACDSYHQLD ADLNMLRALK VKAYRFSISW SRIFPTGRNS SINSHGVDYY NRLINGLVAS NIFPMVTLFH WDLPQALQDI GGWENPALID LFDSYADFCF QTFGDRVKFW MTFNEPMYLA WLGYGSGEFP PGVKDPGWAP YRIAHAVIKA HARVYHTYDE KYRQEQKGVI SLSLSTHWAE PKSPGVPRDV EAADRMLQFS LGWFAHPIFR NGDYPDTMKW KVGNRSELQH LATSRLPSFT EEEKRFIRAT ADVFCLNTYY SRIVQHKTPR LNPPSYEDDQ EMAEEEDPSW PSTAMNRAAP WGTRRLLNWI KEEYGDIPIY ITENGVGLTN PNTEDTDRIF YHKTYINEAL KAYRLDGIDL RGYVAWSLMD NFEWLNGYTV KFGLYHVDFN NTNRPRTARA SARYYTEVIT NNGMPLARED EFLYGRFPEG FIWSAASAAY QIEGAWRADG KGLSIWDTFS HTPLRVENDA IGDVACDSYH KIAEDLVTLQ NLGVSHYRFS ISWSRILPDG TTRYINEAGL NYYVRLIDTL LAASIQPQVT IYHWDLPQTL QDVGGWENET IVQRFKEYAD VLFQRLGDKV KFWITLNEPF VIAYQGYGYG TAAPGVSNRP GTAPYIVGHN LIKAHAEAWH LYNDVYRASQ GGVISITISS DWAEPRDPSN QEDVEAARRY VQFMGGWFAH PIFKNGDYNE VMKTRIRDRS LAAGLNKSRL PEFTESEKRR INGTYDFFGF NHYTTVLAYN LNYATAISSF DADRGVASIA DRSWPDSGSF WLKMTPFGFR RILNWLKEEY NDPPIYVTEN GVSQREETDL NDTARIYYLR TYINEALKAV QDKVDLRGYT VWSAMDNFEW ATGFSERFGL HFVNYSDPSL PRIPKASAKF YASVVRCNGF PDPATGPHAC LHQPDAGPTI SPVRQEEVQF LGLMLGTTEA QTALYVLFSL VLLGVCGLAF LSYKYCKRSK QGKTQRSQQE LSPVSSF
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.