Details for: LCT

Gene ID: 3938

Symbol: LCT

Ensembl ID: ENSG00000115850

Description: lactase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 3.45
    Marker Score: 5317
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.09
    Marker Score: 2105
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1173
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.37
    Marker Score: 2687
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.01
    Marker Score: 2084
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48056
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5344
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.83
    Marker Score: 483
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.79
    Marker Score: 1506
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 697
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 300
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.69
    Marker Score: 167
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2756
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.64
    Marker Score: 363
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 374
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 461
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.54
    Marker Score: 8456
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.53
    Marker Score: 531
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.51
    Marker Score: 530
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.5
    Marker Score: 226
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.46
    Marker Score: 941
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.41
    Marker Score: 1967
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.37
    Marker Score: 193
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.35
    Marker Score: 209
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.32
    Marker Score: 102
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.29
    Marker Score: 92
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.27
    Marker Score: 1090
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.25
    Marker Score: 79
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.25
    Marker Score: 593
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.23
    Marker Score: 1498
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.21
    Marker Score: 77
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.2
    Marker Score: 153
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.18
    Marker Score: 58
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.18
    Marker Score: 85
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.17
    Marker Score: 116
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.17
    Marker Score: 71
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.16
    Marker Score: 56
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.15
    Marker Score: 90
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.15
    Marker Score: 39
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.13
    Marker Score: 52
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.12
    Marker Score: 107
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.11
    Marker Score: 47
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.1
    Marker Score: 69
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.1
    Marker Score: 77
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.09
    Marker Score: 49
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.09
    Marker Score: 114
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.09
    Marker Score: 37
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.09
    Marker Score: 41
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.09
    Marker Score: 123.5
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.09
    Marker Score: 19
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.08
    Marker Score: 41
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.08
    Marker Score: 48
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.08
    Marker Score: 54
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.08
    Marker Score: 36
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.07
    Marker Score: 65
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.07
    Marker Score: 110
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.07
    Marker Score: 20
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.07
    Marker Score: 915
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.07
    Marker Score: 89
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.07
    Marker Score: 118
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.07
    Marker Score: 75
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.07
    Marker Score: 187
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.07
    Marker Score: 164
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.06
    Marker Score: 60
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.06
    Marker Score: 13
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.06
    Marker Score: 13
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.06
    Marker Score: 57
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.05
    Marker Score: 88

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Other Information

**Key characteristics:** * The LCT gene is located on chromosome 1. * It is a single-exon gene with a size of approximately 2.2 kb. * The protein encoded by LCT is a glycoprotein with a molecular weight of approximately 120 kDa. **Pathways and functions:** * The LCT enzyme is involved in the catabolism of lactose. * It is also involved in the digestion of dietary carbohydrates, including galactose and lactose. * The enzyme is also involved in the maintenance of intestinal health by breaking down lactose into smaller molecules that can be absorbed by the body. **Clinical significance:** * Mutations in the LCT gene have been linked to a number of human diseases, including lactose intolerance, galactosemia, and Crohn's disease. * These diseases are caused by defects in the function of the LCT enzyme, which leads to the inability to digest lactose and other dietary carbohydrates. * LCT gene therapy is a promising new treatment for these diseases, as it could provide a way to restore the function of the LCT enzyme and improve the symptoms of these conditions.

Genular Protein ID: 3402442830

Symbol: LPH_HUMAN

Name: N/A

UniProtKB Accession Codes:

P09848 Q4ZG58

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 3 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CTD 1 ChEBI 69 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EC 4 EMBL 19 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 34 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2460343

Title: Complete primary structure of human and rabbit lactase-phlorizin hydrolase: implications for biosynthesis, membrane anchoring and evolution of the enzyme.

PubMed ID: 2460343

DOI: 10.1002/j.1460-2075.1988.tb03124.x

PubMed ID: 1902057

Title: Structure of the chromosomal gene and cDNAs coding for lactase-phlorizin hydrolase in humans with adult-type hypolactasia or persistence of lactase.

PubMed ID: 1902057

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 3929764

Title: Human lactase and the molecular basis of lactase persistence.

PubMed ID: 3929764

DOI: 10.1007/bf00499084

PubMed ID: 9762914

Title: Intestinal lactase-phlorizin hydrolase (LPH): the two catalytic sites; the role of the pancreas in pro-LPH maturation.

PubMed ID: 9762914

DOI: 10.1016/s0014-5793(98)01076-x

PubMed ID: 9593732

Title: Protein domains implicated in intracellular transport and sorting of lactase-phlorizin hydrolase.

PubMed ID: 9593732

DOI: 10.1074/jbc.273.22.13861

PubMed ID: 11788828

Title: Identification of a variant associated with adult-type hypolactasia.

PubMed ID: 11788828

DOI: 10.1038/ng826

PubMed ID: 12594539

Title: Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans.

PubMed ID: 12594539

DOI: 10.1007/s00394-003-0397-3

PubMed ID: 16400612

Title: Mutations in the translated region of the lactase gene (LCT) underlie congenital lactase deficiency.

PubMed ID: 16400612

DOI: 10.1086/500053

Sequence Information:

  • Length: 1927
  • Mass: 218587
  • Checksum: 2FCD55CB47BBA35A
  • Sequence:
    • MELSWHVVFI ALLSFSCWGS DWESDRNFIS TAGPLTNDLL HNLSGLLGDQ SSNFVAGDKD 
MYVCHQPLPT FLPEYFSSLH ASQITHYKVF LSWAQLLPAG STQNPDEKTV QCYRRLLKAL 
KTARLQPMVI LHHQTLPAST LRRTEAFADL FADYATFAFH SFGDLVGIWF TFSDLEEVIK 
ELPHQESRAS QLQTLSDAHR KAYEIYHESY AFQGGKLSVV LRAEDIPELL LEPPISALAQ 
DTVDFLSLDL SYECQNEASL RQKLSKLQTI EPKVKVFIFN LKLPDCPSTM KNPASLLFSL 
FEAINKDQVL TIGFDINEFL SCSSSSKKSM SCSLTGSLAL QPDQQQDHET TDSSPASAYQ 
RIWEAFANQS RAERDAFLQD TFPEGFLWGA STGAFNVEGG WAEGGRGVSI WDPRRPLNTT 
EGQATLEVAS DSYHKVASDV ALLCGLRAQV YKFSISWSRI FPMGHGSSPS LPGVAYYNKL 
IDRLQDAGIE PMATLFHWDL PQALQDHGGW QNESVVDAFL DYAAFCFSTF GDRVKLWVTF 
HEPWVMSYAG YGTGQHPPGI SDPGVASFKV AHLVLKAHAR TWHHYNSHHR PQQQGHVGIV 
LNSDWAEPLS PERPEDLRAS ERFLHFMLGW FAHPVFVDGD YPATLRTQIQ QMNRQCSHPV 
AQLPEFTEAE KQLLKGSADF LGLSHYTSRL ISNAPQNTCI PSYDTIGGFS QHVNHVWPQT 
SSSWIRVVPW GIRRLLQFVS LEYTRGKVPI YLAGNGMPIG ESENLFDDSL RVDYFNQYIN 
EVLKAIKEDS VDVRSYIARS LIDGFEGPSG YSQRFGLHHV NFSDSSKSRT PRKSAYFFTS 
IIEKNGFLTK GAKRLLPPNT VNLPSKVRAF TFPSEVPSKA KVVWEKFSSQ PKFERDLFYH 
GTFRDDFLWG VSSSAYQIEG AWDADGKGPS IWDNFTHTPG SNVKDNATGD IACDSYHQLD 
ADLNMLRALK VKAYRFSISW SRIFPTGRNS SINSHGVDYY NRLINGLVAS NIFPMVTLFH 
WDLPQALQDI GGWENPALID LFDSYADFCF QTFGDRVKFW MTFNEPMYLA WLGYGSGEFP 
PGVKDPGWAP YRIAHAVIKA HARVYHTYDE KYRQEQKGVI SLSLSTHWAE PKSPGVPRDV 
EAADRMLQFS LGWFAHPIFR NGDYPDTMKW KVGNRSELQH LATSRLPSFT EEEKRFIRAT 
ADVFCLNTYY SRIVQHKTPR LNPPSYEDDQ EMAEEEDPSW PSTAMNRAAP WGTRRLLNWI 
KEEYGDIPIY ITENGVGLTN PNTEDTDRIF YHKTYINEAL KAYRLDGIDL RGYVAWSLMD 
NFEWLNGYTV KFGLYHVDFN NTNRPRTARA SARYYTEVIT NNGMPLARED EFLYGRFPEG 
FIWSAASAAY QIEGAWRADG KGLSIWDTFS HTPLRVENDA IGDVACDSYH KIAEDLVTLQ 
NLGVSHYRFS ISWSRILPDG TTRYINEAGL NYYVRLIDTL LAASIQPQVT IYHWDLPQTL 
QDVGGWENET IVQRFKEYAD VLFQRLGDKV KFWITLNEPF VIAYQGYGYG TAAPGVSNRP 
GTAPYIVGHN LIKAHAEAWH LYNDVYRASQ GGVISITISS DWAEPRDPSN QEDVEAARRY 
VQFMGGWFAH PIFKNGDYNE VMKTRIRDRS LAAGLNKSRL PEFTESEKRR INGTYDFFGF 
NHYTTVLAYN LNYATAISSF DADRGVASIA DRSWPDSGSF WLKMTPFGFR RILNWLKEEY 
NDPPIYVTEN GVSQREETDL NDTARIYYLR TYINEALKAV QDKVDLRGYT VWSAMDNFEW 
ATGFSERFGL HFVNYSDPSL PRIPKASAKF YASVVRCNGF PDPATGPHAC LHQPDAGPTI 
SPVRQEEVQF LGLMLGTTEA QTALYVLFSL VLLGVCGLAF LSYKYCKRSK QGKTQRSQQE 
LSPVSSF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.