Details for: GUCA2A

Gene ID: 2980

Symbol: GUCA2A

Ensembl ID: ENSG00000197273

Description: guanylate cyclase activator 2A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 28.5519
    Cell Significance Index: -13.4800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 20.1335
    Cell Significance Index: -13.5100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 5.3140
    Cell Significance Index: 79.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.9117
    Cell Significance Index: -7.8000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.2824
    Cell Significance Index: 103.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.5353
    Cell Significance Index: 44.2400
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.9707
    Cell Significance Index: 10.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8743
    Cell Significance Index: 86.4900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.6769
    Cell Significance Index: 11.5700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6144
    Cell Significance Index: 66.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4133
    Cell Significance Index: 28.5800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3263
    Cell Significance Index: 62.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2604
    Cell Significance Index: 6.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2291
    Cell Significance Index: 8.0500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.2253
    Cell Significance Index: 3.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1729
    Cell Significance Index: 156.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0281
    Cell Significance Index: 0.9000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0200
    Cell Significance Index: 13.8000
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0097
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0122
    Cell Significance Index: -9.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0135
    Cell Significance Index: -10.2500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0145
    Cell Significance Index: -0.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0168
    Cell Significance Index: -9.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0193
    Cell Significance Index: -10.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0278
    Cell Significance Index: -3.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0299
    Cell Significance Index: -6.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0457
    Cell Significance Index: -7.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0510
    Cell Significance Index: -10.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0546
    Cell Significance Index: -10.8300
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.0803
    Cell Significance Index: -0.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0862
    Cell Significance Index: -10.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0970
    Cell Significance Index: -17.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1135
    Cell Significance Index: -11.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1163
    Cell Significance Index: -7.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1226
    Cell Significance Index: -6.3700
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: -0.1261
    Cell Significance Index: -0.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1351
    Cell Significance Index: -6.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1405
    Cell Significance Index: -6.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1424
    Cell Significance Index: -17.5100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1590
    Cell Significance Index: -1.6800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1902
    Cell Significance Index: -4.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1905
    Cell Significance Index: -10.6900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2250
    Cell Significance Index: -6.4500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2377
    Cell Significance Index: -3.0000
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.2604
    Cell Significance Index: -2.3600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2644
    Cell Significance Index: -6.4500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2701
    Cell Significance Index: -3.5000
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.2765
    Cell Significance Index: -2.8600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2880
    Cell Significance Index: -6.2400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3074
    Cell Significance Index: -9.7900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3134
    Cell Significance Index: -10.2600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3238
    Cell Significance Index: -4.8800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3251
    Cell Significance Index: -8.6800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3633
    Cell Significance Index: -9.2800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.3777
    Cell Significance Index: -6.0600
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.3997
    Cell Significance Index: -6.4500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.4095
    Cell Significance Index: -5.2900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4113
    Cell Significance Index: -10.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4218
    Cell Significance Index: -11.4800
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.4264
    Cell Significance Index: -4.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4303
    Cell Significance Index: -11.5300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.4315
    Cell Significance Index: -7.1100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4406
    Cell Significance Index: -6.5100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4492
    Cell Significance Index: -6.4500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4512
    Cell Significance Index: -6.4900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.4699
    Cell Significance Index: -9.3700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4841
    Cell Significance Index: -10.2800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.4853
    Cell Significance Index: -7.8600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4911
    Cell Significance Index: -10.6100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.4946
    Cell Significance Index: -6.3700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5189
    Cell Significance Index: -10.2600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.5263
    Cell Significance Index: -10.2900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5270
    Cell Significance Index: -10.5800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.5291
    Cell Significance Index: -6.9200
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.5298
    Cell Significance Index: -6.4500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.5337
    Cell Significance Index: -10.5100
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.5531
    Cell Significance Index: -4.0200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.5591
    Cell Significance Index: -7.5500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5618
    Cell Significance Index: -11.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5787
    Cell Significance Index: -9.6900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6061
    Cell Significance Index: -8.6800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.6102
    Cell Significance Index: -10.5500
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.6303
    Cell Significance Index: -6.9500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.6481
    Cell Significance Index: -8.3100
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.6508
    Cell Significance Index: -6.0400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.6647
    Cell Significance Index: -11.1800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.6860
    Cell Significance Index: -9.9600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.6880
    Cell Significance Index: -11.5900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.6924
    Cell Significance Index: -8.2800
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.7037
    Cell Significance Index: -6.4400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.7059
    Cell Significance Index: -9.7900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.7221
    Cell Significance Index: -7.3000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.7298
    Cell Significance Index: -18.2000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.7544
    Cell Significance Index: -8.8700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.7690
    Cell Significance Index: -10.2500
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.7800
    Cell Significance Index: -4.8200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.7861
    Cell Significance Index: -10.6000
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.7936
    Cell Significance Index: -6.5600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.7980
    Cell Significance Index: -9.3100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.8045
    Cell Significance Index: -11.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Profile:** GUCA2A is expressed in a diverse range of cell types, including enterocytes, goblet cells, megakaryocytes, and endothelial cells, highlighting its broad functional scope. 2. **Protein Structure:** GUC2A is a guanylate cyclase activator, which means it stimulates the production of cyclic guanosine monophosphate (cGMP) by activating guanylate cyclase enzymes. 3. **Signaling Pathways:** GUC2A is involved in various signaling pathways, including guanylate cyclase activator activity, hormone activity, protein binding, and signal transduction, demonstrating its versatility in modulating cellular responses. **Pathways and Functions:** 1. **Gut Homeostasis:** GUC2A plays a critical role in regulating intestinal ion transport, maintaining fluid and electrolyte balance, and promoting gut motility. 2. **Cardiovascular Function:** GUC2A has been implicated in modulating cardiovascular function, including blood vessel relaxation and vascular tone regulation, through its effects on cGMP signaling. 3. **Immune Response:** GUC2A is also involved in regulating immune responses, particularly in microglial cells, where it modulates inflammatory processes and cytokine production. 4. **Neuroprotection:** Recent studies suggest that GUC2A may have neuroprotective effects, potentially contributing to the maintenance of neural homeostasis and the prevention of neurodegenerative diseases. **Clinical Significance:** 1. **Gastrointestinal Disorders:** Alterations in GUC2A expression or function may contribute to the development of various gastrointestinal disorders, including inflammatory bowel disease, irritable bowel syndrome, and gastrointestinal cancer. 2. **Cardiovascular Diseases:** Dysregulation of GUC2A signaling has been linked to cardiovascular diseases, including hypertension, atherosclerosis, and heart failure. 3. **Neurological Disorders:** GUC2A's role in neuroprotection and immune response modulation may also contribute to the pathogenesis of neurological disorders, such as Alzheimer's disease and multiple sclerosis. 4. **Cancer Therapeutics:** GUC2A's involvement in signaling pathways critical for cell growth and survival makes it a potential target for cancer therapeutics. In conclusion, the GUCA2A gene plays a multifaceted role in maintaining gut homeostasis, regulating cardiovascular function, modulating immune responses, and contributing to the pathogenesis of various diseases. Further research is necessary to fully elucidate the mechanisms underlying GUC2A's functions and to explore its potential as a therapeutic target for the treatment of human diseases.

Genular Protein ID: 3007942390

Symbol: GUC2A_HUMAN

Name: Guanylin

UniProtKB Accession Codes:

Q02747

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 EvolutionaryTrace 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1327879

Title: Human guanylin: cDNA isolation, structure, and activity.

PubMed ID: 1327879

DOI: 10.1016/0014-5793(92)81387-2

PubMed ID: 1409606

Title: Precursor structure, expression, and tissue distribution of human guanylin.

PubMed ID: 1409606

DOI: 10.1073/pnas.89.19.9089

PubMed ID: 7892222

Title: Analysis of the human guanylin gene and the processing and cellular localization of the peptide.

PubMed ID: 7892222

DOI: 10.1073/pnas.92.6.2046

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 8095028

Title: The circulating bioactive form of human guanylin is a high molecular weight peptide (10.3 kDa).

PubMed ID: 8095028

DOI: 10.1016/0014-5793(93)80022-m

PubMed ID: 7947768

Title: Determination of the solution structure of the peptide hormone guanylin: observation of a novel form of topological stereoisomerism.

PubMed ID: 7947768

DOI: 10.1021/bi00250a010

PubMed ID: 12707255

Title: Solution structure of human proguanylin: the role of a hormone prosequence.

PubMed ID: 12707255

DOI: 10.1074/jbc.m300370200

Sequence Information:

  • Length: 115
  • Mass: 12388
  • Checksum: C644DA910EED26FA
  • Sequence:
    • MNAFLLSALC LLGAWAALAG GVTVQDGNFS FSLESVKKLK DLQEPQEPRV GKLRNFAPIP 
GEPVVPILCS NPNFPEELKP LCKEPNAQEI LQRLEEIAED PGTCEICAYA ACTGC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.