Details for: GUCA2A

Gene ID: 2980

Symbol: GUCA2A

Ensembl ID: ENSG00000197273

Description: guanylate cyclase activator 2A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.75
    Marker Score: 6822
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.72
    Marker Score: 4187
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.62
    Marker Score: 8232
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 2.56
    Marker Score: 740
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.2
    Marker Score: 2218.5
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.61
    Marker Score: 1542
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.56
    Marker Score: 7473
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.42
    Marker Score: 808
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.15
    Marker Score: 2170
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.12
    Marker Score: 7419
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.08
    Marker Score: 311
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.04
    Marker Score: 1041
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1
    Marker Score: 376
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71807
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48032.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5294
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.85
    Marker Score: 13231
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.84
    Marker Score: 1361
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.83
    Marker Score: 438
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.81
    Marker Score: 562
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 318.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.75
    Marker Score: 1773
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 675
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.72
    Marker Score: 1162
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 463
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2908
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.66
    Marker Score: 1130
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.66
    Marker Score: 277
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.55
    Marker Score: 319
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.55
    Marker Score: 252
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.51
    Marker Score: 140
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 276
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.45
    Marker Score: 188
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.44
    Marker Score: 488
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.43
    Marker Score: 111
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.4
    Marker Score: 155
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.4
    Marker Score: 262
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.38
    Marker Score: 101
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.37
    Marker Score: 271
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.36
    Marker Score: 112
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.33
    Marker Score: 81
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.31
    Marker Score: 98
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.28
    Marker Score: 89
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.28
    Marker Score: 122
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.27
    Marker Score: 545.5
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.26
    Marker Score: 320
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.23
    Marker Score: 84
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.22
    Marker Score: 210
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.2
    Marker Score: 113
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.19
    Marker Score: 165
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.19
    Marker Score: 42
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.19
    Marker Score: 226
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.19
    Marker Score: 1115.5
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.18
    Marker Score: 195
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.18
    Marker Score: 40
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.18
    Marker Score: 281
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.17
    Marker Score: 155
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.17
    Marker Score: 149
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.17
    Marker Score: 176
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.16
    Marker Score: 96
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.16
    Marker Score: 38
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.15
    Marker Score: 317
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.15
    Marker Score: 43
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.15
    Marker Score: 261
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.15
    Marker Score: 148
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.15
    Marker Score: 78
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.15
    Marker Score: 100.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.15
    Marker Score: 70
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.15
    Marker Score: 151
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.14
    Marker Score: 36
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.14
    Marker Score: 37
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.14
    Marker Score: 39
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.14
    Marker Score: 136
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.14
    Marker Score: 42
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.14
    Marker Score: 45
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.14
    Marker Score: 47
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.14
    Marker Score: 83
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.14
    Marker Score: 104
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.13
    Marker Score: 29
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.13
    Marker Score: 40
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.13
    Marker Score: 150
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.12
    Marker Score: 293
  • Cell Name: type D enteroendocrine cell (CL0000502)
    Fold Change: 0.12
    Marker Score: 38
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.12
    Marker Score: 41
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.12
    Marker Score: 55
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.12
    Marker Score: 28
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 0.12
    Marker Score: 33
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.11
    Marker Score: 57
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.11
    Marker Score: 40
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.11
    Marker Score: 38

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Other Information

**Key characteristics:** * GUCA2A is a protein of the AGC family of guanylate cyclase activators. * It is expressed in a variety of cell types, including microglial cells, enterocytes, and blood vessel endothelial cells. * It is a key regulator of intestinal epithelial function. * It is involved in the regulation of cell migration, proliferation, and differentiation. **Pathways and functions:** GUCA2A is involved in a variety of cellular pathways, including the regulation of epithelial cell migration, proliferation, and differentiation. It is also involved in the regulation of the immune response. **Clinical significance:** Mutations in GUCA2A have been linked to a number of human diseases, including Crohn's disease, ulcerative colitis, and colorectal cancer. These diseases are characterized by inflammation and damage to the intestinal epithelium. GUCA2A is a potential therapeutic target for these diseases. **Additional notes:** * GUCA2A is a highly conserved protein, with a similar protein found in mammals, birds, and fish. * It is a relatively new protein, with the gene encoding GUCA2A first identified in 2002. * It is a well-studied protein, with a number of studies investigating its role in health and disease.

Genular Protein ID: 3007942390

Symbol: GUC2A_HUMAN

Name: Guanylin

UniProtKB Accession Codes:

Q02747

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 EvolutionaryTrace 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1327879

Title: Human guanylin: cDNA isolation, structure, and activity.

PubMed ID: 1327879

DOI: 10.1016/0014-5793(92)81387-2

PubMed ID: 1409606

Title: Precursor structure, expression, and tissue distribution of human guanylin.

PubMed ID: 1409606

DOI: 10.1073/pnas.89.19.9089

PubMed ID: 7892222

Title: Analysis of the human guanylin gene and the processing and cellular localization of the peptide.

PubMed ID: 7892222

DOI: 10.1073/pnas.92.6.2046

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 8095028

Title: The circulating bioactive form of human guanylin is a high molecular weight peptide (10.3 kDa).

PubMed ID: 8095028

DOI: 10.1016/0014-5793(93)80022-m

PubMed ID: 7947768

Title: Determination of the solution structure of the peptide hormone guanylin: observation of a novel form of topological stereoisomerism.

PubMed ID: 7947768

DOI: 10.1021/bi00250a010

PubMed ID: 12707255

Title: Solution structure of human proguanylin: the role of a hormone prosequence.

PubMed ID: 12707255

DOI: 10.1074/jbc.m300370200

Sequence Information:

  • Length: 115
  • Mass: 12388
  • Checksum: C644DA910EED26FA
  • Sequence:
    • MNAFLLSALC LLGAWAALAG GVTVQDGNFS FSLESVKKLK DLQEPQEPRV GKLRNFAPIP 
GEPVVPILCS NPNFPEELKP LCKEPNAQEI LQRLEEIAED PGTCEICAYA ACTGC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.