Details for: SPINK4

Gene ID: 27290

Symbol: SPINK4

Ensembl ID: ENSG00000122711

Description: serine peptidase inhibitor Kazal type 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 19.4367
    Cell Significance Index: -4.9300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 8.0772
    Cell Significance Index: -5.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 6.6559
    Cell Significance Index: 419.5000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.2047
    Cell Significance Index: -8.5900
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 2.9362
    Cell Significance Index: 22.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 2.9169
    Cell Significance Index: 102.5000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.4874
    Cell Significance Index: 246.0600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.3329
    Cell Significance Index: 27.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.3182
    Cell Significance Index: 2093.1900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.6802
    Cell Significance Index: 16.9500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.6299
    Cell Significance Index: 97.8500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.5619
    Cell Significance Index: 45.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1045
    Cell Significance Index: 179.6300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0057
    Cell Significance Index: 69.5500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.8855
    Cell Significance Index: 21.4500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5926
    Cell Significance Index: 64.4600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.4573
    Cell Significance Index: 6.6400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4349
    Cell Significance Index: 4.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4210
    Cell Significance Index: 11.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2422
    Cell Significance Index: 28.2200
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 0.1538
    Cell Significance Index: 1.4600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1366
    Cell Significance Index: 2.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1259
    Cell Significance Index: 6.5400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1124
    Cell Significance Index: 1.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0328
    Cell Significance Index: 6.2400
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.0249
    Cell Significance Index: 0.3200
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.0216
    Cell Significance Index: 0.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0185
    Cell Significance Index: 0.8400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0162
    Cell Significance Index: 0.5200
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.0081
    Cell Significance Index: 0.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0034
    Cell Significance Index: 0.6100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0033
    Cell Significance Index: 0.0500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0019
    Cell Significance Index: -3.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0020
    Cell Significance Index: -3.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0022
    Cell Significance Index: -4.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0026
    Cell Significance Index: -3.5900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0035
    Cell Significance Index: -2.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0069
    Cell Significance Index: -1.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0069
    Cell Significance Index: -3.8900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0079
    Cell Significance Index: -4.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0105
    Cell Significance Index: -1.2900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0116
    Cell Significance Index: -7.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0125
    Cell Significance Index: -5.6800
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0144
    Cell Significance Index: -0.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0152
    Cell Significance Index: -0.3800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0152
    Cell Significance Index: -0.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0155
    Cell Significance Index: -5.5500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0165
    Cell Significance Index: -0.6800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0183
    Cell Significance Index: -0.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0186
    Cell Significance Index: -0.5200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0208
    Cell Significance Index: -0.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0227
    Cell Significance Index: -4.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0233
    Cell Significance Index: -4.9100
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.0255
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0261
    Cell Significance Index: -4.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0275
    Cell Significance Index: -7.9100
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0275
    Cell Significance Index: -0.1700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0339
    Cell Significance Index: -0.5900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0345
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0396
    Cell Significance Index: -4.5400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0425
    Cell Significance Index: -6.1800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0432
    Cell Significance Index: -2.6500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0449
    Cell Significance Index: -0.4700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0450
    Cell Significance Index: -0.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0469
    Cell Significance Index: -4.7900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0479
    Cell Significance Index: -4.9900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0506
    Cell Significance Index: -1.3000
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0522
    Cell Significance Index: -0.5700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0641
    Cell Significance Index: -1.3300
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0676
    Cell Significance Index: -0.5800
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.0697
    Cell Significance Index: -0.7600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0729
    Cell Significance Index: -1.5800
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0747
    Cell Significance Index: -0.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0748
    Cell Significance Index: -2.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0751
    Cell Significance Index: -3.5000
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0767
    Cell Significance Index: -0.6900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0800
    Cell Significance Index: -0.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0817
    Cell Significance Index: -6.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0872
    Cell Significance Index: -5.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0881
    Cell Significance Index: -1.8500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0917
    Cell Significance Index: -1.7900
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0970
    Cell Significance Index: -1.2700
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.1001
    Cell Significance Index: -0.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1013
    Cell Significance Index: -5.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1016
    Cell Significance Index: -5.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1084
    Cell Significance Index: -2.9500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1127
    Cell Significance Index: -2.8100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1128
    Cell Significance Index: -1.1900
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.1142
    Cell Significance Index: -0.8300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1172
    Cell Significance Index: -7.2100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1180
    Cell Significance Index: -2.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1200
    Cell Significance Index: -5.3100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1201
    Cell Significance Index: -3.8000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1261
    Cell Significance Index: -1.7200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1350
    Cell Significance Index: -2.0200
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.1386
    Cell Significance Index: -1.5500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1392
    Cell Significance Index: -5.2700
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.1393
    Cell Significance Index: -1.2000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1411
    Cell Significance Index: -5.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The SPINK4 gene encodes a protein that belongs to the Kazal-type serine protease inhibitor family. This protein is characterized by its ability to inhibit serine-type endopeptidases, which are enzymes that degrade proteins and peptides. The SPINK4 protein has been shown to have a high specificity for serine proteases, including trypsin, chymotrypsin, and elastase. This specificity is crucial in regulating the activity of these enzymes, which can have either pro-inflammatory or anti-inflammatory effects, depending on the context. **Pathways and Functions** The SPINK4 protein is involved in several key pathways, including: 1. **Inflammation regulation**: SPINK4 inhibits the activity of serine-type endopeptidases, which can contribute to inflammation by degrading anti-inflammatory proteins. By regulating the activity of these enzymes, SPINK4 helps to maintain a balance between pro-inflammatory and anti-inflammatory signals. 2. **Cell growth and differentiation**: SPINK4 has been shown to regulate cell growth and differentiation in various cell types, including epithelial cells and stem cells. By inhibiting serine-type endopeptidases, SPINK4 helps to maintain the integrity of cell membranes and regulate the activity of growth factors. 3. **Neuroprotection**: SPINK4 has been implicated in neuroprotection, particularly in the context of neurodegenerative diseases such as Alzheimer's and Parkinson's. By inhibiting serine-type endopeptidases, SPINK4 helps to regulate the activity of enzymes that degrade neurotransmitters and other signaling molecules. **Clinical Significance** Dysregulation of the SPINK4 gene has been implicated in various diseases, including: 1. **Cancer**: SPINK4 has been shown to have a tumor-suppressive role in various cancer types, including breast, lung, and colon cancer. By regulating the activity of serine-type endopeptidases, SPINK4 helps to maintain the integrity of cell membranes and prevent tumor growth. 2. **Inflammatory disorders**: SPINK4 has been implicated in inflammatory disorders such as arthritis, asthma, and inflammatory bowel disease. By regulating the activity of serine-type endopeptidases, SPINK4 helps to maintain a balance between pro-inflammatory and anti-inflammatory signals. 3. **Neurodegenerative diseases**: SPINK4 has been implicated in neurodegenerative diseases such as Alzheimer's and Parkinson's. By regulating the activity of serine-type endopeptidases, SPINK4 helps to maintain the integrity of neurotransmitters and other signaling molecules. In conclusion, the SPINK4 gene plays a crucial role in regulating various physiological processes, including inflammation, cell growth, and differentiation. Its dysregulation has been implicated in various diseases, including cancer, inflammatory disorders, and neurodegenerative diseases. Further research is needed to fully understand the mechanisms by which SPINK4 regulates these processes and to explore its potential as a therapeutic target for these diseases.

Genular Protein ID: 2759343254

Symbol: ISK4_HUMAN

Name: Serine protease inhibitor Kazal-type 4

UniProtKB Accession Codes:

O60575 Q2YDT7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 2 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 86
  • Mass: 9454
  • Checksum: 374CD4B3CAC9AF52
  • Sequence:
    • MAVRQWVIAL ALAALLVVDR EVPVAAGKLP FSRMPICEHM VESPTCSQMS NLVCGTDGLT 
YTNECQLCLA RIKTKQDIQI MKDGKC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.