Details for: GUCY2C

Gene ID: 2984

Symbol: GUCY2C

Ensembl ID: ENSG00000070019

Description: guanylate cyclase 2C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 44.4244
    Cell Significance Index: -6.9100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 5.3806
    Cell Significance Index: 55.7000
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 5.2789
    Cell Significance Index: 40.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 5.1283
    Cell Significance Index: 354.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.8519
    Cell Significance Index: 110.9800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 3.4160
    Cell Significance Index: 34.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.2021
    Cell Significance Index: 145.1400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.5452
    Cell Significance Index: 276.8400
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.4523
    Cell Significance Index: 15.7400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.4469
    Cell Significance Index: 21.6800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.4227
    Cell Significance Index: 30.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3957
    Cell Significance Index: 1260.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3157
    Cell Significance Index: 250.3800
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6373
    Cell Significance Index: 5.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.6205
    Cell Significance Index: 21.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4882
    Cell Significance Index: 15.6400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3171
    Cell Significance Index: 24.3300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.2351
    Cell Significance Index: 3.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.2228
    Cell Significance Index: 32.3800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1698
    Cell Significance Index: 16.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1545
    Cell Significance Index: 27.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1084
    Cell Significance Index: 17.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0384
    Cell Significance Index: 7.7100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0197
    Cell Significance Index: 0.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0196
    Cell Significance Index: 3.9000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0122
    Cell Significance Index: 8.4400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0111
    Cell Significance Index: 20.8100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0079
    Cell Significance Index: 12.1500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0075
    Cell Significance Index: 2.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0065
    Cell Significance Index: 11.9200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0020
    Cell Significance Index: 0.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0015
    Cell Significance Index: 0.9800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0027
    Cell Significance Index: -0.0700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0050
    Cell Significance Index: -0.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0051
    Cell Significance Index: -6.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0066
    Cell Significance Index: -0.8100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0090
    Cell Significance Index: -6.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0112
    Cell Significance Index: -6.1100
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0113
    Cell Significance Index: -0.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0127
    Cell Significance Index: -5.7500
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.0129
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0142
    Cell Significance Index: -8.8700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0148
    Cell Significance Index: -8.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0157
    Cell Significance Index: -0.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0231
    Cell Significance Index: -6.6600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0231
    Cell Significance Index: -0.4500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0244
    Cell Significance Index: -0.3500
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0248
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0272
    Cell Significance Index: -4.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0418
    Cell Significance Index: -8.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0456
    Cell Significance Index: -5.3800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0466
    Cell Significance Index: -0.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0476
    Cell Significance Index: -6.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0477
    Cell Significance Index: -2.1100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0550
    Cell Significance Index: -1.7400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0595
    Cell Significance Index: -3.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0602
    Cell Significance Index: -3.1300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0624
    Cell Significance Index: -0.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0646
    Cell Significance Index: -7.5300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0665
    Cell Significance Index: -1.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0666
    Cell Significance Index: -6.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0673
    Cell Significance Index: -7.7100
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0704
    Cell Significance Index: -0.7300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0705
    Cell Significance Index: -1.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0815
    Cell Significance Index: -8.3300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0856
    Cell Significance Index: -3.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0874
    Cell Significance Index: -4.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0907
    Cell Significance Index: -6.1000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0935
    Cell Significance Index: -4.7300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1061
    Cell Significance Index: -2.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1094
    Cell Significance Index: -6.1400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1205
    Cell Significance Index: -1.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1282
    Cell Significance Index: -8.2700
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.1350
    Cell Significance Index: -0.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1386
    Cell Significance Index: -8.5200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1387
    Cell Significance Index: -3.3600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1431
    Cell Significance Index: -1.9300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1447
    Cell Significance Index: -5.0700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1476
    Cell Significance Index: -4.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1488
    Cell Significance Index: -4.0500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1502
    Cell Significance Index: -3.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1553
    Cell Significance Index: -7.3000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1643
    Cell Significance Index: -2.8200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1700
    Cell Significance Index: -2.9300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1790
    Cell Significance Index: -5.8600
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1827
    Cell Significance Index: -1.5800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1904
    Cell Significance Index: -1.9700
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1912
    Cell Significance Index: -2.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1959
    Cell Significance Index: -5.2300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2017
    Cell Significance Index: -2.9400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2035
    Cell Significance Index: -4.9700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2065
    Cell Significance Index: -8.4600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.2070
    Cell Significance Index: -2.6000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2125
    Cell Significance Index: -1.4400
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.2288
    Cell Significance Index: -2.2200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2321
    Cell Significance Index: -5.7900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2331
    Cell Significance Index: -3.9200
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.2344
    Cell Significance Index: -2.1200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2369
    Cell Significance Index: -3.5700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2411
    Cell Significance Index: -6.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GUCY2C is a member of the guanylate cyclase family, which consists of three main subfamilies: GC-A, GC-B, and GC-C. GUCY2C belongs to the GC-C subfamily, which is primarily expressed in the intestinal epithelium and other tissues involved in immune response. The gene is highly conserved across species, suggesting its essential role in maintaining cellular homeostasis. GUCY2C is a transmembrane receptor that binds to specific ligands, such as bacterial toxins, and activates its downstream signaling pathways. **Pathways and Functions:** GUCY2C is involved in several key signaling pathways, including: 1. **Intracellular signal transduction:** GUCY2C activates the cGMP-PKA pathway, which regulates various cellular processes, such as cell proliferation, differentiation, and survival. 2. **Bacterial infection pathways:** GUCY2C recognizes and binds to bacterial toxins, such as cholera toxin, and activates its signaling pathways to regulate immune response and prevent bacterial invasion. 3. **Digestion and absorption:** GUCY2C plays a crucial role in regulating intestinal fluid and electrolyte balance, as well as nutrient absorption. 4. **Regulation of cell population proliferation:** GUCY2C modulates cell growth and proliferation in various tissues, including the intestinal epithelium and immune cells. **Clinical Significance:** Dysregulation of GUCY2C has been implicated in several diseases, including: 1. **Cholera:** GUCY2C is the primary receptor for cholera toxin, which causes a severe diarrheal disease. 2. **Intestinal infectious diseases:** GUCY2C plays a crucial role in regulating immune response to bacterial infections, such as Shiga toxin-producing E. coli. 3. **Cancer:** GUCY2C is involved in regulating cell growth and proliferation, and its dysregulation has been implicated in various types of cancer. 4. **Cardiovascular disease:** GUCY2C has been implicated in regulating blood pressure and cardiovascular function. In conclusion, GUCY2C is a critical gene involved in various cellular signaling pathways, including those related to immune response, cell proliferation, and bacterial infection. Its dysregulation has been implicated in several diseases, highlighting the importance of GUCY2C in maintaining cellular homeostasis and preventing disease.

Genular Protein ID: 3768647423

Symbol: GUC2C_HUMAN

Name: Intestinal guanylate cyclase

UniProtKB Accession Codes:

P25092 B2RMY6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 1 EMBL 8 EMDB 1 Ensembl 1 GO 14 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TCDB 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1718270

Title: Isolation and expression of a guanylate cyclase-coupled heat stable enterotoxin receptor cDNA from a human colonic cell line.

PubMed ID: 1718270

DOI: 10.1016/0006-291x(91)91736-v

PubMed ID: 1680854

Title: Primary structure and functional expression of the human receptor for Escherichia coli heat-stable enterotoxin.

PubMed ID: 1680854

DOI: 10.1016/s0021-9258(18)55214-5

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8605253

Title: Cell line-specific transcriptional activation of the promoter of the human guanylyl cyclase C/heat-stable enterotoxin receptor gene.

PubMed ID: 8605253

DOI: 10.1016/0167-4781(95)00190-5

PubMed ID: 8381596

Title: Comparison of receptors for Escherichia coli heat-stable enterotoxin: novel receptor present in IEC-6 cells.

PubMed ID: 8381596

DOI: 10.1152/ajpgi.1993.264.1.g172

PubMed ID: 11123935

Title: Biochemical characterization of the intracellular domain of the human guanylyl cyclase C receptor provides evidence for a catalytically active homotrimer.

PubMed ID: 11123935

DOI: 10.1021/bi0013849

PubMed ID: 11950846

Title: A novel PDZ protein regulates the activity of guanylyl cyclase C, the heat-stable enterotoxin receptor.

PubMed ID: 11950846

DOI: 10.1074/jbc.m202434200

PubMed ID: 23269669

Title: Site-specific N-linked glycosylation of receptor guanylyl cyclase C regulates ligand binding, ligand-mediated activation and interaction with vesicular integral membrane protein 36, VIP36.

PubMed ID: 23269669

DOI: 10.1074/jbc.m112.413906

PubMed ID: 22521417

Title: Meconium ileus caused by mutations in GUCY2C, encoding the CFTR-activating guanylate cyclase 2C.

PubMed ID: 22521417

DOI: 10.1016/j.ajhg.2012.03.022

PubMed ID: 22436048

Title: Familial diarrhea syndrome caused by an activating GUCY2C mutation.

PubMed ID: 22436048

DOI: 10.1056/nejmoa1110132

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 1073
  • Mass: 123403
  • Checksum: 486A4DE6F9097E22
  • Sequence:
    • MKTLLLDLAL WSLLFQPGWL SFSSQVSQNC HNGSYEISVL MMGNSAFAEP LKNLEDAVNE 
GLEIVRGRLQ NAGLNVTVNA TFMYSDGLIH NSGDCRSSTC EGLDLLRKIS NAQRMGCVLI 
GPSCTYSTFQ MYLDTELSYP MISAGSFGLS CDYKETLTRL MSPARKLMYF LVNFWKTNDL 
PFKTYSWSTS YVYKNGTETE DCFWYLNALE ASVSYFSHEL GFKVVLRQDK EFQDILMDHN 
RKSNVIIMCG GPEFLYKLKG DRAVAEDIVI ILVDLFNDQY FEDNVTAPDY MKNVLVLTLS 
PGNSLLNSSF SRNLSPTKRD FALAYLNGIL LFGHMLKIFL ENGENITTPK FAHAFRNLTF 
EGYDGPVTLD DWGDVDSTMV LLYTSVDTKK YKVLLTYDTH VNKTYPVDMS PTFTWKNSKL 
PNDITGRGPQ ILMIAVFTLT GAVVLLLLVA LLMLRKYRKD YELRQKKWSH IPPENIFPLE 
TNETNHVSLK IDDDKRRDTI QRLRQCKYDK KRVILKDLKH NDGNFTEKQK IELNKLLQID 
YYNLTKFYGT VKLDTMIFGV IEYCERGSLR EVLNDTISYP DGTFMDWEFK ISVLYDIAKG 
MSYLHSSKTE VHGRLKSTNC VVDSRMVVKI TDFGCNSILP PKKDLWTAPE HLRQANISQK 
GDVYSYGIIA QEIILRKETF YTLSCRDRNE KIFRVENSNG MKPFRPDLFL ETAEEKELEV 
YLLVKNCWEE DPEKRPDFKK IETTLAKIFG LFHDQKNESY MDTLIRRLQL YSRNLEHLVE 
ERTQLYKAER DRADRLNFML LPRLVVKSLK EKGFVEPELY EEVTIYFSDI VGFTTICKYS 
TPMEVVDMLN DIYKSFDHIV DHHDVYKVET IGDAYMVASG LPKRNGNRHA IDIAKMALEI 
LSFMGTFELE HLPGLPIWIR IGVHSGPCAA GVVGIKMPRY CLFGDTVNTA SRMESTGLPL 
RIHVSGSTIA ILKRTECQFL YEVRGETYLK GRGNETTYWL TGMKDQKFNL PTPPTVENQQ 
RLQAEFSDMI ANSLQKRQAA GIRSQKPRRV ASYKKGTLEY LQLNTTDKES TYF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.