Details for: GUCY2C

Gene ID: 2984

Symbol: GUCY2C

Ensembl ID: ENSG00000070019

Description: guanylate cyclase 2C

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 8.63
    Marker Score: 27645
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 2.28
    Marker Score: 30323
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.12
    Marker Score: 2134.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.99
    Marker Score: 4116
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 1.53
    Marker Score: 4388
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 170066
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 1.25
    Marker Score: 3651
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.22
    Marker Score: 5849
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.07
    Marker Score: 2031
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 793.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.01
    Marker Score: 2063
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71817
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48041
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.99
    Marker Score: 3098
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.95
    Marker Score: 1544
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.95
    Marker Score: 14842
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.94
    Marker Score: 904
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5342
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.91
    Marker Score: 344
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.89
    Marker Score: 2102
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.87
    Marker Score: 210
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.76
    Marker Score: 762.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 298
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.74
    Marker Score: 1137
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 664
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.72
    Marker Score: 2149
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.72
    Marker Score: 6123
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.71
    Marker Score: 319
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.7
    Marker Score: 201
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.68
    Marker Score: 15161
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.67
    Marker Score: 215
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.65
    Marker Score: 205
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.64
    Marker Score: 2693
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.64
    Marker Score: 384
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.61
    Marker Score: 152
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.61
    Marker Score: 210
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.6
    Marker Score: 1425
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.55
    Marker Score: 231
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.55
    Marker Score: 1953
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.49
    Marker Score: 341.5
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.46
    Marker Score: 295
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.42
    Marker Score: 109
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.4
    Marker Score: 205
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.4
    Marker Score: 108
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.36
    Marker Score: 171
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.35
    Marker Score: 230
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.34
    Marker Score: 327.5
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.31
    Marker Score: 143
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.31
    Marker Score: 137
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.31
    Marker Score: 81
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3
    Marker Score: 756
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.3
    Marker Score: 65
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.3
    Marker Score: 1981.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.3
    Marker Score: 300
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.29
    Marker Score: 85
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.29
    Marker Score: 182.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.29
    Marker Score: 90
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.28
    Marker Score: 1688
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.27
    Marker Score: 112
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.27
    Marker Score: 67
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.27
    Marker Score: 69
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.26
    Marker Score: 151
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.26
    Marker Score: 187
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.24
    Marker Score: 71
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.23
    Marker Score: 966
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.23
    Marker Score: 131
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.22
    Marker Score: 272
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.22
    Marker Score: 91
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.22
    Marker Score: 125
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.22
    Marker Score: 65
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.22
    Marker Score: 207
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.21
    Marker Score: 61
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.21
    Marker Score: 60
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.2
    Marker Score: 191
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.2
    Marker Score: 96
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.2
    Marker Score: 358
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.2
    Marker Score: 217
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.19
    Marker Score: 249
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.18
    Marker Score: 67
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.18
    Marker Score: 167
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 0.17
    Marker Score: 50
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.17
    Marker Score: 50
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.17
    Marker Score: 172
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.17
    Marker Score: 54
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.17
    Marker Score: 81
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.17
    Marker Score: 98
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.16
    Marker Score: 147

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Other Information

**Key characteristics** * GUCY2C is a single-pass transmembrane protein with a molecular weight of approximately 120 kDa. * It is expressed in a variety of cell types, including immune cells, endothelial cells, and fibroblasts. * It is a key regulator of inflammation and infection. **Pathways and functions** * GUCY2C is a key regulator of the inflammatory response. It is expressed in immune cells, where it is involved in the regulation of inflammation and cell signaling. * It is also expressed in endothelial cells, where it is involved in the regulation of blood pressure and fluid balance. * In immune cells, GUCY2C is activated by guanosine 5'-triphosphate (GTP), which is a second messenger that is produced in response to infection. * Activated GUCY2C phosphorylates a variety of substrates, including p38 MAPK, JNK, and STAT3. These substrates regulate a variety of cellular processes, including inflammation, cell growth, and proliferation. **Clinical significance** GUCY2C is a potential therapeutic target for a variety of diseases. For example, it is a target for autoimmune diseases such as rheumatoid arthritis and Crohn's disease. In these diseases, GUCY2C is overexpressed in immune cells, where it promotes inflammation and tissue damage. By targeting GUCY2C, it is possible to inhibit inflammation and tissue damage. **Additional information** * GUCY2C is a member of the GUCY family of guanylate cyclase enzymes. * It is expressed in high levels in the gastrointestinal tract, where it is involved in the regulation of gut inflammation and barrier function. * Mutations in GUCY2C have been linked to a number of autoimmune diseases, including rheumatoid arthritis and Crohn's disease.

Genular Protein ID: 3768647423

Symbol: GUC2C_HUMAN

Name: Intestinal guanylate cyclase

UniProtKB Accession Codes:

P25092 B2RMY6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 1 EMBL 8 EMDB 1 Ensembl 1 GO 14 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TCDB 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1718270

Title: Isolation and expression of a guanylate cyclase-coupled heat stable enterotoxin receptor cDNA from a human colonic cell line.

PubMed ID: 1718270

DOI: 10.1016/0006-291x(91)91736-v

PubMed ID: 1680854

Title: Primary structure and functional expression of the human receptor for Escherichia coli heat-stable enterotoxin.

PubMed ID: 1680854

DOI: 10.1016/s0021-9258(18)55214-5

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8605253

Title: Cell line-specific transcriptional activation of the promoter of the human guanylyl cyclase C/heat-stable enterotoxin receptor gene.

PubMed ID: 8605253

DOI: 10.1016/0167-4781(95)00190-5

PubMed ID: 8381596

Title: Comparison of receptors for Escherichia coli heat-stable enterotoxin: novel receptor present in IEC-6 cells.

PubMed ID: 8381596

DOI: 10.1152/ajpgi.1993.264.1.g172

PubMed ID: 11123935

Title: Biochemical characterization of the intracellular domain of the human guanylyl cyclase C receptor provides evidence for a catalytically active homotrimer.

PubMed ID: 11123935

DOI: 10.1021/bi0013849

PubMed ID: 11950846

Title: A novel PDZ protein regulates the activity of guanylyl cyclase C, the heat-stable enterotoxin receptor.

PubMed ID: 11950846

DOI: 10.1074/jbc.m202434200

PubMed ID: 23269669

Title: Site-specific N-linked glycosylation of receptor guanylyl cyclase C regulates ligand binding, ligand-mediated activation and interaction with vesicular integral membrane protein 36, VIP36.

PubMed ID: 23269669

DOI: 10.1074/jbc.m112.413906

PubMed ID: 22521417

Title: Meconium ileus caused by mutations in GUCY2C, encoding the CFTR-activating guanylate cyclase 2C.

PubMed ID: 22521417

DOI: 10.1016/j.ajhg.2012.03.022

PubMed ID: 22436048

Title: Familial diarrhea syndrome caused by an activating GUCY2C mutation.

PubMed ID: 22436048

DOI: 10.1056/nejmoa1110132

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 1073
  • Mass: 123403
  • Checksum: 486A4DE6F9097E22
  • Sequence:
    • MKTLLLDLAL WSLLFQPGWL SFSSQVSQNC HNGSYEISVL MMGNSAFAEP LKNLEDAVNE 
GLEIVRGRLQ NAGLNVTVNA TFMYSDGLIH NSGDCRSSTC EGLDLLRKIS NAQRMGCVLI 
GPSCTYSTFQ MYLDTELSYP MISAGSFGLS CDYKETLTRL MSPARKLMYF LVNFWKTNDL 
PFKTYSWSTS YVYKNGTETE DCFWYLNALE ASVSYFSHEL GFKVVLRQDK EFQDILMDHN 
RKSNVIIMCG GPEFLYKLKG DRAVAEDIVI ILVDLFNDQY FEDNVTAPDY MKNVLVLTLS 
PGNSLLNSSF SRNLSPTKRD FALAYLNGIL LFGHMLKIFL ENGENITTPK FAHAFRNLTF 
EGYDGPVTLD DWGDVDSTMV LLYTSVDTKK YKVLLTYDTH VNKTYPVDMS PTFTWKNSKL 
PNDITGRGPQ ILMIAVFTLT GAVVLLLLVA LLMLRKYRKD YELRQKKWSH IPPENIFPLE 
TNETNHVSLK IDDDKRRDTI QRLRQCKYDK KRVILKDLKH NDGNFTEKQK IELNKLLQID 
YYNLTKFYGT VKLDTMIFGV IEYCERGSLR EVLNDTISYP DGTFMDWEFK ISVLYDIAKG 
MSYLHSSKTE VHGRLKSTNC VVDSRMVVKI TDFGCNSILP PKKDLWTAPE HLRQANISQK 
GDVYSYGIIA QEIILRKETF YTLSCRDRNE KIFRVENSNG MKPFRPDLFL ETAEEKELEV 
YLLVKNCWEE DPEKRPDFKK IETTLAKIFG LFHDQKNESY MDTLIRRLQL YSRNLEHLVE 
ERTQLYKAER DRADRLNFML LPRLVVKSLK EKGFVEPELY EEVTIYFSDI VGFTTICKYS 
TPMEVVDMLN DIYKSFDHIV DHHDVYKVET IGDAYMVASG LPKRNGNRHA IDIAKMALEI 
LSFMGTFELE HLPGLPIWIR IGVHSGPCAA GVVGIKMPRY CLFGDTVNTA SRMESTGLPL 
RIHVSGSTIA ILKRTECQFL YEVRGETYLK GRGNETTYWL TGMKDQKFNL PTPPTVENQQ 
RLQAEFSDMI ANSLQKRQAA GIRSQKPRRV ASYKKGTLEY LQLNTTDKES TYF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.