Details for: PRSS2

Gene ID: 5645

Symbol: PRSS2

Ensembl ID: ENSG00000275896

Description: serine protease 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 40.2578
    Cell Significance Index: -123.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 20.7460
    Cell Significance Index: 3542.5000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 3.6525
    Cell Significance Index: 93.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.6221
    Cell Significance Index: 73.5300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.5895
    Cell Significance Index: 50.9100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.9327
    Cell Significance Index: 106.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7985
    Cell Significance Index: 78.9900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6524
    Cell Significance Index: 589.1100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4961
    Cell Significance Index: 53.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4408
    Cell Significance Index: 71.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4143
    Cell Significance Index: 78.8400
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.3862
    Cell Significance Index: 2.9400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.3125
    Cell Significance Index: 7.5700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2505
    Cell Significance Index: 17.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0432
    Cell Significance Index: 1.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0165
    Cell Significance Index: 0.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0109
    Cell Significance Index: 0.3200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0039
    Cell Significance Index: 0.1600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0040
    Cell Significance Index: -0.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0099
    Cell Significance Index: -18.7000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0160
    Cell Significance Index: -0.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0176
    Cell Significance Index: -32.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0199
    Cell Significance Index: -10.8800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0212
    Cell Significance Index: -32.5600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0239
    Cell Significance Index: -32.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0241
    Cell Significance Index: -15.3200
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0261
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0268
    Cell Significance Index: -19.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0397
    Cell Significance Index: -18.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0397
    Cell Significance Index: -22.3900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0541
    Cell Significance Index: -6.3100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0593
    Cell Significance Index: -1.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0673
    Cell Significance Index: -42.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0745
    Cell Significance Index: -4.5700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0761
    Cell Significance Index: -1.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0847
    Cell Significance Index: -15.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0909
    Cell Significance Index: -18.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1056
    Cell Significance Index: -15.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1075
    Cell Significance Index: -22.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1248
    Cell Significance Index: -15.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1287
    Cell Significance Index: -13.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1542
    Cell Significance Index: -30.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1674
    Cell Significance Index: -22.9900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2185
    Cell Significance Index: -3.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2281
    Cell Significance Index: -29.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3890
    Cell Significance Index: -21.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3894
    Cell Significance Index: -29.0200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4526
    Cell Significance Index: -6.8200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.4641
    Cell Significance Index: -5.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4858
    Cell Significance Index: -21.4900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5590
    Cell Significance Index: -14.7000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.5658
    Cell Significance Index: -7.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5691
    Cell Significance Index: -21.5500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5692
    Cell Significance Index: -15.2300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.5720
    Cell Significance Index: -8.8500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.5904
    Cell Significance Index: -9.9300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.6719
    Cell Significance Index: -16.7600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.6846
    Cell Significance Index: -17.1000
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.7076
    Cell Significance Index: -7.3200
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.7174
    Cell Significance Index: -7.8600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7276
    Cell Significance Index: -26.7100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7656
    Cell Significance Index: -26.8200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7831
    Cell Significance Index: -16.9700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.7999
    Cell Significance Index: -15.6400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.8802
    Cell Significance Index: -10.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.9028
    Cell Significance Index: -42.4300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.9082
    Cell Significance Index: -11.4800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.9402
    Cell Significance Index: -48.8400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.9403
    Cell Significance Index: -23.9600
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.9430
    Cell Significance Index: -8.8700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9508
    Cell Significance Index: -31.1300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.9535
    Cell Significance Index: -22.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.9607
    Cell Significance Index: -44.7900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.9626
    Cell Significance Index: -13.5100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9770
    Cell Significance Index: -31.1200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -1.0105
    Cell Significance Index: -12.5000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.0413
    Cell Significance Index: -29.8500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -1.0690
    Cell Significance Index: -15.5200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.0764
    Cell Significance Index: -26.8500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -1.1115
    Cell Significance Index: -19.0000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -1.1123
    Cell Significance Index: -15.9400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.1203
    Cell Significance Index: -18.7500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -1.1459
    Cell Significance Index: -18.5600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -1.1745
    Cell Significance Index: -12.3900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.1746
    Cell Significance Index: -21.7100
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -1.1877
    Cell Significance Index: -7.3400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.2123
    Cell Significance Index: -12.5500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -1.2142
    Cell Significance Index: -16.6500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.2395
    Cell Significance Index: -26.7800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -1.2446
    Cell Significance Index: -16.1100
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -1.2468
    Cell Significance Index: -15.0700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.2564
    Cell Significance Index: -16.0900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -1.2724
    Cell Significance Index: -21.6100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -1.2751
    Cell Significance Index: -16.6800
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -1.3387
    Cell Significance Index: -13.5900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.3449
    Cell Significance Index: -27.0000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -1.3627
    Cell Significance Index: -26.8200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -1.3681
    Cell Significance Index: -17.0900
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -1.4224
    Cell Significance Index: -10.0100
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -1.4307
    Cell Significance Index: -15.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PRSS2 is a serine protease enzyme that exhibits a high degree of specificity for its substrates, particularly trypsinogen, a zymogen that is cleaved into trypsin, a potent protease. The PRSS2 enzyme is primarily expressed in various cell types, including neuroendocrine cells, epithelial cells of the exocrine pancreas, thymocytes, and pancreatic cells. Its expression is also observed in other tissues, such as the thymus and the pancreas. PRSS2 has been shown to be involved in several key processes, including: * Digestion and proteolysis: PRSS2 is involved in the activation of trypsinogen, which is essential for protein digestion and the breakdown of peptides. * Immune response: PRSS2 is expressed in thymocytes and plays a role in the activation of alpha-defensins, which are antimicrobial peptides that help to defend against pathogens. * Tissue remodeling: PRSS2 is involved in the degradation of the extracellular matrix, which is essential for tissue remodeling and repair. **Pathways and Functions** PRSS2 is involved in several key pathways, including: * Activation of matrix metalloproteinases: PRSS2 activates matrix metalloproteinases, which are enzymes that degrade the extracellular matrix. * Activation of alpha-defensins: PRSS2 activates alpha-defensins, which are antimicrobial peptides that help to defend against pathogens. * Neutrophil degranulation: PRSS2 is involved in the degranulation of neutrophils, which is essential for the release of antimicrobial peptides and other pro-inflammatory molecules. * Collagen degradation: PRSS2 is involved in the degradation of collagen, which is essential for tissue remodeling and repair. **Clinical Significance** PRSS2 has been implicated in several diseases and disorders, including: * Pancreatitis: PRSS2 mutations have been associated with pancreatitis, a disease characterized by inflammation of the pancreas. * Cancer: PRSS2 has been shown to be overexpressed in certain types of cancer, including pancreatic cancer. * Autoimmune diseases: PRSS2 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. * Neurological disorders: PRSS2 has been shown to be involved in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, PRSS2 is a serine protease enzyme that plays a crucial role in various physiological and pathological processes, including digestion, immune response, and tissue remodeling. Its involvement in several key pathways, including activation of matrix metalloproteinases and alpha-defensins, highlights its importance in maintaining tissue homeostasis and responding to infection. Further research is needed to fully understand the role of PRSS2 in disease and to develop therapeutic strategies to target this enzyme.

Genular Protein ID: 203143618

Symbol: TRY2_HUMAN

Name: Trypsin-2

UniProtKB Accession Codes:

P07478

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 DrugCentral 1 EC 2 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3011602

Title: Cloning, characterization and nucleotide sequences of two cDNAs encoding human pancreatic trypsinogens.

PubMed ID: 3011602

DOI: 10.1016/0378-1119(86)90111-3

PubMed ID: 2598466

Title: Immunoreactive anionic and cationic trypsin in human serum.

PubMed ID: 2598466

DOI: 10.1016/0009-8981(89)90254-4

PubMed ID: 12021776

Title: Paneth cell trypsin is the processing enzyme for human defensin-5.

PubMed ID: 12021776

DOI: 10.1038/ni797

PubMed ID: 17087724

Title: Human cationic trypsinogen is sulfated on Tyr154.

PubMed ID: 17087724

DOI: 10.1111/j.1742-4658.2006.05501.x

PubMed ID: 25010489

Title: Tyrosine sulfation of human trypsin steers S2' subsite selectivity towards basic amino acids.

PubMed ID: 25010489

DOI: 10.1371/journal.pone.0102063

PubMed ID: 18986305

Title: A common African polymorphism abolishes tyrosine sulfation of human anionic trypsinogen (PRSS2).

PubMed ID: 18986305

DOI: 10.1042/bj20081848

Sequence Information:

  • Length: 247
  • Mass: 26488
  • Checksum: 82B0F41EB8E3D5DB
  • Sequence:
    • MNLLLILTFV AAAVAAPFDD DDKIVGGYIC EENSVPYQVS LNSGYHFCGG SLISEQWVVS 
AGHCYKSRIQ VRLGEHNIEV LEGNEQFINA AKIIRHPKYN SRTLDNDILL IKLSSPAVIN 
SRVSAISLPT APPAAGTESL ISGWGNTLSS GADYPDELQC LDAPVLSQAE CEASYPGKIT 
NNMFCVGFLE GGKDSCQGDS GGPVVSNGEL QGIVSWGYGC AQKNRPGVYT KVYNYVDWIK 
DTIAANS

Genular Protein ID: 3555126052

Symbol: A6XMV9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A6XMV9

Database IDs:

ARBA 6 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 2 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 7 MEROPS 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 261
  • Mass: 28004
  • Checksum: 99256B68336AFB97
  • Sequence:
    • MNLLLILTFV AAAVAAPFDD DDKIVGGYIC EENSVPYQVS LNSGYHFCGG SLISEQWVVS 
AGHCYKSAIN SKLSGRGCEY HRIQVRLGEH NIEVLEGNEQ FINAAKIIRH PKYNSRTLDN 
DILLIKLSSP AVINSRVSAI SLPTAPPAAG TESLISGWGN TLSSGADYPD ELQCLDAPVL 
SQAECEASYP GKITNNMFCV GFLEGGKDSC QGDSGGPVVS NGELQGIVSW GYGCAQKNRP 
GVYTKVYNYV DWIKDTIAAN S

Genular Protein ID: 910273770

Symbol: Q6PK75_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6PK75

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 2 Gene3D 1 InterPro 6 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 2 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 187
  • Mass: 20105
  • Checksum: CAFD01BB2D02BAD7
  • Sequence:
    • MNLLLILTFV AAAVAAPFDD DDKIVGGYIC EENSVPYQVS LNSGYHFCGG SLISEQWVVS 
AGHCYKSRIQ VRLGEHNIEV LEGNEQFINA AKIIRHPKYN SRTLDNDILL IKLSSPAVIN 
SRVSAISLPT APPAAGTESL ISGWGNTLSS GADYPDELQC LDAPVLSQAE CEASYPGKIT 
NNMFCVG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.