Details for: GUCA2B

Gene ID: 2981

Symbol: GUCA2B

Ensembl ID: ENSG00000044012

Description: guanylate cyclase activator 2B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 4.47
    Marker Score: 1737
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6839
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3174
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.4
    Marker Score: 3699
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.66
    Marker Score: 7959.5
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.5
    Marker Score: 4699
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.07
    Marker Score: 7139
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.04
    Marker Score: 1001
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48053
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.97
    Marker Score: 281
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5335
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.88
    Marker Score: 254
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.85
    Marker Score: 339
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.8
    Marker Score: 786
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.8
    Marker Score: 1510
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.77
    Marker Score: 3243
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.76
    Marker Score: 440
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 691
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7
    Marker Score: 10941
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.65
    Marker Score: 731
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 481
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.57
    Marker Score: 1168
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.54
    Marker Score: 1117.5
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.47
    Marker Score: 177
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.45
    Marker Score: 112
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.45
    Marker Score: 446
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.43
    Marker Score: 301
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.43
    Marker Score: 426
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.42
    Marker Score: 992
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.4
    Marker Score: 241
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.4
    Marker Score: 675
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.38
    Marker Score: 167
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.36
    Marker Score: 613
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.33
    Marker Score: 151
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.32
    Marker Score: 515
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.31
    Marker Score: 80
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.3
    Marker Score: 1802
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3
    Marker Score: 123
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.29
    Marker Score: 211
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.27
    Marker Score: 73
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.24
    Marker Score: 82.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.23
    Marker Score: 109
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.23
    Marker Score: 146
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.2
    Marker Score: 252
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.19
    Marker Score: 47
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.18
    Marker Score: 178
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.16
    Marker Score: 71
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.16
    Marker Score: 375
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.15
    Marker Score: 49
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.15
    Marker Score: 244
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.14
    Marker Score: 38
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.13
    Marker Score: 56
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.13
    Marker Score: 152
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.12
    Marker Score: 27
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.12
    Marker Score: 38
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 0.12
    Marker Score: 34
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.12
    Marker Score: 116
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.12
    Marker Score: 61
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.11
    Marker Score: 97
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.11
    Marker Score: 36
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.11
    Marker Score: 75
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.11
    Marker Score: 115
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.1
    Marker Score: 109
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.1
    Marker Score: 110
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1
    Marker Score: 33
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.1
    Marker Score: 22
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.1
    Marker Score: 44
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.09
    Marker Score: 605
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.09
    Marker Score: 50
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.08
    Marker Score: 162
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.08
    Marker Score: 26
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.07
    Marker Score: 49
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: type D enteroendocrine cell (CL0000502)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.07
    Marker Score: 58
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.06
    Marker Score: 34
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.06
    Marker Score: 59
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.06
    Marker Score: 52
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.06
    Marker Score: 39
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.06
    Marker Score: 29
  • Cell Name: follicular dendritic cell (CL0000442)
    Fold Change: 0.06
    Marker Score: 20

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Other Information

**Key characteristics:** - It is a single-pass membrane protein with a molecular weight of approximately 120 kDa. - It is a member of the guanylate cyclase family of proteins. - It is expressed in a variety of cell types, including those that are involved in the regulation of inflammation, metabolism, and cell growth. **Pathways and functions:** - GUCA2B is a key regulator of the cGMP signaling pathway. - It is activated by guanosine 5'-monophosphate (GMP), a second messenger that is produced in response to various stimuli. - Once activated, GUCA2B phosphorylates a variety of targets in the cytosol, which leads to the inhibition of cGMP-dependent protein kinases (CDPKs). - This inhibition of CDPKs blocks the activation of downstream targets, including protein kinases and phosphatases, which are involved in cell growth, differentiation, and apoptosis. - As a result, GUCA2B plays an important role in maintaining cell cycle arrest and preventing cancer. **Clinical significance:** - Mutations in GUCA2B have been linked to a number of human diseases, including cancer, cardiovascular disease, and stroke. - In cancer, mutations in GUCA2B are often seen in tumors that are resistant to chemotherapy. - Targeting GUCA2B with small molecule inhibitors is a promising new strategy for cancer treatment.

Genular Protein ID: 476293291

Symbol: GUC2B_HUMAN

Name: Guanylate cyclase activator 2B

UniProtKB Accession Codes:

Q16661 Q52LV0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8605041

Title: Cloning and characterization of a cDNA encoding a precursor for human uroguanylin.

PubMed ID: 8605041

DOI: 10.1006/bbrc.1996.0287

PubMed ID: 8519795

Title: A new human guanylate cyclase-activating peptide (GCAP-II, uroguanylin): precursor cDNA and colonic expression.

PubMed ID: 8519795

DOI: 10.1016/0167-4838(95)00204-4

PubMed ID: 9268639

Title: Genomic structure and chromosomal localization of human uroguanylin.

PubMed ID: 9268639

DOI: 10.1006/geno.1997.4808

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7589507

Title: GCAP-II: isolation and characterization of the circulating form of human uroguanylin.

PubMed ID: 7589507

DOI: 10.1016/0014-5793(95)01075-p

PubMed ID: 8141334

Title: Characterization of human uroguanylin: a member of the guanylin peptide family.

PubMed ID: 8141334

DOI: 10.1152/ajprenal.1994.266.2.f342

PubMed ID: 9774236

Title: One peptide, two topologies: structure and interconversion dynamics of human uroguanylin isomers.

PubMed ID: 9774236

DOI: 10.1111/j.1399-3011.1998.tb01480.x

Sequence Information:

  • Length: 112
  • Mass: 12069
  • Checksum: AA3030BC3D4EE412
  • Sequence:
    • MGCRAASGLL PGVAVVLLLL LQSTQSVYIQ YQGFRVQLES MKKLSDLEAQ WAPSPRLQAQ 
SLLPAVCHHP ALPQDLQPVC ASQEASSIFK TLRTIANDDC ELCVNVACTG CL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.