Details for: PIK3C2G

Gene ID: 5288

Symbol: PIK3C2G

Ensembl ID: ENSG00000139144

Description: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 4.56
    Marker Score: 14950
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.91
    Marker Score: 11218
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 3.59
    Marker Score: 2769
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.41
    Marker Score: 9726
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.92
    Marker Score: 1311
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.8
    Marker Score: 11680
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 2.51
    Marker Score: 2407
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 2.5
    Marker Score: 7289
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.49
    Marker Score: 6285
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.33
    Marker Score: 2634
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 2.15
    Marker Score: 18223
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.1
    Marker Score: 1818
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.81
    Marker Score: 759
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.78
    Marker Score: 3376.5
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.78
    Marker Score: 9553
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.66
    Marker Score: 10675
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.59
    Marker Score: 2246
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.54
    Marker Score: 6659
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.53
    Marker Score: 1620
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.51
    Marker Score: 796
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 1.5
    Marker Score: 4437
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.42
    Marker Score: 3227
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.38
    Marker Score: 604
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.32
    Marker Score: 2690
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.29
    Marker Score: 283
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.25
    Marker Score: 1107
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.2
    Marker Score: 721.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.08
    Marker Score: 2553
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.07
    Marker Score: 732
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.01
    Marker Score: 15831
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71778
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48001
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.95
    Marker Score: 1044
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.94
    Marker Score: 2147
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2733
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.91
    Marker Score: 340
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5139
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.85
    Marker Score: 11330
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.84
    Marker Score: 897
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.81
    Marker Score: 1254
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.78
    Marker Score: 252
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 311
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.76
    Marker Score: 1266
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 694
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.72
    Marker Score: 187
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.71
    Marker Score: 2532
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.7
    Marker Score: 4203
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2795
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.66
    Marker Score: 5630
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.63
    Marker Score: 4042
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.59
    Marker Score: 283
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 377
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.58
    Marker Score: 182
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.56
    Marker Score: 232
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.56
    Marker Score: 312
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.51
    Marker Score: 2503.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.51
    Marker Score: 1240
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.5
    Marker Score: 180.5
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.49
    Marker Score: 151
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.49
    Marker Score: 215
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.48
    Marker Score: 351
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.47
    Marker Score: 607
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.47
    Marker Score: 324
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.46
    Marker Score: 147
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.46
    Marker Score: 313
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.46
    Marker Score: 159
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.45
    Marker Score: 795
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.44
    Marker Score: 370
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.44
    Marker Score: 440
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.44
    Marker Score: 838
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.43
    Marker Score: 1819
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.42
    Marker Score: 667
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.41
    Marker Score: 369
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.41
    Marker Score: 432
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.41
    Marker Score: 80
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.41
    Marker Score: 1571
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.4
    Marker Score: 126
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.39
    Marker Score: 160
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.39
    Marker Score: 180
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.38
    Marker Score: 420
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.38
    Marker Score: 330
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.38
    Marker Score: 1351
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.38
    Marker Score: 184
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.37
    Marker Score: 169
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.37
    Marker Score: 231
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.36
    Marker Score: 3128
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.36
    Marker Score: 1716.5
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.36
    Marker Score: 134
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.35
    Marker Score: 110
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.34
    Marker Score: 365
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.34
    Marker Score: 125

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Other Information

**Key characteristics:** * PIK3C2G is a serine/threonine kinase that is involved in a variety of cellular processes, including cell migration, cell cycle progression, and apoptosis. * It is a key regulator of hepatocyte migration and survival. * It is also involved in the regulation of retinal development and function. * It is a key regulator of kidney cell migration and differentiation. * It is involved in the regulation of epithelial cell migration and differentiation. **Pathways and functions:** * PIK3C2G is involved in a variety of cellular processes, including cell migration, cell cycle progression, and apoptosis. * In cell migration, PIK3C2G is involved in the regulation of cell adhesion to extracellular matrix proteins and the signaling pathways that control cell migration. * In cell cycle progression, PIK3C2G is involved in the regulation of cell cycle checkpoints and the progression of cells through the cell cycle. * In apoptosis, PIK3C2G is involved in the regulation of cell death. **Clinical significance:** * Mutations in PIK3C2G have been linked to a number of human diseases, including cancer, heart disease, and stroke. * PIK3C2G inhibitors are being developed as potential treatments for these diseases.

Genular Protein ID: 1168575109

Symbol: P3C2G_HUMAN

Name: Phosphoinositide 3-kinase-C2-gamma

UniProtKB Accession Codes:

O75747 A1L3U0 F5H369

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CTD 1 ChEBI 10 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 16 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 8 PROSITE-ProRule 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 3 Rhea 4 SMART 4 SMR 1 STRING 1 SUPFAM 5 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9878262

Title: cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12.

PubMed ID: 9878262

DOI: 10.1006/geno.1998.5621

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 17991425

Title: Association of the PIK3C2G gene polymorphisms with type 2 DM in a Japanese population.

PubMed ID: 17991425

DOI: 10.1016/j.bbrc.2007.10.180

Sequence Information:

  • Length: 1486
  • Mass: 170682
  • Checksum: E1D981018DD2B052
  • Sequence:
    • MAYSWQTDPN PNESHEKQYE HQEFLFVNQP HSSSQVSLGF DQIVDEISGK IPHYESEIDE 
NTFFVPTAPK WDSTGHSLNE AHQISLNEFT SKSRELSWHQ VSKAPAIGFS PSVLPKPQNT 
NKECSWGSPI GKHHGADDSR FSILAPSFTS LDKINLEKEL ENENHNYHIG FESSIPPTNS 
SFSSDFMPKE ENKRSGHVNI VEPSLMLLKG SLQPGMWEST WQKNIESIGC SIQLVEVPQS 
SNTSLASFCN KVKKIRERYH AADVNFNSGK IWSTTTAFPY QLFSKTKFNI HIFIDNSTQP 
LHFMPCANYL VKDLIAEILH FCTNDQLLPK DHILSVCGSE EFLQNDHCLG SHKMFQKDKS 
VIQLHLQKSR EAPGKLSRKH EEDHSQFYLN QLLEFMHIWK VSRQCLLTLI RKYDFHLKYL 
LKTQENVYNI IEEVKKICSV LGCVETKQIT DAVNELSLIL QRKGENFYQS SETSAKGLIE 
KVTTELSTSI YQLINVYCNS FYADFQPVNV PRCTSYLNPG LPSHLSFTVY AAHNIPETWV 
HSYKAFSFTC WLTYAGKKLC QVRNYRNIPD KKLFFFLVNW NETINFPLEI KSLPRESMLT 
VKLFGIACAT NNANLLAWTC LPLFPKEKSI LGSMLFSMTL QSEPPVEMIT PGVWDVSQPS 
PVTLQIDFPA TGWEYMKPDS EENRSNLEEP LKECIKHIAR LSQKQTPLLL SEEKKRYLWF 
YRFYCNNENC SLPLVLGSAP GWDERTVSEM HTILRRWTFS QPLEALGLLT SSFPDQEIRK 
VAVQQLDNLL NDELLEYLPQ LVQAVKFEWN LESPLVQLLL HRSLQSIQVA HRLYWLLKNA 
ENEAYFKSWY QKLLAALQFC AGKALNDEFS KEQKLIKILG DIGERVKSAS DHQRQEVLKK 
EIGRLEEFFQ DVNTCHLPLN PALCIKGIDH DACSYFTSNA LPLKITFINA NPMGKNISII 
FKAGDDLRQD MLVLQLIQVM DNIWLQEGLD MQMIIYRCLS TGKDQGLVQM VPDAVTLAKI 
HRHSGLIGPL KENTIKKWFS QHNHLKADYE KALRNFFYSC AGWCVVTFIL GVCDRHNDNI 
MLTKSGHMFH IDFGKFLGHA QTFGGIKRDR APFIFTSEME YFITEGGKNP QHFQDFVELC 
CRAYNIIRKH SQLLLNLLEM MLYAGLPELS GIQDLKYVYN NLRPQDTDLE ATSHFTKKIK 
ESLECFPVKL NNLIHTLAQM SAISPAKSTS QTFPQESCLL STTRSIERAT ILGFSKKSSN 
LYLIQVTHSN NETSLTEKSF EQFSKLHSQL QKQFASLTLP EFPHWWHLPF TNSDHRRFRD 
LNHYMEQILN VSHEVTNSDC VLSFFLSEAV QQTVEESSPV YLGEKFPDKK PKVQLVISYE 
DVKLTILVKH MKNIHLPDGS APSAHVEFYL LPYPSEVRRR KTKSVPKCTD PTYNEIVVYD 
EVTELQGHVL MLIVKSKTVF VGAINIRLCS VPLDKEKWYP LGNSII

Genular Protein ID: 3971191590

Symbol: B7ZLY6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7ZLY6

Database IDs:

ARBA 6 BioGRID-ORCS 1 CDD 5 CTD 1 ChEBI 10 ChiTaRS 1 DNASU 1 EC 2 EMBL 2 GO 6 Gene3D 4 GenomeRNAi 1 InterPro 16 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 14 PeptideAtlas 1 Pfam 6 RefSeq 3 Rhea 4 SMART 5 SMR 1 SUPFAM 5

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1485
  • Mass: 170617
  • Checksum: E3374B4AA9895148
  • Sequence:
    • MAYSWQTDPN PNESHEKQYE HQEFLFVNQP HSSSQVSLGF DQIVDEISGK IPHYESEIDE 
NTFFVPTAPK WDSTGHSLNE AHQISLNEFT SKSRELSWHQ VSKAPAIGFS PSVLPKPQNT 
NKECSWGSIG KHHGADDSRF SILALSFTSL DKINLEKELE NENHNYHIGF ESSIPPTNSS 
FSSDFMPKEE NKRSGHVNIV EPSLMLLKGS LQPGMWESTW QKNIESIGCS IQLVEVPQSS 
NTSLASFCNK VKKIRERYHA ADVNFNSGKI WSTTTAFPYQ LFSKTKFNIH IFIDNSTQPL 
HFMPCANYLV KDLIAEILHF CTNDQLLPKD HILSVCGSEE FLQNDHCLGS HKMFQKDKSV 
IQLHLQKSRE APGKLSRKHE EDHSQFYLNQ LLEFMHIWKV SRQCLLTLIR KYDFHLKYLL 
KTQENVYNII EEVKKICSVL GCVETKQITD AVNELSLILQ RKGENFYQSS ETSAKGLIEK 
VTTELSTSIY QLINVYCNSF YADFQPVNVP RCTSYLNPGL PSHLSFTVYA AHNIPETWVH 
SYKAFSFTCW LTYAGKKLCQ VRNYRNIPDK KLFFFLVNWN ETINFPLEIK SLPRESMLTV 
KLFGIACATN NANLLAWTCL PLFPKEKSIL GSMLFSMTLQ SEPPVEMITP GVWDVSQPSP 
VTLQIDFPAT GWEYMKPDSE ENRSNLEEPL KECIKHIARL SQKQTPLLLS EEKKRYLWFY 
RFYCNNENCS LPLVLGSAPG WDERTVSEMH TILRRWTFSQ PLEALGLLTS SFPDQEIRKV 
AVQQLDNLLN DELLEYLPQL VQAVKFEWNL ESPLVQLLLH RSLQSIQVAH RLYWLLKNAE 
NEAYFKSWYQ KLLAALQFCA GKALNDEFSK EQKLIKILGD IGERVKSASD HQRQEVLKKE 
IGRLEEFFQD VNTCHLPLNP ALCIKGIDHD ACSYFTSNAL PLKITFINAN LMGKNISIIF 
KAGDDLRQDM LVLQLIQVMD NIWLQEGLDM QMIIYRCLST GKDQGLVQMV PDAVTLAKIH 
RHSGLIGPLK ENTIKKWFSQ HNHLKADYEK ALRNFFYSCA GWCVVTFILG VCDRHNDNIM 
LTKSGHMFHI DFGKFLGHAQ TFGGIKRDRA PFIFTSEMEY FITEGGKNPQ HFQDFVELCC 
RAYNIIRKHS QLLLNLLEMM LYAGLPELSG IQDLKYVYNN LRPQDTDLEA TSHFTKKIKE 
SLECFPVKLN NLIHTLAQMS AISPAKSTSQ TFPQESCLLS TTRSIERATI LGFSKKSSNL 
YLIQVTHSNN ETSLTEKSFE QFSKLHSQLQ KQFASLTLPE FPHWWHLPFT NSDHRRFRDL 
NHYMEQILNV SHEVTNSDCV LSFFLSEAVQ QTVEESSPVY LGEKFPDKKP KVQLVISYED 
VKLTILVKHM KNIHLPDGSA PSAHVEFYLL PYPSEVRRRK TKSVPKCTDP TYNEIVVYDE 
VTELQGHVLM LIVKSKTVFV GAINIRLCSV PLDKEKWYPL GNSII

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.