Details for: BARX2

Gene ID: 8538

Symbol: BARX2

Ensembl ID: ENSG00000043039

Description: BARX homeobox 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 58.6325
    Cell Significance Index: -9.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 36.2320
    Cell Significance Index: -9.1900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 6.5906
    Cell Significance Index: 89.9200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.0889
    Cell Significance Index: 144.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.0036
    Cell Significance Index: 83.9400
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 2.9105
    Cell Significance Index: 2.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.7207
    Cell Significance Index: 327.4600
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 1.6689
    Cell Significance Index: 12.0100
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.3891
    Cell Significance Index: 8.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.3050
    Cell Significance Index: 576.9700
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 1.2651
    Cell Significance Index: 12.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1175
    Cell Significance Index: 24.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0796
    Cell Significance Index: 50.7400
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.0062
    Cell Significance Index: 7.6300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.9181
    Cell Significance Index: 5.6500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.8516
    Cell Significance Index: 12.7600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7786
    Cell Significance Index: 84.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7613
    Cell Significance Index: 56.7400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7006
    Cell Significance Index: 20.1900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6913
    Cell Significance Index: 624.2100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6016
    Cell Significance Index: 77.7300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.6004
    Cell Significance Index: 5.3300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5432
    Cell Significance Index: 53.7300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5367
    Cell Significance Index: 12.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5154
    Cell Significance Index: 23.3600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4243
    Cell Significance Index: 29.3400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3186
    Cell Significance Index: 22.5300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3137
    Cell Significance Index: 3.4100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2817
    Cell Significance Index: 6.0000
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.1699
    Cell Significance Index: 2.1100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1692
    Cell Significance Index: 4.2200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1584
    Cell Significance Index: 3.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1002
    Cell Significance Index: 3.2100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0821
    Cell Significance Index: 1.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0560
    Cell Significance Index: 30.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0558
    Cell Significance Index: 1.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0415
    Cell Significance Index: 1.1300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0309
    Cell Significance Index: 0.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0276
    Cell Significance Index: 5.5300
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 0.0144
    Cell Significance Index: 0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0039
    Cell Significance Index: -7.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0061
    Cell Significance Index: -11.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0074
    Cell Significance Index: -4.6900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0075
    Cell Significance Index: -11.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0078
    Cell Significance Index: -0.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0079
    Cell Significance Index: -0.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0083
    Cell Significance Index: -1.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0087
    Cell Significance Index: -11.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0099
    Cell Significance Index: -3.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0104
    Cell Significance Index: -1.8800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0105
    Cell Significance Index: -7.9700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0115
    Cell Significance Index: -8.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0116
    Cell Significance Index: -0.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0120
    Cell Significance Index: -8.9000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0132
    Cell Significance Index: -8.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0147
    Cell Significance Index: -4.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0168
    Cell Significance Index: -9.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0198
    Cell Significance Index: -2.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0200
    Cell Significance Index: -9.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0207
    Cell Significance Index: -3.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0222
    Cell Significance Index: -4.4100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0248
    Cell Significance Index: -2.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0414
    Cell Significance Index: -2.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0470
    Cell Significance Index: -9.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0498
    Cell Significance Index: -7.2400
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.0623
    Cell Significance Index: -1.3000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0649
    Cell Significance Index: -1.6200
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: -0.0653
    Cell Significance Index: -0.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0662
    Cell Significance Index: -9.0900
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -0.0723
    Cell Significance Index: -0.7800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0758
    Cell Significance Index: -0.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0807
    Cell Significance Index: -9.5200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0823
    Cell Significance Index: -1.2400
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0826
    Cell Significance Index: -1.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0900
    Cell Significance Index: -9.3700
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0985
    Cell Significance Index: -1.0800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1010
    Cell Significance Index: -1.7300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1047
    Cell Significance Index: -4.2900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1171
    Cell Significance Index: -7.8800
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.1276
    Cell Significance Index: -0.7900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1316
    Cell Significance Index: -6.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1361
    Cell Significance Index: -10.4500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1449
    Cell Significance Index: -5.3200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1455
    Cell Significance Index: -9.3900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.1552
    Cell Significance Index: -0.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1561
    Cell Significance Index: -9.6000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1606
    Cell Significance Index: -2.3000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1658
    Cell Significance Index: -4.1400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1679
    Cell Significance Index: -1.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1755
    Cell Significance Index: -9.8500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1768
    Cell Significance Index: -7.8200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1775
    Cell Significance Index: -11.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1815
    Cell Significance Index: -4.6700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1988
    Cell Significance Index: -2.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2025
    Cell Significance Index: -10.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2057
    Cell Significance Index: -10.8000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2121
    Cell Significance Index: -4.4400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2173
    Cell Significance Index: -6.4000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2232
    Cell Significance Index: -4.6300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2258
    Cell Significance Index: -8.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BARX2 is a member of the BarH-like homeobox gene family, which is characterized by its ability to regulate gene expression through DNA binding and transcriptional activation. The BARX2 protein is a transcription factor that binds to specific DNA sequences, influencing the expression of target genes involved in various cellular processes. Its expression is widespread, with significant levels observed in keratinocytes, epithelial cells, and immune cells such as granulocytes and monocytes. **Pathways and Functions:** BARX2 is involved in several key cellular pathways, including: 1. **Actin cytoskeleton regulation**: BARX2 influences the organization and dynamics of the actin cytoskeleton, which is essential for cell migration, differentiation, and survival. 2. **Cartilage condensation**: BARX2 is required for the proper formation and maintenance of cartilage tissue, highlighting its importance in musculoskeletal development and homeostasis. 3. **Myotube differentiation**: BARX2 plays a crucial role in the differentiation of myotubes, which is essential for muscle development and regeneration. 4. **Skeletal muscle cell differentiation**: BARX2 is involved in the regulation of skeletal muscle cell differentiation, highlighting its importance in muscle development and homeostasis. BARX2 functions as a transcriptional activator, regulating the expression of target genes involved in these pathways. Its ability to bind to specific DNA sequences and interact with other transcription factors makes it a key player in regulating gene expression. **Clinical Significance:** The dysregulation of BARX2 has been implicated in various human diseases, including: 1. **Musculoskeletal disorders**: Mutations in the BARX2 gene have been associated with skeletal muscle disorders, such as muscular dystrophy and myotonic dystrophy. 2. **Cardiovascular disease**: BARX2 has been shown to play a role in the regulation of cardiac function and development, highlighting its potential involvement in cardiovascular disease. 3. **Cancer**: The dysregulation of BARX2 has been implicated in various types of cancer, including breast cancer and leukemia. In conclusion, BARX2 is a transcription factor gene that plays a crucial role in regulating gene expression in various cell types. Its dysregulation has been implicated in several human diseases, highlighting its potential as a therapeutic target for the treatment of musculoskeletal disorders, cardiovascular disease, and cancer. Further research is needed to fully elucidate the mechanisms by which BARX2 regulates gene expression and its implications in human health and disease.

Genular Protein ID: 2324714114

Symbol: BARX2_HUMAN

Name: Homeobox protein BarH-like 2

UniProtKB Accession Codes:

Q9UMQ3 O43518 Q6NT51

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10854790

Title: Cloning and chromosomal localization of the human BARX2 homeobox protein gene.

PubMed ID: 10854790

DOI: 10.1016/s0378-1119(00)00169-4

PubMed ID: 10644443

Title: The human BARX2 gene: genomic structure, chromosomal localization, and single nucleotide polymorphisms.

PubMed ID: 10644443

DOI: 10.1006/geno.1999.6037

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 279
  • Mass: 31188
  • Checksum: 8C2537E524528467
  • Sequence:
    • MHCHAELRLS SPGQLKAARR RYKTFMIDEI LSKETCDYFE KLSLYSVCPS LVVRPKPLHS 
CTGSPSLRAY PLLSVITRQP TVISHLVPAT PGIAQALSCH QVTEAVSAEA PGGEALASSE 
SETEQPTPRQ KKPRRSRTIF TELQLMGLEK KFQKQKYLST PDRLDLAQSL GLTQLQVKTW 
YQNRRMKWKK MVLKGGQEAP TKPKGRPKKN SIPTSEEIEA EEKMNSQAQG QEQLEPSQGQ 
EELCEAQEPK ARDVPLEMAE PPDPPQELPI PSSEPPPLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.