Details for: IL1RN

Gene ID: 3557

Symbol: IL1RN

Ensembl ID: ENSG00000136689

Description: interleukin 1 receptor antagonist

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.4
    Marker Score: 26517
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.81
    Marker Score: 24235
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.5
    Marker Score: 1703
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.36
    Marker Score: 1858
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.91
    Marker Score: 2809
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.79
    Marker Score: 11425
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.55
    Marker Score: 86944
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.54
    Marker Score: 9330
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.52
    Marker Score: 513
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.48
    Marker Score: 3680
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.46
    Marker Score: 1539
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.31
    Marker Score: 1449
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.27
    Marker Score: 1137
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.16
    Marker Score: 1181
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.1
    Marker Score: 2239
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251790
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.02
    Marker Score: 246
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.01
    Marker Score: 684.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71808
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48033
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.97
    Marker Score: 395
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.95
    Marker Score: 795
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 368
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5193
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.9
    Marker Score: 3758
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5281
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.86
    Marker Score: 1116
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.86
    Marker Score: 988
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.84
    Marker Score: 350
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 631
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.83
    Marker Score: 2138
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.82
    Marker Score: 529
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.81
    Marker Score: 20643
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.8
    Marker Score: 694
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.79
    Marker Score: 794
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1256
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 695
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.76
    Marker Score: 1387
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3112.5
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.73
    Marker Score: 182
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 456
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.66
    Marker Score: 1249
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.65
    Marker Score: 1584
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.63
    Marker Score: 824
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.63
    Marker Score: 418
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.61
    Marker Score: 981
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.6
    Marker Score: 1176
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.58
    Marker Score: 352
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 447
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.55
    Marker Score: 616
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.54
    Marker Score: 1328
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.54
    Marker Score: 611
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.53
    Marker Score: 1281
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.53
    Marker Score: 1198
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.51
    Marker Score: 5966.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5
    Marker Score: 7845
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.47
    Marker Score: 150
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 274
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.45
    Marker Score: 307
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.43
    Marker Score: 282
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.41
    Marker Score: 81
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.41
    Marker Score: 233
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.39
    Marker Score: 199
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.39
    Marker Score: 143
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.38
    Marker Score: 231
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.38
    Marker Score: 297
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.37
    Marker Score: 160
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.36
    Marker Score: 436
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.36
    Marker Score: 155
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.35
    Marker Score: 337
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.33
    Marker Score: 333
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.32
    Marker Score: 371
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.32
    Marker Score: 83.5
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.31
    Marker Score: 172
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.31
    Marker Score: 319
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.3
    Marker Score: 1313
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.3
    Marker Score: 94
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.3
    Marker Score: 625
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.3
    Marker Score: 126
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.3
    Marker Score: 104
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.29
    Marker Score: 692
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.29
    Marker Score: 197
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.28
    Marker Score: 785
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.28
    Marker Score: 118
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.28
    Marker Score: 70
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.28
    Marker Score: 453
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.27
    Marker Score: 70
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.27
    Marker Score: 135
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.27
    Marker Score: 750
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.26
    Marker Score: 53
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 88

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Other Information

**Key characteristics:** * The IL1RN gene is located on chromosome 1q21.1. * It is a single-exon gene encoding a protein of 145 amino acids. * It is a member of the interleukin-1 receptor family, which is involved in the regulation of innate immunity. **Pathways and functions:** * The IL1RN gene is primarily expressed in epithelial cells, where it plays a role in maintaining tissue integrity and preventing inflammation. * It acts as an antagonist to interleukin-1 (IL-1), a cytokine that promotes inflammation and tissue damage. * IL1RN binds to IL-1 receptors on epithelial cells, inhibiting their signaling and preventing the inflammatory response. * By blocking IL-1 signaling, IL1RN helps to maintain tissue homeostasis and prevent excessive inflammation. **Clinical significance:** * Mutations in the IL1RN gene have been linked to various inflammatory diseases, including rheumatoid arthritis, inflammatory bowel disease, and asthma. * IL1RN antagonists are being investigated as potential therapeutic agents for these diseases, as they could help to suppress inflammation and protect tissue integrity. **Other important points:** * IL1RN is a highly expressed protein in the skin, where it plays a role in maintaining skin barrier function. * It is also expressed in the gut, where it helps to regulate immune responses to pathogens. * IL1RN is a pleiotropic protein that can have both pro-inflammatory and anti-inflammatory effects depending on the cellular context.

Genular Protein ID: 1419908218

Symbol: IL1RA_HUMAN

Name: Interleukin-1 receptor antagonist protein

UniProtKB Accession Codes:

P18510 A8K4G1 Q14628 Q53SC2 Q7RTZ4 Q96GD6 Q9UPC0

Database IDs:

AGR 1 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 17 EPD 1 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 5 PIR 2 PRIDE 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 2 RefSeq 7 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2139180

Title: Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein.

PubMed ID: 2139180

DOI: 10.1038/344633a0

PubMed ID: 2137201

Title: Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist.

PubMed ID: 2137201

DOI: 10.1038/343341a0

PubMed ID: 1828896

Title: Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: evolution of a cytokine control mechanism.

PubMed ID: 1828896

DOI: 10.1073/pnas.88.12.5232

PubMed ID: 1385987

Title: Cloning and chromosome mapping of the human interleukin-1 receptor antagonist gene.

PubMed ID: 1385987

DOI: 10.1016/1043-4666(92)90041-o

PubMed ID: 8992991

Title: Intracellular IL-1 receptor antagonist promoter: cell type-specific and inducible regulatory regions.

PubMed ID: 8992991

PubMed ID: 1827201

Title: cDNA cloning of an intracellular form of the human interleukin 1 receptor antagonist associated with epithelium.

PubMed ID: 1827201

DOI: 10.1073/pnas.88.9.3681

PubMed ID: 7629520

Title: Cloning and characterization of a new isoform of the interleukin 1 receptor antagonist.

PubMed ID: 7629520

DOI: 10.1084/jem.182.2.623

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2137200

Title: Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor.

PubMed ID: 2137200

DOI: 10.1038/343336a0

PubMed ID: 2143761

Title: Purification and characterization of interleukin 1 receptor level antagonist proteins from THP-1 cells.

PubMed ID: 2143761

DOI: 10.1016/s0021-9258(18)77331-6

PubMed ID: 9514884

Title: Detection of an interleukin-1 intracellular receptor antagonist mRNA variant.

PubMed ID: 9514884

DOI: 10.1006/bbrc.1998.8217

PubMed ID: 7989776

Title: Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses.

PubMed ID: 7989776

PubMed ID: 7775431

Title: Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex.

PubMed ID: 7775431

DOI: 10.1074/jbc.270.23.13757

PubMed ID: 11991722

Title: A sequence-based map of the nine genes of the human interleukin-1 cluster.

PubMed ID: 11991722

DOI: 10.1006/geno.2002.6751

PubMed ID: 8786086

Title: Interleukin-1 receptor antagonist allele (IL1RN*2) associated with nephropathy in diabetes mellitus.

PubMed ID: 8786086

DOI: 10.1007/bf02185776

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19494218

Title: An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist.

PubMed ID: 19494218

DOI: 10.1056/nejmoa0807865

PubMed ID: 32384874

Title: Serum level of IL-1ra was associated with the treatment of latent tuberculosis infection in a Chinese population.

PubMed ID: 32384874

DOI: 10.1186/s12879-020-05047-x

PubMed ID: 1534997

Title: Secondary structure and topology of interleukin-1 receptor antagonist protein determined by heteronuclear three-dimensional NMR spectroscopy.

PubMed ID: 1534997

DOI: 10.1021/bi00138a001

PubMed ID: 8045306

Title: Solution structure of human interleukin-1 receptor antagonist protein.

PubMed ID: 8045306

DOI: 10.1016/0014-5793(94)00643-1

PubMed ID: 8175703

Title: X-ray structure of interleukin-1 receptor antagonist at 2.0-A resolution.

PubMed ID: 8175703

DOI: 10.1016/s0021-9258(18)99957-6

PubMed ID: 7867645

Title: Refined crystal structure of the interleukin-1 receptor antagonist. Presence of a disulfide link and a cis-proline.

PubMed ID: 7867645

DOI: 10.1111/j.1432-1033.1995.tb20209.x

PubMed ID: 9062194

Title: A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist.

PubMed ID: 9062194

DOI: 10.1038/386194a0

PubMed ID: 18987736

Title: DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.

PubMed ID: 18987736

DOI: 10.1038/nature07485

Sequence Information:

  • Length: 177
  • Mass: 20055
  • Checksum: D1690776A7394057
  • Sequence:
    • MEICRGLRSH LITLLLFLFH SETICRPSGR KSSKMQAFRI WDVNQKTFYL RNNQLVAGYL 
QGPNVNLEEK IDVVPIEPHA LFLGIHGGKM CLSCVKSGDE TRLQLEAVNI TDLSENRKQD 
KRFAFIRSDS GPTTSFESAA CPGWFLCTAM EADQPVSLTN MPDEGVMVTK FYFQEDE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.