Details for: OVOL1

Gene ID: 5017

Symbol: OVOL1

Ensembl ID: ENSG00000172818

Description: ovo like transcriptional repressor 1

Associated with

  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Epidermal cell differentiation
    (GO:0009913)
  • Germline cell cycle switching, mitotic to meiotic cell cycle
    (GO:0051729)
  • Keratinocyte proliferation
    (GO:0043616)
  • Kidney development
    (GO:0001822)
  • Meiotic cell cycle phase transition
    (GO:0044771)
  • Mesoderm development
    (GO:0007498)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of keratinocyte proliferation
    (GO:0010839)
  • Negative regulation of meiotic cell cycle phase transition
    (GO:1901994)
  • Negative regulation of stem cell proliferation
    (GO:2000647)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Skin development
    (GO:0043588)
  • Spermatogenesis
    (GO:0007283)
  • Stem cell proliferation
    (GO:0072089)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 17.2305
    Cell Significance Index: -7.0000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 11.0130
    Cell Significance Index: -7.3900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 9.5751
    Cell Significance Index: 497.4000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 7.3737
    Cell Significance Index: -7.0400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.6396
    Cell Significance Index: -9.7500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.5390
    Cell Significance Index: -10.8700
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 3.0870
    Cell Significance Index: 11.8200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.3223
    Cell Significance Index: 27.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.0919
    Cell Significance Index: 94.8200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.0786
    Cell Significance Index: 22.0900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.0081
    Cell Significance Index: 30.0900
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.9748
    Cell Significance Index: 14.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.7840
    Cell Significance Index: 51.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.7683
    Cell Significance Index: 38.3100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.7298
    Cell Significance Index: 24.0000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5018
    Cell Significance Index: 20.4900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.3706
    Cell Significance Index: 8.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1004
    Cell Significance Index: 108.8500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.9746
    Cell Significance Index: 8.9800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9706
    Cell Significance Index: 58.2700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8719
    Cell Significance Index: 787.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8599
    Cell Significance Index: 23.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8377
    Cell Significance Index: 151.0100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.8377
    Cell Significance Index: 7.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7485
    Cell Significance Index: 87.2300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.7109
    Cell Significance Index: 10.1200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.6742
    Cell Significance Index: 11.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6244
    Cell Significance Index: 101.5500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6182
    Cell Significance Index: 13.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5460
    Cell Significance Index: 241.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5015
    Cell Significance Index: 61.6700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4508
    Cell Significance Index: 31.1800
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.4290
    Cell Significance Index: 2.6600
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.4051
    Cell Significance Index: 4.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3114
    Cell Significance Index: 14.6400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3029
    Cell Significance Index: 10.6500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2783
    Cell Significance Index: 20.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2470
    Cell Significance Index: 31.9200
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 0.2446
    Cell Significance Index: 1.7600
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: 0.2294
    Cell Significance Index: 1.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2217
    Cell Significance Index: 7.1000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1906
    Cell Significance Index: 36.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1847
    Cell Significance Index: 100.8900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1396
    Cell Significance Index: 9.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1319
    Cell Significance Index: 6.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1034
    Cell Significance Index: 2.7600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0831
    Cell Significance Index: 0.8600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.0826
    Cell Significance Index: 0.7100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0624
    Cell Significance Index: 38.9900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0531
    Cell Significance Index: 6.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0382
    Cell Significance Index: 6.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0376
    Cell Significance Index: 5.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0293
    Cell Significance Index: 0.8200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0270
    Cell Significance Index: 0.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0110
    Cell Significance Index: 1.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0007
    Cell Significance Index: -1.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0022
    Cell Significance Index: -1.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0030
    Cell Significance Index: -1.6800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0032
    Cell Significance Index: -0.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0045
    Cell Significance Index: -3.3100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0051
    Cell Significance Index: -0.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0052
    Cell Significance Index: -9.6200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0062
    Cell Significance Index: -0.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0070
    Cell Significance Index: -9.5500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0075
    Cell Significance Index: -5.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0122
    Cell Significance Index: -7.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0176
    Cell Significance Index: -8.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0180
    Cell Significance Index: -6.4400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0211
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0222
    Cell Significance Index: -2.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0244
    Cell Significance Index: -4.8500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0317
    Cell Significance Index: -9.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0331
    Cell Significance Index: -6.6500
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0344
    Cell Significance Index: -0.2500
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.0353
    Cell Significance Index: -0.3100
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0355
    Cell Significance Index: -0.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0508
    Cell Significance Index: -6.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0521
    Cell Significance Index: -7.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0571
    Cell Significance Index: -3.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0716
    Cell Significance Index: -7.4600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0834
    Cell Significance Index: -0.8800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0924
    Cell Significance Index: -2.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0951
    Cell Significance Index: -7.5300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0959
    Cell Significance Index: -1.9900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1093
    Cell Significance Index: -7.3500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1157
    Cell Significance Index: -2.8900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1202
    Cell Significance Index: -3.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1277
    Cell Significance Index: -6.6500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1289
    Cell Significance Index: -1.6600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1354
    Cell Significance Index: -4.9700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1356
    Cell Significance Index: -8.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1479
    Cell Significance Index: -9.0900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.1584
    Cell Significance Index: -0.3600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1717
    Cell Significance Index: -1.1400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1774
    Cell Significance Index: -6.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1820
    Cell Significance Index: -10.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1863
    Cell Significance Index: -8.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1878
    Cell Significance Index: -9.8600
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: -0.1908
    Cell Significance Index: -0.6600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2125
    Cell Significance Index: -7.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OVOL1 is a member of the ovo-like transcriptional repressor family, characterized by its ability to bind to specific DNA sequences and regulate gene expression. This gene is specifically expressed in various cell types, including respiratory basal cells, bladder urothelial cells, and epithelial cells of the urethra. OVOL1's primary function is to act as a negative regulator of transcription by RNA polymerase II, thereby suppressing the expression of target genes involved in cell proliferation and differentiation. **Pathways and Functions:** OVOL1's regulatory activities are mediated through its interactions with various signaling pathways, including: 1. **Epidermal cell differentiation:** OVOL1 plays a crucial role in regulating the differentiation of epithelial cells, particularly in the skin and kidney development. 2. **Germline cell cycle switching:** OVOL1 is involved in the transition from mitosis to meiosis, ensuring proper gamete formation and development. 3. **Keratinocyte proliferation:** OVOL1 acts as a negative regulator of keratinocyte proliferation, preventing excessive cell growth and maintaining tissue homeostasis. 4. **Stem cell proliferation:** OVOL1's regulatory activities also extend to stem cell proliferation, where it helps maintain the balance between self-renewal and differentiation. **Clinical Significance:** Dysregulation of OVOL1 has been implicated in various diseases, including: 1. **Cancer:** Overexpression of OVOL1 has been observed in certain types of cancer, such as bladder and kidney cancer, highlighting its potential as a prognostic marker. 2. **Neurological disorders:** Alterations in OVOL1 expression have been linked to neurodevelopmental disorders, such as autism and schizophrenia. 3. **Skin diseases:** OVOL1's role in regulating keratinocyte proliferation makes it a potential target for the treatment of skin diseases, such as psoriasis and acne. In conclusion, OVOL1 is a critical regulator of epithelial cell differentiation, stem cell proliferation, and meiotic cell cycle phase transition. Its dysregulation has significant implications for various disease states, highlighting the need for further research into the molecular mechanisms underlying OVOL1's functions.

Genular Protein ID: 3718614747

Symbol: OVOL1_HUMAN

Name: Putative transcription factor Ovo-like 1

UniProtKB Accession Codes:

O14753 Q6PCB1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9383297

Title: Characterization of a human homolog (OVOL1) of the Drosophila ovo gene, which maps to chromosome 11q13.

PubMed ID: 9383297

DOI: 10.1007/s003359900620

Sequence Information:

  • Length: 267
  • Mass: 30259
  • Checksum: 57C67CD8A060A9B8
  • Sequence:
    • MPRAFLVKKP CVSTCKRNWS ELPDEERGEI YVPVSLGFCP PQPYREPEPS VAEPPSCPLA 
LNMSLRDSSY SMAPGPCVVA QLPSEDMGHL TDPQSRDHGF LRTKMKVTLG DSPSGDLFTC 
RVCQKAFTYQ RMLNRHMKCH NDVKRHLCTY CGKGFNDTFD LKRHVRTHTG VRPYKCSLCD 
KAFTQRCSLE SHLKKIHGVQ QKYAYKERRA KLYVCEECGC TSESQEGHVL HLKEHHPDSP 
LLRKTSKKVA VALQNTVTSL LQGSPHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.