Details for: PSCA

Gene ID: 8000

Symbol: PSCA

Ensembl ID: ENSG00000167653

Description: prostate stem cell antigen

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 53.9340
    Cell Significance Index: -13.6800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 19.1059
    Cell Significance Index: 175.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 18.5472
    Cell Significance Index: 963.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 6.3971
    Cell Significance Index: 1153.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.9968
    Cell Significance Index: 491.4400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.4038
    Cell Significance Index: 396.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.0762
    Cell Significance Index: 44.9800
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.0474
    Cell Significance Index: 21.1200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.1689
    Cell Significance Index: 16.6400
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 1.0742
    Cell Significance Index: 8.8800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.0485
    Cell Significance Index: 10.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6702
    Cell Significance Index: 66.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6609
    Cell Significance Index: 125.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6222
    Cell Significance Index: 28.2000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5795
    Cell Significance Index: 523.2400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3719
    Cell Significance Index: 5.4200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3578
    Cell Significance Index: 8.9500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3484
    Cell Significance Index: 56.6700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2913
    Cell Significance Index: 31.6800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2876
    Cell Significance Index: 6.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1594
    Cell Significance Index: 11.0300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1459
    Cell Significance Index: 8.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1363
    Cell Significance Index: 1.8600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1044
    Cell Significance Index: 11.9200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0567
    Cell Significance Index: 35.4100
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.0501
    Cell Significance Index: 0.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0091
    Cell Significance Index: 0.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0076
    Cell Significance Index: 0.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0010
    Cell Significance Index: 0.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0020
    Cell Significance Index: -0.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0063
    Cell Significance Index: -11.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0074
    Cell Significance Index: -4.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0076
    Cell Significance Index: -5.6400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0107
    Cell Significance Index: -1.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0120
    Cell Significance Index: -22.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0129
    Cell Significance Index: -9.8000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0139
    Cell Significance Index: -0.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0143
    Cell Significance Index: -10.4500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0149
    Cell Significance Index: -6.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0153
    Cell Significance Index: -23.4800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0155
    Cell Significance Index: -9.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0159
    Cell Significance Index: -8.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0164
    Cell Significance Index: -5.8700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0198
    Cell Significance Index: -26.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0249
    Cell Significance Index: -4.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0252
    Cell Significance Index: -5.3000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0290
    Cell Significance Index: -1.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0432
    Cell Significance Index: -7.3700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0469
    Cell Significance Index: -1.2100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0486
    Cell Significance Index: -1.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0491
    Cell Significance Index: -22.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0505
    Cell Significance Index: -10.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0683
    Cell Significance Index: -9.9300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0723
    Cell Significance Index: -2.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0764
    Cell Significance Index: -7.8100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.0797
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0814
    Cell Significance Index: -9.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1060
    Cell Significance Index: -14.5600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1109
    Cell Significance Index: -2.9600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1155
    Cell Significance Index: -13.6200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1225
    Cell Significance Index: -1.3900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1231
    Cell Significance Index: -8.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1326
    Cell Significance Index: -13.8100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1327
    Cell Significance Index: -9.8900
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1342
    Cell Significance Index: -1.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1455
    Cell Significance Index: -4.6600
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1457
    Cell Significance Index: -0.9500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1489
    Cell Significance Index: -10.0100
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.1543
    Cell Significance Index: -1.5100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1700
    Cell Significance Index: -1.3100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1752
    Cell Significance Index: -3.6400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1961
    Cell Significance Index: -12.6500
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1986
    Cell Significance Index: -1.0400
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.2154
    Cell Significance Index: -2.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2271
    Cell Significance Index: -17.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2376
    Cell Significance Index: -11.0800
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.2424
    Cell Significance Index: -1.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2468
    Cell Significance Index: -15.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2538
    Cell Significance Index: -11.9300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2673
    Cell Significance Index: -2.8200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2743
    Cell Significance Index: -10.0700
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.2855
    Cell Significance Index: -1.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2880
    Cell Significance Index: -16.1600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3073
    Cell Significance Index: -10.6800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3191
    Cell Significance Index: -7.7300
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.3216
    Cell Significance Index: -3.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3247
    Cell Significance Index: -10.6300
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.3269
    Cell Significance Index: -2.1700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3327
    Cell Significance Index: -10.6000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3338
    Cell Significance Index: -11.7000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3341
    Cell Significance Index: -8.3500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3522
    Cell Significance Index: -10.0500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3617
    Cell Significance Index: -9.0200
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.3722
    Cell Significance Index: -4.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3937
    Cell Significance Index: -20.6700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4324
    Cell Significance Index: -19.1300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4366
    Cell Significance Index: -6.5800
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.4465
    Cell Significance Index: -5.6600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4541
    Cell Significance Index: -12.3600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4576
    Cell Significance Index: -13.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PSCA is a GPI-anchored protein, which allows it to interact with the cell membrane and regulate various cellular processes. Its expression is significant in epithelial cells, where it plays a crucial role in maintaining tissue homeostasis and immune tolerance. Notably, PSCA is overexpressed in several types of cancer, including prostate cancer, gastric cancer, and bladder cancer, suggesting its potential as a biomarker and therapeutic target. **Pathways and Functions:** PSCA is involved in several signaling pathways, including: 1. **Negative regulation of the ERK1/2 cascade**: PSCA inhibits the activation of ERK1/2, a key signaling pathway involved in cell proliferation, differentiation, and survival. By regulating this pathway, PSCA may contribute to the maintenance of tissue homeostasis and immune tolerance. 2. **Regulation of neurotransmitter receptor activity**: PSCA interacts with neurotransmitter receptors, modulating their activity and influencing neuronal function. This interaction may also have implications for the development of neurological disorders. 3. **Metabolism of proteins**: PSCA is involved in protein modification and degradation, influencing cellular protein homeostasis and immune function. **Clinical Significance:** PSCA's role in cancer progression and immune regulation has significant clinical implications: 1. **Cancer biomarker**: Overexpression of PSCA in various cancers, including prostate cancer, gastric cancer, and bladder cancer, makes it a potential biomarker for early detection and diagnosis. 2. **Therapeutic target**: Inhibiting PSCA may offer a novel therapeutic strategy for cancer treatment, particularly in combination with existing therapies. 3. **Immune regulation**: PSCA's involvement in immune tolerance and regulation suggests its potential as a target for immunotherapies, particularly in the treatment of autoimmune diseases. 4. **Neurological disorders**: PSCA's interaction with neurotransmitter receptors may also have implications for the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, PSCA is a multifaceted protein with significant implications for immune regulation, cancer progression, and neurological disorders. Further research is needed to fully elucidate its functions and potential therapeutic applications, but its role as a key player in these processes is undeniable.

Genular Protein ID: 1977282067

Symbol: PSCA_HUMAN

Name: Prostate stem cell antigen

UniProtKB Accession Codes:

O43653 Q6UW92

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9465086

Title: Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer.

PubMed ID: 9465086

DOI: 10.1073/pnas.95.4.1735

PubMed ID: 10973799

Title: Reduced expression of PSCA, a member of the LY-6 family of cell surface antigens, in bladder, esophagus, and stomach tumors.

PubMed ID: 10973799

DOI: 10.1006/bbrc.2000.3393

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 10713670

Title: Prostate stem cell antigen (PSCA) expression increases with high gleason score, advanced stage and bone metastasis in prostate cancer.

PubMed ID: 10713670

DOI: 10.1038/sj.onc.1203426

PubMed ID: 18488030

Title: Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer.

PubMed ID: 18488030

DOI: 10.1038/ng.152

PubMed ID: 19648920

Title: Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer.

PubMed ID: 19648920

DOI: 10.1038/ng.421

PubMed ID: 25680266

Title: Prostate stem cell antigen interacts with nicotinic acetylcholine receptors and is affected in Alzheimer's disease.

PubMed ID: 25680266

DOI: 10.1016/j.neurobiolaging.2015.01.001

Sequence Information:

  • Length: 114
  • Mass: 11959
  • Checksum: 65B3683767990740
  • Sequence:
    • MAGLALQPGT ALLCYSCKAQ VSNEDCLQVE NCTQLGEQCW TARIRAVGLL TVISKGCSLN 
CVDDSQDYYV GKKNITCCDT DLCNASGAHA LQPAAAILAL LPALGLLLWG PGQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.