Details for: CXCL6

Gene ID: 6372

Symbol: CXCL6

Ensembl ID: ENSG00000124875

Description: C-X-C motif chemokine ligand 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 38.0061
    Cell Significance Index: -9.6400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 6.2517
    Cell Significance Index: 180.1300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 6.2205
    Cell Significance Index: 102.5100
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 5.7420
    Cell Significance Index: 59.2300
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 5.3621
    Cell Significance Index: 20.2000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.8331
    Cell Significance Index: 120.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 4.0558
    Cell Significance Index: 248.6600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 3.3906
    Cell Significance Index: 70.3400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.9820
    Cell Significance Index: 64.6100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.4252
    Cell Significance Index: -9.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.1681
    Cell Significance Index: 69.4400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.5873
    Cell Significance Index: 23.9200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5286
    Cell Significance Index: 69.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.4851
    Cell Significance Index: 282.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9301
    Cell Significance Index: 48.3200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7397
    Cell Significance Index: 20.1400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7008
    Cell Significance Index: 69.3200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6292
    Cell Significance Index: 568.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6028
    Cell Significance Index: 17.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5278
    Cell Significance Index: 11.2400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4028
    Cell Significance Index: 43.8100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3827
    Cell Significance Index: 62.2400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3069
    Cell Significance Index: 18.4300
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.2973
    Cell Significance Index: 1.8400
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.2862
    Cell Significance Index: 3.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2016
    Cell Significance Index: 13.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1932
    Cell Significance Index: 22.5200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1884
    Cell Significance Index: 2.7400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0743
    Cell Significance Index: 5.5400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0617
    Cell Significance Index: 33.6700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0601
    Cell Significance Index: 37.5600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0493
    Cell Significance Index: 2.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0200
    Cell Significance Index: 2.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0116
    Cell Significance Index: 1.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0065
    Cell Significance Index: 1.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0048
    Cell Significance Index: 0.1700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0045
    Cell Significance Index: 0.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0027
    Cell Significance Index: 2.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0019
    Cell Significance Index: -1.4000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0023
    Cell Significance Index: -0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0053
    Cell Significance Index: -10.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0072
    Cell Significance Index: -4.0400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0086
    Cell Significance Index: -0.4400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0116
    Cell Significance Index: -8.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0117
    Cell Significance Index: -1.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0123
    Cell Significance Index: -7.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0198
    Cell Significance Index: -4.1700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0205
    Cell Significance Index: -0.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0207
    Cell Significance Index: -9.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0223
    Cell Significance Index: -8.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0309
    Cell Significance Index: -3.9900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0345
    Cell Significance Index: -9.9400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0419
    Cell Significance Index: -4.7800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0423
    Cell Significance Index: -8.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0469
    Cell Significance Index: -9.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0496
    Cell Significance Index: -2.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0532
    Cell Significance Index: -1.4900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0533
    Cell Significance Index: -1.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0545
    Cell Significance Index: -7.9200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0596
    Cell Significance Index: -0.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0647
    Cell Significance Index: -8.2900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0661
    Cell Significance Index: -0.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0734
    Cell Significance Index: -3.4200
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0744
    Cell Significance Index: -0.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0847
    Cell Significance Index: -11.6300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0881
    Cell Significance Index: -9.0000
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.1146
    Cell Significance Index: -0.8700
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.1282
    Cell Significance Index: -1.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1291
    Cell Significance Index: -8.6800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1311
    Cell Significance Index: -3.2700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1420
    Cell Significance Index: -3.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1559
    Cell Significance Index: -11.9600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1604
    Cell Significance Index: -4.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1687
    Cell Significance Index: -10.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1969
    Cell Significance Index: -11.0500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2066
    Cell Significance Index: -7.5900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2079
    Cell Significance Index: -3.4800
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.2423
    Cell Significance Index: -1.6800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2544
    Cell Significance Index: -8.8400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2646
    Cell Significance Index: -9.2700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2650
    Cell Significance Index: -8.4400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2700
    Cell Significance Index: -8.8400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2953
    Cell Significance Index: -13.0600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3019
    Cell Significance Index: -8.0900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3045
    Cell Significance Index: -8.6900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3147
    Cell Significance Index: -3.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3172
    Cell Significance Index: -8.4700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3336
    Cell Significance Index: -4.7800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3351
    Cell Significance Index: -8.5600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3430
    Cell Significance Index: -9.0200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3655
    Cell Significance Index: -9.1300
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.3716
    Cell Significance Index: -3.9500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3748
    Cell Significance Index: -9.5500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3780
    Cell Significance Index: -9.4300
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.3849
    Cell Significance Index: -4.1500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3932
    Cell Significance Index: -8.2300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3950
    Cell Significance Index: -8.2500
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.4002
    Cell Significance Index: -4.3600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.4271
    Cell Significance Index: -8.6900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4309
    Cell Significance Index: -7.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CXCL6 is a member of the CXC chemokine family, which is characterized by the presence of two conserved cysteine residues separated by three amino acids. This chemokine is produced by various cell types, including enterocytes, goblet cells, and stromal cells of the lamina propria, in the gastrointestinal tract. CXCL6 has a unique structure, with a hydrophobic N-terminus and a hydrophilic C-terminus, which allows it to interact with specific receptors and signaling molecules. **Pathways and Functions** CXCL6 is involved in several key pathways, including: 1. **Antimicrobial Humoral Immune Response**: CXCL6 plays a crucial role in the recruitment of neutrophils and other immune cells to sites of bacterial infection, where they can eliminate pathogens through mechanisms such as phagocytosis and degranulation. 2. **Cell-Cell Signaling**: CXCL6 interacts with the chemokine receptor CXCR1, which is expressed on the surface of neutrophils and other immune cells. This interaction triggers a signaling cascade that regulates the migration and activation of these cells. 3. **Chemotaxis**: CXCL6 is a potent chemoattractant for neutrophils, which are recruited to sites of inflammation and infection in response to this chemokine. 4. **Regulation of Chemokine Production**: CXCL6 can regulate the production of other chemokines and cytokines, which are involved in the immune response to infection. **Clinical Significance** CXCL6 has been implicated in various inflammatory and immune disorders, including: 1. **Gastrointestinal Inflammatory Diseases**: CXCL6 has been shown to play a role in the pathogenesis of inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. 2. **Respiratory Infections**: CXCL6 has been implicated in the pathogenesis of respiratory infections, including pneumonia and bronchiolitis. 3. **Cancer**: CXCL6 has been shown to be overexpressed in certain types of cancer, including colorectal cancer, where it may contribute to tumor progression and metastasis. In conclusion, CXCL6 is a critical chemokine that plays a key role in the regulation of immune responses, particularly in the context of antimicrobial defense. Further research is needed to fully understand the mechanisms by which CXCL6 regulates immune responses and to explore its therapeutic potential in the treatment of inflammatory and immune disorders.

Genular Protein ID: 3040819570

Symbol: CXCL6_HUMAN

Name: C-X-C motif chemokine 6

UniProtKB Accession Codes:

P80162 B2R4X3 Q4W5D4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9164944

Title: Cloning and characterization of the human granulocyte chemotactic protein-2 gene.

PubMed ID: 9164944

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9057843

Title: Cloning, bacterial expression and biological characterization of recombinant human granulocyte chemotactic protein-2 and differential expression of granulocyte chemotactic protein-2 and epithelial cell-derived neutrophil activating peptide-78 mRNAs.

PubMed ID: 9057843

DOI: 10.1111/j.1432-1033.1997.00762.x

PubMed ID: 8399143

Title: Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines.

PubMed ID: 8399143

DOI: 10.1021/bi00089a037

PubMed ID: 8423327

Title: Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8.

PubMed ID: 8423327

PubMed ID: 18443119

Title: The human CXC chemokine granulocyte chemotactic protein 2 (GCP-2)/CXCL6 possesses membrane-disrupting properties and is antibacterial.

PubMed ID: 18443119

DOI: 10.1128/aac.00028-08

Sequence Information:

  • Length: 114
  • Mass: 11897
  • Checksum: 5A58B38C17F25178
  • Sequence:
    • MSLPSSRAAR VPGPSGSLCA LLALLLLLTP PGPLASAGPV SAVLTELRCT CLRVTLRVNP 
KTIGKLQVFP AGPQCSKVEV VASLKNGKQV CLDPEAPFLK KVIQKILDSG NKKN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.