Details for: HAS2

Gene ID: 3037

Symbol: HAS2

Ensembl ID: ENSG00000170961

Description: hyaluronan synthase 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.49
    Marker Score: 643
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 862
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4796
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.1
    Marker Score: 868
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.1
    Marker Score: 2077.5
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.07
    Marker Score: 1297
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251789
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 789
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71807
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48032
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5315
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.93
    Marker Score: 1944.5
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.93
    Marker Score: 628
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.93
    Marker Score: 384
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.88
    Marker Score: 5302
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.84
    Marker Score: 1157.5
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.79
    Marker Score: 445
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1253
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.77
    Marker Score: 2014
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 702
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.75
    Marker Score: 1526
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.72
    Marker Score: 177
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 457
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.71
    Marker Score: 201
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.69
    Marker Score: 368
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.65
    Marker Score: 631.5
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.63
    Marker Score: 663
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.62
    Marker Score: 891
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.62
    Marker Score: 301
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.61
    Marker Score: 255
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.6
    Marker Score: 586
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.6
    Marker Score: 510
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.59
    Marker Score: 390
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.58
    Marker Score: 896
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.56
    Marker Score: 971
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.55
    Marker Score: 332.5
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.55
    Marker Score: 126
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.52
    Marker Score: 8160
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.51
    Marker Score: 1571
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.5
    Marker Score: 965
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5
    Marker Score: 1218
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.5
    Marker Score: 220
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.48
    Marker Score: 108
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.48
    Marker Score: 107
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.47
    Marker Score: 299
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.44
    Marker Score: 547
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.44
    Marker Score: 14820
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.43
    Marker Score: 192
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.41
    Marker Score: 180
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.41
    Marker Score: 151
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.41
    Marker Score: 510
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.4
    Marker Score: 191
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.39
    Marker Score: 375
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.38
    Marker Score: 332
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.38
    Marker Score: 273
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.35
    Marker Score: 12002
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.34
    Marker Score: 194
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.34
    Marker Score: 141
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.34
    Marker Score: 394
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.33
    Marker Score: 357
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.33
    Marker Score: 295
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.33
    Marker Score: 85
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.31
    Marker Score: 1165
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.31
    Marker Score: 313
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.31
    Marker Score: 171
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.3
    Marker Score: 146
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.29
    Marker Score: 192
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.29
    Marker Score: 131
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.29
    Marker Score: 415
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.28
    Marker Score: 194
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.28
    Marker Score: 197
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.27
    Marker Score: 86
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.27
    Marker Score: 560
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.27
    Marker Score: 257
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.26
    Marker Score: 174
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.26
    Marker Score: 94
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.26
    Marker Score: 154
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.25
    Marker Score: 194
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.25
    Marker Score: 134
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.25
    Marker Score: 113
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.25
    Marker Score: 308
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.24
    Marker Score: 136
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.24
    Marker Score: 238
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.23
    Marker Score: 72
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.23
    Marker Score: 105

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Other Information

## Summary HAS2 is a transmembrane protein that is involved in the biosynthesis and export of hyaluronan, a large extracellular matrix protein. Hyaluronan is a polymer of glucuronic acid and galactose, and it is found in the extracellular matrix of many tissues, including skin, cartilage, and blood vessels. HAS2 is expressed in a variety of cells, including immune cells, epithelial cells, and endothelial cells. ## Key characteristics * HAS2 is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is found in the extracellular matrix of many tissues, including skin, cartilage, and blood vessels. * HAS2 is a key enzyme in the biosynthesis of hyaluronic acid, a linear polymer of glucuronic acid and galactose. * HAS2 is also involved in the degradation of hyaluronic acid by the enzyme hyaluronidase. * HAS2 is a highly conserved protein, with a similar sequence found in organisms from yeast to humans. ## Pathways and functions * HAS2 is involved in the regulation of cell migration, proliferation, and differentiation. * It is expressed in high levels in inflammatory cell, granulocyte monocyte progenitor cell, enterocyte of epithelium of small intestine, epithelial cell of urethra, cardiac endothelial cell, and mesangial cell. * HAS2 is a key regulator of the development of the kidney. * It is involved in the metabolism of carbohydrates, and it may play a role in the regulation of urine volume. * HAS2 is a positive regulator of cell migration, proliferation, and differentiation. * It is involved in the positive regulation of cell population proliferation, positive regulation of keratinocyte proliferation, positive regulation of smooth muscle cell migration, and positive regulation of urine volume. ## Clinical significance Mutations in HAS2 have been linked to a number of human diseases, including osteoarthritis, rheumatoid arthritis, and diabetic retinopathy. These diseases are characterized by the buildup of hyaluronic acid in the joints, cartilage, and blood vessels. HAS2 is a promising target for the treatment of these diseases.

Genular Protein ID: 433406772

Symbol: HYAS2_HUMAN

Name: Hyaluronan synthase 2

UniProtKB Accession Codes:

Q92819 Q32MM3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 11 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 4 Ensembl 1 GO 34 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 8 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8798477

Title: Molecular identification of a putative human hyaluronan synthase.

PubMed ID: 8798477

DOI: 10.1074/jbc.271.38.22945

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15642402

Title: PLAG1-HAS2 fusion in lipoblastoma with masked 8q intrachromosomal rearrangement.

PubMed ID: 15642402

DOI: 10.1016/j.cancergencyto.2004.04.017

PubMed ID: 23303191

Title: Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GlcNAc concentration than HAS2 and HAS3.

PubMed ID: 23303191

DOI: 10.1074/jbc.m112.443879

PubMed ID: 20507985

Title: The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination.

PubMed ID: 20507985

DOI: 10.1074/jbc.m110.127050

PubMed ID: 21228273

Title: Hyaluronan synthesis is inhibited by adenosine monophosphate-activated protein kinase through the regulation of HAS2 activity in human aortic smooth muscle cells.

PubMed ID: 21228273

DOI: 10.1074/jbc.m110.193656

PubMed ID: 22887999

Title: Role of UDP-N-acetylglucosamine (GlcNAc) and O-GlcNAcylation of hyaluronan synthase 2 in the control of chondroitin sulfate and hyaluronan synthesis.

PubMed ID: 22887999

DOI: 10.1074/jbc.m112.402347

PubMed ID: 25795779

Title: Fluorescence resonance energy transfer (FRET) and proximity ligation assays reveal functionally relevant homo- and heteromeric complexes among hyaluronan synthases HAS1, HAS2, and HAS3.

PubMed ID: 25795779

DOI: 10.1074/jbc.m115.640581

PubMed ID: 28604766

Title: The deubiquitinating enzymes USP4 and USP17 target hyaluronan synthase 2 and differentially affect its function.

PubMed ID: 28604766

DOI: 10.1038/oncsis.2017.45

PubMed ID: 30394292

Title: Effects of mutations in the post-translational modification sites on the trafficking of hyaluronan synthase 2 (HAS2).

PubMed ID: 30394292

DOI: 10.1016/j.matbio.2018.10.004

PubMed ID: 32993960

Title: Phosphorylation of Thr328 in hyaluronan synthase 2 is essential for hyaluronan synthesis.

PubMed ID: 32993960

DOI: 10.1016/j.bbrc.2020.08.093

Sequence Information:

  • Length: 552
  • Mass: 63566
  • Checksum: EEEF58D97B131F9D
  • Sequence:
    • MHCERFLCIL RIIGTTLFGV SLLLGITAAY IVGYQFIQTD NYYFSFGLYG AFLASHLIIQ 
SLFAFLEHRK MKKSLETPIK LNKTVALCIA AYQEDPDYLR KCLQSVKRLT YPGIKVVMVI 
DGNSEDDLYM MDIFSEVMGR DKSATYIWKN NFHEKGPGET DESHKESSQH VTQLVLSNKS 
ICIMQKWGGK REVMYTAFRA LGRSVDYVQV CDSDTMLDPA SSVEMVKVLE EDPMVGGVGG 
DVQILNKYDS WISFLSSVRY WMAFNIERAC QSYFGCVQCI SGPLGMYRNS LLHEFVEDWY 
NQEFMGNQCS FGDDRHLTNR VLSLGYATKY TARSKCLTET PIEYLRWLNQ QTRWSKSYFR 
EWLYNAMWFH KHHLWMTYEA IITGFFPFFL IATVIQLFYR GKIWNILLFL LTVQLVGLIK 
SSFASCLRGN IVMVFMSLYS VLYMSSLLPA KMFAIATINK AGWGTSGRKT IVVNFIGLIP 
VSVWFTILLG GVIFTIYKES KRPFSESKQT VLIVGTLLYA CYWVMLLTLY VVLINKCGRR 
KKGQQYDMVL DV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.