Details for: HAS2

Gene ID: 3037

Symbol: HAS2

Ensembl ID: ENSG00000170961

Description: hyaluronan synthase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 45.4969
    Cell Significance Index: -11.5400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 22.2888
    Cell Significance Index: -9.0600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 8.8382
    Cell Significance Index: 75.1200
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 6.6117
    Cell Significance Index: 37.9100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.9244
    Cell Significance Index: -11.5400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.2298
    Cell Significance Index: 13.8000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.1948
    Cell Significance Index: 47.5500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.5965
    Cell Significance Index: 24.7000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.2977
    Cell Significance Index: 45.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.1805
    Cell Significance Index: 29.5100
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.9468
    Cell Significance Index: 5.5900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.9358
    Cell Significance Index: 20.4900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.7165
    Cell Significance Index: 21.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6452
    Cell Significance Index: 13.7400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.6183
    Cell Significance Index: 9.9200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5252
    Cell Significance Index: 10.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4507
    Cell Significance Index: 89.4500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.4148
    Cell Significance Index: 6.5800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3935
    Cell Significance Index: 74.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3801
    Cell Significance Index: 37.6000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.3540
    Cell Significance Index: 21.7100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3356
    Cell Significance Index: 16.9600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2982
    Cell Significance Index: 53.7600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2967
    Cell Significance Index: 6.2100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2670
    Cell Significance Index: 16.0300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2007
    Cell Significance Index: 21.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1897
    Cell Significance Index: 30.8500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1831
    Cell Significance Index: 2.6300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1626
    Cell Significance Index: 4.6600
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.1107
    Cell Significance Index: 0.6900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0839
    Cell Significance Index: 75.7900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0572
    Cell Significance Index: 35.7200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0524
    Cell Significance Index: 3.6300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0413
    Cell Significance Index: 1.0300
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.0375
    Cell Significance Index: 0.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0368
    Cell Significance Index: 1.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0251
    Cell Significance Index: 1.3100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.0239
    Cell Significance Index: 0.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0141
    Cell Significance Index: 1.7300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0099
    Cell Significance Index: 0.1700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0030
    Cell Significance Index: 0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0019
    Cell Significance Index: -1.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0031
    Cell Significance Index: -5.9000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0046
    Cell Significance Index: -0.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0056
    Cell Significance Index: -0.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0076
    Cell Significance Index: -4.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0080
    Cell Significance Index: -14.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0097
    Cell Significance Index: -14.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0110
    Cell Significance Index: -14.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0119
    Cell Significance Index: -2.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0141
    Cell Significance Index: -8.9800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0147
    Cell Significance Index: -11.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0181
    Cell Significance Index: -9.8600
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: -0.0262
    Cell Significance Index: -0.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0273
    Cell Significance Index: -12.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0276
    Cell Significance Index: -9.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0335
    Cell Significance Index: -5.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0355
    Cell Significance Index: -10.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0389
    Cell Significance Index: -4.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0407
    Cell Significance Index: -8.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0526
    Cell Significance Index: -7.2200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0580
    Cell Significance Index: -6.6200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0620
    Cell Significance Index: -7.2300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0627
    Cell Significance Index: -1.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0678
    Cell Significance Index: -9.8600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0889
    Cell Significance Index: -10.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0950
    Cell Significance Index: -12.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1014
    Cell Significance Index: -10.3600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1068
    Cell Significance Index: -1.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1121
    Cell Significance Index: -11.6700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1269
    Cell Significance Index: -9.7400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.1299
    Cell Significance Index: -0.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1564
    Cell Significance Index: -5.0100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1573
    Cell Significance Index: -10.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1574
    Cell Significance Index: -8.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1644
    Cell Significance Index: -12.2500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1651
    Cell Significance Index: -4.0000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1681
    Cell Significance Index: -1.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1768
    Cell Significance Index: -4.9400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1875
    Cell Significance Index: -4.8200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1877
    Cell Significance Index: -11.8300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1904
    Cell Significance Index: -11.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1910
    Cell Significance Index: -5.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1935
    Cell Significance Index: -10.0500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1991
    Cell Significance Index: -8.1600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2125
    Cell Significance Index: -5.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2136
    Cell Significance Index: -10.0400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2297
    Cell Significance Index: -12.0600
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.2488
    Cell Significance Index: -3.2200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2559
    Cell Significance Index: -3.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2617
    Cell Significance Index: -12.2000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2681
    Cell Significance Index: -11.8600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2869
    Cell Significance Index: -3.9200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3073
    Cell Significance Index: -8.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3095
    Cell Significance Index: -11.7200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3204
    Cell Significance Index: -11.7600
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.3265
    Cell Significance Index: -2.0000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3288
    Cell Significance Index: -5.8100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3323
    Cell Significance Index: -11.6400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3470
    Cell Significance Index: -11.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Hyaluronic acid biosynthesis**: HAS2 is responsible for the production of hyaluronic acid, a polysaccharide that provides structural support and lubrication to tissues. 2. **Extracellular matrix assembly**: HAS2 contributes to the formation and maintenance of the ECM, which is essential for tissue development, wound healing, and immune response. 3. **Cell migration and proliferation**: HAS2 regulates cell migration and proliferation by modulating the expression of adhesion molecules and signaling pathways involved in these processes. 4. **Inflammation and immune response**: HAS2 is expressed in inflammatory cells and plays a role in regulating the immune response by modulating the production of cytokines and chemokines. **Pathways and Functions:** 1. **Cellular response to fluid shear stress**: HAS2 is involved in regulating cell migration and adhesion in response to fluid shear stress, which is critical in developing tissues and organs. 2. **Endocardial cushion to mesenchymal transition**: HAS2 plays a role in the development of the heart by regulating the transition of endocardial cushions to mesenchymal cells. 3. **Glycosaminoglycan metabolism**: HAS2 is involved in regulating the metabolism of glycosaminoglycans, which are essential components of the ECM. 4. **Positive regulation of cell migration and proliferation**: HAS2 regulates the expression of adhesion molecules and signaling pathways involved in cell migration and proliferation. **Clinical Significance:** 1. **Cardiovascular diseases**: HAS2 has been implicated in the development of cardiovascular diseases, including atherosclerosis and cardiac fibrosis. 2. **Cancer**: HAS2 is overexpressed in various types of cancer, including breast, lung, and colon cancer, and has been associated with tumor progression and metastasis. 3. **Inflammatory disorders**: HAS2 has been linked to inflammatory disorders, including rheumatoid arthritis and multiple sclerosis. 4. **Wound healing**: HAS2 plays a crucial role in wound healing by regulating the production of hyaluronic acid and the assembly of the ECM. In conclusion, HAS2 is a critical gene that plays a pivotal role in various physiological processes, including tissue development, immune response, and disease pathogenesis. Further research is needed to fully elucidate the mechanisms by which HAS2 regulates these processes and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 433406772

Symbol: HYAS2_HUMAN

Name: Hyaluronan synthase 2

UniProtKB Accession Codes:

Q92819 Q32MM3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 11 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 4 Ensembl 1 GO 34 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 8 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8798477

Title: Molecular identification of a putative human hyaluronan synthase.

PubMed ID: 8798477

DOI: 10.1074/jbc.271.38.22945

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15642402

Title: PLAG1-HAS2 fusion in lipoblastoma with masked 8q intrachromosomal rearrangement.

PubMed ID: 15642402

DOI: 10.1016/j.cancergencyto.2004.04.017

PubMed ID: 23303191

Title: Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GlcNAc concentration than HAS2 and HAS3.

PubMed ID: 23303191

DOI: 10.1074/jbc.m112.443879

PubMed ID: 20507985

Title: The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination.

PubMed ID: 20507985

DOI: 10.1074/jbc.m110.127050

PubMed ID: 21228273

Title: Hyaluronan synthesis is inhibited by adenosine monophosphate-activated protein kinase through the regulation of HAS2 activity in human aortic smooth muscle cells.

PubMed ID: 21228273

DOI: 10.1074/jbc.m110.193656

PubMed ID: 22887999

Title: Role of UDP-N-acetylglucosamine (GlcNAc) and O-GlcNAcylation of hyaluronan synthase 2 in the control of chondroitin sulfate and hyaluronan synthesis.

PubMed ID: 22887999

DOI: 10.1074/jbc.m112.402347

PubMed ID: 25795779

Title: Fluorescence resonance energy transfer (FRET) and proximity ligation assays reveal functionally relevant homo- and heteromeric complexes among hyaluronan synthases HAS1, HAS2, and HAS3.

PubMed ID: 25795779

DOI: 10.1074/jbc.m115.640581

PubMed ID: 28604766

Title: The deubiquitinating enzymes USP4 and USP17 target hyaluronan synthase 2 and differentially affect its function.

PubMed ID: 28604766

DOI: 10.1038/oncsis.2017.45

PubMed ID: 30394292

Title: Effects of mutations in the post-translational modification sites on the trafficking of hyaluronan synthase 2 (HAS2).

PubMed ID: 30394292

DOI: 10.1016/j.matbio.2018.10.004

PubMed ID: 32993960

Title: Phosphorylation of Thr328 in hyaluronan synthase 2 is essential for hyaluronan synthesis.

PubMed ID: 32993960

DOI: 10.1016/j.bbrc.2020.08.093

Sequence Information:

  • Length: 552
  • Mass: 63566
  • Checksum: EEEF58D97B131F9D
  • Sequence:
    • MHCERFLCIL RIIGTTLFGV SLLLGITAAY IVGYQFIQTD NYYFSFGLYG AFLASHLIIQ 
SLFAFLEHRK MKKSLETPIK LNKTVALCIA AYQEDPDYLR KCLQSVKRLT YPGIKVVMVI 
DGNSEDDLYM MDIFSEVMGR DKSATYIWKN NFHEKGPGET DESHKESSQH VTQLVLSNKS 
ICIMQKWGGK REVMYTAFRA LGRSVDYVQV CDSDTMLDPA SSVEMVKVLE EDPMVGGVGG 
DVQILNKYDS WISFLSSVRY WMAFNIERAC QSYFGCVQCI SGPLGMYRNS LLHEFVEDWY 
NQEFMGNQCS FGDDRHLTNR VLSLGYATKY TARSKCLTET PIEYLRWLNQ QTRWSKSYFR 
EWLYNAMWFH KHHLWMTYEA IITGFFPFFL IATVIQLFYR GKIWNILLFL LTVQLVGLIK 
SSFASCLRGN IVMVFMSLYS VLYMSSLLPA KMFAIATINK AGWGTSGRKT IVVNFIGLIP 
VSVWFTILLG GVIFTIYKES KRPFSESKQT VLIVGTLLYA CYWVMLLTLY VVLINKCGRR 
KKGQQYDMVL DV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.