Details for: SULT2B1

Gene ID: 6820

Symbol: SULT2B1

Ensembl ID: ENSG00000088002

Description: sulfotransferase family 2B member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 8.7823
    Cell Significance Index: 10.1100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.5065
    Cell Significance Index: 35.6800
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.2423
    Cell Significance Index: 23.1300
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 1.9091
    Cell Significance Index: 2.4700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.8825
    Cell Significance Index: 11.5900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.8217
    Cell Significance Index: -4.8800
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.7964
    Cell Significance Index: 4.0500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.1009
    Cell Significance Index: 9.4600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9490
    Cell Significance Index: 56.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8960
    Cell Significance Index: 25.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8610
    Cell Significance Index: 85.1700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7333
    Cell Significance Index: 662.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7254
    Cell Significance Index: 78.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6718
    Cell Significance Index: 50.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6053
    Cell Significance Index: 17.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5294
    Cell Significance Index: 14.4100
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.4992
    Cell Significance Index: 3.0800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4874
    Cell Significance Index: 79.2700
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.4524
    Cell Significance Index: 2.8000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.4252
    Cell Significance Index: 4.4000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4006
    Cell Significance Index: 27.7100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3244
    Cell Significance Index: 5.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2926
    Cell Significance Index: 6.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2918
    Cell Significance Index: 15.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2620
    Cell Significance Index: 5.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2488
    Cell Significance Index: 11.6000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2148
    Cell Significance Index: 5.3700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1366
    Cell Significance Index: 15.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1349
    Cell Significance Index: 6.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1339
    Cell Significance Index: 17.3100
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.1228
    Cell Significance Index: 1.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1172
    Cell Significance Index: 22.3100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1120
    Cell Significance Index: 49.5200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1019
    Cell Significance Index: 2.6200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0628
    Cell Significance Index: 34.2900
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.0592
    Cell Significance Index: 0.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0528
    Cell Significance Index: 1.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0409
    Cell Significance Index: 8.2100
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.0359
    Cell Significance Index: 0.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0319
    Cell Significance Index: 5.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0295
    Cell Significance Index: 5.8600
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0232
    Cell Significance Index: 0.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0190
    Cell Significance Index: 0.8600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0171
    Cell Significance Index: 11.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0128
    Cell Significance Index: 4.5900
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.0116
    Cell Significance Index: 0.1000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0096
    Cell Significance Index: 0.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0089
    Cell Significance Index: 1.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0074
    Cell Significance Index: 0.9100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0026
    Cell Significance Index: 4.9000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0019
    Cell Significance Index: 2.8900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0018
    Cell Significance Index: 3.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0017
    Cell Significance Index: 0.2400
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.0014
    Cell Significance Index: 0.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0009
    Cell Significance Index: 1.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0001
    Cell Significance Index: -0.0600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0029
    Cell Significance Index: -0.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0037
    Cell Significance Index: -2.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0041
    Cell Significance Index: -0.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0048
    Cell Significance Index: -3.4900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0051
    Cell Significance Index: -2.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0061
    Cell Significance Index: -4.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0074
    Cell Significance Index: -2.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0075
    Cell Significance Index: -4.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0076
    Cell Significance Index: -4.2600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0094
    Cell Significance Index: -1.6100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0117
    Cell Significance Index: -0.1600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0206
    Cell Significance Index: -2.6400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0208
    Cell Significance Index: -4.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0215
    Cell Significance Index: -1.3200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0222
    Cell Significance Index: -0.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0228
    Cell Significance Index: -3.1400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0237
    Cell Significance Index: -0.3400
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0266
    Cell Significance Index: -0.2200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0271
    Cell Significance Index: -0.2500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0279
    Cell Significance Index: -0.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0336
    Cell Significance Index: -3.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0356
    Cell Significance Index: -1.8700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0373
    Cell Significance Index: -0.4800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0399
    Cell Significance Index: -0.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0403
    Cell Significance Index: -4.2000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0484
    Cell Significance Index: -1.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0490
    Cell Significance Index: -3.3000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0491
    Cell Significance Index: -0.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0491
    Cell Significance Index: -1.3100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0500
    Cell Significance Index: -1.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0511
    Cell Significance Index: -3.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0527
    Cell Significance Index: -2.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0572
    Cell Significance Index: -4.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0625
    Cell Significance Index: -3.8400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0642
    Cell Significance Index: -4.5400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0671
    Cell Significance Index: -2.5400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0708
    Cell Significance Index: -0.4800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0739
    Cell Significance Index: -0.7700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0768
    Cell Significance Index: -2.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0770
    Cell Significance Index: -4.9700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0792
    Cell Significance Index: -4.1300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0811
    Cell Significance Index: -2.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0884
    Cell Significance Index: -4.9600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0895
    Cell Significance Index: -2.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SULT2B1 is a member of the sulfotransferase family, which consists of enzymes that catalyze the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to a variety of substrates, including steroids, xenobiotics, and other small molecules. The SULT2B1 protein is specifically involved in the sulfonation of steroids, which is essential for their metabolism and regulation of various cellular processes. The protein is characterized by its high affinity for PAPS and its ability to catalyze the sulfonation of a wide range of substrates. **Pathways and Functions** The SULT2B1 protein is involved in several key pathways, including: 1. **Cholesterol metabolism**: SULT2B1 is responsible for the sulfonation of cholesterol, which is a critical step in its metabolism and regulation of various cellular processes, including cell growth and differentiation. 2. **Steroid hormone regulation**: The SULT2B1 protein is involved in the sulfonation of steroid hormones, which is essential for their regulation of various cellular processes, including cell growth, differentiation, and metabolism. 3. **Detoxification**: SULT2B1 is involved in the sulfonation of xenobiotics, which is essential for their detoxification and removal from the body. 4. **Cell growth and differentiation**: The SULT2B1 protein is involved in the regulation of cell growth and differentiation, particularly in stratified epithelial cells and respiratory goblet cells. 5. **Metabolism**: SULT2B1 is involved in the sulfonation of various substrates, including steroids, xenobiotics, and other small molecules, which is essential for their metabolism and regulation of various cellular processes. **Clinical Significance** Dysregulation of the SULT2B1 gene has been implicated in various diseases, including: 1. **Cancer**: Overexpression of SULT2B1 has been observed in various types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis and reduced survival rates. 2. **Metabolic disorders**: Dysregulation of SULT2B1 has been implicated in various metabolic disorders, including obesity, type 2 diabetes, and dyslipidemia. 3. **Neurological disorders**: SULT2B1 has been implicated in the pathogenesis of various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 4. **Allergic diseases**: Dysregulation of SULT2B1 has been implicated in the pathogenesis of various allergic diseases, including asthma and allergic rhinitis. In conclusion, the SULT2B1 gene plays a critical role in various cellular processes, including metabolism, detoxification, and regulation of cell growth and differentiation. Its dysregulation has been implicated in various diseases, including cancer, metabolic disorders, neurological disorders, and allergic diseases. Further research is needed to fully understand the mechanisms of SULT2B1 and its role in human disease.

Genular Protein ID: 3516704555

Symbol: ST2B1_HUMAN

Name: Sulfotransferase 2B1

UniProtKB Accession Codes:

O00204 O00205 O75814

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 31 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DisProt 2 DrugBank 4 EC 1 EMBL 17 Ensembl 2 EvolutionaryTrace 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRIDE 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 Rhea 9 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9799594

Title: Human hydroxysteroid sulfotransferase SULT2B1: two enzymes encoded by a single chromosome 19 gene.

PubMed ID: 9799594

DOI: 10.1006/geno.1998.5518

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12145317

Title: Mutational analysis of human hydroxysteroid sulfotransferase SULT2B1 isoforms reveals that exon 1B of the SULT2B1 gene produces cholesterol sulfotransferase, whereas exon 1A yields pregnenolone sulfotransferase.

PubMed ID: 12145317

DOI: 10.1074/jbc.m207165200

PubMed ID: 16855051

Title: Characterization of proline-serine-rich carboxyl terminus in human sulfotransferase 2B1b: immunogenicity, subcellular localization, kinetic properties, and phosphorylation.

PubMed ID: 16855051

DOI: 10.1124/dmd.106.011114

PubMed ID: 19589875

Title: 24-hydroxycholesterol sulfation by human cytosolic sulfotransferases: formation of monosulfates and disulfates, molecular modeling, sulfatase sensitivity, and inhibition of liver x receptor activation.

PubMed ID: 19589875

DOI: 10.1124/dmd.108.025759

PubMed ID: 21855633

Title: Site-directed mutagenesis of human cytosolic sulfotransferase (SULT) 2B1b to phospho-mimetic Ser348Asp results in an isoform with increased catalytic activity.

PubMed ID: 21855633

DOI: 10.1016/j.jsbmb.2011.07.010

PubMed ID: 12923182

Title: Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms.

PubMed ID: 12923182

DOI: 10.1074/jbc.m308312200

PubMed ID: 28575648

Title: Mutations in SULT2B1 cause autosomal-recessive congenital ichthyosis in humans.

PubMed ID: 28575648

DOI: 10.1016/j.ajhg.2017.05.007

Sequence Information:

  • Length: 365
  • Mass: 41308
  • Checksum: 13E95248DD40DF91
  • Sequence:
    • MDGPAEPQIP GLWDTYEDDI SEISQKLPGE YFRYKGVPFP VGLYSLESIS LAENTQDVRD 
DDIFIITYPK SGTTWMIEII CLILKEGDPS WIRSVPIWER APWCETIVGA FSLPDQYSPR 
LMSSHLPIQI FTKAFFSSKA KVIYMGRNPR DVVVSLYHYS KIAGQLKDPG TPDQFLRDFL 
KGEVQFGSWF DHIKGWLRMK GKDNFLFITY EELQQDLQGS VERICGFLGR PLGKEALGSV 
VAHSTFSAMK ANTMSNYTLL PPSLLDHRRG AFLRKGVCGD WKNHFTVAQS EAFDRAYRKQ 
MRGMPTFPWD EDPEEDGSPD PEPSPEPEPK PSLEPNTSLE REPRPNSSPS PSPGQASETP 
HPRPS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.