Details for: PLPP2

Gene ID: 8612

Symbol: PLPP2

Ensembl ID: ENSG00000141934

Description: phospholipid phosphatase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 28.7993
    Cell Significance Index: -19.3300
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 8.1050
    Cell Significance Index: 61.4600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.5144
    Cell Significance Index: -20.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 6.2611
    Cell Significance Index: 291.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 4.9183
    Cell Significance Index: 255.4900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 4.1102
    Cell Significance Index: 94.9600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.4453
    Cell Significance Index: 41.0700
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.9102
    Cell Significance Index: 30.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.6881
    Cell Significance Index: 169.4200
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 2.6572
    Cell Significance Index: 14.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.3672
    Cell Significance Index: 305.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.3509
    Cell Significance Index: 63.9900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.9175
    Cell Significance Index: 28.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.8586
    Cell Significance Index: 1015.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.8032
    Cell Significance Index: 51.9600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.6793
    Cell Significance Index: 10.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.6644
    Cell Significance Index: 75.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.5011
    Cell Significance Index: 70.5500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4279
    Cell Significance Index: 232.2400
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 1.4039
    Cell Significance Index: 29.2800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1037
    Cell Significance Index: 82.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0526
    Cell Significance Index: 22.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9867
    Cell Significance Index: 68.2400
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.6130
    Cell Significance Index: 6.0700
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.5549
    Cell Significance Index: 2.0900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5229
    Cell Significance Index: 5.9400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5088
    Cell Significance Index: 4.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4888
    Cell Significance Index: 10.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4846
    Cell Significance Index: 47.9400
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.4127
    Cell Significance Index: 1.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3816
    Cell Significance Index: 168.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.3694
    Cell Significance Index: 42.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3664
    Cell Significance Index: 9.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3581
    Cell Significance Index: 11.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3455
    Cell Significance Index: 65.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2957
    Cell Significance Index: 20.9100
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.2503
    Cell Significance Index: 2.0700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2440
    Cell Significance Index: 6.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2421
    Cell Significance Index: 31.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2319
    Cell Significance Index: 8.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1919
    Cell Significance Index: 34.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1357
    Cell Significance Index: 16.6800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0649
    Cell Significance Index: 0.9000
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.0629
    Cell Significance Index: 0.5200
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.0515
    Cell Significance Index: 0.5200
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.0488
    Cell Significance Index: 0.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0191
    Cell Significance Index: 5.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0025
    Cell Significance Index: -0.4200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0080
    Cell Significance Index: -6.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0096
    Cell Significance Index: -18.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0167
    Cell Significance Index: -25.7700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0177
    Cell Significance Index: -0.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0190
    Cell Significance Index: -25.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0191
    Cell Significance Index: -14.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0208
    Cell Significance Index: -2.8600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0208
    Cell Significance Index: -1.0500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0266
    Cell Significance Index: -1.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0281
    Cell Significance Index: -17.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0308
    Cell Significance Index: -22.8200
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0380
    Cell Significance Index: -0.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0398
    Cell Significance Index: -22.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0403
    Cell Significance Index: -14.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0443
    Cell Significance Index: -20.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0564
    Cell Significance Index: -0.7700
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0599
    Cell Significance Index: -0.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0610
    Cell Significance Index: -12.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0764
    Cell Significance Index: -15.3200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0853
    Cell Significance Index: -9.9500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1053
    Cell Significance Index: -12.4200
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.1110
    Cell Significance Index: -0.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1175
    Cell Significance Index: -24.7600
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1212
    Cell Significance Index: -0.7900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1273
    Cell Significance Index: -1.6400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1294
    Cell Significance Index: -18.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1423
    Cell Significance Index: -14.5400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1739
    Cell Significance Index: -4.4700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1885
    Cell Significance Index: -19.6300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2201
    Cell Significance Index: -3.8900
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.2212
    Cell Significance Index: -1.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2376
    Cell Significance Index: -18.8200
  • Cell Name: airway submucosal gland collecting duct epithelial cell (CL4033023)
    Fold Change: -0.2579
    Cell Significance Index: -1.8100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2611
    Cell Significance Index: -4.0400
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.2637
    Cell Significance Index: -2.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2763
    Cell Significance Index: -18.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2832
    Cell Significance Index: -21.7300
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: -0.2938
    Cell Significance Index: -0.2100
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.2956
    Cell Significance Index: -3.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3119
    Cell Significance Index: -19.1200
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.3161
    Cell Significance Index: -1.9500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3223
    Cell Significance Index: -20.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3255
    Cell Significance Index: -17.0900
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.3288
    Cell Significance Index: -2.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3298
    Cell Significance Index: -18.5100
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: -0.3340
    Cell Significance Index: -2.2300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3473
    Cell Significance Index: -12.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3631
    Cell Significance Index: -22.3200
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.3651
    Cell Significance Index: -2.2700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3782
    Cell Significance Index: -3.9900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4393
    Cell Significance Index: -10.6400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4458
    Cell Significance Index: -13.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PLPP2 is a lysosomal enzyme that exhibits phospholipid dephosphorylation activity, specifically targeting phosphatidate and phosphoinositides. The enzyme is characterized by its ability to hydrolyze the phosphorus moiety from these lipids, resulting in the formation of phosphocholine and inositol. PLPP2 is highly expressed in various tissues, including the tracheobronchial tree, salivary glands, and bladder urothelial cells, suggesting its involvement in maintaining cellular homeostasis and regulating lipid metabolism. **Pathways and Functions:** PLPP2 is implicated in multiple signaling pathways, including: 1. **Ceramide-1-phosphate phosphatase activity**: PLPP2 dephosphorylates ceramide-1-phosphate, a key lipid mediator involved in cellular signaling and membrane trafficking. 2. **Sphingolipid catabolism**: PLPP2 contributes to the breakdown of sphingolipids, which are essential for maintaining cellular membrane structure and function. 3. **Early endosome and endoplasmic reticulum**: PLPP2 regulates the activity of early endosomes and the endoplasmic reticulum, which are critical for membrane trafficking and lipid metabolism. 4. **Signal transduction**: PLPP2 modulates signal transduction pathways, including those involved in cell growth, differentiation, and survival. **Clinical Significance:** Dysregulation of PLPP2 has been implicated in various diseases, including: 1. **Respiratory diseases**: PLPP2 expression is altered in respiratory cells, suggesting its involvement in the pathogenesis of respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and asthma. 2. **Cancer**: PLPP2 is overexpressed in certain types of cancer, including lung and breast cancer, indicating its potential role in tumorigenesis and cancer progression. 3. **Neurological disorders**: PLPP2 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, where dysregulation of sphingolipid metabolism is thought to contribute to disease pathology. In conclusion, PLPP2 plays a critical role in regulating lipid metabolism and signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms underlying PLPP2 function and its clinical significance.

Genular Protein ID: 3643183641

Symbol: PLPP2_HUMAN

Name: Lipid phosphate phosphohydrolase 2

UniProtKB Accession Codes:

O43688 A6NLV0 E9PAY8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 36 ChiTaRS 1 DEPOD 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 Ensembl 3 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 18 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9570154

Title: Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells.

PubMed ID: 9570154

DOI: 10.1089/dna.1998.17.377

PubMed ID: 9705349

Title: Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform.

PubMed ID: 9705349

DOI: 10.1074/jbc.273.34.22059

PubMed ID: 9607309

Title: Identification of a novel human phosphatidic acid phosphatase type 2 isoform.

PubMed ID: 9607309

DOI: 10.1016/s0014-5793(98)00421-9

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16467304

Title: Lipid phosphate phosphatase-2 activity regulates S-phase entry of the cell cycle in Rat2 fibroblasts.

PubMed ID: 16467304

DOI: 10.1074/jbc.m511710200

PubMed ID: 18215144

Title: Lipid phosphate phosphatases form homo- and hetero-oligomers: catalytic competency, subcellular distribution and function.

PubMed ID: 18215144

DOI: 10.1042/bj20071607

Sequence Information:

  • Length: 288
  • Mass: 32574
  • Checksum: F7C6A09A28DA9AC8
  • Sequence:
    • MQRRWVFVLL DVLCLLVASL PFAILTLVNA PYKRGFYCGD DSIRYPYRPD TITHGLMAGV 
TITATVILVS AGEAYLVYTD RLYSRSDFNN YVAAVYKVLG TFLFGAAVSQ SLTDLAKYMI 
GRLRPNFLAV CDPDWSRVNC SVYVQLEKVC RGNPADVTEA RLSFYSGHSS FGMYCMVFLA 
LYVQARLCWK WARLLRPTVQ FFLVAFALYV GYTRVSDYKH HWSDVLVGLL QGALVAALTV 
CYISDFFKAR PPQHCLKEEE LERKPSLSLT LTLGEADHNH YGYPHSSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.