Details for: LAD1

Gene ID: 3898

Symbol: LAD1

Ensembl ID: ENSG00000159166

Description: ladinin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 42.0670
    Cell Significance Index: -17.0900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 17.9106
    Cell Significance Index: -17.1000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.8358
    Cell Significance Index: -23.6700
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 7.6579
    Cell Significance Index: 58.0700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 5.3882
    Cell Significance Index: 88.7900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 3.4066
    Cell Significance Index: 7.6800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.2502
    Cell Significance Index: 29.9300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 3.2212
    Cell Significance Index: 27.6800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.9393
    Cell Significance Index: 152.6900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.9031
    Cell Significance Index: 43.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.5445
    Cell Significance Index: 413.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.1881
    Cell Significance Index: 99.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.5342
    Cell Significance Index: 276.5700
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 1.3015
    Cell Significance Index: 22.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2639
    Cell Significance Index: 155.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2043
    Cell Significance Index: 26.0900
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.9450
    Cell Significance Index: 10.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9361
    Cell Significance Index: 25.4800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.9153
    Cell Significance Index: 22.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9148
    Cell Significance Index: 499.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8262
    Cell Significance Index: 23.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6364
    Cell Significance Index: 18.3400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5695
    Cell Significance Index: 7.7700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.5416
    Cell Significance Index: 7.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5197
    Cell Significance Index: 67.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4139
    Cell Significance Index: 183.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3372
    Cell Significance Index: 8.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2677
    Cell Significance Index: 12.4800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1819
    Cell Significance Index: 20.7600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1708
    Cell Significance Index: 6.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1669
    Cell Significance Index: 12.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1567
    Cell Significance Index: 15.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1546
    Cell Significance Index: 26.4000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1374
    Cell Significance Index: 4.4000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1291
    Cell Significance Index: 2.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1195
    Cell Significance Index: 22.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0825
    Cell Significance Index: 16.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0473
    Cell Significance Index: 35.8000
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.0266
    Cell Significance Index: 0.1000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0081
    Cell Significance Index: -0.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0096
    Cell Significance Index: -7.0100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0096
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0118
    Cell Significance Index: -7.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0123
    Cell Significance Index: -23.2000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0129
    Cell Significance Index: -0.9100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0131
    Cell Significance Index: -9.6800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0166
    Cell Significance Index: -11.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0236
    Cell Significance Index: -36.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0290
    Cell Significance Index: -3.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0301
    Cell Significance Index: -19.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0305
    Cell Significance Index: -17.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0307
    Cell Significance Index: -1.4500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0343
    Cell Significance Index: -0.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0386
    Cell Significance Index: -4.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0555
    Cell Significance Index: -25.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0573
    Cell Significance Index: -20.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0810
    Cell Significance Index: -17.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0833
    Cell Significance Index: -23.9600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1079
    Cell Significance Index: -2.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1182
    Cell Significance Index: -23.7200
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.1212
    Cell Significance Index: -1.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1315
    Cell Significance Index: -19.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1622
    Cell Significance Index: -22.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1810
    Cell Significance Index: -18.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1986
    Cell Significance Index: -15.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2066
    Cell Significance Index: -26.4900
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.2156
    Cell Significance Index: -1.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2235
    Cell Significance Index: -23.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2585
    Cell Significance Index: -15.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2935
    Cell Significance Index: -15.2900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3083
    Cell Significance Index: -20.7300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3261
    Cell Significance Index: -20.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3395
    Cell Significance Index: -26.0600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3459
    Cell Significance Index: -8.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3546
    Cell Significance Index: -22.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3558
    Cell Significance Index: -21.8700
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.3691
    Cell Significance Index: -2.2900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4054
    Cell Significance Index: -11.9400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.4580
    Cell Significance Index: -19.9100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4833
    Cell Significance Index: -17.7400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4927
    Cell Significance Index: -10.2200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.4977
    Cell Significance Index: -5.2500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5045
    Cell Significance Index: -22.3200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.5313
    Cell Significance Index: -13.2700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5422
    Cell Significance Index: -6.1600
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.5442
    Cell Significance Index: -3.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5508
    Cell Significance Index: -30.9100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5738
    Cell Significance Index: -19.9400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5896
    Cell Significance Index: -22.3300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6320
    Cell Significance Index: -22.1400
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.6343
    Cell Significance Index: -5.8700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.6576
    Cell Significance Index: -11.0600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7133
    Cell Significance Index: -16.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7263
    Cell Significance Index: -23.7800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7296
    Cell Significance Index: -20.8200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7327
    Cell Significance Index: -23.3400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.7451
    Cell Significance Index: -18.5800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7453
    Cell Significance Index: -19.9400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7505
    Cell Significance Index: -20.1100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.7706
    Cell Significance Index: -6.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural uniqueness:** LAD1 exhibits a distinct structure, consisting of a short N-terminal domain and a longer C-terminal domain, which is rich in acidic amino acids. 2. **Epithelial cell specificity:** LAD1 is specifically expressed in epithelial cells, suggesting its role in maintaining epithelial cell homeostasis. 3. **Actin cytoskeleton regulation:** LAD1 interacts with actin-binding proteins, modulating actin filament dynamics and cytoskeleton organization. 4. **Cell adhesion:** LAD1 binds to cadherins, a family of cell adhesion molecules, facilitating cell-cell interactions and maintaining tissue architecture. **Pathways and Functions:** 1. **Actin cytoskeleton regulation:** LAD1 interacts with actin-binding proteins, such as profilin and actin depolymerizing factor (ADF), to regulate actin filament dynamics and cytoskeleton organization. 2. **Cell adhesion:** LAD1 binds to cadherins, including E-cadherin and N-cadherin, facilitating cell-cell interactions and maintaining tissue architecture. 3. **Epithelial barrier function:** LAD1 contributes to the maintenance of the epithelial barrier by regulating actin cytoskeleton dynamics and cell adhesion. 4. **Signaling pathways:** LAD1 may interact with signaling pathways, such as the Wnt/β-catenin pathway, to regulate epithelial cell behavior and homeostasis. **Clinical Significance:** 1. **Cancer progression:** Dysregulation of LAD1 has been implicated in various cancers, including esophageal, colonic, and prostate cancers, where it can contribute to tumor progression and metastasis. 2. **Epithelial disorders:** LAD1 may play a role in maintaining epithelial barrier function, and dysregulation of LAD1 may contribute to epithelial disorders, such as ulcers and bleeding. 3. **Targeted therapy:** LAD1 may serve as a potential target for therapeutic interventions in cancer and epithelial disorders, where its dysregulation contributes to disease progression. 4. **Basic research:** Further studies on LAD1 are necessary to elucidate its mechanisms of action and to understand its role in maintaining epithelial cell homeostasis and function. In conclusion, Ladinin-1 (LAD1) is a novel protein that plays a critical role in maintaining epithelial cell integrity and function. Its dysregulation has been implicated in various diseases, including cancer and epithelial disorders. Further research is necessary to fully understand the mechanisms of action of LAD1 and to explore its potential as a therapeutic target.

Genular Protein ID: 1348408138

Symbol: LAD1_HUMAN

Name: Ladinin-1

UniProtKB Accession Codes:

O00515 O95614 Q96GD8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

  • Length: 517
  • Mass: 57131
  • Checksum: 622E81B9412A924B
  • Sequence:
    • MAVSRKDWSA LSSLARQRTL EDEEEQERER RRRHRNLSST TDDEAPRLSQ NGDRQASASE 
RLPSVEEAEV PKPLPPASKD EDEDIQSILR TRQERRQRRQ VVEAAQAPIQ ERLEAEEGRN 
SLSPVQATQK PLVSKKELEI PPRRRLSREQ RGPWALEEES LVGREPEERK KGVPEKSPVL 
EKSSMPKKTA PEKSLVSDKT SISEKVLASE KTSLSEKIAV SEKRNSSEKK SVLEKTSVSE 
KSLAPGMALG SGRRLVSEKA SIFEKALASE KSPTADAKPA PKRATASEQP LAQEPPASGG 
SPATTKEQRG RALPGKNLPS LAKQGASDPP TVASRLPPVT LQVKIPSKEE EADMSSPTQR 
TYSSSLKRSS PRTISFRMKP KKENSETTLT RSASMKLPDN TVKLGEKLER YHTAIRRSES 
VKSRGLPCTE LFVAPVGVAS KRHLFEKELA GQSRAEPASS RKENLRLSGV VTSRLNLWIS 
RTQESGDQDP QEAQKASSAT ERTQWGQKSD SSLDAEV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.