Details for: LAD1

Gene ID: 3898

Symbol: LAD1

Ensembl ID: ENSG00000159166

Description: ladinin 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.58
    Marker Score: 20128
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.34
    Marker Score: 20200
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.1
    Marker Score: 1652
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.09
    Marker Score: 28043
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.04
    Marker Score: 6402
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.96
    Marker Score: 2887
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.93
    Marker Score: 9272
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.9
    Marker Score: 4513
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.65
    Marker Score: 4039
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.62
    Marker Score: 10351
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.45
    Marker Score: 1501
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.44
    Marker Score: 2217
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.44
    Marker Score: 355
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.43
    Marker Score: 3234
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 867
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.35
    Marker Score: 46876
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.34
    Marker Score: 703
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.3
    Marker Score: 488
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.27
    Marker Score: 2041
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.26
    Marker Score: 1253
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.23
    Marker Score: 19307
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.17
    Marker Score: 1868
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.16
    Marker Score: 8663
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.14
    Marker Score: 1261
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.12
    Marker Score: 271
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1
    Marker Score: 1161
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.05
    Marker Score: 356
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.05
    Marker Score: 2574
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251796
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71814
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48039
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.96
    Marker Score: 2186
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.96
    Marker Score: 1551
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.95
    Marker Score: 817
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5340
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.93
    Marker Score: 225
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.92
    Marker Score: 2166
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9
    Marker Score: 224
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.89
    Marker Score: 175
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.85
    Marker Score: 813
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.85
    Marker Score: 565
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.83
    Marker Score: 5422.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 629
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.82
    Marker Score: 4318
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 319
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.8
    Marker Score: 332.5
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.79
    Marker Score: 3890
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.77
    Marker Score: 439
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.76
    Marker Score: 3205
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.75
    Marker Score: 216
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 672
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.74
    Marker Score: 2612
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 469
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.72
    Marker Score: 487
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.7
    Marker Score: 587
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.7
    Marker Score: 247
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.68
    Marker Score: 223
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.68
    Marker Score: 2503
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.66
    Marker Score: 277
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.65
    Marker Score: 1061
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.64
    Marker Score: 650
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.6
    Marker Score: 1066
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.59
    Marker Score: 670
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.59
    Marker Score: 303
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.58
    Marker Score: 2229
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.57
    Marker Score: 116
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.57
    Marker Score: 1037
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.56
    Marker Score: 1192
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.54
    Marker Score: 253
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.54
    Marker Score: 691
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.52
    Marker Score: 548
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.51
    Marker Score: 133
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.51
    Marker Score: 1275
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.5
    Marker Score: 947
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.5
    Marker Score: 1336
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.49
    Marker Score: 242
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.47
    Marker Score: 163
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.47
    Marker Score: 217
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.47
    Marker Score: 326
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.47
    Marker Score: 662
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.46
    Marker Score: 488
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.45
    Marker Score: 522
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.44
    Marker Score: 127
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.43
    Marker Score: 179
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.42
    Marker Score: 279
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.42
    Marker Score: 133
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.42
    Marker Score: 451
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.42
    Marker Score: 98

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - Protein type: transmembrane protein - Ensembl ID: ENSG00000159166 - Protein sequence length: 1,321 amino acids - Cellular location: cell surface - Expression: highly expressed in stratified epithelial cells, epithelial cells of esophagus, urethra, colon epithelial cells, bladder urothelial cells, enterocytes, stem cells, and basal cells of prostate epithelium. **Pathways and functions:** - Actin cytoskeleton: LAD1 is a key component of the actin cytoskeleton, where it is involved in maintaining cell shape, cell adhesion, and cell migration. - Basement membrane: LAD1 is also involved in the basement membrane, where it helps to hold the cells together and provide them with structural support. - Cadherin binding: LAD1 is a receptor for cadherins, which are cell adhesion molecules that help to hold cells together. - Extracellular exosome: LAD1 is a ligand for the protein CD63, which is expressed on the surface of extracellular vesicles. This interaction is important for the internalization of extracellular vesicles by cells. - Structural molecule activity: LAD1 is involved in the assembly of structural molecules, such as microfilaments and intermediate filaments. **Clinical significance:** Mutations in the LAD1 gene have been linked to a number of human diseases, including breast cancer, lung cancer, and colon cancer. These mutations can disrupt the function of LAD1, leading to the development of cancer.

Genular Protein ID: 1348408138

Symbol: LAD1_HUMAN

Name: Ladinin-1

UniProtKB Accession Codes:

O00515 O95614 Q96GD8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 5 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

  • Length: 517
  • Mass: 57131
  • Checksum: 622E81B9412A924B
  • Sequence:
    • MAVSRKDWSA LSSLARQRTL EDEEEQERER RRRHRNLSST TDDEAPRLSQ NGDRQASASE 
RLPSVEEAEV PKPLPPASKD EDEDIQSILR TRQERRQRRQ VVEAAQAPIQ ERLEAEEGRN 
SLSPVQATQK PLVSKKELEI PPRRRLSREQ RGPWALEEES LVGREPEERK KGVPEKSPVL 
EKSSMPKKTA PEKSLVSDKT SISEKVLASE KTSLSEKIAV SEKRNSSEKK SVLEKTSVSE 
KSLAPGMALG SGRRLVSEKA SIFEKALASE KSPTADAKPA PKRATASEQP LAQEPPASGG 
SPATTKEQRG RALPGKNLPS LAKQGASDPP TVASRLPPVT LQVKIPSKEE EADMSSPTQR 
TYSSSLKRSS PRTISFRMKP KKENSETTLT RSASMKLPDN TVKLGEKLER YHTAIRRSES 
VKSRGLPCTE LFVAPVGVAS KRHLFEKELA GQSRAEPASS RKENLRLSGV VTSRLNLWIS 
RTQESGDQDP QEAQKASSAT ERTQWGQKSD SSLDAEV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.