Details for: LYPD3

Gene ID: 27076

Symbol: LYPD3

Ensembl ID: ENSG00000124466

Description: LY6/PLAUR domain containing 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 47.9603
    Cell Significance Index: -7.4600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 29.2734
    Cell Significance Index: -7.4300
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 19.3947
    Cell Significance Index: 57.6800
  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 15.8099
    Cell Significance Index: 18.2000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 15.2079
    Cell Significance Index: -7.1800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.0424
    Cell Significance Index: -7.4500
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 6.0125
    Cell Significance Index: 13.5600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 5.4415
    Cell Significance Index: 77.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 5.1903
    Cell Significance Index: 138.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 4.9915
    Cell Significance Index: 259.3000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.0647
    Cell Significance Index: 25.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.6307
    Cell Significance Index: 161.2900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 2.6196
    Cell Significance Index: 22.5100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.9730
    Cell Significance Index: 147.0500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.9139
    Cell Significance Index: -7.5500
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 1.6092
    Cell Significance Index: 11.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.3056
    Cell Significance Index: 168.6700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.2991
    Cell Significance Index: -3.9900
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.1488
    Cell Significance Index: 7.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.0538
    Cell Significance Index: 465.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0495
    Cell Significance Index: 29.3300
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.8441
    Cell Significance Index: 4.8400
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.7924
    Cell Significance Index: 5.2600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.7493
    Cell Significance Index: -1.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6839
    Cell Significance Index: 48.3700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5527
    Cell Significance Index: 5.0900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5498
    Cell Significance Index: 25.8400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4628
    Cell Significance Index: 45.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4362
    Cell Significance Index: 9.2900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4049
    Cell Significance Index: 365.5700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3473
    Cell Significance Index: 66.1000
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.3376
    Cell Significance Index: 3.3900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2795
    Cell Significance Index: 30.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2624
    Cell Significance Index: 42.6800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2350
    Cell Significance Index: 14.1100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1910
    Cell Significance Index: 2.6500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.1754
    Cell Significance Index: 1.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1525
    Cell Significance Index: 18.7600
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.1298
    Cell Significance Index: 1.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1275
    Cell Significance Index: 22.9800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1271
    Cell Significance Index: 3.4100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1096
    Cell Significance Index: 14.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0689
    Cell Significance Index: 8.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0435
    Cell Significance Index: 23.7600
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0390
    Cell Significance Index: 0.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0379
    Cell Significance Index: 1.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0272
    Cell Significance Index: 3.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0251
    Cell Significance Index: 1.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0222
    Cell Significance Index: 0.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0124
    Cell Significance Index: 0.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0044
    Cell Significance Index: 0.1100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0041
    Cell Significance Index: 2.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0013
    Cell Significance Index: -2.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0014
    Cell Significance Index: -0.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0015
    Cell Significance Index: -2.7800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0019
    Cell Significance Index: -2.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0063
    Cell Significance Index: -8.5300
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.0064
    Cell Significance Index: -0.0400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0065
    Cell Significance Index: -0.1400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0066
    Cell Significance Index: -0.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0081
    Cell Significance Index: -5.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0082
    Cell Significance Index: -6.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0083
    Cell Significance Index: -6.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0086
    Cell Significance Index: -6.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0123
    Cell Significance Index: -6.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0149
    Cell Significance Index: -5.3400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0153
    Cell Significance Index: -6.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0160
    Cell Significance Index: -4.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0205
    Cell Significance Index: -1.2900
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: -0.0267
    Cell Significance Index: -0.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0268
    Cell Significance Index: -5.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0270
    Cell Significance Index: -3.9300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0331
    Cell Significance Index: -1.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0338
    Cell Significance Index: -6.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0354
    Cell Significance Index: -7.4500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0384
    Cell Significance Index: -1.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0407
    Cell Significance Index: -6.9500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0421
    Cell Significance Index: -0.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0426
    Cell Significance Index: -4.3500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0477
    Cell Significance Index: -5.4600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0501
    Cell Significance Index: -1.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0583
    Cell Significance Index: -6.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0588
    Cell Significance Index: -1.6000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0626
    Cell Significance Index: -1.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0713
    Cell Significance Index: -7.4200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0713
    Cell Significance Index: -0.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0718
    Cell Significance Index: -2.3000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0730
    Cell Significance Index: -0.9400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0808
    Cell Significance Index: -6.4000
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: -0.0902
    Cell Significance Index: -0.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0938
    Cell Significance Index: -6.0500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0998
    Cell Significance Index: -2.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1081
    Cell Significance Index: -7.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1102
    Cell Significance Index: -8.4600
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1190
    Cell Significance Index: -1.7800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1212
    Cell Significance Index: -4.4500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1230
    Cell Significance Index: -7.5600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1234
    Cell Significance Index: -1.8600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1260
    Cell Significance Index: -1.9500
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.1316
    Cell Significance Index: -1.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Cellular localization**: LYPD3 is a transmembrane protein, with a significant portion of its sequence localized in the extracellular space, where it can interact with other proteins and ligands. 2. **Domain structure**: The protein contains a Ly6/PLAUR domain, which is known for its involvement in cell adhesion, migration, and signaling. 3. **Expression pattern**: LYPD3 is significantly expressed in multiple cell types, including epithelial cells, stem cells, and progenitor cells, suggesting its role in tissue development and maintenance. 4. **Functional roles**: The protein product of LYPD3 is involved in cell-matrix adhesion, negative regulation of smooth muscle cell apoptotic process, and post-translational modification of GPI-anchored proteins. **Pathways and Functions** 1. **Cell-matrix adhesion**: LYPD3 interacts with laminin, a key component of the extracellular matrix, to regulate cell adhesion and migration. 2. **Negative regulation of smooth muscle cell apoptotic process**: LYPD3 modulates the apoptotic process in smooth muscle cells, potentially contributing to tissue repair and maintenance. 3. **Post-translational modification of GPI-anchored proteins**: LYPD3 is involved in the synthesis of GPI-anchored proteins, which are essential for cell signaling and membrane trafficking. 4. **Laminin binding**: LYPD3 interacts with laminin, a key component of the extracellular matrix, to regulate cell adhesion and migration. **Clinical Significance** 1. **Cancer**: Alterations in LYPD3 expression have been observed in various cancers, including esophageal and bladder cancer, suggesting its potential role as a tumor suppressor or oncogene. 2. **Inflammatory diseases**: LYPD3 may play a role in the regulation of inflammatory responses, given its involvement in cell-matrix adhesion and negative regulation of smooth muscle cell apoptotic process. 3. **Wound healing**: LYPD3 may contribute to wound healing by regulating cell-matrix adhesion and post-translational modification of GPI-anchored proteins. 4. **Neurological disorders**: LYPD3 may be involved in the regulation of neuronal development and function, given its expression in neural stem cells and progenitor cells. In conclusion, LYPD3 is a multifunctional protein that plays a crucial role in various cellular processes, including cell-matrix adhesion, negative regulation of smooth muscle cell apoptotic process, and post-translational modification of GPI-anchored proteins. Its widespread expression in epithelial cells, stem cells, and progenitor cells suggests its potential role in tissue development and maintenance. Further studies are needed to elucidate the clinical significance of LYPD3 in various diseases and disorders.

Genular Protein ID: 2642297898

Symbol: LYPD3_HUMAN

Name: Ly6/PLAUR domain-containing protein 3

UniProtKB Accession Codes:

O95274 Q9UJ74

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRIDE 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11245483

Title: Identification of genes involved in human urothelial cell-matrix interactions: implications for the progression pathways of malignant urothelium.

PubMed ID: 11245483

PubMed ID: 11179665

Title: Cloning of the human homologue of the metastasis-associated rat C4.4A.

PubMed ID: 11179665

DOI: 10.1016/s0378-1119(00)00515-1

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15012588

Title: Structural analysis and tissue localization of human C4.4A: a protein homologue of the urokinase receptor.

PubMed ID: 15012588

DOI: 10.1042/bj20031478

PubMed ID: 12592373

Title: hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan.

PubMed ID: 12592373

DOI: 10.1038/sj.bjc.6600740

Sequence Information:

  • Length: 346
  • Mass: 35971
  • Checksum: 97FF9B4A554934FF
  • Sequence:
    • MDPARKAGAQ AMIWTAGWLL LLLLRGGAQA LECYSCVQKA DDGCSPNKMK TVKCAPGVDV 
CTEAVGAVET IHGQFSLAVR GCGSGLPGKN DRGLDLHGLL AFIQLQQCAQ DRCNAKLNLT 
SRALDPAGNE SAYPPNGVEC YSCVGLSREA CQGTSPPVVS CYNASDHVYK GCFDGNVTLT 
AANVTVSLPV RGCVQDEFCT RDGVTGPGFT LSGSCCQGSR CNSDLRNKTY FSPRIPPLVR 
LPPPEPTTVA STTSVTTSTS APVRPTSTTK PMPAPTSQTP RQGVEHEASR DEEPRLTGGA 
AGHQDRSNSG QYPAKGGPQQ PHNKGCVAPT AGLAALLLAV AAGVLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.