Gene EFNB1 - ENSG00000090776 | NCBI Gene ID: 1947

Details for: EFNB1

Gene ID: 1947

Symbol: EFNB1

Ensembl ID: ENSG00000090776

Description: ephrin B1

Associated with

Developmental biology
(R-HSA-1266738)
Eph-ephrin mediated repulsion of cells
(R-HSA-3928665)
Eph-ephrin signaling
(R-HSA-2682334)
Ephb-mediated forward signaling
(R-HSA-3928662)
Ephrin signaling
(R-HSA-3928664)
Nervous system development
(R-HSA-9675108)
Axon guidance
(GO:0007411)
Cell-cell signaling
(GO:0007267)
Cell adhesion
(GO:0007155)
Cell surface
(GO:0009986)
Cytoplasm
(GO:0005737)
Embryonic pattern specification
(GO:0009880)
Ephrin receptor binding
(GO:0046875)
Ephrin receptor signaling pathway
(GO:0048013)
Extracellular exosome
(GO:0070062)
Glutamatergic synapse
(GO:0098978)
Membrane raft
(GO:0045121)
Neural crest cell migration
(GO:0001755)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of t cell proliferation
(GO:0042102)
Presynaptic membrane
(GO:0042734)
Protein binding
(GO:0005515)
Regulation of autophagosome assembly
(GO:2000785)
Synapse
(GO:0045202)
T cell costimulation
(GO:0031295)
T cell proliferation
(GO:0042098)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 4.4
Marker Score: 3525
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 2.77
Marker Score: 24311.5
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 2.74
Marker Score: 3965
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 2.1
Marker Score: 5341
Cell Name: Leydig cell (CL0000178)
Fold Change: 1.8
Marker Score: 1939
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.59
Marker Score: 3314
Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 1.57
Marker Score: 366
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.52
Marker Score: 1196
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 169071
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.46
Marker Score: 2152
Cell Name: kidney cell (CL1000497)
Fold Change: 1.36
Marker Score: 906
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.35
Marker Score: 2559.5
Cell Name: mesodermal cell (CL0000222)
Fold Change: 1.33
Marker Score: 17559
Cell Name: Unknown (CL0002371)
Fold Change: 1.29
Marker Score: 1370
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.26
Marker Score: 2572
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1.25
Marker Score: 424
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 1.23
Marker Score: 313
Cell Name: glomerular endothelial cell (CL0002188)
Fold Change: 1.2
Marker Score: 305
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.16
Marker Score: 18194.5
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 1.08
Marker Score: 3402
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.05
Marker Score: 2553
Cell Name: preosteoblast (CL0007010)
Fold Change: 1.04
Marker Score: 296
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71789
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48013
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30405
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 494
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 448
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2409
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5235
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2727
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.91
Marker Score: 5890
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 316
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5269
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.84
Marker Score: 3097
Cell Name: enterocyte (CL0000584)
Fold Change: 0.83
Marker Score: 3968
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.81
Marker Score: 5166.5
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 0.8
Marker Score: 194
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1265
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 0.78
Marker Score: 838
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.77
Marker Score: 808
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.77
Marker Score: 2965
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.77
Marker Score: 763
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.76
Marker Score: 1797
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.76
Marker Score: 582
Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.76
Marker Score: 219
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.74
Marker Score: 146
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.74
Marker Score: 385
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.74
Marker Score: 4363
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.73
Marker Score: 230
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 0.73
Marker Score: 658
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.72
Marker Score: 289
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.71
Marker Score: 167
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.71
Marker Score: 175
Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.71
Marker Score: 194
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 0.7
Marker Score: 1024
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.7
Marker Score: 627
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7
Marker Score: 2926.5
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.7
Marker Score: 657
Cell Name: brush cell (CL0002204)
Fold Change: 0.7
Marker Score: 636
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.69
Marker Score: 441
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.68
Marker Score: 149
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 173
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 0.67
Marker Score: 261
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.67
Marker Score: 1570
Cell Name: vasa recta ascending limb cell (CL1001131)
Fold Change: 0.66
Marker Score: 175
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 0.64
Marker Score: 266
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.62
Marker Score: 6216.5
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.62
Marker Score: 371
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 0.6
Marker Score: 511
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 0.59
Marker Score: 567
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 0.59
Marker Score: 726
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.58
Marker Score: 279
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 0.58
Marker Score: 4339
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.58
Marker Score: 187
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.58
Marker Score: 945
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 0.58
Marker Score: 134
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 0.56
Marker Score: 140
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.56
Marker Score: 211
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.56
Marker Score: 19024.5
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 0.56
Marker Score: 140
Cell Name: basal cell (CL0000646)
Fold Change: 0.55
Marker Score: 715
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.55
Marker Score: 876
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 435
Cell Name: stem cell (CL0000034)
Fold Change: 0.54
Marker Score: 1287
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.54
Marker Score: 1080
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 0.54
Marker Score: 4220
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 0.54
Marker Score: 339
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.53
Marker Score: 815
Cell Name: osteoclast (CL0000092)
Fold Change: 0.53
Marker Score: 263
Cell Name: neural crest cell (CL0011012)
Fold Change: 0.53
Marker Score: 564
Cell Name: neural cell (CL0002319)
Fold Change: 0.52
Marker Score: 252
Cell Name: podocyte (CL0000653)
Fold Change: 0.52
Marker Score: 191
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.51
Marker Score: 546
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.51
Marker Score: 614
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.51
Marker Score: 146
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 0.49
Marker Score: 419
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.48
Marker Score: 1320
Cell Name: germ cell (CL0000586)
Fold Change: 0.47
Marker Score: 820
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.47
Marker Score: 2295
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.46
Marker Score: 1170

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**Key characteristics:** * EFNB1 is a type of Eph receptor, which are a family of cell surface proteins that are involved in cell adhesion, migration, and signaling. * It is expressed in a variety of cell types, including endothelial cells, fibroblasts, and neurons. * It is a key regulator of neural crest cell migration, as well as the development of the blood-brain barrier. **Pathways and functions:** * EFNB1 is involved in the axonal guidance of neurons. * It is also involved in cell-cell signaling in the nervous system, where it helps to regulate the migration and differentiation of neurons. * It is involved in cell adhesion, migration, and signaling in various tissues, including the skin, lungs, and kidneys. **Clinical significance:** * Mutations in EFNB1 have been linked to a number of human diseases, including autism, schizophrenia, and cancer. * EFNB1 is a potential therapeutic target for these diseases, as it is involved in the regulation of neural development and function. **Additional information:** * EFNB1 is a highly conserved protein, with a similar protein being found in mice. * It is a member of the Eph family of cell surface glycoproteins, which are expressed in a variety of cell types. * It is a key regulator of the development of the human nervous system.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Ephrin-B1

Genular Protein ID: 2634816224

Symbol: EFNB1_HUMAN

Name: Ephrin-B1

UniProtKB Accession Codes:

P98172 D3DVU0

Database IDs:

Citations:

PubMed ID: 8070404

Title: Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors.

PubMed ID: 8070404

DOI: 10.1002/j.1460-2075.1994.tb06685.x

PubMed ID: 7973638

Title: Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity.

PubMed ID: 7973638

DOI: 10.1126/science.7973638

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 10197531

Title: EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains.

PubMed ID: 10197531

DOI: 10.1016/s0896-6273(00)80706-0

PubMed ID: 16930449

Title: Presenilin-dependent intramembrane cleavage of ephrin-B1.

PubMed ID: 16930449

DOI: 10.1186/1750-1326-1-2

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21429299

Title: EphrinB1 interacts with the transcriptional co-repressor Groucho/xTLE4.

PubMed ID: 21429299

DOI: 10.5483/bmbrep.2011.44.3.199

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 15124102

Title: Mutations of the ephrin-B1 gene cause craniofrontonasal syndrome.

PubMed ID: 15124102

DOI: 10.1086/421532

PubMed ID: 15166289

Title: Mutations of ephrin-B1 (EFNB1), a marker of tissue boundary formation, cause craniofrontonasal syndrome.

PubMed ID: 15166289

DOI: 10.1073/pnas.0402819101

PubMed ID: 15959873

Title: Twenty-six novel EFNB1 mutations in familial and sporadic craniofrontonasal syndrome (CFNS).

PubMed ID: 15959873

DOI: 10.1002/humu.20193

Sequence Information:

Length: 346
Mass: 38007
Checksum: 473DD2F1A5BF89DE
Sequence:

MARPGQRWLG KWLVAMVVWA LCRLATPLAK NLEPVSWSSL NPKFLSGKGL VIYPKIGDKL 
DIICPRAEAG RPYEYYKLYL VRPEQAAACS TVLDPNVLVT CNRPEQEIRF TIKFQEFSPN 
YMGLEFKKHH DYYITSTSNG SLEGLENREG GVCRTRTMKI IMKVGQDPNA VTPEQLTTSR 
PSKEADNTVK MATQAPGSRG SLGDSDGKHE TVNQEEKSGP GASGGSSGDP DGFFNSKVAL 
FAAVGAGCVI FLLIIIFLTV LLLKLRKRHR KHTQQRAAAL SLSTLASPKG GSGTAGTEPS 
DIIIPLRTTE NNYCPHYEKV SGDYGHPVYI VQEMPPQSPA NIYYKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: EFNB1

Associated with

Cells (max top 100)

Other Information

Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors. PubMed ID: 8070404

Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. PubMed ID: 7973638

The DNA sequence of the human X chromosome. PubMed ID: 15772651

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Signal peptide prediction based on analysis of experimentally verified cleavage sites. PubMed ID: 15340161

EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. PubMed ID: 10197531

Presenilin-dependent intramembrane cleavage of ephrin-B1. PubMed ID: 16930449

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

EphrinB1 interacts with the transcriptional co-repressor Groucho/xTLE4. PubMed ID: 21429299

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Mutations of the ephrin-B1 gene cause craniofrontonasal syndrome. PubMed ID: 15124102

Mutations of ephrin-B1 (EFNB1), a marker of tissue boundary formation, cause craniofrontonasal syndrome. PubMed ID: 15166289

Twenty-six novel EFNB1 mutations in familial and sporadic craniofrontonasal syndrome (CFNS). PubMed ID: 15959873