Details for: EFNB1

Gene ID: 1947

Symbol: EFNB1

Ensembl ID: ENSG00000090776

Description: ephrin B1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 103.1854
    Cell Significance Index: -16.0500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 62.4499
    Cell Significance Index: -15.8400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 35.5204
    Cell Significance Index: -16.7700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 34.4117
    Cell Significance Index: -13.9800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.6846
    Cell Significance Index: -14.0200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.2527
    Cell Significance Index: -16.3400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 6.3474
    Cell Significance Index: 39.2700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.2825
    Cell Significance Index: -16.8300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 5.2317
    Cell Significance Index: 272.5100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 4.1983
    Cell Significance Index: 33.5200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.1155
    Cell Significance Index: -16.2400
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.7681
    Cell Significance Index: 8.2300
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 2.6778
    Cell Significance Index: 9.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.3741
    Cell Significance Index: 64.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.2648
    Cell Significance Index: 117.6500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.0104
    Cell Significance Index: -4.4000
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.9544
    Cell Significance Index: 9.7500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.8933
    Cell Significance Index: 28.3700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.4720
    Cell Significance Index: 51.1500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.2602
    Cell Significance Index: 7.8300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.1958
    Cell Significance Index: 25.0300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1175
    Cell Significance Index: 24.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0780
    Cell Significance Index: 48.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0523
    Cell Significance Index: 114.4600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.0260
    Cell Significance Index: 23.7100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.9176
    Cell Significance Index: 15.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9010
    Cell Significance Index: 110.7900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8843
    Cell Significance Index: 143.8300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8353
    Cell Significance Index: 754.2500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.8324
    Cell Significance Index: 10.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8068
    Cell Significance Index: 23.2500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7785
    Cell Significance Index: 20.4700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.7662
    Cell Significance Index: 8.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6572
    Cell Significance Index: 118.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6260
    Cell Significance Index: 80.2500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.4855
    Cell Significance Index: 6.8100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4682
    Cell Significance Index: 206.9900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4311
    Cell Significance Index: 29.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4216
    Cell Significance Index: 29.8200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.2665
    Cell Significance Index: 2.2900
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.2564
    Cell Significance Index: 1.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2524
    Cell Significance Index: 8.8700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2500
    Cell Significance Index: 34.3300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2200
    Cell Significance Index: 21.7600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1702
    Cell Significance Index: 3.6300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1688
    Cell Significance Index: 4.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1467
    Cell Significance Index: 4.1000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1449
    Cell Significance Index: 2.5600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1425
    Cell Significance Index: 77.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1420
    Cell Significance Index: 3.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1296
    Cell Significance Index: 4.1500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1003
    Cell Significance Index: 19.0900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0877
    Cell Significance Index: 0.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0820
    Cell Significance Index: 2.1900
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.0631
    Cell Significance Index: 0.6000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0270
    Cell Significance Index: 0.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0114
    Cell Significance Index: 4.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0059
    Cell Significance Index: 1.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0019
    Cell Significance Index: 0.3800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0026
    Cell Significance Index: -1.8300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0059
    Cell Significance Index: -11.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0105
    Cell Significance Index: -19.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0129
    Cell Significance Index: -19.8000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0151
    Cell Significance Index: -20.5200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0174
    Cell Significance Index: -0.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0187
    Cell Significance Index: -14.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0189
    Cell Significance Index: -13.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0214
    Cell Significance Index: -13.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0247
    Cell Significance Index: -18.3000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0296
    Cell Significance Index: -18.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0314
    Cell Significance Index: -17.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0336
    Cell Significance Index: -3.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0350
    Cell Significance Index: -10.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0351
    Cell Significance Index: -15.9300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0463
    Cell Significance Index: -0.7800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0464
    Cell Significance Index: -5.4100
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0598
    Cell Significance Index: -0.3700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0624
    Cell Significance Index: -0.3700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0666
    Cell Significance Index: -8.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0682
    Cell Significance Index: -0.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0755
    Cell Significance Index: -4.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0766
    Cell Significance Index: -4.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0807
    Cell Significance Index: -13.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0811
    Cell Significance Index: -3.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0900
    Cell Significance Index: -10.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0900
    Cell Significance Index: -18.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1020
    Cell Significance Index: -14.8300
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1102
    Cell Significance Index: -0.6900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1307
    Cell Significance Index: -15.4100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1332
    Cell Significance Index: -8.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1563
    Cell Significance Index: -16.2700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1584
    Cell Significance Index: -1.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1686
    Cell Significance Index: -12.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1805
    Cell Significance Index: -13.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1925
    Cell Significance Index: -11.8000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1931
    Cell Significance Index: -15.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2166
    Cell Significance Index: -11.3700
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.2285
    Cell Significance Index: -1.4000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2369
    Cell Significance Index: -14.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2396
    Cell Significance Index: -16.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell surface receptor:** EFNB1 is a transmembrane receptor that interacts with ephrin ligands, triggering a signaling cascade that regulates various cellular processes. 2. **Receptor tyrosine kinase:** EFNB1 belongs to the Eph receptor family, which is characterized by its receptor tyrosine kinase (RTK) activity. This kinase activity is essential for the phosphorylation and activation of downstream signaling molecules. 3. **Biphasic signaling:** EFNB1 exhibits biphasic signaling, meaning that it can both repel and attract cells, depending on the context and the specific ephrin ligand involved. 4. **Tissue-specific expression:** EFNB1 is predominantly expressed in various cell types, including endothelial cells, epithelial cells, and immune cells. **Pathways and Functions:** 1. **Axon guidance:** EFNB1 plays a crucial role in axon guidance during neural development, influencing the migration and patterning of neurons. 2. **Cell-cell signaling:** EFNB1 interacts with ephrin ligands to regulate cell-cell signaling, influencing cell adhesion, migration, and differentiation. 3. **Cell adhesion:** EFNB1 facilitates cell adhesion by interacting with specific ephrin ligands, which in turn regulate the formation of cell-cell junctions. 4. **Developmental biology:** EFNB1 is involved in various developmental processes, including embryonic pattern specification, neural crest cell migration, and nephron development. 5. **Immune cell function:** EFNB1 has been implicated in the regulation of immune cell function, including T cell proliferation, costimulation, and autophagosome assembly. **Clinical Significance:** 1. **Cancer:** Dysregulation of EFNB1 has been observed in various types of cancer, including lung, breast, and colon cancer. EFNB1 may serve as a potential biomarker for cancer diagnosis and prognosis. 2. **Neurological disorders:** EFNB1 has been implicated in the pathogenesis of neurological disorders, such as autism spectrum disorder, schizophrenia, and Alzheimer's disease. 3. **Cardiovascular disease:** EFNB1 may play a role in the development of cardiovascular disease, particularly in the regulation of endothelial cell function and vascular remodeling. 4. **Autoimmune diseases:** EFNB1 has been implicated in the regulation of immune cell function, which may contribute to the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. In conclusion, EFNB1 is a multifaceted gene that plays a critical role in regulating cell signaling, development, and immune function. Its dysregulation has been implicated in various human diseases, highlighting the importance of further research into the molecular mechanisms underlying EFNB1's functions.

Genular Protein ID: 2634816224

Symbol: EFNB1_HUMAN

Name: Ephrin-B1

UniProtKB Accession Codes:

P98172 D3DVU0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8070404

Title: Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors.

PubMed ID: 8070404

DOI: 10.1002/j.1460-2075.1994.tb06685.x

PubMed ID: 7973638

Title: Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity.

PubMed ID: 7973638

DOI: 10.1126/science.7973638

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 10197531

Title: EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains.

PubMed ID: 10197531

DOI: 10.1016/s0896-6273(00)80706-0

PubMed ID: 16930449

Title: Presenilin-dependent intramembrane cleavage of ephrin-B1.

PubMed ID: 16930449

DOI: 10.1186/1750-1326-1-2

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21429299

Title: EphrinB1 interacts with the transcriptional co-repressor Groucho/xTLE4.

PubMed ID: 21429299

DOI: 10.5483/bmbrep.2011.44.3.199

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 15124102

Title: Mutations of the ephrin-B1 gene cause craniofrontonasal syndrome.

PubMed ID: 15124102

DOI: 10.1086/421532

PubMed ID: 15166289

Title: Mutations of ephrin-B1 (EFNB1), a marker of tissue boundary formation, cause craniofrontonasal syndrome.

PubMed ID: 15166289

DOI: 10.1073/pnas.0402819101

PubMed ID: 15959873

Title: Twenty-six novel EFNB1 mutations in familial and sporadic craniofrontonasal syndrome (CFNS).

PubMed ID: 15959873

DOI: 10.1002/humu.20193

Sequence Information:

  • Length: 346
  • Mass: 38007
  • Checksum: 473DD2F1A5BF89DE
  • Sequence:
    • MARPGQRWLG KWLVAMVVWA LCRLATPLAK NLEPVSWSSL NPKFLSGKGL VIYPKIGDKL 
DIICPRAEAG RPYEYYKLYL VRPEQAAACS TVLDPNVLVT CNRPEQEIRF TIKFQEFSPN 
YMGLEFKKHH DYYITSTSNG SLEGLENREG GVCRTRTMKI IMKVGQDPNA VTPEQLTTSR 
PSKEADNTVK MATQAPGSRG SLGDSDGKHE TVNQEEKSGP GASGGSSGDP DGFFNSKVAL 
FAAVGAGCVI FLLIIIFLTV LLLKLRKRHR KHTQQRAAAL SLSTLASPKG GSGTAGTEPS 
DIIIPLRTTE NNYCPHYEKV SGDYGHPVYI VQEMPPQSPA NIYYKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.