Details for: SOX15

Gene ID: 6665

Symbol: SOX15

Ensembl ID: ENSG00000129194

Description: SRY-box transcription factor 15

Associated with

  • Brain development
    (GO:0007420)
  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Chromatin binding
    (GO:0003682)
  • Chromatin organization
    (GO:0006325)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Male gonad development
    (GO:0008584)
  • Myoblast development
    (GO:0048627)
  • Negative regulation of striated muscle tissue development
    (GO:0045843)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuron differentiation
    (GO:0030182)
  • Nucleus
    (GO:0005634)
  • Positive regulation of g0 to g1 transition
    (GO:0070318)
  • Positive regulation of myoblast proliferation
    (GO:2000288)
  • Positive regulation of satellite cell activation involved in skeletal muscle regeneration
    (GO:0014718)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Skeletal muscle tissue regeneration
    (GO:0043403)
  • Transcription regulator complex
    (GO:0005667)
  • Trophoblast giant cell differentiation
    (GO:0060707)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 60.0468
    Cell Significance Index: -9.3400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 36.9811
    Cell Significance Index: -9.3800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 18.8299
    Cell Significance Index: -8.8900
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 12.2562
    Cell Significance Index: 36.4500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.6077
    Cell Significance Index: -9.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 4.1155
    Cell Significance Index: 56.1500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.6319
    Cell Significance Index: 136.7200
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.2230
    Cell Significance Index: 16.7900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.0189
    Cell Significance Index: 28.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.9238
    Cell Significance Index: 52.3700
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 1.0158
    Cell Significance Index: 7.3100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8710
    Cell Significance Index: 54.9000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8230
    Cell Significance Index: 43.2100
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.7642
    Cell Significance Index: 6.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6561
    Cell Significance Index: 80.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5799
    Cell Significance Index: 256.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5724
    Cell Significance Index: 103.1800
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.5631
    Cell Significance Index: 3.4900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5564
    Cell Significance Index: 15.5500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5267
    Cell Significance Index: 13.1700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.4964
    Cell Significance Index: 6.3600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.4888
    Cell Significance Index: 4.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.4783
    Cell Significance Index: 29.3300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.3438
    Cell Significance Index: 2.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2301
    Cell Significance Index: 46.1600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2116
    Cell Significance Index: 27.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1890
    Cell Significance Index: 54.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1691
    Cell Significance Index: 23.2200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1632
    Cell Significance Index: 3.5400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1469
    Cell Significance Index: 2.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1350
    Cell Significance Index: 48.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1194
    Cell Significance Index: 5.4100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0858
    Cell Significance Index: 77.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0837
    Cell Significance Index: 15.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0769
    Cell Significance Index: 7.6100
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.0244
    Cell Significance Index: 0.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0215
    Cell Significance Index: 0.3600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0204
    Cell Significance Index: 0.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0168
    Cell Significance Index: 2.7300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0128
    Cell Significance Index: 0.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0052
    Cell Significance Index: 9.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0013
    Cell Significance Index: 1.9900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0009
    Cell Significance Index: -1.6400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0046
    Cell Significance Index: -0.5900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0057
    Cell Significance Index: -0.6300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0058
    Cell Significance Index: -7.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0078
    Cell Significance Index: -0.2800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0089
    Cell Significance Index: -0.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0095
    Cell Significance Index: -6.9600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0103
    Cell Significance Index: -4.6600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0115
    Cell Significance Index: -7.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0117
    Cell Significance Index: -8.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0121
    Cell Significance Index: -9.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0139
    Cell Significance Index: -0.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0152
    Cell Significance Index: -8.5900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0163
    Cell Significance Index: -8.9100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0373
    Cell Significance Index: -2.6400
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.0399
    Cell Significance Index: -0.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0400
    Cell Significance Index: -5.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0425
    Cell Significance Index: -8.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0456
    Cell Significance Index: -9.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0478
    Cell Significance Index: -5.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0532
    Cell Significance Index: -1.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0534
    Cell Significance Index: -9.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0570
    Cell Significance Index: -2.6800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0578
    Cell Significance Index: -3.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0600
    Cell Significance Index: -4.4700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0659
    Cell Significance Index: -4.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0659
    Cell Significance Index: -4.4300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0664
    Cell Significance Index: -1.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0713
    Cell Significance Index: -8.1700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0723
    Cell Significance Index: -1.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0735
    Cell Significance Index: -1.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0736
    Cell Significance Index: -7.5200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0738
    Cell Significance Index: -1.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0779
    Cell Significance Index: -9.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0863
    Cell Significance Index: -8.9900
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0979
    Cell Significance Index: -0.6500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0990
    Cell Significance Index: -1.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1023
    Cell Significance Index: -5.7400
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.1038
    Cell Significance Index: -0.6100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1056
    Cell Significance Index: -8.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1064
    Cell Significance Index: -4.9600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1229
    Cell Significance Index: -2.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1252
    Cell Significance Index: -9.6100
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.1277
    Cell Significance Index: -1.1300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1351
    Cell Significance Index: -1.9400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1354
    Cell Significance Index: -1.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1411
    Cell Significance Index: -9.1100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1461
    Cell Significance Index: -0.9900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1580
    Cell Significance Index: -5.8000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1592
    Cell Significance Index: -1.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1620
    Cell Significance Index: -5.1900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1758
    Cell Significance Index: -2.1800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1832
    Cell Significance Index: -3.8000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1840
    Cell Significance Index: -4.9300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1866
    Cell Significance Index: -3.9600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1871
    Cell Significance Index: -5.9600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1889
    Cell Significance Index: -4.5300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1904
    Cell Significance Index: -6.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SOX15 is a highly conserved transcription factor, with a high degree of sequence similarity across species. It belongs to the SOX family, which is characterized by the presence of a SOX domain, a C2H2 zinc finger motif, and a DNA-binding domain. SOX15 is primarily expressed in tissues that undergo significant developmental and cellular changes, including the brain, gonads, and skeletal muscle. Its expression is also observed in various cell types, including stem cells, epithelial cells, and immune cells. **Pathways and Functions:** SOX15 modulates the expression of numerous genes involved in cellular proliferation, differentiation, and survival through various transcriptional regulatory pathways. These pathways include: 1. **Brain development:** SOX15 regulates the expression of genes involved in neuronal differentiation, proliferation, and survival, contributing to the development of the central nervous system. 2. **Cell differentiation:** SOX15 modulates the expression of genes involved in cell fate determination, ensuring proper differentiation of cells into specific lineages. 3. **Chromatin organization:** SOX15 interacts with chromatin-modifying enzymes, influencing chromatin structure and gene expression. 4. **Transcriptional regulation:** SOX15 acts as a transcriptional activator or repressor, modulating the expression of target genes in response to various cellular signals. **Clinical Significance:** Dysregulation of SOX15 has been implicated in various diseases, including: 1. **Cancer:** SOX15 is overexpressed in several types of cancer, including leukemia, lymphoma, and breast cancer, contributing to tumorigenesis and tumour progression. 2. **Neurodevelopmental disorders:** SOX15 mutations have been associated with neurodevelopmental disorders, such as autism spectrum disorder and intellectual disability. 3. **Reproductive abnormalities:** SOX15 dysregulation has been implicated in reproductive abnormalities, including gonadal dysgenesis and infertility. 4. **Skeletal muscle disorders:** SOX15 mutations have been associated with skeletal muscle disorders, including muscular dystrophy and myositis. In conclusion, SOX15 is a critical transcription factor that plays a pivotal role in various developmental processes, including brain development, cell differentiation, and gonad development. Its dysregulation has been implicated in various diseases, highlighting the importance of SOX15 in maintaining tissue homeostasis and preventing disease. Further research is necessary to fully understand the mechanisms of SOX15 regulation and its role in disease pathogenesis.

Genular Protein ID: 3200823241

Symbol: SOX15_HUMAN

Name: Protein SOX-12

UniProtKB Accession Codes:

O60248 B4DWU7 D3DTQ0 P35717 Q9Y6W7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 3 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9540826

Title: Isolation and expression of a human SRY-related cDNA hSOX20.

PubMed ID: 9540826

DOI: 10.1016/s0167-4781(97)00186-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8978787

Title: SOX20, a new member of the SOX gene family, is located on chromosome 17p13.

PubMed ID: 8978787

DOI: 10.1159/000134200

PubMed ID: 8332506

Title: Partial cloning of SOX-11 and SOX-12, two new human SOX genes.

PubMed ID: 8332506

DOI: 10.1093/nar/21.12.2943

PubMed ID: 9880678

Title: cDNA characterization and high resolution mapping of the human SOX20 gene.

PubMed ID: 9880678

DOI: 10.1007/s003359900925

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

Sequence Information:

  • Length: 233
  • Mass: 25251
  • Checksum: 6B52AE455C7C8CCE
  • Sequence:
    • MALPGSSQDQ AWSLEPPAAT AAASSSSGPQ EREGAGSPAA PGTLPLEKVK RPMNAFMVWS 
SAQRRQMAQQ NPKMHNSEIS KRLGAQWKLL DEDEKRPFVE EAKRLRARHL RDYPDYKYRP 
RRKAKSSGAG PSRCGQGRGN LASGGPLWGP GYATTQPSRG FGYRPPSYST AYLPGSYGSS 
HCKLEAPSPC SLPQSDPRLQ GELLPTYTHY LPPGSPTPYN PPLAGAPMPL THL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.