Details for: TIAM1

Gene ID: 7074

Symbol: TIAM1

Ensembl ID: ENSG00000156299

Description: TIAM Rac1 associated GEF 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 5.45
    Marker Score: 18275
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 4.65
    Marker Score: 24370
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 4.56
    Marker Score: 2047
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 4.38
    Marker Score: 23541
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 3.48
    Marker Score: 16107
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 3.2
    Marker Score: 1536
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 3.05
    Marker Score: 8704
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.86
    Marker Score: 56974
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.76
    Marker Score: 41196
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.69
    Marker Score: 90895
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.61
    Marker Score: 10818
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.6
    Marker Score: 98795
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.55
    Marker Score: 1268.5
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.54
    Marker Score: 2194
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.51
    Marker Score: 1406
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.4
    Marker Score: 88617
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.38
    Marker Score: 18257
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 2.32
    Marker Score: 766
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.28
    Marker Score: 2584
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.25
    Marker Score: 715
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.18
    Marker Score: 2411
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.17
    Marker Score: 634
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.17
    Marker Score: 16332
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.03
    Marker Score: 2132
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.97
    Marker Score: 7634
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.96
    Marker Score: 4690
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.94
    Marker Score: 2075
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.91
    Marker Score: 18171
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.8
    Marker Score: 3022
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.78
    Marker Score: 644.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.76
    Marker Score: 107940
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.61
    Marker Score: 3710
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.61
    Marker Score: 2479
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.61
    Marker Score: 1265
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.6
    Marker Score: 828
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.59
    Marker Score: 6468
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.56
    Marker Score: 14629
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167876
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.45
    Marker Score: 2139
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.44
    Marker Score: 464
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.42
    Marker Score: 30380
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.42
    Marker Score: 12224
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.4
    Marker Score: 1726
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.39
    Marker Score: 3266
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.37
    Marker Score: 429
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.36
    Marker Score: 2716
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.35
    Marker Score: 519
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.32
    Marker Score: 769
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.31
    Marker Score: 788
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.28
    Marker Score: 8238
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.26
    Marker Score: 1777
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.25
    Marker Score: 1311
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.22
    Marker Score: 6556
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2
    Marker Score: 869
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.18
    Marker Score: 5105
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.17
    Marker Score: 1641
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.16
    Marker Score: 18209
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.16
    Marker Score: 2832
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.15
    Marker Score: 573
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4762
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.13
    Marker Score: 1974
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.09
    Marker Score: 941
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.08
    Marker Score: 4488
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.07
    Marker Score: 11088
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.06
    Marker Score: 6389
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.06
    Marker Score: 1935
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.06
    Marker Score: 427
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.04
    Marker Score: 609
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.04
    Marker Score: 1341
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1
    Marker Score: 680
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1
    Marker Score: 304
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71745
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47970
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.99
    Marker Score: 315
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.98
    Marker Score: 7678
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30400
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.96
    Marker Score: 205
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 493
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.95
    Marker Score: 192
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 447
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.93
    Marker Score: 295.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2725
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.91
    Marker Score: 805
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 363
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.91
    Marker Score: 596
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 317
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.87
    Marker Score: 935
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.87
    Marker Score: 1090
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4978
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.86
    Marker Score: 705
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.86
    Marker Score: 3585
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.85
    Marker Score: 1508
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.85
    Marker Score: 7313
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.84
    Marker Score: 500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.83
    Marker Score: 543
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.82
    Marker Score: 412
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 625
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.82
    Marker Score: 568

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key Characteristics:** 1. **Rac1-associated GEF**: TIAM1 is a specific GEF for Rac1, a small GTPase involved in various cellular processes, including cell migration, cytoskeleton reorganization, and cell signaling. 2. **Multifunctional**: TIAM1 is expressed in a wide range of cell types, including neuronal cells, epithelial cells, and immune cells, underscoring its broad functional significance. 3. **Regulatory of Rac1 GTPase Cycle**: TIAM1 modulates the activity of Rac1, influencing its GTPase cycle and downstream signaling events. 4. **Positive Regulation**: TIAM1 acts as a positive regulator of various cellular processes, including axonogenesis, cell migration, and dendritic spine morphogenesis. **Pathways and Functions:** 1. **Axonal Growth Cone Formation**: TIAM1 regulates the formation and reorganization of axonal growth cones, essential for neuronal development and axon guidance. 2. **Cell Migration**: TIAM1 facilitates cell migration by modulating the activity of Rac1, influencing the cytoskeleton and cell adhesion molecules. 3. **Signal Transduction**: TIAM1 integrates signals from various receptors, including NTRK2, Eph receptors, and death receptors, to regulate downstream signaling events. 4. **Cytoskeleton Organization**: TIAM1 regulates the organization of the cytoskeleton, particularly microtubules, to facilitate cell migration, axonal growth, and dendritic spine formation. 5. **Neurodevelopmental Processes**: TIAM1 is involved in the regulation of neuronal cell body development, axon extension, and dendritic spine morphogenesis. **Clinical Significance:** 1. **Neurological Disorders**: Alterations in TIAM1 expression and activity have been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Cancer Metastasis**: TIAM1's role in cell migration and invasion suggests its involvement in cancer metastasis, particularly in epithelial-to-mesenchymal transition (EMT) and small GTPase-mediated signal transduction. 3. **Neuroinflammation**: TIAM1's regulatory function in immune responses, including microglial activation and cytokine production, highlights its potential role in neuroinflammation. 4. **Regenerative Medicine**: Understanding TIAM1's roles in axonal regeneration and neuronal development may provide insights into the development of novel therapeutic strategies for neurological disorders. In conclusion, TIAM1 is a multifaceted gene that plays a crucial role in regulating various cellular processes, including axonal growth cone formation, cell migration, and signal transduction. Its significance in both physiological and pathological contexts underscores the importance of further research into TIAM1's functions and potential therapeutic applications.

Genular Protein ID: 282087469

Symbol: TIAM1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q13009 B7ZLR6 F5GZ53 Q17RT7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 11 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 44 Gene3D 4 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 10 PRO 1 PROSITE 5 PROSITE-ProRule 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 10 RefSeq 13 SAM 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7731688

Title: Sequence of the human invasion-inducing TIAM1 gene, its conservation in evolution and its expression in tumor cell lines of different tissue origin.

PubMed ID: 7731688

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7753201

Title: A role for Rac in Tiam1-induced membrane ruffling and invasion.

PubMed ID: 7753201

DOI: 10.1038/375338a0

PubMed ID: 7736788

Title: The invasion-inducing TIAM1 gene maps to human chromosome band 21q22 and mouse chromosome 16.

PubMed ID: 7736788

DOI: 10.1159/000133989

PubMed ID: 15899863

Title: Tiam1-IRSp53 complex formation directs specificity of rac-mediated actin cytoskeleton regulation.

PubMed ID: 15899863

DOI: 10.1128/mcb.25.11.4602-4614.2005

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20332120

Title: CCM1 regulates vascular-lumen organization by inducing endothelial polarity.

PubMed ID: 20332120

DOI: 10.1242/jcs.059329

PubMed ID: 20496116

Title: EphA8-ephrinA5 signaling and clathrin-mediated endocytosis is regulated by Tiam-1, a Rac-specific guanine nucleotide exchange factor.

PubMed ID: 20496116

DOI: 10.1007/s10059-010-0075-2

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 25684205

Title: CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.

PubMed ID: 25684205

DOI: 10.1016/j.molcel.2014.12.040

PubMed ID: 20361982

Title: The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion.

PubMed ID: 20361982

DOI: 10.1016/j.jmb.2010.03.047

PubMed ID: 23832200

Title: High-resolution structure of the Tiam1 PHn-CC-Ex domain.

PubMed ID: 23832200

DOI: 10.1107/s1744309113014206

PubMed ID: 23395182

Title: The structure of the Tiam1 PDZ domain/ phospho-syndecan1 complex reveals a ligand conformation that modulates protein dynamics.

PubMed ID: 23395182

DOI: 10.1016/j.str.2013.01.004

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 22100072

Title: Recessive mutations in ELOVL4 cause ichthyosis, intellectual disability, and spastic quadriplegia.

PubMed ID: 22100072

DOI: 10.1016/j.ajhg.2011.10.011

PubMed ID: 35240055

Title: Loss-of-function variants in TIAM1 are associated with developmental delay, intellectual disability, and seizures.

PubMed ID: 35240055

DOI: 10.1016/j.ajhg.2022.01.020

Sequence Information:

  • Length: 1591
  • Mass: 177508
  • Checksum: 0DAFBEE9A84B3452
  • Sequence:
    • MGNAESQHVE HEFYGEKHAS LGRKHTSRSL RLSHKTRRTR HASSGKVIHR NSEVSTRSSS 
TPSIPQSLAE NGLEPFSQDG TLEDFGSPIW VDRVDMGLRP VSYTDSSVTP SVDSSIVLTA 
ASVQSMPDTE ESRLYGDDAT YLAEGGRRQH SYTSNGPTFM ETASFKKKRS KSADIWREDS 
LEFSLSDLSQ EHLTSNEEIL GSAEEKDCEE ARGMETRASP RQLSTCQRAN SLGDLYAQKN 
SGVTANGGPG SKFAGYCRNL VSDIPNLANH KMPPAAAEET PPYSNYNTLP CRKSHCLSEG 
ATNPQISHSN SMQGRRAKTT QDVNAGEGSE FADSGIEGAT TDTDLLSRRS NATNSSYSPT 
TGRAFVGSDS GSSSTGDAAR QGVYENFRRE LEMSTTNSES LEEAGSAHSD EQSSGTLSSP 
GQSDILLTAA QGTVRKAGAL AVKNFLVHKK NKKVESATRR KWKHYWVSLK GCTLFFYESD 
GRSGIDHNSI PKHAVWVENS IVQAVPEHPK KDFVFCLSNS LGDAFLFQTT SQTELENWIT 
AIHSACATAV ARHHHKEDTL RLLKSEIKKL EQKIDMDEKM KKMGEMQLSS VTDSKKKKTI 
LDQIFVWEQN LEQFQMDLFR FRCYLASLQG GELPNPKRLL AFASRPTKVA MGRLGIFSVS 
SFHALVAART GETGVRRRTQ AMSRSASKRR SRFSSLWGLD TTSKKKQGRP SINQVFGEGT 
EAVKKSLEGI FDDIVPDGKR EKEVVLPNVH QHNPDCDIWV HEYFTPSWFC LPNNQPALTV 
VRPGDTARDT LELICKTHQL DHSAHYLRLK FLIENKMQLY VPQPEEDIYE LLYKEIEICP 
KVTQSIHIEK SDTAADTYGF SLSSVEEDGI RRLYVNSVKE TGLASKKGLK AGDEILEINN 
RAADALNSSM LKDFLSQPSL GLLVRTYPEL EEGVELLESP PHRVDGPADL GESPLAFLTS 
NPGHSLCSEQ GSSAETAPEE TEGPDLESSD ETDHSSKSTE QVAAFCRSLH EMNPSDQSPS 
PQDSTGPQLA TMRQLSDADK LRKVICELLE TERTYVKDLN CLMERYLKPL QKETFLTQDE 
LDVLFGNLTE MVEFQVEFLK TLEDGVRLVP DLEKLEKVDQ FKKVLFSLGG SFLYYADRFK 
LYSAFCASHT KVPKVLVKAK TDTAFKAFLD AQNPKQQHSS TLESYLIKPI QRILKYPLLL 
RELFALTDAE SEEHYHLDVA IKTMNKVASH INEMQKIHEE FGAVFDQLIA EQTGEKKEVA 
DLSMGDLLLH TTVIWLNPPA SLGKWKKEPE LAAFVFKTAV VLVYKDGSKQ KKKLVGSHRL 
SIYEDWDPFR FRHMIPTEAL QVRALASADA EANAVCEIVH VKSESEGRPE RVFHLCCSSP 
ESRKDFLKAV HSILRDKHRR QLLKTESLPS SQQYVPFGGK RLCALKGARP AMSRAVSAPS 
KSLGRRRRRL ARNRFTIDSD AVSASSPEKE SQQPPGGGDT DRWVEEQFDL AQYEEQDDIK 
ETDILSDDDE FCESVKGASV DRDLQERLQA TSISQRERGR KTLDSHASRM AQLKKQAALS 
GINGGLESAS EEVIWVRRED FAPSRKLNTE I

Genular Protein ID: 1382732093

Symbol: A0A8V8TN84_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8V8TN84

Database IDs:

CDD 4 CTD 1 EMBL 6 EPD 1 Ensembl 2 GO 3 Gene3D 4 GeneTree 1 HGNC 1 InterPro 10 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 9 Pfam 5 Proteomes 2 RefSeq 1 SAM 2 SMART 4 SMR 1 SUPFAM 3

Citations:

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

Sequence Information:

  • Length: 1452
  • Mass: 161795
  • Checksum: 4BDDFCAA3E0237F7
  • Sequence:
    • MGNAESQHVE HEFYGEKHAS LGRKHTSRSL RLSHKTRRTR HASSGKVIHR NSEVSTRSSS 
TPSIPQSLAE NGLEPFSQDG TLEDFGSPIW VDRVDMGLRP VSYTDSSVTP SVDSSIVLTA 
ASVQSMPDTE ESRLYGDDAT YLAEGGRRQH SYTSNGPTFM ETASFKKKRS KSADIWREDS 
LEFSLSDLSQ EHLTSNEEIL GSAEEKDCEE ARGMETRASP RQLSTCQRAN SLGDLYAQKN 
SGVTANGGPG SKFAGYCRNL VSDIPNLANH KMPPAAAEET PPYSNYNTLP CRKSHCLSEG 
ATNPQISHSN SMQGRRAKTT QDVNAGEGSE FADSGIEGAT TDTDLLSRRS NATNSSYSPT 
TGRAFVGSDS GSSSTGDAAR QGVYENFRRE LEMSTTNSES LEEAGSAHSD EQSSGTLSSP 
GQSDILLTAA QGTVRKAGAL AVKNFLVHKK NKKVESATRR KWKHYWVSLK GCTLFFYESD 
GRSGIDHNSI PKHAVWVENS IVQAVPEHPK KDFVFCLSNS LGDAFLFQTT SQTELENWIT 
AIHSACATAV ARHHHKEDTL RLLKSEIKKL EQKIDMDEKM KKMGEMQLSS VTDSKKKKTI 
LDQIFVWEQN LEQFQMDLFR FRCYLASLQG GELPNPKRLL AFASRPTKVA MGRLGIFSVS 
SFHALVAART GETGVRRRTQ AMSRSASKRR SRFSSLWGLD TTSKKKQGRP SINQVFGEGT 
EAVKKSLEGI FDDIVPDGKR EKEVVLPNVH QHNPDCDIWV HEYFTPSWFC LPNNQPALTV 
VRPGDTARDT LELICKTHQL DHSAHYLRLK FLIENKMQLY VPQPEEDIYE LLYKEIEICP 
KVTQSIHIEK SDTAADTYGF SLSSVEEDGI RRLYVNSVKE TGLASKKGLK AGDEILEINN 
RAADALNSSM LKDFLSQPSL GLLVRTYPEL EEGVELLESP PHRVDGPADL GESPLAFLTS 
NPGHSLCSEQ GSSAETAPEE TEGPDLESSD ETDHSSKSTE QVAAFCRSLH EMNPSDQSPS 
PQDSTGPQLA TMRQLSDADK LRKVICELLE TERTYVKDLN CLMERYLKPL QKETFLTQDE 
LDVLFGNLTE MVEFQVEFLK TLEDGVRLVP DLEKLEKVDQ FKKVLFSLGG SFLYYADRFK 
LYSAFCASHT KVPKVLVKAK TDTAFKAFLD AQNPKQQHSS TLESYLIKPI QRILKYPLLL 
RELFALTDAE SEEHYHLDVA IKTMNKVASH INEMQKIHEE FGAVFDQLIA EQTGEKKEVA 
DLSMGDLLLH TTVIWLNPPA SLGKWKKEPE LAAFVFKTAV VLVYKDGSKQ KKKLVGSHRL 
SIYEDWDPFR FRHMIPTEAL QVRALASADA EANAVCEIVH VKSESEGRPE RVFHLCCSSP 
ESRKDFLKAV HSILRDKHRR QLLKTESLPS SQQYVPFGGK RLCALKGARP AMSRAGTVGI 
RTFKIPVTPT PQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.