Details for: TIAM1

Gene ID: 7074

Symbol: TIAM1

Ensembl ID: ENSG00000156299

Description: TIAM Rac1 associated GEF 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 317.8818
    Cell Significance Index: -49.4500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 195.9838
    Cell Significance Index: -49.7100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 93.7707
    Cell Significance Index: -38.1000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 93.0237
    Cell Significance Index: -47.8500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 40.3355
    Cell Significance Index: -38.5100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 40.1150
    Cell Significance Index: -49.4600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.3533
    Cell Significance Index: -53.3000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.6161
    Cell Significance Index: -29.8000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 12.1184
    Cell Significance Index: 207.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 6.2068
    Cell Significance Index: 417.3500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 4.1230
    Cell Significance Index: 98.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 3.0292
    Cell Significance Index: 186.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.8977
    Cell Significance Index: 80.9800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.8352
    Cell Significance Index: 1960.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.7636
    Cell Significance Index: 155.0800
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 2.1562
    Cell Significance Index: 17.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.0915
    Cell Significance Index: 750.1800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.0321
    Cell Significance Index: 76.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.9861
    Cell Significance Index: 87.8500
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 1.8183
    Cell Significance Index: 23.5800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.8074
    Cell Significance Index: 24.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8033
    Cell Significance Index: 361.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4698
    Cell Significance Index: 76.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.3744
    Cell Significance Index: 44.0200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.1089
    Cell Significance Index: 24.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0423
    Cell Significance Index: 128.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.0164
    Cell Significance Index: 130.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9349
    Cell Significance Index: 168.5400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.8869
    Cell Significance Index: 25.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6674
    Cell Significance Index: 127.0100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5669
    Cell Significance Index: 5.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.5408
    Cell Significance Index: 343.4800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.4753
    Cell Significance Index: 9.8600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.4685
    Cell Significance Index: 7.7200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3863
    Cell Significance Index: 170.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3333
    Cell Significance Index: 182.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3103
    Cell Significance Index: 61.5900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2676
    Cell Significance Index: 241.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2423
    Cell Significance Index: 23.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2171
    Cell Significance Index: 7.6300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.1295
    Cell Significance Index: 2.5600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1242
    Cell Significance Index: 20.2100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1089
    Cell Significance Index: 14.0700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1008
    Cell Significance Index: 1.4400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0742
    Cell Significance Index: 139.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0707
    Cell Significance Index: 3.7100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0390
    Cell Significance Index: 2.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0243
    Cell Significance Index: 33.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0197
    Cell Significance Index: 36.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0118
    Cell Significance Index: 18.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0079
    Cell Significance Index: -0.9200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0146
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0172
    Cell Significance Index: -10.7600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0210
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0274
    Cell Significance Index: -20.2600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0469
    Cell Significance Index: -5.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0569
    Cell Significance Index: -32.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0576
    Cell Significance Index: -42.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0644
    Cell Significance Index: -29.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0708
    Cell Significance Index: -2.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0727
    Cell Significance Index: -55.0700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1256
    Cell Significance Index: -3.1400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1320
    Cell Significance Index: -1.8900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1483
    Cell Significance Index: -42.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1555
    Cell Significance Index: -32.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1819
    Cell Significance Index: -26.4400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1831
    Cell Significance Index: -2.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2043
    Cell Significance Index: -9.2600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2140
    Cell Significance Index: -36.5400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2276
    Cell Significance Index: -4.8300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.2833
    Cell Significance Index: -1.7600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3028
    Cell Significance Index: -6.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.3050
    Cell Significance Index: -41.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3101
    Cell Significance Index: -31.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3152
    Cell Significance Index: -21.8000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3397
    Cell Significance Index: -6.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3626
    Cell Significance Index: -42.7600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3810
    Cell Significance Index: -7.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3903
    Cell Significance Index: -18.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3921
    Cell Significance Index: -24.0400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4206
    Cell Significance Index: -48.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4515
    Cell Significance Index: -51.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4516
    Cell Significance Index: -47.0200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4818
    Cell Significance Index: -10.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5418
    Cell Significance Index: -40.3800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5470
    Cell Significance Index: -43.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5562
    Cell Significance Index: -42.6800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5671
    Cell Significance Index: -18.0600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.6648
    Cell Significance Index: -7.9500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6687
    Cell Significance Index: -9.8700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6814
    Cell Significance Index: -48.1900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.7017
    Cell Significance Index: -45.2700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7069
    Cell Significance Index: -15.1100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.7118
    Cell Significance Index: -11.9900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.7401
    Cell Significance Index: -9.1800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8428
    Cell Significance Index: -53.1200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.8687
    Cell Significance Index: -18.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8827
    Cell Significance Index: -18.8000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.9324
    Cell Significance Index: -32.4000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9337
    Cell Significance Index: -30.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Rac1-associated GEF**: TIAM1 is a specific GEF for Rac1, a small GTPase involved in various cellular processes, including cell migration, cytoskeleton reorganization, and cell signaling. 2. **Multifunctional**: TIAM1 is expressed in a wide range of cell types, including neuronal cells, epithelial cells, and immune cells, underscoring its broad functional significance. 3. **Regulatory of Rac1 GTPase Cycle**: TIAM1 modulates the activity of Rac1, influencing its GTPase cycle and downstream signaling events. 4. **Positive Regulation**: TIAM1 acts as a positive regulator of various cellular processes, including axonogenesis, cell migration, and dendritic spine morphogenesis. **Pathways and Functions:** 1. **Axonal Growth Cone Formation**: TIAM1 regulates the formation and reorganization of axonal growth cones, essential for neuronal development and axon guidance. 2. **Cell Migration**: TIAM1 facilitates cell migration by modulating the activity of Rac1, influencing the cytoskeleton and cell adhesion molecules. 3. **Signal Transduction**: TIAM1 integrates signals from various receptors, including NTRK2, Eph receptors, and death receptors, to regulate downstream signaling events. 4. **Cytoskeleton Organization**: TIAM1 regulates the organization of the cytoskeleton, particularly microtubules, to facilitate cell migration, axonal growth, and dendritic spine formation. 5. **Neurodevelopmental Processes**: TIAM1 is involved in the regulation of neuronal cell body development, axon extension, and dendritic spine morphogenesis. **Clinical Significance:** 1. **Neurological Disorders**: Alterations in TIAM1 expression and activity have been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Cancer Metastasis**: TIAM1's role in cell migration and invasion suggests its involvement in cancer metastasis, particularly in epithelial-to-mesenchymal transition (EMT) and small GTPase-mediated signal transduction. 3. **Neuroinflammation**: TIAM1's regulatory function in immune responses, including microglial activation and cytokine production, highlights its potential role in neuroinflammation. 4. **Regenerative Medicine**: Understanding TIAM1's roles in axonal regeneration and neuronal development may provide insights into the development of novel therapeutic strategies for neurological disorders. In conclusion, TIAM1 is a multifaceted gene that plays a crucial role in regulating various cellular processes, including axonal growth cone formation, cell migration, and signal transduction. Its significance in both physiological and pathological contexts underscores the importance of further research into TIAM1's functions and potential therapeutic applications.

Genular Protein ID: 282087469

Symbol: TIAM1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q13009 B7ZLR6 F5GZ53 Q17RT7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 11 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 44 Gene3D 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 10 RefSeq 13 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7731688

Title: Sequence of the human invasion-inducing TIAM1 gene, its conservation in evolution and its expression in tumor cell lines of different tissue origin.

PubMed ID: 7731688

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7753201

Title: A role for Rac in Tiam1-induced membrane ruffling and invasion.

PubMed ID: 7753201

DOI: 10.1038/375338a0

PubMed ID: 7736788

Title: The invasion-inducing TIAM1 gene maps to human chromosome band 21q22 and mouse chromosome 16.

PubMed ID: 7736788

DOI: 10.1159/000133989

PubMed ID: 15899863

Title: Tiam1-IRSp53 complex formation directs specificity of rac-mediated actin cytoskeleton regulation.

PubMed ID: 15899863

DOI: 10.1128/mcb.25.11.4602-4614.2005

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20332120

Title: CCM1 regulates vascular-lumen organization by inducing endothelial polarity.

PubMed ID: 20332120

DOI: 10.1242/jcs.059329

PubMed ID: 20496116

Title: EphA8-ephrinA5 signaling and clathrin-mediated endocytosis is regulated by Tiam-1, a Rac-specific guanine nucleotide exchange factor.

PubMed ID: 20496116

DOI: 10.1007/s10059-010-0075-2

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 25684205

Title: CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.

PubMed ID: 25684205

DOI: 10.1016/j.molcel.2014.12.040

PubMed ID: 20361982

Title: The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion.

PubMed ID: 20361982

DOI: 10.1016/j.jmb.2010.03.047

PubMed ID: 23832200

Title: High-resolution structure of the Tiam1 PHn-CC-Ex domain.

PubMed ID: 23832200

DOI: 10.1107/s1744309113014206

PubMed ID: 23395182

Title: The structure of the Tiam1 PDZ domain/ phospho-syndecan1 complex reveals a ligand conformation that modulates protein dynamics.

PubMed ID: 23395182

DOI: 10.1016/j.str.2013.01.004

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 22100072

Title: Recessive mutations in ELOVL4 cause ichthyosis, intellectual disability, and spastic quadriplegia.

PubMed ID: 22100072

DOI: 10.1016/j.ajhg.2011.10.011

PubMed ID: 35240055

Title: Loss-of-function variants in TIAM1 are associated with developmental delay, intellectual disability, and seizures.

PubMed ID: 35240055

DOI: 10.1016/j.ajhg.2022.01.020

Sequence Information:

  • Length: 1591
  • Mass: 177508
  • Checksum: 0DAFBEE9A84B3452
  • Sequence:
    • MGNAESQHVE HEFYGEKHAS LGRKHTSRSL RLSHKTRRTR HASSGKVIHR NSEVSTRSSS 
TPSIPQSLAE NGLEPFSQDG TLEDFGSPIW VDRVDMGLRP VSYTDSSVTP SVDSSIVLTA 
ASVQSMPDTE ESRLYGDDAT YLAEGGRRQH SYTSNGPTFM ETASFKKKRS KSADIWREDS 
LEFSLSDLSQ EHLTSNEEIL GSAEEKDCEE ARGMETRASP RQLSTCQRAN SLGDLYAQKN 
SGVTANGGPG SKFAGYCRNL VSDIPNLANH KMPPAAAEET PPYSNYNTLP CRKSHCLSEG 
ATNPQISHSN SMQGRRAKTT QDVNAGEGSE FADSGIEGAT TDTDLLSRRS NATNSSYSPT 
TGRAFVGSDS GSSSTGDAAR QGVYENFRRE LEMSTTNSES LEEAGSAHSD EQSSGTLSSP 
GQSDILLTAA QGTVRKAGAL AVKNFLVHKK NKKVESATRR KWKHYWVSLK GCTLFFYESD 
GRSGIDHNSI PKHAVWVENS IVQAVPEHPK KDFVFCLSNS LGDAFLFQTT SQTELENWIT 
AIHSACATAV ARHHHKEDTL RLLKSEIKKL EQKIDMDEKM KKMGEMQLSS VTDSKKKKTI 
LDQIFVWEQN LEQFQMDLFR FRCYLASLQG GELPNPKRLL AFASRPTKVA MGRLGIFSVS 
SFHALVAART GETGVRRRTQ AMSRSASKRR SRFSSLWGLD TTSKKKQGRP SINQVFGEGT 
EAVKKSLEGI FDDIVPDGKR EKEVVLPNVH QHNPDCDIWV HEYFTPSWFC LPNNQPALTV 
VRPGDTARDT LELICKTHQL DHSAHYLRLK FLIENKMQLY VPQPEEDIYE LLYKEIEICP 
KVTQSIHIEK SDTAADTYGF SLSSVEEDGI RRLYVNSVKE TGLASKKGLK AGDEILEINN 
RAADALNSSM LKDFLSQPSL GLLVRTYPEL EEGVELLESP PHRVDGPADL GESPLAFLTS 
NPGHSLCSEQ GSSAETAPEE TEGPDLESSD ETDHSSKSTE QVAAFCRSLH EMNPSDQSPS 
PQDSTGPQLA TMRQLSDADK LRKVICELLE TERTYVKDLN CLMERYLKPL QKETFLTQDE 
LDVLFGNLTE MVEFQVEFLK TLEDGVRLVP DLEKLEKVDQ FKKVLFSLGG SFLYYADRFK 
LYSAFCASHT KVPKVLVKAK TDTAFKAFLD AQNPKQQHSS TLESYLIKPI QRILKYPLLL 
RELFALTDAE SEEHYHLDVA IKTMNKVASH INEMQKIHEE FGAVFDQLIA EQTGEKKEVA 
DLSMGDLLLH TTVIWLNPPA SLGKWKKEPE LAAFVFKTAV VLVYKDGSKQ KKKLVGSHRL 
SIYEDWDPFR FRHMIPTEAL QVRALASADA EANAVCEIVH VKSESEGRPE RVFHLCCSSP 
ESRKDFLKAV HSILRDKHRR QLLKTESLPS SQQYVPFGGK RLCALKGARP AMSRAVSAPS 
KSLGRRRRRL ARNRFTIDSD AVSASSPEKE SQQPPGGGDT DRWVEEQFDL AQYEEQDDIK 
ETDILSDDDE FCESVKGASV DRDLQERLQA TSISQRERGR KTLDSHASRM AQLKKQAALS 
GINGGLESAS EEVIWVRRED FAPSRKLNTE I

Genular Protein ID: 1382732093

Symbol: A0A8V8TN84_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8V8TN84

Database IDs:

CDD 4 CTD 1 EMBL 6 Ensembl 2 GO 3 Gene3D 4 GeneTree 1 HGNC 1 InterPro 10 NCBI Taxonomy 1 PANTHER 2 PROSITE 9 PeptideAtlas 2 Pfam 6 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SMART 4 SMR 1 SUPFAM 3

Citations:

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 1452
  • Mass: 161795
  • Checksum: 4BDDFCAA3E0237F7
  • Sequence:
    • MGNAESQHVE HEFYGEKHAS LGRKHTSRSL RLSHKTRRTR HASSGKVIHR NSEVSTRSSS 
TPSIPQSLAE NGLEPFSQDG TLEDFGSPIW VDRVDMGLRP VSYTDSSVTP SVDSSIVLTA 
ASVQSMPDTE ESRLYGDDAT YLAEGGRRQH SYTSNGPTFM ETASFKKKRS KSADIWREDS 
LEFSLSDLSQ EHLTSNEEIL GSAEEKDCEE ARGMETRASP RQLSTCQRAN SLGDLYAQKN 
SGVTANGGPG SKFAGYCRNL VSDIPNLANH KMPPAAAEET PPYSNYNTLP CRKSHCLSEG 
ATNPQISHSN SMQGRRAKTT QDVNAGEGSE FADSGIEGAT TDTDLLSRRS NATNSSYSPT 
TGRAFVGSDS GSSSTGDAAR QGVYENFRRE LEMSTTNSES LEEAGSAHSD EQSSGTLSSP 
GQSDILLTAA QGTVRKAGAL AVKNFLVHKK NKKVESATRR KWKHYWVSLK GCTLFFYESD 
GRSGIDHNSI PKHAVWVENS IVQAVPEHPK KDFVFCLSNS LGDAFLFQTT SQTELENWIT 
AIHSACATAV ARHHHKEDTL RLLKSEIKKL EQKIDMDEKM KKMGEMQLSS VTDSKKKKTI 
LDQIFVWEQN LEQFQMDLFR FRCYLASLQG GELPNPKRLL AFASRPTKVA MGRLGIFSVS 
SFHALVAART GETGVRRRTQ AMSRSASKRR SRFSSLWGLD TTSKKKQGRP SINQVFGEGT 
EAVKKSLEGI FDDIVPDGKR EKEVVLPNVH QHNPDCDIWV HEYFTPSWFC LPNNQPALTV 
VRPGDTARDT LELICKTHQL DHSAHYLRLK FLIENKMQLY VPQPEEDIYE LLYKEIEICP 
KVTQSIHIEK SDTAADTYGF SLSSVEEDGI RRLYVNSVKE TGLASKKGLK AGDEILEINN 
RAADALNSSM LKDFLSQPSL GLLVRTYPEL EEGVELLESP PHRVDGPADL GESPLAFLTS 
NPGHSLCSEQ GSSAETAPEE TEGPDLESSD ETDHSSKSTE QVAAFCRSLH EMNPSDQSPS 
PQDSTGPQLA TMRQLSDADK LRKVICELLE TERTYVKDLN CLMERYLKPL QKETFLTQDE 
LDVLFGNLTE MVEFQVEFLK TLEDGVRLVP DLEKLEKVDQ FKKVLFSLGG SFLYYADRFK 
LYSAFCASHT KVPKVLVKAK TDTAFKAFLD AQNPKQQHSS TLESYLIKPI QRILKYPLLL 
RELFALTDAE SEEHYHLDVA IKTMNKVASH INEMQKIHEE FGAVFDQLIA EQTGEKKEVA 
DLSMGDLLLH TTVIWLNPPA SLGKWKKEPE LAAFVFKTAV VLVYKDGSKQ KKKLVGSHRL 
SIYEDWDPFR FRHMIPTEAL QVRALASADA EANAVCEIVH VKSESEGRPE RVFHLCCSSP 
ESRKDFLKAV HSILRDKHRR QLLKTESLPS SQQYVPFGGK RLCALKGARP AMSRAGTVGI 
RTFKIPVTPT PQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.