Details for: GABRP

Gene ID: 2568

Symbol: GABRP

Ensembl ID: ENSG00000094755

Description: gamma-aminobutyric acid type A receptor subunit pi

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.41
    Marker Score: 1611
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.83
    Marker Score: 13607
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.46
    Marker Score: 1148
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.37
    Marker Score: 642
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.3
    Marker Score: 888
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.3
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 847
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.22
    Marker Score: 2320.5
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.2
    Marker Score: 590
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.19
    Marker Score: 344
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.19
    Marker Score: 864
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.15
    Marker Score: 17977
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.13
    Marker Score: 359
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.1
    Marker Score: 1944
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.07
    Marker Score: 1253
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.06
    Marker Score: 306
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.05
    Marker Score: 727
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71810
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48035
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.94
    Marker Score: 482.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5317
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.92
    Marker Score: 422
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.88
    Marker Score: 1784
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.87
    Marker Score: 210
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.87
    Marker Score: 1588
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.82
    Marker Score: 224
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.81
    Marker Score: 574
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.8
    Marker Score: 787
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 684
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 458
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2979
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.66
    Marker Score: 208
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.63
    Marker Score: 561.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.58
    Marker Score: 348
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 461
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.53
    Marker Score: 165
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.52
    Marker Score: 1800
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.51
    Marker Score: 319
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.48
    Marker Score: 198
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.46
    Marker Score: 1047
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.45
    Marker Score: 102
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.44
    Marker Score: 3757
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.43
    Marker Score: 430
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.43
    Marker Score: 885
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.43
    Marker Score: 4789
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.42
    Marker Score: 182
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.41
    Marker Score: 432
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.41
    Marker Score: 666
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.4
    Marker Score: 193
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.37
    Marker Score: 2918
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.37
    Marker Score: 482
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.37
    Marker Score: 225
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.35
    Marker Score: 351
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.33
    Marker Score: 2905
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.3
    Marker Score: 176
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3
    Marker Score: 299
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.3
    Marker Score: 919.5
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.29
    Marker Score: 705
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.28
    Marker Score: 123
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.26
    Marker Score: 158
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.26
    Marker Score: 632
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.25
    Marker Score: 78
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.24
    Marker Score: 681
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.23
    Marker Score: 468
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.23
    Marker Score: 741
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.23
    Marker Score: 202
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.22
    Marker Score: 98
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.21
    Marker Score: 401
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.2
    Marker Score: 133
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.2
    Marker Score: 469
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.2
    Marker Score: 38.5
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.2
    Marker Score: 1251
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.19
    Marker Score: 458
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.18
    Marker Score: 40
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.18
    Marker Score: 157
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.18
    Marker Score: 41
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.17
    Marker Score: 45
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.17
    Marker Score: 40
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.16
    Marker Score: 62
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.16
    Marker Score: 42
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.15
    Marker Score: 49
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.15
    Marker Score: 37
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.15
    Marker Score: 39

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Other Information

**Key characteristics:** * The GABRP gene is located on chromosome 19p13.3. * It is a single-exon gene with a size of approximately 1.9 kb. * The protein encoded by the GABRP gene is a type A gamma-aminobutyric acid receptor. * It is a transmembrane protein that is expressed in the plasma membrane. * It is a ligand-gated channel that is permeable to chloride ions. * It is involved in chemical synaptic transmission and chloride channel activity. **Pathways and functions:** * The GABRP gene is involved in chemical synaptic transmission. * It is a ligand-gated channel that is expressed in the plasma membrane of neurons. * When the channel is opened by a ligand, it allows chloride ions to flow into the neuron. * This influx of chloride ions changes the electrical potential of the neuron, which can lead to the generation of an action potential. **Clinical significance:** * Mutations in the GABRP gene have been linked to several neurological disorders, including epilepsy, depression, and schizophrenia. * In epilepsy, mutations in the GABRP gene can lead to the development of seizures. * In depression, mutations in the GABRP gene can lead to a decrease in the activity of the GABRP receptor, which can result in depression-like symptoms. * In schizophrenia, mutations in the GABRP gene can lead to the development of psychotic symptoms, such as hallucinations and delusions. **Additional information:** * The GABRP gene is also known as GBRP, NR2A, and PYGL. * It is a member of the gamma-aminobutyric acid receptor family of ion channels. * It is expressed in high levels in the central nervous system, where it is involved in synaptic transmission.

Genular Protein ID: 3367013845

Symbol: GBRP_HUMAN

Name: Gamma-aminobutyric acid receptor subunit pi

UniProtKB Accession Codes:

O00591 A8KA36 D3DQL2 Q32MJ1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 75 DrugCentral 1 EMBL 17 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 10 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9182563

Title: A novel class of GABAA receptor subunit in tissues of the reproductive system.

PubMed ID: 9182563

DOI: 10.1074/jbc.272.24.15346

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 440
  • Mass: 50640
  • Checksum: 92CA66C264560718
  • Sequence:
    • MNYSLHLAFV CLSLFTERMC IQGSQFNVEV GRSDKLSLPG FENLTAGYNK FLRPNFGGEP 
VQIALTLDIA SISSISESNM DYTATIYLRQ RWMDQRLVFE GNKSFTLDAR LVEFLWVPDT 
YIVESKKSFL HEVTVGNRLI RLFSNGTVLY ALRITTTVAC NMDLSKYPMD TQTCKLQLES 
WGYDGNDVEF TWLRGNDSVR GLEHLRLAQY TIERYFTLVT RSQQETGNYT RLVLQFELRR 
NVLYFILETY VPSTFLVVLS WVSFWISLDS VPARTCIGVT TVLSMTTLMI GSRTSLPNTN 
CFIKAIDVYL GICFSFVFGA LLEYAVAHYS SLQQMAAKDR GTTKEVEEVS ITNIINSSIS 
SFKRKISFAS IEISSDNVDY SDLTMKTSDK FKFVFREKMG RIVDYFTIQN PSNVDHYSKL 
LFPLIFMLAN VFYWAYYMYF

Genular Protein ID: 1397251713

Symbol: E7EWG0_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7EWG0

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 8 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 1 PeptideAtlas 2 Pfam 2 Proteomes 2 RefSeq 1 RuleBase 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

Sequence Information:

  • Length: 289
  • Mass: 33447
  • Checksum: 5F9BAFC3887A1136
  • Sequence:
    • MNYSLHLAFV CLSLFTERMC IQGSQFNVEV GRSDKLSLPG FENLTAGYNK FLRPNFGGEP 
VQIALTLDIA SISSISESNM DYTATIYLRQ RWMDQRLVFE GNKSFTLDAR LVEFLWVPDT 
YIVESKKSFL HEVTVGNRLI RLFSNGTVLY ALRITTTVAC NMDLSKYPMD TQTCKLQLES 
WGYDGNDVEF TWLRGNDSVR GLEHLRLAQY TIERYFTLVT RSQQETGNYT RLVLQFELRR 
NVLYFILETY VPSTFLVVLS WVSFWISLDS VPARTCIGDN KGSRRSQYY

Genular Protein ID: 2462961063

Symbol: B4DTP4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DTP4

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 2 GenomeRNAi 1 InterPro 8 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 1 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 1 SUPFAM 2

Sequence Information:

  • Length: 289
  • Mass: 33419
  • Checksum: 7895927B608BD37F
  • Sequence:
    • MNYSLHLAFV CLSLFTERMC IQGSQFNVEV GRSDKLSLPG FENLTAGYNK FLRPNFGGEP 
VQIALTLDIA SISSISESNM DYTATIYLRQ RWMDQRLVFE GNKSFTLDAR LAEFLWVPDT 
YIVESKKSFL HEVTVGNRLI RLFSNGTVLY ALRITTTVAC NMDLSKYPMD TQTCKLQLES 
WGYDGNDVEF TWLRGNDSVR GLEHLRLAQY TIERYFTLVT RSQQETGNYT RLVLQFELRR 
NVLYFILETY VPSTFLVVLS WVSFWISLDS VPARTCIGDN KGSRRSQYY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.