Details for: SDCBP2

Gene ID: 27111

Symbol: SDCBP2

Ensembl ID: ENSG00000125775

Description: syndecan binding protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 84.0270
    Cell Significance Index: -13.0700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 51.1742
    Cell Significance Index: -12.9800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 25.7965
    Cell Significance Index: -10.4800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 19.1201
    Cell Significance Index: -12.8300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.6005
    Cell Significance Index: -13.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 6.4373
    Cell Significance Index: 334.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 6.3786
    Cell Significance Index: 138.1900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 6.1080
    Cell Significance Index: 63.2300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.9270
    Cell Significance Index: -10.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.3936
    Cell Significance Index: 153.8200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.3274
    Cell Significance Index: -13.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.1596
    Cell Significance Index: 91.0400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.9605
    Cell Significance Index: 44.3600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.7837
    Cell Significance Index: -8.5500
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 2.3509
    Cell Significance Index: 5.3000
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.1151
    Cell Significance Index: 13.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.8520
    Cell Significance Index: 201.4400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.3987
    Cell Significance Index: 19.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.1063
    Cell Significance Index: 76.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0908
    Cell Significance Index: 984.9100
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.9218
    Cell Significance Index: 9.9900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9185
    Cell Significance Index: 32.2800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7315
    Cell Significance Index: 19.9100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6879
    Cell Significance Index: 14.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5510
    Cell Significance Index: 54.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4976
    Cell Significance Index: 64.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3810
    Cell Significance Index: 76.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3400
    Cell Significance Index: 64.7100
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.2860
    Cell Significance Index: 0.3700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.2654
    Cell Significance Index: 1.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2404
    Cell Significance Index: 7.7000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2394
    Cell Significance Index: 2.2100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2218
    Cell Significance Index: 16.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2093
    Cell Significance Index: 9.7600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1932
    Cell Significance Index: 4.8300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.1653
    Cell Significance Index: 2.7800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1612
    Cell Significance Index: 71.2600
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.1505
    Cell Significance Index: 0.9300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1227
    Cell Significance Index: 6.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1211
    Cell Significance Index: 14.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1103
    Cell Significance Index: 19.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1094
    Cell Significance Index: 21.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1092
    Cell Significance Index: 59.6300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0837
    Cell Significance Index: 1.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0819
    Cell Significance Index: 2.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0741
    Cell Significance Index: 5.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0723
    Cell Significance Index: 25.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0236
    Cell Significance Index: 1.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0182
    Cell Significance Index: 0.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0086
    Cell Significance Index: 1.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.7100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0006
    Cell Significance Index: -0.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0076
    Cell Significance Index: -14.0900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0083
    Cell Significance Index: -0.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0092
    Cell Significance Index: -14.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0097
    Cell Significance Index: -13.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0117
    Cell Significance Index: -8.8600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0135
    Cell Significance Index: -9.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0147
    Cell Significance Index: -9.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0167
    Cell Significance Index: -12.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0184
    Cell Significance Index: -2.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0208
    Cell Significance Index: -3.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0227
    Cell Significance Index: -6.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0239
    Cell Significance Index: -13.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0268
    Cell Significance Index: -16.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0280
    Cell Significance Index: -12.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0317
    Cell Significance Index: -3.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0352
    Cell Significance Index: -4.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0363
    Cell Significance Index: -5.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0396
    Cell Significance Index: -0.5400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0519
    Cell Significance Index: -0.5900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0557
    Cell Significance Index: -5.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0581
    Cell Significance Index: -2.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0697
    Cell Significance Index: -14.6900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0729
    Cell Significance Index: -2.0900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0837
    Cell Significance Index: -3.1700
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0903
    Cell Significance Index: -0.5600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0975
    Cell Significance Index: -0.7000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1023
    Cell Significance Index: -1.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1110
    Cell Significance Index: -13.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1263
    Cell Significance Index: -13.1500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1466
    Cell Significance Index: -11.6100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1485
    Cell Significance Index: -7.7400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1542
    Cell Significance Index: -11.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1577
    Cell Significance Index: -9.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1630
    Cell Significance Index: -10.0200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1693
    Cell Significance Index: -10.9200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1849
    Cell Significance Index: -4.9600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1926
    Cell Significance Index: -2.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2208
    Cell Significance Index: -12.3900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2269
    Cell Significance Index: -8.3300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2283
    Cell Significance Index: -3.2700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2354
    Cell Significance Index: -11.9000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2427
    Cell Significance Index: -6.4800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2564
    Cell Significance Index: -6.5900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2603
    Cell Significance Index: -4.6000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2688
    Cell Significance Index: -11.0200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2707
    Cell Significance Index: -6.7600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2726
    Cell Significance Index: -8.0300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2761
    Cell Significance Index: -5.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SDCBP2 is a protein that belongs to the syndecan binding protein family. It is characterized by its ability to bind to syndecans, which are transmembrane proteoglycans that play a crucial role in cell-cell interactions and signaling. SDCBP2 has been shown to interact with various proteins, including cytoskeletal proteins, kinases, and transcription factors, which modulates its functions. The protein is highly expressed in epithelial cells, which are responsible for forming the lining of various organs, including the skin, lungs, and gastrointestinal tract. **Pathways and Functions:** SDCBP2 is involved in various cellular processes, including cell proliferation, migration, and differentiation. Its binding to syndecans influences the organization of the cytoskeleton and modulates the activity of downstream signaling pathways. Specifically, SDCBP2 has been shown to: 1. Regulate cell proliferation by modulating the activity of cyclin-dependent kinases (CDKs) and cyclin-dependent kinase inhibitors (CKIs). 2. Influence cell migration by regulating the activity of Rho GTPases and the cytoskeleton. 3. Modulate intracellular signal transduction pathways, including the PI3K/AKT and MAPK/ERK pathways. 4. Interact with cytoskeletal proteins, such as actin and tubulin, to regulate cell shape and movement. **Clinical Significance:** SDCBP2 has been implicated in various diseases, including cancer, cardiovascular disease, and neurological disorders. Its dysregulation has been linked to: 1. Cancer progression: Overexpression of SDCBP2 has been observed in various types of cancer, including breast, lung, and colon cancer, suggesting its role in tumor growth and metastasis. 2. Cardiovascular disease: SDCBP2 has been implicated in the development of atherosclerosis and cardiac hypertrophy, highlighting its potential role in cardiovascular disease. 3. Neurological disorders: Dysregulation of SDCBP2 has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, suggesting its role in neuronal function and survival. In conclusion, SDCBP2 is a multifunctional protein that plays a crucial role in various cellular processes, including cell proliferation, migration, and differentiation. Its dysregulation has been linked to various diseases, highlighting its potential as a therapeutic target. Further research is needed to fully elucidate the mechanisms of SDCBP2 and its role in human disease.

Genular Protein ID: 824632551

Symbol: SDCB2_HUMAN

Name: Syntenin-2

UniProtKB Accession Codes:

Q9H190 O95892 Q5W0X1 Q9BZ42 Q9H567 Q9NRY8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 4 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11152476

Title: The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity.

PubMed ID: 11152476

DOI: 10.1074/jbc.m010647200

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11102519

Title: The carboxy-terminal cysteine of the tetraspanin L6 antigen is required for its interaction with SITAC, a novel PDZ protein.

PubMed ID: 11102519

DOI: 10.1091/mbc.11.12.4217

PubMed ID: 15961997

Title: Nuclear speckles and nucleoli targeting by PIP2-PDZ domain interactions.

PubMed ID: 15961997

DOI: 10.1038/sj.emboj.7600722

PubMed ID: 22623796

Title: Human papillomavirus type 8 E6 oncoprotein inhibits transcription of the PDZ protein syntenin-2.

PubMed ID: 22623796

DOI: 10.1128/jvi.00132-12

PubMed ID: 23300061

Title: The characterization of the nuclear dynamics of syntenin-2, a PIP2 binding PDZ protein.

PubMed ID: 23300061

DOI: 10.1002/cyto.a.22246

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 292
  • Mass: 31594
  • Checksum: E12536839E1CD91C
  • Sequence:
    • MSSLYPSLED LKVDQAIQAQ VRASPKMPAL PVQATAISPP PVLYPNLAEL ENYMGLSLSS 
QEVQESLLQI PEGDSTAVSG PGPGQMVAPV TGYSLGVRRA EIKPGVREIH LCKDERGKTG 
LRLRKVDQGL FVQLVQANTP ASLVGLRFGD QLLQIDGRDC AGWSSHKAHQ VVKKASGDKI 
VVVVRDRPFQ RTVTMHKDSM GHVGFVIKKG KIVSLVKGSS AARNGLLTNH YVCEVDGQNV 
IGLKDKKIME ILATAGNVVT LTIIPSVIYE HMVKKLPPVL LHHTMDHSIP DA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.