Details for: SSR4

Gene ID: 6748

Symbol: SSR4

Ensembl ID: ENSG00000180879

Description: signal sequence receptor subunit 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 5.51
    Marker Score: 4697
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 4.59
    Marker Score: 3240
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 4.5
    Marker Score: 3013.5
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.2
    Marker Score: 2551
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.99
    Marker Score: 39529
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.91
    Marker Score: 8914
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.74
    Marker Score: 3336
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.71
    Marker Score: 19482
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 3.7
    Marker Score: 1086
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 3.67
    Marker Score: 3113
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.66
    Marker Score: 10122
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.61
    Marker Score: 1245
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.59
    Marker Score: 11321
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.51
    Marker Score: 40799
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.36
    Marker Score: 21878
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 3.31
    Marker Score: 1866
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.29
    Marker Score: 20977
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 3.28
    Marker Score: 1311
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.28
    Marker Score: 113569
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.26
    Marker Score: 2909
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.24
    Marker Score: 7924
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.24
    Marker Score: 7362
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.24
    Marker Score: 8680
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.2
    Marker Score: 178942
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 3.18
    Marker Score: 1333
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.17
    Marker Score: 13608
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.13
    Marker Score: 8774
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.12
    Marker Score: 9095
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 3.1
    Marker Score: 164032
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.08
    Marker Score: 2622
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 3.02
    Marker Score: 40579
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.02
    Marker Score: 2538
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 3.01
    Marker Score: 1098
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 3
    Marker Score: 1747
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3
    Marker Score: 2898
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.97
    Marker Score: 2328
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 2.97
    Marker Score: 815
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.95
    Marker Score: 4744
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 2.93
    Marker Score: 2042
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.93
    Marker Score: 2298.5
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.92
    Marker Score: 4848
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.92
    Marker Score: 2800
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.92
    Marker Score: 1512
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.92
    Marker Score: 2959
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.91
    Marker Score: 1504
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 2.89
    Marker Score: 1611
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.88
    Marker Score: 7543
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.87
    Marker Score: 32275
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.86
    Marker Score: 1845
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.86
    Marker Score: 37763
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.86
    Marker Score: 22311
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.86
    Marker Score: 1409
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 2.85
    Marker Score: 785
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.84
    Marker Score: 1421
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.84
    Marker Score: 2529
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.84
    Marker Score: 3160
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.82
    Marker Score: 20980
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.8
    Marker Score: 95284
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.8
    Marker Score: 4312
  • Cell Name: PP cell (CL0000696)
    Fold Change: 2.79
    Marker Score: 629
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.78
    Marker Score: 12003
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.77
    Marker Score: 1032
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.77
    Marker Score: 10671
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.76
    Marker Score: 3911
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.76
    Marker Score: 6957
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.76
    Marker Score: 4061
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.76
    Marker Score: 2171
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.75
    Marker Score: 2577
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.75
    Marker Score: 1562
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.75
    Marker Score: 1995
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.74
    Marker Score: 3770
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.74
    Marker Score: 3136.5
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.74
    Marker Score: 2740
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.73
    Marker Score: 900
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.73
    Marker Score: 876
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.72
    Marker Score: 862
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.71
    Marker Score: 17647
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.71
    Marker Score: 5277
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.71
    Marker Score: 1530
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.7
    Marker Score: 17287
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.7
    Marker Score: 1390
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.7
    Marker Score: 12954
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.69
    Marker Score: 833
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 2.68
    Marker Score: 11145
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.68
    Marker Score: 1253
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.68
    Marker Score: 23256
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.67
    Marker Score: 2847
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.66
    Marker Score: 2181
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.64
    Marker Score: 1358
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.64
    Marker Score: 4530
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.63
    Marker Score: 1502
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.63
    Marker Score: 2734
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.63
    Marker Score: 4588
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.63
    Marker Score: 1869
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.62
    Marker Score: 626
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.61
    Marker Score: 1127
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 2.61
    Marker Score: 686
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 2.61
    Marker Score: 1389
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.6
    Marker Score: 1232
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.59
    Marker Score: 22316

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Other Information

**Key characteristics:** * The gene is located on chromosome 17q21.1. * It is a large gene with a length of approximately 2.4 kb. * The protein is encoded by a transcript of approximately 2.7 kb. * The protein is a transmembrane protein with a molecular weight of approximately 130 kDa. **Pathways and functions:** * The SSR4 protein is involved in the endoplasmic reticulum (ER) chaperone protein complex (SRP) which is responsible for the cotranslational targeting of secretory and membrane proteins to the ER. * The SRP complex is composed of several proteins, including SSR4, SRBP1, and SRP5. * The SSR4 protein is responsible for the targeting of a number of secretory and membrane proteins, including those encoded by the SRG genes. * The protein is also involved in the sorting of proteins into the secretory pathway. **Clinical significance:** * Mutations in the SSR4 gene have been linked to a number of human diseases, including primary sialic aciduria, which is an inherited disorder caused by a deficiency of the sialic acid receptor. * The SSR4 gene is also involved in the development of some types of cancer.

Genular Protein ID: 1992589426

Symbol: SSRD_HUMAN

Name: Translocon-associated protein subunit delta

UniProtKB Accession Codes:

P51571 A8K378 Q53XY1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 1 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 4 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7492314

Title: Translocon-associated protein TRAP delta and a novel TRAP-like protein are coordinately expressed with pro-opiomelanocortin in Xenopus intermediate pituitary.

PubMed ID: 7492314

DOI: 10.1042/bj3120205

PubMed ID: 9286695

Title: Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse.

PubMed ID: 9286695

DOI: 10.1006/geno.1997.4822

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24218363

Title: A new congenital disorder of glycosylation caused by a mutation in SSR4, the signal sequence receptor 4 protein of the TRAP complex.

PubMed ID: 24218363

DOI: 10.1093/hmg/ddt550

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 20598277

Title: Terminal osseous dysplasia is caused by a single recurrent mutation in the FLNA gene.

PubMed ID: 20598277

DOI: 10.1016/j.ajhg.2010.06.008

Sequence Information:

  • Length: 173
  • Mass: 18999
  • Checksum: 063CD2C8F6CE368B
  • Sequence:
    • MAAMASLGAL ALLLLSSLSR CSAEACLEPQ ITPSYYTTSD AVISTETVFI VEISLTCKNR 
VQNMALYADV GGKQFPVTRG QDVGRYQVSW SLDHKSAHAG TYEVRFFDEE SYSLLRKAQR 
NNEDISIIPP LFTVSVDHRG TWNGPWVSTE VLAAAIGLVI YYLAFSAKSH IQA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.