Details for: SSR4

Gene ID: 6748

Symbol: SSR4

Ensembl ID: ENSG00000180879

Description: signal sequence receptor subunit 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 646.3072
    Cell Significance Index: -100.5300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 354.2572
    Cell Significance Index: -89.8600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 315.4285
    Cell Significance Index: -129.9400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 277.2136
    Cell Significance Index: -112.6200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 262.7283
    Cell Significance Index: -124.0400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 241.5310
    Cell Significance Index: -124.2400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 185.5527
    Cell Significance Index: -124.5100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 120.1685
    Cell Significance Index: -114.7300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 89.4112
    Cell Significance Index: -110.2400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 33.2676
    Cell Significance Index: -102.1800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 30.2264
    Cell Significance Index: -119.2800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 25.8020
    Cell Significance Index: -69.1200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.2799
    Cell Significance Index: -35.6300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 8.5321
    Cell Significance Index: 197.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 8.0284
    Cell Significance Index: 374.3200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 7.9718
    Cell Significance Index: 213.2400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.3554
    Cell Significance Index: 2378.5900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.0592
    Cell Significance Index: 37.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.9494
    Cell Significance Index: 185.6200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.9186
    Cell Significance Index: 106.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.8222
    Cell Significance Index: 689.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.6650
    Cell Significance Index: 503.3000
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 3.4398
    Cell Significance Index: 71.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.4225
    Cell Significance Index: 420.8300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.3760
    Cell Significance Index: 99.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.3109
    Cell Significance Index: 565.3600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 3.0069
    Cell Significance Index: 34.1600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.8047
    Cell Significance Index: 209.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.7548
    Cell Significance Index: 177.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.5307
    Cell Significance Index: 326.9500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.7666
    Cell Significance Index: 781.0500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.7526
    Cell Significance Index: 123.9500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.6246
    Cell Significance Index: 97.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5576
    Cell Significance Index: 253.3300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.4611
    Cell Significance Index: 38.4200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.3520
    Cell Significance Index: 70.4300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.3196
    Cell Significance Index: 24.3900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.3119
    Cell Significance Index: 27.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2858
    Cell Significance Index: 127.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.1340
    Cell Significance Index: 145.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0480
    Cell Significance Index: 54.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9307
    Cell Significance Index: 26.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8661
    Cell Significance Index: 102.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.8569
    Cell Significance Index: 648.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7887
    Cell Significance Index: 35.7500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6819
    Cell Significance Index: 47.1600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5327
    Cell Significance Index: 15.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4149
    Cell Significance Index: 78.9500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2076
    Cell Significance Index: 152.1900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1347
    Cell Significance Index: 4.6800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0459
    Cell Significance Index: 41.4700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0307
    Cell Significance Index: 0.8200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0168
    Cell Significance Index: -1.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0284
    Cell Significance Index: -2.9000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0286
    Cell Significance Index: -21.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0341
    Cell Significance Index: -6.7600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0508
    Cell Significance Index: -95.5800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0795
    Cell Significance Index: -49.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0877
    Cell Significance Index: -161.6900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1046
    Cell Significance Index: -160.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1219
    Cell Significance Index: -165.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1521
    Cell Significance Index: -85.7900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1646
    Cell Significance Index: -104.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1970
    Cell Significance Index: -70.6800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2181
    Cell Significance Index: -45.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2481
    Cell Significance Index: -28.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2647
    Cell Significance Index: -120.1400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.3169
    Cell Significance Index: -1.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.3406
    Cell Significance Index: -68.3300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3760
    Cell Significance Index: -4.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4305
    Cell Significance Index: -123.8800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5814
    Cell Significance Index: -18.6200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7484
    Cell Significance Index: -19.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7727
    Cell Significance Index: -40.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7789
    Cell Significance Index: -49.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.7864
    Cell Significance Index: -114.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.8198
    Cell Significance Index: -22.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.8414
    Cell Significance Index: -98.0500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.8873
    Cell Significance Index: -101.2900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.0180
    Cell Significance Index: -21.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.1729
    Cell Significance Index: -122.1300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.1926
    Cell Significance Index: -21.0800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.2070
    Cell Significance Index: -20.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.2184
    Cell Significance Index: -68.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.3438
    Cell Significance Index: -106.4300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -1.4002
    Cell Significance Index: -8.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.4260
    Cell Significance Index: -87.6500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.4549
    Cell Significance Index: -21.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.5634
    Cell Significance Index: -119.9700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.6208
    Cell Significance Index: -17.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.7726
    Cell Significance Index: -119.1900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -1.9845
    Cell Significance Index: -15.8500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -2.0030
    Cell Significance Index: -34.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.0181
    Cell Significance Index: -123.7300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -2.5506
    Cell Significance Index: -34.8000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.6156
    Cell Significance Index: -77.0400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.8135
    Cell Significance Index: -103.2800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.8631
    Cell Significance Index: -126.6400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -3.0482
    Cell Significance Index: -124.9000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -3.0963
    Cell Significance Index: -36.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SSR4 is a subunit of the Sec61 complex, which is responsible for the translocation of proteins across the ER membrane. The Sec61 complex is a hetero-oligomeric assembly consisting of three subunits: α, β, and γ. SSR4, also known as delta subunit, is a conserved protein that interacts with the α subunit to form the Sec61 complex. SSR4 has been shown to be highly expressed in various cell types, including immune cells, epithelial cells, and muscle cells. **Pathways and Functions:** SSR4 is involved in several key pathways, including: 1. **Protein translocation:** SSR4 plays a critical role in the translocation of proteins across the ER membrane, ensuring proper protein folding and integration into the ER membrane. 2. **Endoplasmic reticulum (ER) stress response:** SSR4 is involved in the regulation of ER stress response, which is mediated by the unfolded protein response (UPR). 3. **Immune response:** SSR4 is highly expressed in immune cells, such as T cells and monocytes, and is involved in the regulation of immune response, particularly in the context of protein metabolism. 4. **Cell signaling:** SSR4 interacts with other proteins to regulate cell signaling pathways, including the activation of protein kinases and the regulation of transcription factors. **Clinical Significance:** SSR4 has been implicated in various diseases, including: 1. **Autoimmune diseases:** SSR4 has been shown to be involved in the regulation of immune response in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer:** SSR4 has been implicated in the regulation of protein metabolism in cancer cells, leading to the development of cancer. 3. **Neurological disorders:** SSR4 has been shown to be involved in the regulation of ER stress response in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 4. **Muscle diseases:** SSR4 has been implicated in the regulation of protein metabolism in muscle diseases, such as muscular dystrophy. In conclusion, SSR4 is a critical component of the Sec61 complex, playing a pivotal role in regulating protein metabolism, particularly in the context of immune response. Its dysregulation has been implicated in various diseases, highlighting the importance of SSR4 in maintaining cellular homeostasis. Further research is needed to fully elucidate the role of SSR4 in human disease and to develop therapeutic strategies targeting this protein.

Genular Protein ID: 1992589426

Symbol: SSRD_HUMAN

Name: Translocon-associated protein subunit delta

UniProtKB Accession Codes:

P51571 A8K378 Q53XY1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 1 Ensembl 3 ExpressionAtlas 1 GO 4 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7492314

Title: Translocon-associated protein TRAP delta and a novel TRAP-like protein are coordinately expressed with pro-opiomelanocortin in Xenopus intermediate pituitary.

PubMed ID: 7492314

DOI: 10.1042/bj3120205

PubMed ID: 9286695

Title: Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse.

PubMed ID: 9286695

DOI: 10.1006/geno.1997.4822

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24218363

Title: A new congenital disorder of glycosylation caused by a mutation in SSR4, the signal sequence receptor 4 protein of the TRAP complex.

PubMed ID: 24218363

DOI: 10.1093/hmg/ddt550

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 20598277

Title: Terminal osseous dysplasia is caused by a single recurrent mutation in the FLNA gene.

PubMed ID: 20598277

DOI: 10.1016/j.ajhg.2010.06.008

Sequence Information:

  • Length: 173
  • Mass: 18999
  • Checksum: 063CD2C8F6CE368B
  • Sequence:
    • MAAMASLGAL ALLLLSSLSR CSAEACLEPQ ITPSYYTTSD AVISTETVFI VEISLTCKNR 
VQNMALYADV GGKQFPVTRG QDVGRYQVSW SLDHKSAHAG TYEVRFFDEE SYSLLRKAQR 
NNEDISIIPP LFTVSVDHRG TWNGPWVSTE VLAAAIGLVI YYLAFSAKSH IQA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.