Details for: LTB

Gene ID: 4050

Symbol: LTB

Ensembl ID: ENSG00000227507

Description: lymphotoxin beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 90.1988
    Cell Significance Index: -14.0300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 64.1466
    Cell Significance Index: -26.0600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 59.5718
    Cell Significance Index: -15.1100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 57.1556
    Cell Significance Index: -29.4000
  • Cell Name: centroblast (CL0009112)
    Fold Change: 41.8420
    Cell Significance Index: 97.6200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 41.6629
    Cell Significance Index: -19.6700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.4425
    Cell Significance Index: -28.1100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 29.2688
    Cell Significance Index: -19.6400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 19.8976
    Cell Significance Index: 584.3700
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 13.9169
    Cell Significance Index: 42.4200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.4464
    Cell Significance Index: -12.8800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.6566
    Cell Significance Index: -12.3800
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 5.5814
    Cell Significance Index: 24.9600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.7262
    Cell Significance Index: -18.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 4.6145
    Cell Significance Index: 544.1900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.7132
    Cell Significance Index: -11.4100
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.0628
    Cell Significance Index: 30.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.1420
    Cell Significance Index: 46.4100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.7092
    Cell Significance Index: 9.3200
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.4480
    Cell Significance Index: 8.7500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.0411
    Cell Significance Index: 27.8500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9694
    Cell Significance Index: 184.4800
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.8906
    Cell Significance Index: 4.4600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.6540
    Cell Significance Index: 5.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6524
    Cell Significance Index: 64.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5486
    Cell Significance Index: 495.3500
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.4691
    Cell Significance Index: 3.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4345
    Cell Significance Index: 237.2700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4087
    Cell Significance Index: 8.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3345
    Cell Significance Index: 54.4100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2178
    Cell Significance Index: 23.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1967
    Cell Significance Index: 22.9300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0928
    Cell Significance Index: 4.3600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0814
    Cell Significance Index: 1.2600
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.0791
    Cell Significance Index: 0.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0449
    Cell Significance Index: 28.0600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0019
    Cell Significance Index: 1.3300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0064
    Cell Significance Index: -0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0091
    Cell Significance Index: -17.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0100
    Cell Significance Index: -0.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0114
    Cell Significance Index: -8.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0115
    Cell Significance Index: -21.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0139
    Cell Significance Index: -21.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0152
    Cell Significance Index: -11.5000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0153
    Cell Significance Index: -0.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0154
    Cell Significance Index: -3.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0156
    Cell Significance Index: -6.8800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0213
    Cell Significance Index: -12.0100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0219
    Cell Significance Index: -1.1100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0235
    Cell Significance Index: -1.4100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0267
    Cell Significance Index: -0.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0292
    Cell Significance Index: -6.1600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0299
    Cell Significance Index: -0.2800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0336
    Cell Significance Index: -0.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0365
    Cell Significance Index: -26.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0365
    Cell Significance Index: -6.2300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0384
    Cell Significance Index: -13.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0462
    Cell Significance Index: -29.3700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0524
    Cell Significance Index: -2.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0548
    Cell Significance Index: -10.8700
  • Cell Name: centrocyte (CL0009111)
    Fold Change: -0.0551
    Cell Significance Index: -0.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0559
    Cell Significance Index: -3.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0561
    Cell Significance Index: -25.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0598
    Cell Significance Index: -2.7100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0684
    Cell Significance Index: -1.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0697
    Cell Significance Index: -7.9900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0766
    Cell Significance Index: -22.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0872
    Cell Significance Index: -11.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0887
    Cell Significance Index: -5.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1150
    Cell Significance Index: -15.7900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1241
    Cell Significance Index: -12.6800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1251
    Cell Significance Index: -14.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1436
    Cell Significance Index: -25.8800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1475
    Cell Significance Index: -3.0600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1502
    Cell Significance Index: -4.8100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1644
    Cell Significance Index: -7.1500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1647
    Cell Significance Index: -21.2800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1696
    Cell Significance Index: -12.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2012
    Cell Significance Index: -29.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2128
    Cell Significance Index: -26.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2328
    Cell Significance Index: -17.8700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2396
    Cell Significance Index: -4.0700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2414
    Cell Significance Index: -14.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2478
    Cell Significance Index: -13.0100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.2695
    Cell Significance Index: -2.5900
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.2708
    Cell Significance Index: -2.4600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3010
    Cell Significance Index: -18.9700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3128
    Cell Significance Index: -23.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3493
    Cell Significance Index: -19.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3565
    Cell Significance Index: -18.5200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.3624
    Cell Significance Index: -4.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3730
    Cell Significance Index: -29.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3959
    Cell Significance Index: -20.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4002
    Cell Significance Index: -17.7000
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.4057
    Cell Significance Index: -3.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4219
    Cell Significance Index: -19.6700
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.4415
    Cell Significance Index: -4.4600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4440
    Cell Significance Index: -14.1400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4550
    Cell Significance Index: -15.9400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4621
    Cell Significance Index: -12.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LTB is a type II transmembrane protein, consisting of two extracellular domains (LTB-A and LTB-B) and a single transmembrane domain. The extracellular domains are responsible for ligand binding to its receptor, TNFR2, which activates non-canonical NF-κB signaling pathways. The intracellular domain of LTB is involved in the regulation of apoptosis and the production of cytokines, such as interleukin-12. **Pathways and Functions:** LTB's functions are mediated through its interaction with TNFR2, which activates non-canonical NF-κB signaling pathways. This pathway is involved in various cellular processes, including: 1. **Lymph node development**: LTB plays a crucial role in the development and organization of lymphoid tissues, including lymph nodes and Peyer's patches. 2. **Immune response**: LTB promotes the activation and differentiation of T cells, including T-helper 22 cells, and the production of cytokines, such as interleukin-12. 3. **Apoptosis regulation**: LTB can induce apoptosis in certain cell types, including cancer cells, through the activation of extrinsic apoptotic signaling pathways. 4. **Cytokine signaling**: LTB is involved in the regulation of cytokine production, including the production of interleukin-12, which is essential for the development of immune responses. **Clinical Significance:** The dysregulation of LTB has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases**: LTB's involvement in the regulation of immune responses makes it a potential target for the treatment of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: LTB's ability to induce apoptosis in cancer cells makes it a potential therapeutic target for cancer treatment. 3. **Infectious diseases**: LTB's role in the regulation of immune responses makes it a potential target for the treatment of infectious diseases, such as tuberculosis and HIV. 4. **Immunodeficiency disorders**: LTB's involvement in the regulation of immune responses makes it a potential target for the treatment of immunodeficiency disorders, such as severe combined immunodeficiency (SCID). In conclusion, Lymphotoxin beta is a critical immune regulator with diverse functions, involved in various cellular processes, including lymph node development, immune response, apoptosis regulation, and cytokine signaling. Its dysregulation has been implicated in various immune-related disorders, making it a potential target for the treatment of these diseases.

Genular Protein ID: 4217291156

Symbol: TNFC_HUMAN

Name: Lymphotoxin-beta

UniProtKB Accession Codes:

Q06643 P78370 Q52LU8 Q99761

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 9 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7916655

Title: Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface.

PubMed ID: 7916655

DOI: 10.1016/0092-8674(93)90574-a

PubMed ID: 9299492

Title: Identification of two lymphotoxin beta isoforms expressed in human lymphoid cell lines and non-Hodgkin's lymphomas.

PubMed ID: 9299492

DOI: 10.1006/bbrc.1997.7277

PubMed ID: 10202016

Title: A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC.

PubMed ID: 10202016

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24248355

Title: Dimerization of LTbetaR by LTalpha1beta2 is necessary and sufficient for signal transduction.

PubMed ID: 24248355

DOI: 10.1073/pnas.1310838110

Sequence Information:

  • Length: 244
  • Mass: 25390
  • Checksum: F41569459830ED4C
  • Sequence:
    • MGALGLEGRG GRLQGRGSLL LAVAGATSLV TLLLAVPITV LAVLALVPQD QGGLVTETAD 
PGAQAQQGLG FQKLPEEEPE TDLSPGLPAA HLIGAPLKGQ GLGWETTKEQ AFLTSGTQFS 
DAEGLALPQD GLYYLYCLVG YRGRAPPGGG DPQGRSVTLR SSLYRAGGAY GPGTPELLLE 
GAETVTPVLD PARRQGYGPL WYTSVGFGGL VQLRRGERVY VNISHPDMVD FARGKTFFGA 
VMVG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.