Gene LTB - ENSG00000227507 | NCBI Gene ID: 4050

Details for: LTB

Gene ID: 4050

Symbol: LTB

Ensembl ID: ENSG00000227507

Description: lymphotoxin beta

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Immune system
(R-HSA-168256)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Tnf receptor superfamily (tnfsf) members mediating non-canonical nf-kb pathway
(R-HSA-5676594)
Cell-cell signaling
(GO:0007267)
Cellular_component
(GO:0005575)
Cytokine activity
(GO:0005125)
Extracellular space
(GO:0005615)
Gene expression
(GO:0010467)
Immune response
(GO:0006955)
Lymph node development
(GO:0048535)
Plasma membrane
(GO:0005886)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of extrinsic apoptotic signaling pathway
(GO:2001238)
Positive regulation of interleukin-12 production
(GO:0032735)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Skin development
(GO:0043588)
Tumor necrosis factor receptor binding
(GO:0005164)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 4.56
Marker Score: 7824
Cell Name: naive T cell (CL0000898)
Fold Change: 4.39
Marker Score: 2827
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 4.35
Marker Score: 230231
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 4.18
Marker Score: 17916
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 3.93
Marker Score: 3699.5
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 3.92
Marker Score: 8214
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 3.85
Marker Score: 3791
Cell Name: germinal center B cell (CL0000844)
Fold Change: 3.73
Marker Score: 2271
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 3.44
Marker Score: 8396
Cell Name: naive B cell (CL0000788)
Fold Change: 3.25
Marker Score: 2904
Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 3.24
Marker Score: 1130
Cell Name: centroblast (CL0009112)
Fold Change: 3.23
Marker Score: 1590
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 3.12
Marker Score: 5574
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 3.11
Marker Score: 2907
Cell Name: B-1 B cell (CL0000819)
Fold Change: 3.04
Marker Score: 5296.5
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 3.02
Marker Score: 19293
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 3.01
Marker Score: 2205
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 2.98
Marker Score: 1797
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 2.95
Marker Score: 1475
Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 2.79
Marker Score: 614
Cell Name: late pro-B cell (CL0002048)
Fold Change: 2.77
Marker Score: 3270
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 2.76
Marker Score: 976
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 2.75
Marker Score: 6200
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 2.75
Marker Score: 729
Cell Name: regulatory T cell (CL0000815)
Fold Change: 2.71
Marker Score: 3002
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 2.69
Marker Score: 2902
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 2.65
Marker Score: 1916
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.58
Marker Score: 7654
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 2.57
Marker Score: 2592.5
Cell Name: pro-T cell (CL0000827)
Fold Change: 2.56
Marker Score: 10464
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 2.48
Marker Score: 1272
Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
Fold Change: 2.42
Marker Score: 548.5
Cell Name: memory B cell (CL0000787)
Fold Change: 2.41
Marker Score: 1825
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 2.37
Marker Score: 2106
Cell Name: type I NK T cell (CL0000921)
Fold Change: 2.29
Marker Score: 1797
Cell Name: B-1b B cell (CL0000821)
Fold Change: 2.26
Marker Score: 521.5
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 2.21
Marker Score: 1356.5
Cell Name: thymocyte (CL0000893)
Fold Change: 2.2
Marker Score: 2307
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 2.2
Marker Score: 1827.5
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 2.13
Marker Score: 1044.5
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 2.12
Marker Score: 645
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 2.12
Marker Score: 5942
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 2.02
Marker Score: 1702.5
Cell Name: follicular B cell (CL0000843)
Fold Change: 2
Marker Score: 2165
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 1.99
Marker Score: 618
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.95
Marker Score: 1946
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 1.88
Marker Score: 1597
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 1.84
Marker Score: 3600
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 1.83
Marker Score: 2597
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 1.79
Marker Score: 1052
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 1.78
Marker Score: 5632
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 1.67
Marker Score: 931
Cell Name: blood cell (CL0000081)
Fold Change: 1.66
Marker Score: 19328
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 1.65
Marker Score: 1164
Cell Name: centrocyte (CL0009111)
Fold Change: 1.65
Marker Score: 392
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 1.63
Marker Score: 991
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 1.62
Marker Score: 951
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 1.61
Marker Score: 1168
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.57
Marker Score: 1138
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 1.48
Marker Score: 674.5
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 1.48
Marker Score: 514
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 1.45
Marker Score: 521
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 1.4
Marker Score: 462
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.38
Marker Score: 3579.5
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 1.36
Marker Score: 1313
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 1.29
Marker Score: 418
Cell Name: immature B cell (CL0000816)
Fold Change: 1.28
Marker Score: 849
Cell Name: B cell (CL0000236)
Fold Change: 1.26
Marker Score: 1200
Cell Name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human (CL0001074)
Fold Change: 1.23
Marker Score: 338
Cell Name: exhausted T cell (CL0011025)
Fold Change: 1.22
Marker Score: 699
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 1.21
Marker Score: 990
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 1.2
Marker Score: 906
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 1.17
Marker Score: 1908
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 1.16
Marker Score: 486
Cell Name: Unknown (CL0000548)
Fold Change: 1.13
Marker Score: 826.5
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.13
Marker Score: 4743
Cell Name: ILC1, human (CL0001077)
Fold Change: 1.13
Marker Score: 286
Cell Name: T follicular regulatory cell (CL0009113)
Fold Change: 1.12
Marker Score: 304
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 1.11
Marker Score: 1211.5
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 1.08
Marker Score: 284
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 1.08
Marker Score: 2596
Cell Name: T-helper 1 cell (CL0000545)
Fold Change: 1.05
Marker Score: 411
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 1.05
Marker Score: 1447
Cell Name: mature B cell (CL0000785)
Fold Change: 1.05
Marker Score: 767
Cell Name: B-1a B cell (CL0000820)
Fold Change: 1.04
Marker Score: 250
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 1.03
Marker Score: 902
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 1.02
Marker Score: 315
Cell Name: neutrophil (CL0000775)
Fold Change: 0.99
Marker Score: 604
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30396
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 496
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 0.96
Marker Score: 1865
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 450
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2406
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5273
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.91
Marker Score: 631
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.91
Marker Score: 314
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2721
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.91
Marker Score: 364
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.91
Marker Score: 3763
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.9
Marker Score: 484

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**Key characteristics:** * LTB is a type I cytokine, which means that it is produced and released by cells in the immune system. * It is a glycoprotein with a molecular weight of approximately 120 kDa. * LTB is a potent activator of the canonical NF-kappaB signaling pathway. * It also modulates the extrinsic apoptotic signaling pathway and the production of interleukin-12. **Pathways and functions:** * LTB binds to the TNFR2 receptor, which is expressed on various immune cells. * This binding activates the canonical NF-kappaB signaling pathway, which is a major regulator of inflammation and cell death. * LTB also modulates the extrinsic apoptotic signaling pathway, which is a pathway that is responsible for the regulation of cell death. * It also plays a role in the development of lymph nodes. **Clinical significance:** * Mutations in the LTB gene have been linked to a number of human diseases, including cancer, autoimmune disorders, and inflammatory diseases. * LTB is a potential therapeutic target for these diseases. **Additional notes:** * LTB is a highly conserved protein, with a similar sequence found in mammals, birds, and fish. * It is produced by a variety of cell types, including thymus-derived cells, T cells, B cells, and macrophages. * LTB is a potent activator of the canonical NF-kappaB signaling pathway. * It also modulates the extrinsic apoptotic signaling pathway and the production of interleukin-12.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Lymphotoxin-beta

Genular Protein ID: 4217291156

Symbol: TNFC_HUMAN

Name: Lymphotoxin-beta

UniProtKB Accession Codes:

Q06643 P78370 Q52LU8 Q99761

Database IDs:

Citations:

PubMed ID: 7916655

Title: Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface.

PubMed ID: 7916655

DOI: 10.1016/0092-8674(93)90574-a

PubMed ID: 9299492

Title: Identification of two lymphotoxin beta isoforms expressed in human lymphoid cell lines and non-Hodgkin's lymphomas.

PubMed ID: 9299492

DOI: 10.1006/bbrc.1997.7277

PubMed ID: 10202016

Title: A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC.

PubMed ID: 10202016

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 244
Mass: 25390
Checksum: F41569459830ED4C
Sequence:

MGALGLEGRG GRLQGRGSLL LAVAGATSLV TLLLAVPITV LAVLALVPQD QGGLVTETAD 
PGAQAQQGLG FQKLPEEEPE TDLSPGLPAA HLIGAPLKGQ GLGWETTKEQ AFLTSGTQFS 
DAEGLALPQD GLYYLYCLVG YRGRAPPGGG DPQGRSVTLR SSLYRAGGAY GPGTPELLLE 
GAETVTPVLD PARRQGYGPL WYTSVGFGGL VQLRRGERVY VNISHPDMVD FARGKTFFGA 
VMVG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: LTB

Associated with

Cells (max top 100)

Other Information

Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface. PubMed ID: 7916655

Identification of two lymphotoxin beta isoforms expressed in human lymphoid cell lines and non-Hodgkin's lymphomas. PubMed ID: 9299492

A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC. PubMed ID: 10202016

Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. PubMed ID: 14656967

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039