Details for: IL7R

Gene ID: 3575

Symbol: IL7R

Ensembl ID: ENSG00000168685

Description: interleukin 7 receptor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 4.36
    Marker Score: 11080
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.18
    Marker Score: 220842.5
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 4.11
    Marker Score: 2649
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4
    Marker Score: 17135.5
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 3.51
    Marker Score: 1804
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.43
    Marker Score: 1715
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 3.34
    Marker Score: 5734.5
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.3
    Marker Score: 2939
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 3.25
    Marker Score: 1904
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 3.22
    Marker Score: 3010
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.1
    Marker Score: 9776
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 3.01
    Marker Score: 2205
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.88
    Marker Score: 2092
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.87
    Marker Score: 5632
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 2.77
    Marker Score: 968
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.74
    Marker Score: 850
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 2.72
    Marker Score: 2935
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 2.69
    Marker Score: 6062
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 2.64
    Marker Score: 580
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.59
    Marker Score: 22758
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 2.55
    Marker Score: 1569
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.54
    Marker Score: 7116
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 2.52
    Marker Score: 569
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 2.49
    Marker Score: 1392
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.49
    Marker Score: 24656
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.41
    Marker Score: 2326
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 2.38
    Marker Score: 724
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.3
    Marker Score: 26776
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.29
    Marker Score: 1798
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 2.07
    Marker Score: 891
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.89
    Marker Score: 2035
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.87
    Marker Score: 2575
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.79
    Marker Score: 1503
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.77
    Marker Score: 582
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.64
    Marker Score: 1184
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.64
    Marker Score: 9937
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.59
    Marker Score: 6493
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.57
    Marker Score: 565
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 1.57
    Marker Score: 714
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.57
    Marker Score: 1141
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 1.54
    Marker Score: 408
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.53
    Marker Score: 4155
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.49
    Marker Score: 822
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.49
    Marker Score: 1484
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.46
    Marker Score: 714
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.44
    Marker Score: 1598
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.38
    Marker Score: 14029
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.29
    Marker Score: 1132
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.25
    Marker Score: 281
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.25
    Marker Score: 1037
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.23
    Marker Score: 835
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 1.23
    Marker Score: 2001
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.22
    Marker Score: 7829
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.22
    Marker Score: 31247
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.2
    Marker Score: 2136
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.19
    Marker Score: 898
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.18
    Marker Score: 796
  • Cell Name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human (CL0001074)
    Fold Change: 1.18
    Marker Score: 326
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.18
    Marker Score: 1003
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 1.14
    Marker Score: 480
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.13
    Marker Score: 4760
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.09
    Marker Score: 1189
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 1.09
    Marker Score: 962
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.09
    Marker Score: 1286
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.06
    Marker Score: 1528
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.04
    Marker Score: 252
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.03
    Marker Score: 753
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.03
    Marker Score: 445
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 1.03
    Marker Score: 402
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.01
    Marker Score: 1435.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71750
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47976
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.99
    Marker Score: 412
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.99
    Marker Score: 1035
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.98
    Marker Score: 3803
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.98
    Marker Score: 1180
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30401
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 496
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 450
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2408
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.95
    Marker Score: 478
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.93
    Marker Score: 2409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5285
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.92
    Marker Score: 422.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 366
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2727
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.91
    Marker Score: 1318
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.87
    Marker Score: 750
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5279
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.85
    Marker Score: 1472
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.85
    Marker Score: 2070.5
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.85
    Marker Score: 916
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 634.5
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.83
    Marker Score: 475
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.79
    Marker Score: 1158
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.78
    Marker Score: 534.5
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.77
    Marker Score: 508
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1247
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.77
    Marker Score: 485.5

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Other Information

**Key characteristics:** - The IL7R gene is located on chromosome 2. - It is a single gene with a length of approximately 27,000 base pairs. - The IL7R protein is a glycoprotein with a molecular weight of approximately 140 kDa. - It is a transmembrane protein that is expressed on the surface of immune cells. **Pathways and functions:** - The IL7R gene is involved in a variety of immune pathways, including antigen binding, B cell homeostasis, cargo recognition for clathrin-mediated endocytosis, cell morphogenesis, clathrin-mediated endocytosis, cytokine receptor activity, cytokine signaling in the immune system, immune response, and T cell mediated cytotoxicity. **Clinical significance:** - Mutations in the IL7R gene have been linked to a number of human diseases, including rheumatoid arthritis, inflammatory bowel disease, and cancer. - Dysregulation of the IL7R signaling pathway has been implicated in the pathogenesis of these diseases. - Therefore, targeting the IL7R signaling pathway is a promising strategy for the treatment of these diseases.

Genular Protein ID: 698399574

Symbol: IL7RA_HUMAN

Name: Interleukin-7 receptor subunit alpha

UniProtKB Accession Codes:

P16871 B2RCS6 B4DVT1 Q05CU8 Q6NSP4 Q6NWM0 Q6NWM1 Q6NWM2 Q6NWM3 Q6SV45 Q9UPC1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 18 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 32 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 7 PIR 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 3 RefSeq 1 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2317865

Title: Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily.

PubMed ID: 2317865

DOI: 10.1016/0092-8674(90)90342-c

PubMed ID: 2038316

Title: Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter.

PubMed ID: 2038316

DOI: 10.1128/mcb.11.6.3052-3059.1991

PubMed ID: 9843216

Title: Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency.

PubMed ID: 9843216

DOI: 10.1038/3877

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19141282

Title: Structural and biophysical studies of the human IL-7/IL-7Ralpha complex.

PubMed ID: 19141282

DOI: 10.1016/j.str.2008.10.019

PubMed ID: 11023514

Title: A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency.

PubMed ID: 11023514

PubMed ID: 17660817

Title: Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis.

PubMed ID: 17660817

DOI: 10.1038/ng2103

Sequence Information:

  • Length: 459
  • Mass: 51579
  • Checksum: EF50BF2615EEF50C
  • Sequence:
    • MTILGTTFGM VFSLLQVVSG ESGYAQNGDL EDAELDDYSF SCYSQLEVNG SQHSLTCAFE 
DPDVNITNLE FEICGALVEV KCLNFRKLQE IYFIETKKFL LIGKSNICVK VGEKSLTCKK 
IDLTTIVKPE APFDLSVVYR EGANDFVVTF NTSHLQKKYV KVLMHDVAYR QEKDENKWTH 
VNLSSTKLTL LQRKLQPAAM YEIKVRSIPD HYFKGFWSEW SPSYYFRTPE INNSSGEMDP 
ILLTISILSF FSVALLVILA CVLWKKRIKP IVWPSLPDHK KTLEHLCKKP RKNLNVSFNP 
ESFLDCQIHR VDDIQARDEV EGFLQDTFPQ QLEESEKQRL GGDVQSPNCP SEDVVITPES 
FGRDSSLTCL AGNVSACDAP ILSSSRSLDC RESGKNGPHV YQDLLLSLGT TNSTLPPPFS 
LQSGILTLNP VAQGQPILTS LGSNQEEAYV TMSSFYQNQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.