Details for: IL7R

Gene ID: 3575

Symbol: IL7R

Ensembl ID: ENSG00000168685

Description: interleukin 7 receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 141.5665
    Cell Significance Index: -22.0200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 90.0674
    Cell Significance Index: -22.8500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 72.5403
    Cell Significance Index: -29.4700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 61.3159
    Cell Significance Index: -31.5400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 52.5075
    Cell Significance Index: -24.7900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 32.9932
    Cell Significance Index: -31.5000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.9386
    Cell Significance Index: -22.1200
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 11.3215
    Cell Significance Index: 34.5100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.0851
    Cell Significance Index: -18.9800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.4204
    Cell Significance Index: -19.7200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.8223
    Cell Significance Index: -22.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 4.4533
    Cell Significance Index: 231.9700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 4.1987
    Cell Significance Index: 64.9600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.6888
    Cell Significance Index: 26.9600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 2.4564
    Cell Significance Index: 21.4900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.4522
    Cell Significance Index: 72.0200
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 2.0507
    Cell Significance Index: 35.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.7191
    Cell Significance Index: 110.9100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3312
    Cell Significance Index: 60.3400
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.9442
    Cell Significance Index: 7.0300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9100
    Cell Significance Index: 173.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7438
    Cell Significance Index: 16.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6722
    Cell Significance Index: 66.5000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6149
    Cell Significance Index: 555.1700
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.6144
    Cell Significance Index: 6.3700
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.4169
    Cell Significance Index: 3.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2850
    Cell Significance Index: 46.3600
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.2724
    Cell Significance Index: 2.3200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.2036
    Cell Significance Index: 1.1100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0828
    Cell Significance Index: 9.0100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0754
    Cell Significance Index: 1.3000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0359
    Cell Significance Index: 22.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0042
    Cell Significance Index: 0.2600
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: 0.0029
    Cell Significance Index: 0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0051
    Cell Significance Index: -3.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0077
    Cell Significance Index: -0.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0119
    Cell Significance Index: -22.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0145
    Cell Significance Index: -8.1500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0160
    Cell Significance Index: -0.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0187
    Cell Significance Index: -34.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0198
    Cell Significance Index: -0.5700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0222
    Cell Significance Index: -34.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0243
    Cell Significance Index: -18.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0254
    Cell Significance Index: -34.5300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0258
    Cell Significance Index: -5.4400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0336
    Cell Significance Index: -0.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0395
    Cell Significance Index: -28.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0447
    Cell Significance Index: -24.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0473
    Cell Significance Index: -30.0600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0564
    Cell Significance Index: -1.4400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0594
    Cell Significance Index: -3.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0628
    Cell Significance Index: -22.5100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0658
    Cell Significance Index: -29.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0780
    Cell Significance Index: -14.0600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0811
    Cell Significance Index: -5.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0880
    Cell Significance Index: -15.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0889
    Cell Significance Index: -25.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0959
    Cell Significance Index: -19.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1027
    Cell Significance Index: -20.3800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1279
    Cell Significance Index: -16.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1317
    Cell Significance Index: -16.1900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1467
    Cell Significance Index: -2.1500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1614
    Cell Significance Index: -7.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1732
    Cell Significance Index: -23.7900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1747
    Cell Significance Index: -19.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1748
    Cell Significance Index: -20.6100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1872
    Cell Significance Index: -3.1800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1962
    Cell Significance Index: -9.2200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1963
    Cell Significance Index: -22.8800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1972
    Cell Significance Index: -25.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2034
    Cell Significance Index: -29.5600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2054
    Cell Significance Index: -8.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2196
    Cell Significance Index: -22.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2223
    Cell Significance Index: -23.1500
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.2465
    Cell Significance Index: -2.2300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2477
    Cell Significance Index: -2.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2499
    Cell Significance Index: -28.6300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.2611
    Cell Significance Index: -2.5100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.2752
    Cell Significance Index: -2.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3436
    Cell Significance Index: -26.3700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3514
    Cell Significance Index: -23.6300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.3561
    Cell Significance Index: -2.7700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3579
    Cell Significance Index: -21.4900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.3694
    Cell Significance Index: -5.0300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.3718
    Cell Significance Index: -4.3900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3828
    Cell Significance Index: -28.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3843
    Cell Significance Index: -30.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4011
    Cell Significance Index: -10.7300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4104
    Cell Significance Index: -8.7400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4527
    Cell Significance Index: -9.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4667
    Cell Significance Index: -26.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4712
    Cell Significance Index: -28.9600
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.4833
    Cell Significance Index: -4.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4874
    Cell Significance Index: -15.6100
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.5273
    Cell Significance Index: -4.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5411
    Cell Significance Index: -28.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5435
    Cell Significance Index: -15.1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5468
    Cell Significance Index: -28.7100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5468
    Cell Significance Index: -34.4600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.5516
    Cell Significance Index: -5.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Receptor Structure**: The IL-7R is a heteromeric receptor, consisting of two subunits: the IL-7Rα subunit and the IL-7Rγ subunit. The IL-7Rα subunit is responsible for ligand binding, while the IL-7Rγ subunit mediates signal transduction. 2. **Expression**: IL-7R is expressed on various immune cells, including mature alpha-beta T cells, naive T cells, T-regulatory cells, and thymocytes. 3. **Signaling Pathway**: The IL-7R signaling pathway is mediated by the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. This pathway is involved in the positive regulation of T cell proliferation, differentiation, and homeostasis. 4. **Function**: IL-7R plays a critical role in the development, homeostasis, and function of T cells, particularly in the thymus and peripheral tissues. **Pathways and Functions** 1. **B Cell Homeostasis**: IL-7R is involved in the regulation of B cell homeostasis, particularly in the differentiation and survival of B cells. 2. **B Cell Proliferation**: IL-7R promotes the proliferation of B cells, particularly in response to antigens. 3. **T Cell Differentiation**: IL-7R is essential for the positive regulation of T cell differentiation, particularly in the thymus and peripheral tissues. 4. **T Cell Homeostasis**: IL-7R regulates T cell homeostasis, particularly in the maintenance of T cell populations and the prevention of T cell exhaustion. 5. **Negative Regulation of T Cell-Mediated Cytotoxicity**: IL-7R negatively regulates T cell-mediated cytotoxicity, preventing excessive immune responses. 6. **Regulation of Gene Expression**: IL-7R regulates gene expression, particularly in the expression of cytokines and chemokines involved in immune responses. **Clinical Significance** 1. **Immunodeficiency Diseases**: Mutations or deletions in the IL7R gene have been associated with immunodeficiency diseases, such as severe combined immunodeficiency (SCID). 2. **Cancer**: IL-7R has been implicated in the development and progression of various cancers, including T cell lymphomas and leukemia. 3. **Autoimmune Diseases**: IL-7R has been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 4. **Vaccine Development**: IL-7R has been targeted for vaccine development, particularly for the enhancement of T cell responses and the induction of immune tolerance. In conclusion, the IL7R gene plays a critical role in the development, homeostasis, and function of T cells, and its dysregulation has been implicated in various immunodeficiency diseases, cancers, and autoimmune diseases. Further research is needed to fully understand the mechanisms of IL-7R-mediated signaling and to explore its therapeutic potential.

Genular Protein ID: 698399574

Symbol: IL7RA_HUMAN

Name: Interleukin-7 receptor subunit alpha

UniProtKB Accession Codes:

P16871 B2RCS6 B4DVT1 Q05CU8 Q6NSP4 Q6NWM0 Q6NWM1 Q6NWM2 Q6NWM3 Q6SV45 Q9UPC1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 18 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 34 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 3 RefSeq 1 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2317865

Title: Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily.

PubMed ID: 2317865

DOI: 10.1016/0092-8674(90)90342-c

PubMed ID: 2038316

Title: Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter.

PubMed ID: 2038316

DOI: 10.1128/mcb.11.6.3052-3059.1991

PubMed ID: 9843216

Title: Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency.

PubMed ID: 9843216

DOI: 10.1038/3877

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 31748347

Title: The Tetraspanin CD53 Regulates Early B Cell Development by Promoting IL-7R Signaling.

PubMed ID: 31748347

DOI: 10.4049/jimmunol.1900539

PubMed ID: 19141282

Title: Structural and biophysical studies of the human IL-7/IL-7Ralpha complex.

PubMed ID: 19141282

DOI: 10.1016/j.str.2008.10.019

PubMed ID: 11023514

Title: A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency.

PubMed ID: 11023514

PubMed ID: 17660817

Title: Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis.

PubMed ID: 17660817

DOI: 10.1038/ng2103

Sequence Information:

  • Length: 459
  • Mass: 51579
  • Checksum: EF50BF2615EEF50C
  • Sequence:
    • MTILGTTFGM VFSLLQVVSG ESGYAQNGDL EDAELDDYSF SCYSQLEVNG SQHSLTCAFE 
DPDVNITNLE FEICGALVEV KCLNFRKLQE IYFIETKKFL LIGKSNICVK VGEKSLTCKK 
IDLTTIVKPE APFDLSVVYR EGANDFVVTF NTSHLQKKYV KVLMHDVAYR QEKDENKWTH 
VNLSSTKLTL LQRKLQPAAM YEIKVRSIPD HYFKGFWSEW SPSYYFRTPE INNSSGEMDP 
ILLTISILSF FSVALLVILA CVLWKKRIKP IVWPSLPDHK KTLEHLCKKP RKNLNVSFNP 
ESFLDCQIHR VDDIQARDEV EGFLQDTFPQ QLEESEKQRL GGDVQSPNCP SEDVVITPES 
FGRDSSLTCL AGNVSACDAP ILSSSRSLDC RESGKNGPHV YQDLLLSLGT TNSTLPPPFS 
LQSGILTLNP VAQGQPILTS LGSNQEEAYV TMSSFYQNQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.