Details for: IGLV3 10

Gene ID: 28803

Symbol: IGLV3 10

Ensembl ID: ENSG00000211669

Description: immunoglobulin lambda variable 3-10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.4070
    Cell Significance Index: 15.7300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.2803
    Cell Significance Index: 4.0700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2511
    Cell Significance Index: 3.8900
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.2458
    Cell Significance Index: 2.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0059
    Cell Significance Index: -4.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0376
    Cell Significance Index: -3.8500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0444
    Cell Significance Index: -2.0700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0488
    Cell Significance Index: -1.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0733
    Cell Significance Index: -4.7300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0766
    Cell Significance Index: -2.0800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1192
    Cell Significance Index: -1.4800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1256
    Cell Significance Index: -3.3600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1312
    Cell Significance Index: -2.2600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1341
    Cell Significance Index: -3.5900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1582
    Cell Significance Index: -3.4700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1643
    Cell Significance Index: -2.4300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1768
    Cell Significance Index: -4.4100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1808
    Cell Significance Index: -3.7500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1872
    Cell Significance Index: -4.5400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1931
    Cell Significance Index: -7.0900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2110
    Cell Significance Index: -3.9000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2288
    Cell Significance Index: -5.8300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2355
    Cell Significance Index: -4.0000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2422
    Cell Significance Index: -4.1400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2470
    Cell Significance Index: -4.8300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.2488
    Cell Significance Index: -2.7800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2538
    Cell Significance Index: -3.2600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2544
    Cell Significance Index: -4.1200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.2596
    Cell Significance Index: -3.2900
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.2689
    Cell Significance Index: -2.2200
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2720
    Cell Significance Index: -3.2000
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.2721
    Cell Significance Index: -3.0900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2749
    Cell Significance Index: -3.7700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2907
    Cell Significance Index: -3.3500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2914
    Cell Significance Index: -3.7700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2992
    Cell Significance Index: -4.0700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.3004
    Cell Significance Index: -3.9200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.3020
    Cell Significance Index: -3.9500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3052
    Cell Significance Index: -3.4700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.3056
    Cell Significance Index: -3.6600
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.3088
    Cell Significance Index: -3.6500
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.3098
    Cell Significance Index: -2.5300
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.3153
    Cell Significance Index: -2.1000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.3210
    Cell Significance Index: -3.2800
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.3223
    Cell Significance Index: -2.5900
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.3243
    Cell Significance Index: -3.9200
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.3377
    Cell Significance Index: -2.8500
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.3427
    Cell Significance Index: -3.6600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.3486
    Cell Significance Index: -4.4700
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.3538
    Cell Significance Index: -3.2000
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.3569
    Cell Significance Index: -3.9100
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.3598
    Cell Significance Index: -4.3400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.3679
    Cell Significance Index: -4.1700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.3737
    Cell Significance Index: -3.9700
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.3770
    Cell Significance Index: -4.7700
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.3771
    Cell Significance Index: -3.6200
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.3798
    Cell Significance Index: -3.5300
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.3806
    Cell Significance Index: -4.7600
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.3821
    Cell Significance Index: -4.2300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.3833
    Cell Significance Index: -5.0300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3838
    Cell Significance Index: -5.1000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.3867
    Cell Significance Index: -4.4500
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.3875
    Cell Significance Index: -4.5000
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.3875
    Cell Significance Index: -4.1400
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.3888
    Cell Significance Index: -3.7900
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.3888
    Cell Significance Index: -3.5100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.3893
    Cell Significance Index: -4.6000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.3897
    Cell Significance Index: -4.6100
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.3903
    Cell Significance Index: -3.8500
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.3929
    Cell Significance Index: -2.7700
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.3940
    Cell Significance Index: -4.0000
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.3948
    Cell Significance Index: -4.2000
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.3957
    Cell Significance Index: -4.0400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.3960
    Cell Significance Index: -4.7800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.4058
    Cell Significance Index: -5.3400
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.4127
    Cell Significance Index: -4.4500
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.4145
    Cell Significance Index: -4.7600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.4146
    Cell Significance Index: -3.9300
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.4183
    Cell Significance Index: -3.9000
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.4196
    Cell Significance Index: -3.9700
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.4227
    Cell Significance Index: -4.5700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.4235
    Cell Significance Index: -4.6900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.4237
    Cell Significance Index: -4.4700
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.4238
    Cell Significance Index: -3.7800
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.4245
    Cell Significance Index: -4.4700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.4277
    Cell Significance Index: -5.0500
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.4287
    Cell Significance Index: -4.4100
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.4303
    Cell Significance Index: -4.5100
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: -0.4378
    Cell Significance Index: -4.0800
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.4384
    Cell Significance Index: -4.9800
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.4390
    Cell Significance Index: -5.0600
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: -0.4419
    Cell Significance Index: -4.8300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.4426
    Cell Significance Index: -4.1400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.4431
    Cell Significance Index: -5.1400
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.4471
    Cell Significance Index: -4.9300
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.4522
    Cell Significance Index: -5.6800
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.4560
    Cell Significance Index: -4.8400
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.4563
    Cell Significance Index: -5.0800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.4570
    Cell Significance Index: -5.1500
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.4589
    Cell Significance Index: -4.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Location and Structure:** IGLV3-10 is located on chromosome 22q11.23 and is part of the immunoglobulin gene family. The gene consists of several exons that encode for the variable region of the lambda light chain. 2. **Cell Type Expression:** IGLV3-10 is expressed in a variety of cell types, including CD16-positive natural killer cells, CD56-dim natural killer cells, goblet cells, and certain types of cancer cells. 3. **Alternative Splicing:** IGLV3-10 undergoes alternative splicing, resulting in multiple isoforms of the lambda light chain. 4. **Evolutionary Conservation:** IGLV3-10 is highly conserved across species, suggesting its importance in the immune system. **Pathways and Functions:** 1. **Adaptive Immune Response:** IGLV3-10 plays a crucial role in the adaptive immune response by encoding for the lambda light chain of antibodies. This light chain is essential for the proper assembly and secretion of antibodies. 2. **Immune Cell Activation:** IGLV3-10 is also involved in the activation of immune cells, including natural killer cells and T cells. This activation is mediated through the expression of specific cytokines and chemokines. 3. **Antibody Production:** The lambda light chain encoded by IGLV3-10 is involved in the production of antibodies, which are essential for the neutralization of pathogens and the elimination of foreign substances. 4. **Immune Cell Development:** IGLV3-10 is also involved in the development and maturation of immune cells, including natural killer cells and T cells. **Clinical Significance:** 1. **Cancer Immunosuppression:** Abnormal expression of IGLV3-10 has been observed in certain types of cancer, including multiple myeloma and lymphoma. This aberrant expression can contribute to immune suppression and tumor progression. 2. **Autoimmune Diseases:** IGLV3-10 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus. The expression of lambda light chains can contribute to the formation of autoantibodies and immune complex-mediated tissue damage. 3. **Immunodeficiency Disorders:** Mutations in the IGLV3-10 gene can lead to immunodeficiency disorders, such as X-linked agammaglobulinemia. This condition is characterized by a lack of antibody production and increased susceptibility to infections. In conclusion, IGLV3-10 is a critical gene that plays a significant role in the adaptive immune response, immune cell activation, and antibody production. Its expression and function are tightly linked to the immune system, and aberrant expression can contribute to various diseases, including cancer and autoimmune disorders. Further research is needed to fully elucidate the role of IGLV3-10 in the immune system and its clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.