Details for: IGLV3 10

Gene ID: 28803

Symbol: IGLV3 10

Ensembl ID: ENSG00000211669

Description: immunoglobulin lambda variable 3-10

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 1.77
    Marker Score: 1,370
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.62
    Marker Score: 10,799
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 873
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7,574
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3,643
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32,725
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 799
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,815
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,400
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,951
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.83
    Marker Score: 1,099
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.8
    Marker Score: 734
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,258
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.74
    Marker Score: 624
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.56
    Marker Score: 318
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.55
    Marker Score: 591
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 435
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.53
    Marker Score: 6,121
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.51
    Marker Score: 496
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.51
    Marker Score: 1,268
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.41
    Marker Score: 363
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.36
    Marker Score: 169
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.35
    Marker Score: 684
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.34
    Marker Score: 143
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.32
    Marker Score: 169
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.28
    Marker Score: 76
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.27
    Marker Score: 221
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.2
    Marker Score: 52
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.19
    Marker Score: 126
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.18
    Marker Score: 196
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.16
    Marker Score: 56
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.16
    Marker Score: 55
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.15
    Marker Score: 128
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.14
    Marker Score: 170
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.12
    Marker Score: 103
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.12
    Marker Score: 69
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.11
    Marker Score: 51
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.11
    Marker Score: 101
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.1
    Marker Score: 136
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.1
    Marker Score: 167
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.1
    Marker Score: 96
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.1
    Marker Score: 63
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.09
    Marker Score: 86
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.09
    Marker Score: 114
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.08
    Marker Score: 63
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.08
    Marker Score: 55
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.08
    Marker Score: 68
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.08
    Marker Score: 102
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.08
    Marker Score: 173
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.08
    Marker Score: 36
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.08
    Marker Score: 55
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.08
    Marker Score: 42
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.08
    Marker Score: 42
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.07
    Marker Score: 167
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.07
    Marker Score: 119
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 133
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.07
    Marker Score: 45
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.06
    Marker Score: 58
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.06
    Marker Score: 61
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: enucleated reticulocyte (CL0002422)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.06
    Marker Score: 36
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.06
    Marker Score: 38
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.06
    Marker Score: 31
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.06
    Marker Score: 45
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.06
    Marker Score: 48
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.06
    Marker Score: 3,309
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.06
    Marker Score: 175
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.06
    Marker Score: 155
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.05
    Marker Score: 57
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.05
    Marker Score: 29
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.05
    Marker Score: 11
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.04
    Marker Score: 101
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.04
    Marker Score: 46
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.04
    Marker Score: 2,129
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.04
    Marker Score: 40
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.04
    Marker Score: 66
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.04
    Marker Score: 28
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.04
    Marker Score: 32
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.04
    Marker Score: 36
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.03
    Marker Score: 16

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Location and Structure:** IGLV3-10 is located on chromosome 22q11.23 and is part of the immunoglobulin gene family. The gene consists of several exons that encode for the variable region of the lambda light chain. 2. **Cell Type Expression:** IGLV3-10 is expressed in a variety of cell types, including CD16-positive natural killer cells, CD56-dim natural killer cells, goblet cells, and certain types of cancer cells. 3. **Alternative Splicing:** IGLV3-10 undergoes alternative splicing, resulting in multiple isoforms of the lambda light chain. 4. **Evolutionary Conservation:** IGLV3-10 is highly conserved across species, suggesting its importance in the immune system. **Pathways and Functions:** 1. **Adaptive Immune Response:** IGLV3-10 plays a crucial role in the adaptive immune response by encoding for the lambda light chain of antibodies. This light chain is essential for the proper assembly and secretion of antibodies. 2. **Immune Cell Activation:** IGLV3-10 is also involved in the activation of immune cells, including natural killer cells and T cells. This activation is mediated through the expression of specific cytokines and chemokines. 3. **Antibody Production:** The lambda light chain encoded by IGLV3-10 is involved in the production of antibodies, which are essential for the neutralization of pathogens and the elimination of foreign substances. 4. **Immune Cell Development:** IGLV3-10 is also involved in the development and maturation of immune cells, including natural killer cells and T cells. **Clinical Significance:** 1. **Cancer Immunosuppression:** Abnormal expression of IGLV3-10 has been observed in certain types of cancer, including multiple myeloma and lymphoma. This aberrant expression can contribute to immune suppression and tumor progression. 2. **Autoimmune Diseases:** IGLV3-10 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus. The expression of lambda light chains can contribute to the formation of autoantibodies and immune complex-mediated tissue damage. 3. **Immunodeficiency Disorders:** Mutations in the IGLV3-10 gene can lead to immunodeficiency disorders, such as X-linked agammaglobulinemia. This condition is characterized by a lack of antibody production and increased susceptibility to infections. In conclusion, IGLV3-10 is a critical gene that plays a significant role in the adaptive immune response, immune cell activation, and antibody production. Its expression and function are tightly linked to the immune system, and aberrant expression can contribute to various diseases, including cancer and autoimmune disorders. Further research is needed to fully elucidate the role of IGLV3-10 in the immune system and its clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.