Details for: SNRPD2

Gene ID: 6633

Symbol: SNRPD2

Ensembl ID: ENSG00000125743

Description: small nuclear ribonucleoprotein D2 polypeptide

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 535.1498
    Cell Significance Index: -83.2400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 285.0853
    Cell Significance Index: -72.3100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 276.9770
    Cell Significance Index: -114.1000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 258.3585
    Cell Significance Index: -104.9600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 236.2945
    Cell Significance Index: -111.5600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 223.1596
    Cell Significance Index: -114.7900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 166.7605
    Cell Significance Index: -111.9000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 111.2027
    Cell Significance Index: -106.1700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 83.1417
    Cell Significance Index: -102.5100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 28.3321
    Cell Significance Index: -111.8000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 25.7891
    Cell Significance Index: -79.2100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.2899
    Cell Significance Index: -51.6800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.5436
    Cell Significance Index: -31.8300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 6.3265
    Cell Significance Index: 169.2300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 6.1634
    Cell Significance Index: 129.0100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 5.9415
    Cell Significance Index: 156.2300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 5.8668
    Cell Significance Index: 63.7800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 5.4376
    Cell Significance Index: 43.4200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 4.7608
    Cell Significance Index: 60.9700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.7516
    Cell Significance Index: 139.5500
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.5013
    Cell Significance Index: 26.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.3604
    Cell Significance Index: 598.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 4.0991
    Cell Significance Index: 483.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.8286
    Cell Significance Index: 179.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.7582
    Cell Significance Index: 485.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 3.6774
    Cell Significance Index: 260.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.4631
    Cell Significance Index: 425.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.4226
    Cell Significance Index: 616.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.3268
    Cell Significance Index: 1816.8700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.1520
    Cell Significance Index: 1393.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.1364
    Cell Significance Index: 233.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.0835
    Cell Significance Index: 83.9300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.6281
    Cell Significance Index: 91.3300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.4856
    Cell Significance Index: 57.4300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.3934
    Cell Significance Index: 27.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.3348
    Cell Significance Index: 108.8600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.2316
    Cell Significance Index: 286.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.1189
    Cell Significance Index: 136.7000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.8162
    Cell Significance Index: 16.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.6252
    Cell Significance Index: 85.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5629
    Cell Significance Index: 70.8400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2900
    Cell Significance Index: 209.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2354
    Cell Significance Index: 35.6000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.1154
    Cell Significance Index: 19.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7779
    Cell Significance Index: 40.4100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.6594
    Cell Significance Index: 189.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.6480
    Cell Significance Index: 110.6500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6330
    Cell Significance Index: 11.7000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5344
    Cell Significance Index: 14.2700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4985
    Cell Significance Index: 450.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4562
    Cell Significance Index: 90.5300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.4519
    Cell Significance Index: 342.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1906
    Cell Significance Index: 38.2300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1858
    Cell Significance Index: 3.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1013
    Cell Significance Index: 19.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0974
    Cell Significance Index: 34.9400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0113
    Cell Significance Index: -8.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0315
    Cell Significance Index: -23.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0378
    Cell Significance Index: -3.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0425
    Cell Significance Index: -80.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0608
    Cell Significance Index: -112.1800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0645
    Cell Significance Index: -40.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0744
    Cell Significance Index: -114.5600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0816
    Cell Significance Index: -8.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0876
    Cell Significance Index: -119.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1293
    Cell Significance Index: -72.9300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1599
    Cell Significance Index: -4.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1603
    Cell Significance Index: -101.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2264
    Cell Significance Index: -102.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2386
    Cell Significance Index: -50.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3018
    Cell Significance Index: -34.5800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3593
    Cell Significance Index: -9.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3631
    Cell Significance Index: -12.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5002
    Cell Significance Index: -13.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6189
    Cell Significance Index: -72.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6491
    Cell Significance Index: -40.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.7327
    Cell Significance Index: -106.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7330
    Cell Significance Index: -15.8800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.7657
    Cell Significance Index: -6.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7896
    Cell Significance Index: -41.1300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.8063
    Cell Significance Index: -13.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.8104
    Cell Significance Index: -49.8100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.9366
    Cell Significance Index: -106.9100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.9381
    Cell Significance Index: -56.3200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.9443
    Cell Significance Index: -14.1500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0330
    Cell Significance Index: -81.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.0655
    Cell Significance Index: -110.9400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.1712
    Cell Significance Index: -65.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.1864
    Cell Significance Index: -38.0000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.3358
    Cell Significance Index: -102.5100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.3754
    Cell Significance Index: -8.3100
  • Cell Name: germ cell (CL0000586)
    Fold Change: -1.3813
    Cell Significance Index: -10.4300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.4937
    Cell Significance Index: -20.3800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -1.5305
    Cell Significance Index: -9.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.5336
    Cell Significance Index: -103.1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.6031
    Cell Significance Index: -110.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.6150
    Cell Significance Index: -99.0100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.8965
    Cell Significance Index: -55.8600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.9638
    Cell Significance Index: -49.0900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -2.1643
    Cell Significance Index: -18.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNRPD2 is a protein component of the spliceosome complex, which is responsible for the splicing of pre-mRNA into mature mRNA. The spliceosome complex is a dynamic and highly regulated process that requires precise coordination between various RNA and protein factors. SNRPD2 is specifically involved in the catalytic step 2 of the spliceosome, where it interacts with other spliceosomal components to facilitate the removal of introns and the joining of exons. This process is essential for the production of mature mRNA, which is then translated into proteins. **Pathways and Functions:** SNRPD2 is involved in several key pathways, including: 1. **RNA Splicing:** SNRPD2 plays a critical role in the catalytic step 2 of the spliceosome, where it facilitates the removal of introns and the joining of exons. 2. **Metabolism of Non-Coding RNA:** SNRPD2 is involved in the metabolism of non-coding RNA, including the regulation of microRNA and long non-coding RNA expression. 3. **Infectious Disease:** SNRPD2 has been implicated in the modulation of host translation machinery by SARS-CoV-2, a significant finding in the context of COVID-19. 4. **Cytosol and Nucleus:** SNRPD2 is localized to both the cytosol and nucleus, where it interacts with other RNA and protein factors to regulate gene expression. **Clinical Significance:** The clinical significance of SNRPD2 is multifaceted: 1. **Immunological Disorders:** SNRPD2 has been implicated in various immunological disorders, including cancer and autoimmune diseases, where its dysregulation can lead to impaired immune function. 2. **SARS-CoV-2 Infection:** SNRPD2's role in modulating host translation machinery by SARS-CoV-2 highlights its potential as a therapeutic target for COVID-19 treatment. 3. **Cancer:** SNRPD2 has been identified as a potential biomarker for cancer diagnosis and prognosis, where its expression levels can be used to predict disease outcome. 4. **Neurological Disorders:** SNRPD2's involvement in the metabolism of non-coding RNA suggests its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, SNRPD2 is a multifaceted gene that plays a critical role in regulating immune responses and modulating host translation machinery in response to SARS-CoV-2 infection. Its dysregulation has been implicated in various immunological disorders, and its potential as a therapeutic target and biomarker warrants further investigation.

Genular Protein ID: 1010762685

Symbol: SMD2_HUMAN

Name: Small nuclear ribonucleoprotein Sm D2

UniProtKB Accession Codes:

P62316 A8K797 J3KPM5 P43330

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 4 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 8 EMDB 49 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 55 PDBsum 55 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7527560

Title: cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction.

PubMed ID: 7527560

DOI: 10.1073/pnas.91.25.12317

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10500148

Title: SMN mutants of spinal muscular atrophy patients are defective in binding to snRNP proteins.

PubMed ID: 10500148

DOI: 10.1073/pnas.96.20.11167

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15146077

Title: The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.

PubMed ID: 15146077

DOI: 10.1261/rna.7320604

PubMed ID: 16314521

Title: Specific sequence features, recognized by the SMN complex, identify snRNAs and determine their fate as snRNPs.

PubMed ID: 16314521

DOI: 10.1128/mcb.25.24.10989-11004.2005

PubMed ID: 18984161

Title: An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs.

PubMed ID: 18984161

DOI: 10.1016/j.cell.2008.09.020

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 10025403

Title: Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs.

PubMed ID: 10025403

DOI: 10.1016/s0092-8674(00)80550-4

PubMed ID: 19325628

Title: Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution.

PubMed ID: 19325628

DOI: 10.1038/nature07851

PubMed ID: 21816274

Title: Structure of a key intermediate of the SMN complex reveals Gemin2's crucial function in snRNP assembly.

PubMed ID: 21816274

DOI: 10.1016/j.cell.2011.06.043

PubMed ID: 21516107

Title: Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis.

PubMed ID: 21516107

DOI: 10.1038/nature09956

PubMed ID: 23333303

Title: Structural basis of assembly chaperone-mediated snRNP formation.

PubMed ID: 23333303

DOI: 10.1016/j.molcel.2012.12.009

PubMed ID: 25555158

Title: Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition.

PubMed ID: 25555158

DOI: 10.7554/elife.04986

PubMed ID: 26912367

Title: Molecular architecture of the human U4/U6.U5 tri-snRNP.

PubMed ID: 26912367

DOI: 10.1126/science.aad2085

PubMed ID: 28502770

Title: An Atomic Structure of the Human Spliceosome.

PubMed ID: 28502770

DOI: 10.1016/j.cell.2017.04.033

PubMed ID: 28781166

Title: Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.

PubMed ID: 28781166

DOI: 10.1016/j.cell.2017.07.011

PubMed ID: 28076346

Title: Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

PubMed ID: 28076346

DOI: 10.1038/nature21079

PubMed ID: 31799625

Title: Negative cooperativity between Gemin2 and RNA provides insights into RNA selection and the SMN complex's release in snRNP assembly.

PubMed ID: 31799625

DOI: 10.1093/nar/gkz1135

PubMed ID: 32494006

Title: Molecular architecture of the human 17S U2 snRNP.

PubMed ID: 32494006

DOI: 10.1038/s41586-020-2344-3

PubMed ID: 33509932

Title: Structure of the activated human minor spliceosome.

PubMed ID: 33509932

DOI: 10.1126/science.abg0879

PubMed ID: 36797247

Title: Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly.

PubMed ID: 36797247

DOI: 10.1038/s41467-023-36489-x

Sequence Information:

  • Length: 118
  • Mass: 13527
  • Checksum: D986059D82B7E045
  • Sequence:
    • MSLLNKPKSE MTPEELQKRE EEEFNTGPLS VLTQSVKNNT QVLINCRNNK KLLGRVKAFD 
RHCNMVLENV KEMWTEVPKS GKGKKKSKPV NKDRYISKMF LRGDSVIVVL RNPLIAGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.