Details for: FXYD5
Gene ID: 53827
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: FXYD5
Ensembl ID: ENSG00000089327
Description: FXYD domain containing ion transport regulator 5
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 108.24rCSI 71.95%PRS 6.8
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CSI 96.56rCSI 57.02%PRS 7.93
-
CSI 94.73rCSI 63.82%PRS 6.88
-
CSI 86.53rCSI 69.96%PRS 5.6
-
CSI 84.7rCSI 73.34%PRS 6.35
-
CSI 82.32rCSI 61.85%PRS 5.87
-
CSI 81.34rCSI 61.53%PRS 7.96
-
CSI 78.34rCSI 70.74%PRS 5.04
-
CSI 74.44rCSI 77.98%PRS 6.08
-
CSI 71.04rCSI 53.16%PRS 9.32
-
CSI 68.8rCSI 49.39%PRS 7.78
-
CSI 66.39rCSI 44.25%PRS 15.89
-
CSI 64.6rCSI 49.77%PRS 5.16
-
CSI 63.66rCSI 44.71%PRS 16.65
-
CSI 61.18rCSI 48.58%PRS 10.11
-
CSI 60.25rCSI 48.68%PRS 12.57
-
CSI 57.93rCSI 45.57%PRS 6.79
-
CSI 54.63rCSI 40.78%PRS 9.67
-
CSI 54.58rCSI 46.82%PRS 14.01
-
CSI 54.09rCSI 78.01%PRS 7.95
-
CSI 52.2rCSI 39.14%PRS 17
-
CSI 51.7rCSI 47.47%PRS 6.54
-
CSI 51.48rCSI 70.13%PRS 14.31
-
CSI 50.16rCSI 40.18%PRS 10.53
-
CSI 49.8rCSI 48.91%PRS 9.11
-
CSI 49.61rCSI 62.34%PRS 29.43
-
CSI 48.78rCSI 45.1%PRS 10.46
-
CSI 48.04rCSI 82.3%PRS 7.65
-
CSI 47.79rCSI 57.72%PRS 6.71
-
CSI 45.42rCSI 77.7%PRS 12.38
-
CSI 43.48rCSI 48.94%PRS 9.4
-
CSI 41.69rCSI 83.11%PRS 9.8
-
CSI 40.81rCSI 40.3%PRS 24.49
-
CSI 38.98rCSI 34.23%PRS 6.4
-
CSI 37.23rCSI 38.89%PRS 18.19
-
CSI 35.93rCSI 42.2%PRS 48.57
-
CSI 35.55rCSI 43.97%PRS 4.99
-
CSI 34.88rCSI 43.77%PRS 7.26
-
CSI 34.25rCSI 54.89%PRS 18.88
-
CSI 33.39rCSI 60.27%PRS 17.01
-
CSI 33.16rCSI 28.82%PRS 7.02
-
CSI 29.87rCSI 24.93%PRS 18.41
-
CSI 29.27rCSI 20.37%PRS 8.26
-
CSI 29.11rCSI 33.75%PRS 19.21
-
CSI 28.49rCSI 19.89%PRS 6.01
-
CSI 26.07rCSI 20.28%PRS 8.21
-
CSI 25.4rCSI 37.66%PRS 52.76
-
CSI 24.83rCSI 31.78%PRS 73.8
-
CSI 24.68rCSI 36.15%PRS 32.86
-
CSI 24rCSI 23.59%PRS 16.97
-
CSI 23.73rCSI 32.6%PRS 12.26
-
CSI 23.11rCSI 28%PRS 8.38
-
CSI 22.9rCSI 37.72%PRS 6.7
-
CSI 22.7rCSI 29.03%PRS 26
-
CSI 21.76rCSI 44.93%PRS 9.22
-
CSI 21.75rCSI 28.5%PRS 8.01
-
CSI 21.25rCSI 26.46%PRS 8.31
-
CSI 20.59rCSI 23.57%PRS 11.84
-
CSI 20.58rCSI 20.85%PRS 35.33
-
CSI 20.26rCSI 15.41%PRS 7.54
-
CSI 19.72rCSI 23.54%PRS 9.95
-
CSI 19.38rCSI 46.64%PRS 8.99
-
CSI 18.02rCSI 33.02%PRS 34.61
-
CSI 17.97rCSI 16.37%PRS 8.91
-
CSI 17.47rCSI 24.71%PRS 8.38
-
CSI 17.37rCSI 38.23%PRS 6.26
-
CSI 16.63rCSI 20.91%PRS 8.8
-
CSI 16.6rCSI 15.31%PRS 5.78
-
CSI 16.24rCSI 14.22%PRS 7.71
-
CSI 15.85rCSI 24.22%PRS 7.16
-
CSI 15.81rCSI 13.25%PRS 6.83
-
CSI 15.4rCSI 30.1%PRS 56.95
-
CSI 15.33rCSI 82.95%PRS 20.16
-
CSI 15.3rCSI 23.86%PRS 14.63
-
CSI 15.09rCSI 13.01%PRS 9.45
-
CSI 14.8rCSI 12.26%PRS 5.71
-
CSI 14.6rCSI 63.33%PRS 10.61
-
CSI 14.58rCSI 47.72%PRS 17.41
-
CSI 14.52rCSI 74.98%PRS 11.47
-
CSI 14.36rCSI 19.22%PRS 30.58
-
CSI 14.08rCSI 17.35%PRS 19.31
-
CSI 13.63rCSI 9.48%PRS 6.69
-
CSI 13.63rCSI 28.28%PRS 5.7
-
CSI 13.36rCSI 11.24%PRS 9.52
-
CSI 13.17rCSI 13.55%PRS 9.27
-
CSI 13.11rCSI 25.41%PRS 64.04
-
CSI 12.79rCSI 49.8%PRS 9.44
-
CSI 12.74rCSI 21.76%PRS 11.84
-
CSI 12.49rCSI 24.05%PRS 13.06
-
CSI 12.45rCSI 26.89%PRS 32.29
-
CSI 12.35rCSI 50.85%PRS 30.39
-
CSI 11.96rCSI 32.63%PRS 25.52
-
CSI 11.91rCSI 18.19%PRS 10.05
-
CSI 11.8rCSI 16.05%PRS 8.8
-
CSI 11.54rCSI 20.99%PRS 27.02
-
CSI 11.5rCSI 15.92%PRS 8.24
-
CSI 11.43rCSI 14.99%PRS 29.68
-
CSI 11.33rCSI 23.29%PRS 6.3
-
CSI 11.3rCSI 20.42%PRS 16.31
-
CSI 11.27rCSI 29.9%PRS 9.73
-
CSI -14.6rCSI -54.7%PRS 4.9%
-
CSI -11.3rCSI -36.5%PRS 7.0%
-
CSI -5.0rCSI -5.2%PRS 5.9%
-
CSI -4.2rCSI -11.0%PRS 6.5%
-
CSI -4.2rCSI -33.8%PRS 6.1%
-
CSI -3.7rCSI -8.5%PRS 5.6%
-
CSI -3.5rCSI -9.1%PRS 6.9%
-
CSI -3.0rCSI -14.2%PRS 9.0%
-
CSI -2.1rCSI -4.0%PRS 9.2%
-
CSI -1.8rCSI -2.5%PRS 5.1%
-
CSI -1.4rCSI -2.2%PRS 5.8%
-
CSI -1.3rCSI -2.4%PRS 12.8%
-
CSI 0.0rCSI 0.1%PRS 5.3%
-
CSI 0.2rCSI 5.1%PRS 13.8%
-
CSI 0.2rCSI 0.2%PRS 6.2%
-
CSI 0.3rCSI 0.6%PRS 5.8%
-
CSI 0.3rCSI 7.1%PRS 20.2%
-
CSI 0.3rCSI 1.4%PRS 14.3%
-
CSI 0.3rCSI 0.5%PRS 5.2%
-
CSI 0.5rCSI 4.0%PRS 32.4%
-
CSI 0.5rCSI 10.7%PRS 73.9%
-
CSI 0.6rCSI 3.2%PRS 28.5%
-
CSI 0.6rCSI 10.8%PRS 44.4%
-
CSI 0.6rCSI 5.7%PRS 22.9%
-
CSI 0.7rCSI 15.4%PRS 39.1%
-
CSI 0.8rCSI 1.2%PRS 9.3%
-
CSI 0.8rCSI 0.9%PRS 6.7%
-
CSI 0.8rCSI 1.5%PRS 8.7%
-
CSI 0.8rCSI 0.9%PRS 6.7%
-
CSI 0.9rCSI 17.8%PRS 20.5%
-
CSI 1.0rCSI 9.5%PRS 52.8%
-
CSI 1.0rCSI 30.0%PRS 60.9%
-
CSI 1.0rCSI 1.4%PRS 6.6%
-
CSI 1.0rCSI 5.6%PRS 8.8%
-
CSI 1.1rCSI 1.5%PRS 8.4%
-
CSI 1.1rCSI 8.0%PRS 18.6%
-
CSI 1.2rCSI 2.6%PRS 11.7%
-
CSI 1.2rCSI 31.6%PRS 32.6%
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CSI 1.4rCSI 10.9%PRS 25.8%
-
CSI 1.4rCSI 2.4%PRS 4.4%
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CSI 1.5rCSI 7.4%PRS 7.8%
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CSI 1.5rCSI 32.0%PRS 34.9%
-
CSI 1.5rCSI 1.5%PRS 6.0%
-
CSI 1.6rCSI 3.7%PRS 7.6%
-
CSI 1.6rCSI 2.2%PRS 6.2%
-
CSI 1.6rCSI 7.4%PRS 25.4%
-
CSI 1.7rCSI 7.7%PRS 25.8%
-
CSI 1.9rCSI 3.6%PRS 7.1%
-
CSI 2.0rCSI 3.1%PRS 5.4%
-
CSI 2.1rCSI 5.8%PRS 26.9%
-
CSI 2.1rCSI 4.5%PRS 9.3%
-
CSI 2.2rCSI 3.2%PRS 6.1%
-
CSI 2.2rCSI 10.2%PRS 15.0%
-
CSI 2.2rCSI 6.3%PRS 11.6%
-
CSI 2.3rCSI 10.5%PRS 30.3%
-
CSI 2.5rCSI 25.2%PRS 47.5%
-
CSI 2.5rCSI 59.5%PRS 21.5%
-
CSI 2.5rCSI 2.6%PRS 8.2%
-
CSI 2.6rCSI 7.6%PRS 15.2%
-
CSI 2.7rCSI 4.1%PRS 6.6%
-
CSI 2.9rCSI 54.4%PRS 43.9%
-
CSI 2.9rCSI 2.3%PRS 3.9%
-
CSI 3.0rCSI 3.1%PRS 10.2%
-
CSI 3.0rCSI 7.2%PRS 19.6%
-
CSI 3.4rCSI 4.9%PRS 6.8%
-
CSI 3.4rCSI 8.1%PRS 38.3%
-
CSI 3.4rCSI 9.8%PRS 6.5%
-
CSI 3.5rCSI 5.4%PRS 5.7%
-
CSI 3.6rCSI 4.1%PRS 4.2%
-
CSI 3.6rCSI 14.2%PRS 10.2%
-
CSI 3.6rCSI 6.4%PRS 9.9%
-
CSI 3.6rCSI 39.0%PRS 27.5%
-
CSI 3.6rCSI 22.1%PRS 19.2%
-
CSI 3.7rCSI 21.0%PRS 9.0%
-
CSI 3.8rCSI 5.6%PRS 9.0%
-
CSI 4.2rCSI 19.3%PRS 12.6%
-
CSI 4.2rCSI 14.9%PRS 9.4%
-
CSI 4.4rCSI 20.0%PRS 21.4%
-
CSI 4.4rCSI 80.7%PRS 15.3%
-
CSI 4.5rCSI 7.3%PRS 9.3%
-
CSI 4.6rCSI 4.3%PRS 5.8%
-
CSI 4.7rCSI 25.5%PRS 13.4%
-
CSI 4.8rCSI 4.6%PRS 12.3%
-
CSI 5.0rCSI 8.6%PRS 4.4%
-
CSI 5.0rCSI 15.4%PRS 11.1%
-
CSI 5.1rCSI 6.8%PRS 6.2%
-
CSI 5.2rCSI 14.9%PRS 10.1%
-
CSI 5.3rCSI 12.6%PRS 9.3%
-
CSI 5.5rCSI 31.9%PRS 8.6%
-
CSI 5.5rCSI 7.5%PRS 6.5%
-
CSI 5.6rCSI 5.8%PRS 6.0%
-
CSI 5.6rCSI 23.0%PRS 15.9%
-
CSI 5.7rCSI 75.4%PRS 20.1%
-
CSI 5.8rCSI 5.2%PRS 5.7%
-
CSI 6.0rCSI 43.6%PRS 16.2%
-
CSI 6.0rCSI 33.9%PRS 18.7%
-
CSI 6.0rCSI 7.1%PRS 8.9%
-
CSI 6.2rCSI 22.3%PRS 9.9%
-
CSI 6.5rCSI 12.3%PRS 16.4%
-
CSI 6.6rCSI 12.8%PRS 5.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1775809277
Symbol: FXYD5_HUMAN
Name: FXYD domain-containing ion transport regulator 5
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11342114
Title: A cDNA from human bone marrow encoding a protein exhibiting homology to the ATP11/PLM/MAT8 family of transmembrane proteins.
PubMed ID: 11342114
PubMed ID: 11756660
Title: Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis.
PubMed ID: 11756660
PubMed ID: 11042152
Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
PubMed ID: 11042152
DOI: 10.1101/gr.140200
PubMed ID: 12975309
Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
PubMed ID: 12975309
DOI: 10.1101/gr.1293003
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 18263667
Title: FXYD5 modulates Na+ absorption and is increased in cystic fibrosis airway epithelia.
PubMed ID: 18263667
Sequence Information:
- Length: 178
- Mass: 19472
- Checksum: 7429C04838B75AA1
- Sequence:
MSPSGRLCLL TIVGLILPTR GQTLKDTTSS SSADSTIMDI QVPTRAPDAV YTELQPTSPT PTWPADETPQ PQTQTQQLEG TDGPLVTDPE THKSTKAAHP TDDTTTLSER PSPSTDVQTD PQTLKPSGFH EDDPFFYDEH TLRKRGLLVA AVLFITGIII LTSGKCRQLS RLCRNRCR
Genular Protein ID: 1591861194
Symbol: F5H4X8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
Sequence Information:
- Length: 194
- Mass: 21092
- Checksum: DC72E64276C81AA4
- Sequence:
MSPSGRLCLL TIVGLILPTR GQTLKDTTSS SSADSTIMDI QVPTRAPDAV YTELQPTSPT PTWPADETPQ PQTQTQQLEG TDGPLVTDPE THKSTKAAHP TDDTTTLSER PSPSTDVQTD PQTLKPSGFH EDDPFFYDEH TLRKRGLLVA AVLFITGIII LTSENWGWVG RTPRPGGGLM TEGWVLKGPW AILF