Details for: CUTA

Gene ID: 51596

Symbol: CUTA

Ensembl ID: ENSG00000112514

Description: cutA divalent cation tolerance homolog

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 442.6365
    Cell Significance Index: -68.8500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 210.8278
    Cell Significance Index: -86.8500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 209.3096
    Cell Significance Index: -53.0900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 192.4643
    Cell Significance Index: -78.1900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 182.5585
    Cell Significance Index: -86.1900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 168.5702
    Cell Significance Index: -86.7100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 128.9525
    Cell Significance Index: -86.5300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 83.3628
    Cell Significance Index: -79.5900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 63.1247
    Cell Significance Index: -77.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 21.0394
    Cell Significance Index: -83.0200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 18.2747
    Cell Significance Index: -56.1300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.4991
    Cell Significance Index: -41.5200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.5672
    Cell Significance Index: -18.7500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 6.9261
    Cell Significance Index: 55.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.2955
    Cell Significance Index: 246.9000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.3771
    Cell Significance Index: 119.1400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.8418
    Cell Significance Index: 133.5000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.7890
    Cell Significance Index: 111.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.5040
    Cell Significance Index: 481.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.4177
    Cell Significance Index: 441.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.2740
    Cell Significance Index: 244.0100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.0015
    Cell Significance Index: 32.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.9305
    Cell Significance Index: 137.7300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.7984
    Cell Significance Index: 58.5800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.7497
    Cell Significance Index: 35.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.4916
    Cell Significance Index: 1360.7200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.4828
    Cell Significance Index: 57.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.4598
    Cell Significance Index: 64.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.4486
    Cell Significance Index: 128.5600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.4341
    Cell Significance Index: 14.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.9013
    Cell Significance Index: 134.4700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.8948
    Cell Significance Index: 232.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.7794
    Cell Significance Index: 320.7700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.7705
    Cell Significance Index: 782.7900
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.7038
    Cell Significance Index: 10.0100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5104
    Cell Significance Index: 245.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.4345
    Cell Significance Index: 169.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.3607
    Cell Significance Index: 174.4400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.3525
    Cell Significance Index: 12.4600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3147
    Cell Significance Index: 84.8200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.1681
    Cell Significance Index: 13.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1317
    Cell Significance Index: 58.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.8250
    Cell Significance Index: 140.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8163
    Cell Significance Index: 80.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7203
    Cell Significance Index: 32.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6776
    Cell Significance Index: 128.9500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3912
    Cell Significance Index: 11.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2048
    Cell Significance Index: 40.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1754
    Cell Significance Index: 35.1800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1592
    Cell Significance Index: 116.7000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1586
    Cell Significance Index: 120.0100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1159
    Cell Significance Index: 1.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0763
    Cell Significance Index: 27.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0142
    Cell Significance Index: -0.8900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0173
    Cell Significance Index: -0.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0175
    Cell Significance Index: -32.8900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0187
    Cell Significance Index: -0.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0252
    Cell Significance Index: -18.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0400
    Cell Significance Index: -4.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0522
    Cell Significance Index: -96.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0601
    Cell Significance Index: -92.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0696
    Cell Significance Index: -94.5700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0803
    Cell Significance Index: -3.2900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0859
    Cell Significance Index: -53.6400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0980
    Cell Significance Index: -62.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1015
    Cell Significance Index: -57.2400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1480
    Cell Significance Index: -2.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1516
    Cell Significance Index: -31.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1689
    Cell Significance Index: -5.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1716
    Cell Significance Index: -77.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2439
    Cell Significance Index: -8.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2458
    Cell Significance Index: -6.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2969
    Cell Significance Index: -34.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3002
    Cell Significance Index: -86.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3101
    Cell Significance Index: -17.4000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3335
    Cell Significance Index: -8.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4360
    Cell Significance Index: -63.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4370
    Cell Significance Index: -50.9300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4804
    Cell Significance Index: -54.8400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5529
    Cell Significance Index: -28.8000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6449
    Cell Significance Index: -11.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.6525
    Cell Significance Index: -45.1300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7875
    Cell Significance Index: -62.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7988
    Cell Significance Index: -83.1700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.8279
    Cell Significance Index: -49.7000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.9389
    Cell Significance Index: -12.8100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.9892
    Cell Significance Index: -21.4300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.9931
    Cell Significance Index: -17.1200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.0784
    Cell Significance Index: -18.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.0950
    Cell Significance Index: -84.0300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.3852
    Cell Significance Index: -40.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.4078
    Cell Significance Index: -86.3100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.4957
    Cell Significance Index: -17.8300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.5757
    Cell Significance Index: -23.6100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.7601
    Cell Significance Index: -38.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.8098
    Cell Significance Index: -80.0500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.8524
    Cell Significance Index: -15.5600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.8761
    Cell Significance Index: -68.8700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.8866
    Cell Significance Index: -19.5300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.9331
    Cell Significance Index: -49.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Divalent cation tolerance homolog**: CUTA is a homolog of copper ion binding proteins, which suggests its role in regulating metal ion homeostasis. 2. **Cellular expression**: CUTA is expressed in diverse cell types, including polychromatophilic erythroblasts, embryonic stem cells, and hematopoietic oligopotent progenitor cells. 3. **Metal ion binding**: CUTA's ability to bind divalent cations, such as copper and zinc, is essential for its function in regulating metal ion homeostasis. 4. **Response to metal ion stress**: CUTA's expression is induced in response to metal ion stress, suggesting its role in protecting cells against oxidative damage. **Pathways and Functions:** 1. **Copper ion homeostasis**: CUTA regulates copper ion homeostasis by binding and sequestering copper ions, preventing their accumulation and oxidative damage. 2. **Redox balance**: CUTA helps maintain redox balance by regulating the activity of enzymes involved in redox reactions. 3. **Protein stability**: CUTA's ability to bind divalent cations helps maintain protein stability by preventing protein misfolding and aggregation. 4. **Cellular signaling**: CUTA may participate in cellular signaling pathways, including those involved in inflammation and immune responses. **Clinical Significance:** 1. **Copper metabolism disorders**: Mutations in the CUTA gene may contribute to copper metabolism disorders, such as Menkes disease and Wilson's disease. 2. **Cancer**: CUTA's role in regulating metal ion homeostasis may be involved in cancer development and progression, particularly in tumors with high metal ion content. 3. **Inflammatory diseases**: CUTA's involvement in cellular signaling pathways may contribute to the development of inflammatory diseases, such as atherosclerosis and autoimmune disorders. 4. **Stem cell regulation**: CUTA's expression in embryonic stem cells and hematopoietic oligopotent progenitor cells suggests its role in regulating stem cell fate and differentiation. In conclusion, CUTA is a critical gene involved in regulating metal ion homeostasis, maintaining redox balance, and participating in cellular signaling pathways. Its dysregulation may contribute to various diseases, including copper metabolism disorders, cancer, and inflammatory diseases. Further research is needed to fully elucidate the functions of CUTA and its role in human disease.

Genular Protein ID: 2057687587

Symbol: CUTA_HUMAN

Name: Protein CutA

UniProtKB Accession Codes:

O60888 A2AB26 A2BEL4 Q3B784 Q5JXM9 Q5SU05 Q9NYQ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 8 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRIDE 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 5 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10800960

Title: Hydrophobic protein that copurifies with human brain acetylcholinesterase: amino acid sequence, genomic organization, and chromosomal localization.

PubMed ID: 10800960

DOI: 10.1046/j.1471-4159.2000.0742146.x

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10954708

Title: Two distinct proteins are associated with tetrameric acetylcholinesterase on the cell surface.

PubMed ID: 10954708

DOI: 10.1074/jbc.m004289200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 179
  • Mass: 19116
  • Checksum: B8EBD7F8C069862A
  • Sequence:
    • MSGGRAPAVL LGGVASLLLS FVWMPALLPV ASRLLLLPRV LLTMASGSPP TQPSPASDSG 
SGYVPGSVSA AFVTCPNEKV AKEIARAVVE KRLAACVNLI PQITSIYEWK GKIEEDSEVL 
MMIKTQSSLV PALTDFVRSV HPYEVAEVIA LPVEQGNFPY LQWVRQVTES VSDSITVLP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.