Details for: ARL1

Gene ID: 400

Symbol: ARL1

Ensembl ID: ENSG00000120805

Description: ARF like GTPase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 262.8175
    Cell Significance Index: -40.8800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 156.7949
    Cell Significance Index: -39.7700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 104.0424
    Cell Significance Index: -42.8600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 96.2462
    Cell Significance Index: -45.4400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 88.6631
    Cell Significance Index: -36.0200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 67.8517
    Cell Significance Index: -45.5300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.9788
    Cell Significance Index: -36.2600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.3054
    Cell Significance Index: -43.5300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.0993
    Cell Significance Index: -37.7700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.2112
    Cell Significance Index: -44.2400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.9236
    Cell Significance Index: -30.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.7884
    Cell Significance Index: 130.0100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.4109
    Cell Significance Index: 144.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.2231
    Cell Significance Index: 60.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4848
    Cell Significance Index: 77.1300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4718
    Cell Significance Index: 1328.8900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.4587
    Cell Significance Index: 33.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.4388
    Cell Significance Index: 197.5900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.3699
    Cell Significance Index: 12.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3269
    Cell Significance Index: 239.2000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.1624
    Cell Significance Index: 12.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.1560
    Cell Significance Index: 54.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1415
    Cell Significance Index: 140.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1334
    Cell Significance Index: 618.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0378
    Cell Significance Index: 77.3500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.0070
    Cell Significance Index: 8.0400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8753
    Cell Significance Index: 25.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8734
    Cell Significance Index: 111.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8412
    Cell Significance Index: 136.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8331
    Cell Significance Index: 52.5100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.7484
    Cell Significance Index: 9.5900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7475
    Cell Significance Index: 51.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7319
    Cell Significance Index: 323.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7009
    Cell Significance Index: 18.7800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6214
    Cell Significance Index: 123.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6090
    Cell Significance Index: 43.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6062
    Cell Significance Index: 27.4800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5924
    Cell Significance Index: 12.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5864
    Cell Significance Index: 117.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5705
    Cell Significance Index: 12.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5591
    Cell Significance Index: 14.9300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5472
    Cell Significance Index: 70.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5070
    Cell Significance Index: 86.5800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4789
    Cell Significance Index: 16.6400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3106
    Cell Significance Index: 8.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2846
    Cell Significance Index: 102.0700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1843
    Cell Significance Index: 21.7300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1490
    Cell Significance Index: 14.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1480
    Cell Significance Index: 7.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1335
    Cell Significance Index: 25.4100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1129
    Cell Significance Index: 2.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0962
    Cell Significance Index: 5.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0700
    Cell Significance Index: 52.9900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0566
    Cell Significance Index: 39.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0553
    Cell Significance Index: 0.9300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0509
    Cell Significance Index: 37.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0138
    Cell Significance Index: 25.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0035
    Cell Significance Index: -2.6000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0198
    Cell Significance Index: -36.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0241
    Cell Significance Index: -37.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0251
    Cell Significance Index: -15.9700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0318
    Cell Significance Index: -43.1800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0338
    Cell Significance Index: -21.1100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0372
    Cell Significance Index: -7.8300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0383
    Cell Significance Index: -3.9100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0458
    Cell Significance Index: -0.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0477
    Cell Significance Index: -26.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0608
    Cell Significance Index: -27.6000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0803
    Cell Significance Index: -5.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0976
    Cell Significance Index: -28.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1039
    Cell Significance Index: -11.9000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.1438
    Cell Significance Index: -0.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1537
    Cell Significance Index: -9.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1802
    Cell Significance Index: -5.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1915
    Cell Significance Index: -22.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1930
    Cell Significance Index: -28.0600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2612
    Cell Significance Index: -7.6700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2847
    Cell Significance Index: -3.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3149
    Cell Significance Index: -21.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3168
    Cell Significance Index: -24.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3242
    Cell Significance Index: -9.0600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3367
    Cell Significance Index: -5.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3527
    Cell Significance Index: -19.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3737
    Cell Significance Index: -29.6000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3938
    Cell Significance Index: -44.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4061
    Cell Significance Index: -42.2800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4630
    Cell Significance Index: -5.2600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5062
    Cell Significance Index: -25.5800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5941
    Cell Significance Index: -17.5000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5999
    Cell Significance Index: -36.7800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6122
    Cell Significance Index: -27.0800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6345
    Cell Significance Index: -16.2100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.6851
    Cell Significance Index: -7.0900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7089
    Cell Significance Index: -17.7200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7214
    Cell Significance Index: -14.0800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.7448
    Cell Significance Index: -7.7100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7467
    Cell Significance Index: -19.9800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7590
    Cell Significance Index: -28.7400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.8129
    Cell Significance Index: -9.6900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.8199
    Cell Significance Index: -13.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The ARL1 gene is characterized by its ability to regulate the dynamics of intracellular vesicle trafficking, including endocytosis, exocytosis, and retrograde transport. The protein is a GTPase, which means it hydrolyzes GTP to GDP, regulating its activity and localization within the cell. ARL1 interacts with other proteins, such as ARF GTPase-activating proteins (GAPs) and ARF GTP-binding proteins (GBPs), to modulate its activity and regulate membrane trafficking. The gene is also involved in the regulation of protein localization, including the targeting of proteins to specific compartments within the cell. **Pathways and Functions** The ARL1 gene is involved in several key pathways, including: 1. **Intracellular protein transport**: ARL1 regulates the transport of proteins between different compartments within the cell, including the Golgi apparatus, endosomes, and lysosomes. 2. **Vesicle-mediated transport**: ARL1 modulates the formation and movement of vesicles within the cell, including endocytosis and exocytosis. 3. **Retrograde transport**: ARL1 is involved in the transport of proteins from the Golgi apparatus to the endoplasmic reticulum (ER) and other compartments within the cell. 4. **Golgi organization**: ARL1 regulates the organization and function of the Golgi apparatus, including the targeting of proteins to specific compartments within the Golgi. **Clinical Significance** Dysregulation of the ARL1 gene has been implicated in several diseases, including: 1. **Cancer**: Overexpression of ARL1 has been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Neurodegenerative diseases**: Mutations in the ARL1 gene have been associated with neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Immunological disorders**: ARL1 has been implicated in the regulation of immune cell function and has been associated with autoimmune diseases, such as rheumatoid arthritis and lupus. In summary, the ARL1 gene plays a critical role in regulating various cellular processes, including vesicle-mediated transport, protein localization, and intracellular trafficking. Its dysregulation has been implicated in several diseases, highlighting the importance of this gene in maintaining cellular homeostasis and preventing disease.

Genular Protein ID: 608855532

Symbol: ARL1_HUMAN

Name: ADP-ribosylation factor-like protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7814376

Title: Different ARF domains are required for the activation of cholera toxin and phospholipase D.

PubMed ID: 7814376

DOI: 10.1074/jbc.270.1.21

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9624189

Title: Phospholipid- and GTP-dependent activation of cholera toxin and phospholipase D by human ADP-ribosylation factor-like protein 1 (HARL1).

PubMed ID: 9624189

DOI: 10.1074/jbc.273.25.15872

PubMed ID: 11303027

Title: ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins.

PubMed ID: 11303027

DOI: 10.1074/jbc.m102359200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21239483

Title: Arfaptins are localized to the trans-Golgi by interaction with Arl1, but not Arfs.

PubMed ID: 21239483

DOI: 10.1074/jbc.m110.201442

PubMed ID: 22981988

Title: The BAR domain protein Arfaptin-1 controls secretory granule biogenesis at the trans-Golgi network.

PubMed ID: 22981988

DOI: 10.1016/j.devcel.2012.07.019

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 14580338

Title: Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus.

PubMed ID: 14580338

DOI: 10.1016/s1097-2765(03)00356-3

PubMed ID: 27436755

Title: Structural basis for targeting BIG1 to Golgi apparatus through interaction of its DCB domain with Arl1.

PubMed ID: 27436755

DOI: 10.1093/jmcb/mjw033

PubMed ID: 22679020

Title: Structural basis for membrane binding specificity of the Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin-2 determined by Arl1 GTPase.

PubMed ID: 22679020

DOI: 10.1074/jbc.m112.365783

PubMed ID: 27373159

Title: Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi.

PubMed ID: 27373159

DOI: 10.1016/j.celrep.2016.06.022

Sequence Information:

  • Length: 181
  • Mass: 20418
  • Checksum: 9FB736C8ED60DC3D
  • Sequence:
  • MGGFFSSIFS SLFGTREMRI LILGLDGAGK TTILYRLQVG EVVTTIPTIG FNVETVTYKN 
    LKFQVWDLGG QTSIRPYWRC YYSNTDAVIY VVDSCDRDRI GISKSELVAM LEEEELRKAI 
    LVVFANKQDM EQAMTSSEMA NSLGLPALKD RKWQIFKTSA TKGTGLDEAM EWLVETLKSR 
    Q

Genular Protein ID: 240668589

Symbol: B4DZG7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 135
  • Mass: 15443
  • Checksum: 072FA0F481008BB8
  • Sequence:
  • MAIGFNVETV TYKNLKFQVW DLGGQTSIRP YWRCYYSNTD AVIYVVDSCD RDRIGISKSE 
    LVAMLEEEEL RKAILVVFAN KQDMEQAMTS SEMANSLGLP ALKDRKWQIF KTSATKGTGL 
    DEAMEWLVET LKSRQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.