Details for: ARL1

Gene ID: 400

Symbol: ARL1

Ensembl ID: ENSG00000120805

Description: ADP ribosylation factor like GTPase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.98
    Marker Score: 4501
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.95
    Marker Score: 4908
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.87
    Marker Score: 3107
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.87
    Marker Score: 3308
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.85
    Marker Score: 1058
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.82
    Marker Score: 2614
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.79
    Marker Score: 15409
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.78
    Marker Score: 876
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.76
    Marker Score: 2596
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.75
    Marker Score: 1562.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.73
    Marker Score: 4631
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.7
    Marker Score: 490
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.69
    Marker Score: 58616.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.68
    Marker Score: 10942
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.68
    Marker Score: 57130
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.68
    Marker Score: 6594
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.67
    Marker Score: 2687
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.66
    Marker Score: 7158
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.62
    Marker Score: 647
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.57
    Marker Score: 1049
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.56
    Marker Score: 441
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.55
    Marker Score: 5961
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.54
    Marker Score: 1031
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.51
    Marker Score: 17014
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.5
    Marker Score: 2745
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.49
    Marker Score: 697
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.47
    Marker Score: 5452
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.46
    Marker Score: 3317
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.46
    Marker Score: 1543
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.46
    Marker Score: 3815
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.45
    Marker Score: 3037.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.45
    Marker Score: 2058
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.44
    Marker Score: 685
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.43
    Marker Score: 1453
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.43
    Marker Score: 597
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.41
    Marker Score: 502
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.4
    Marker Score: 10403
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.39
    Marker Score: 1619
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.38
    Marker Score: 710
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.38
    Marker Score: 2121
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.37
    Marker Score: 2248
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.37
    Marker Score: 11898
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.37
    Marker Score: 433
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.35
    Marker Score: 1435.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.35
    Marker Score: 2149
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.35
    Marker Score: 1851
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.34
    Marker Score: 1682
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.34
    Marker Score: 3174
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.32
    Marker Score: 1376
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.32
    Marker Score: 1268
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.32
    Marker Score: 6348
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.32
    Marker Score: 335
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.3
    Marker Score: 306
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.3
    Marker Score: 4617
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.3
    Marker Score: 819
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.29
    Marker Score: 754
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.28
    Marker Score: 707
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 1.28
    Marker Score: 577
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.27
    Marker Score: 3463
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.27
    Marker Score: 1364
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.25
    Marker Score: 467
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.24
    Marker Score: 9685
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.24
    Marker Score: 369
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.23
    Marker Score: 878
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.23
    Marker Score: 2097
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.23
    Marker Score: 305
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.23
    Marker Score: 612
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.23
    Marker Score: 1514
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.22
    Marker Score: 281
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.22
    Marker Score: 492
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.22
    Marker Score: 1038
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.21
    Marker Score: 1420
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.2
    Marker Score: 1598
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.18
    Marker Score: 2226
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.18
    Marker Score: 801
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.18
    Marker Score: 7510
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.17
    Marker Score: 2869.5
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.17
    Marker Score: 2233
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.17
    Marker Score: 377
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.17
    Marker Score: 975
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.17
    Marker Score: 288
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.16
    Marker Score: 2457
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.16
    Marker Score: 821
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.16
    Marker Score: 440
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.16
    Marker Score: 15310
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.15
    Marker Score: 332
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 1.15
    Marker Score: 314
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.14
    Marker Score: 3913
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.14
    Marker Score: 1209
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.13
    Marker Score: 1454
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.12
    Marker Score: 253
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.12
    Marker Score: 885
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.12
    Marker Score: 317
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.12
    Marker Score: 466
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 1.1
    Marker Score: 766
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1
    Marker Score: 1157
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.09
    Marker Score: 601
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.08
    Marker Score: 2553.5
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.08
    Marker Score: 1303
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.07
    Marker Score: 7005

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Other Information

## Summary The ARL1 gene encodes for ADP-ribosylation factor like GTPase 1, a protein that plays a crucial role in the intracellular protein transport. It is significantly expressed in various cell types, including acinar cells of the salivary gland, kidney collecting duct principal cells, and luminal epithelial cells of the mammary gland. ## Key characteristics * ARL1 is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is a GTP-dependent protein kinase that is involved in various cellular processes, including protein trafficking, endocytosis, and exocytosis. * It is a key regulator of the secretory pathway, which is responsible for the transport of proteins from the endoplasmic reticulum to the cell surface. * It is also involved in the regulation of cell migration and differentiation. ## Pathways and functions * The ARL1 gene is involved in the following pathways: * Protein trafficking: It is responsible for the transport of proteins from the endoplasmic reticulum to the cell surface. * Endocytosis: It is involved in the internalization of proteins and organelles. * Exocytosis: It is involved in the release of proteins and organelles from the cell surface. * Cell migration and differentiation: It is involved in the migration of cells and the differentiation of tissues. ## Clinical significance * Mutations in the ARL1 gene have been linked to several human diseases, including cancer and neurodegenerative disorders. * In cancer, ARL1 mutations can lead to the activation of oncogenes and the development of tumors. * In neurodegenerative disorders, ARL1 mutations can disrupt the normal function of neurons, leading to cell death and disease. ## Additional notes * ARL1 is a highly conserved protein, with similar genes found in other mammals. * It is a well-studied protein that has been extensively characterized in both physiological and pathological contexts.

Genular Protein ID: 608855532

Symbol: ARL1_HUMAN

Name: ADP-ribosylation factor-like protein 1

UniProtKB Accession Codes:

P40616 B4DWW1 P80417 Q53XB1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 9 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 4 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7814376

Title: Different ARF domains are required for the activation of cholera toxin and phospholipase D.

PubMed ID: 7814376

DOI: 10.1074/jbc.270.1.21

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9624189

Title: Phospholipid- and GTP-dependent activation of cholera toxin and phospholipase D by human ADP-ribosylation factor-like protein 1 (HARL1).

PubMed ID: 9624189

DOI: 10.1074/jbc.273.25.15872

PubMed ID: 11303027

Title: ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins.

PubMed ID: 11303027

DOI: 10.1074/jbc.m102359200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21239483

Title: Arfaptins are localized to the trans-Golgi by interaction with Arl1, but not Arfs.

PubMed ID: 21239483

DOI: 10.1074/jbc.m110.201442

PubMed ID: 22981988

Title: The BAR domain protein Arfaptin-1 controls secretory granule biogenesis at the trans-Golgi network.

PubMed ID: 22981988

DOI: 10.1016/j.devcel.2012.07.019

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 14580338

Title: Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus.

PubMed ID: 14580338

DOI: 10.1016/s1097-2765(03)00356-3

PubMed ID: 27436755

Title: Structural basis for targeting BIG1 to Golgi apparatus through interaction of its DCB domain with Arl1.

PubMed ID: 27436755

DOI: 10.1093/jmcb/mjw033

PubMed ID: 22679020

Title: Structural basis for membrane binding specificity of the Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin-2 determined by Arl1 GTPase.

PubMed ID: 22679020

DOI: 10.1074/jbc.m112.365783

PubMed ID: 27373159

Title: Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi.

PubMed ID: 27373159

DOI: 10.1016/j.celrep.2016.06.022

Sequence Information:

  • Length: 181
  • Mass: 20418
  • Checksum: 9FB736C8ED60DC3D
  • Sequence:
    • MGGFFSSIFS SLFGTREMRI LILGLDGAGK TTILYRLQVG EVVTTIPTIG FNVETVTYKN 
LKFQVWDLGG QTSIRPYWRC YYSNTDAVIY VVDSCDRDRI GISKSELVAM LEEEELRKAI 
LVVFANKQDM EQAMTSSEMA NSLGLPALKD RKWQIFKTSA TKGTGLDEAM EWLVETLKSR 
Q

Genular Protein ID: 240668589

Symbol: B4DZG7_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DZG7

Database IDs:

ARBA 3 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 1 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 135
  • Mass: 15443
  • Checksum: 072FA0F481008BB8
  • Sequence:
    • MAIGFNVETV TYKNLKFQVW DLGGQTSIRP YWRCYYSNTD AVIYVVDSCD RDRIGISKSE 
LVAMLEEEEL RKAILVVFAN KQDMEQAMTS SEMANSLGLP ALKDRKWQIF KTSATKGTGL 
DEAMEWLVET LKSRQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.