Details for: ARL3

Gene ID: 403

Symbol: ARL3

Ensembl ID: ENSG00000138175

Description: ARF like GTPase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 358.3524
    Cell Significance Index: -55.7400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 211.7540
    Cell Significance Index: -53.7100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 119.3122
    Cell Significance Index: -56.3300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 115.2088
    Cell Significance Index: -47.4600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 99.9640
    Cell Significance Index: -51.4200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 84.7215
    Cell Significance Index: -56.8500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 46.3115
    Cell Significance Index: -57.1000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.9703
    Cell Significance Index: -48.1400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.5513
    Cell Significance Index: -57.4200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.9194
    Cell Significance Index: -36.6100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.6664
    Cell Significance Index: -14.5900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 5.2557
    Cell Significance Index: 40.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 5.0342
    Cell Significance Index: 317.2900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 4.6108
    Cell Significance Index: 38.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.4438
    Cell Significance Index: 517.8700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.4423
    Cell Significance Index: 19.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.9956
    Cell Significance Index: 1089.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8931
    Cell Significance Index: 51.5300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.8921
    Cell Significance Index: 99.3400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.8441
    Cell Significance Index: 64.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.7131
    Cell Significance Index: 235.2500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.5349
    Cell Significance Index: 1385.9200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.4052
    Cell Significance Index: 14.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3249
    Cell Significance Index: 162.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2863
    Cell Significance Index: 258.0300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1551
    Cell Significance Index: 125.6500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.1213
    Cell Significance Index: 143.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1124
    Cell Significance Index: 200.5300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.0835
    Cell Significance Index: 22.6800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.0782
    Cell Significance Index: 24.9100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.0770
    Cell Significance Index: 28.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7579
    Cell Significance Index: 271.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7400
    Cell Significance Index: 55.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7337
    Cell Significance Index: 41.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6783
    Cell Significance Index: 31.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6659
    Cell Significance Index: 34.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5973
    Cell Significance Index: 36.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5503
    Cell Significance Index: 243.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4809
    Cell Significance Index: 33.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3508
    Cell Significance Index: 69.6200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2699
    Cell Significance Index: 43.8900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2268
    Cell Significance Index: 43.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1874
    Cell Significance Index: 4.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1803
    Cell Significance Index: 5.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1400
    Cell Significance Index: 23.9000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1152
    Cell Significance Index: 79.6900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1126
    Cell Significance Index: 7.2700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1049
    Cell Significance Index: 1.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0966
    Cell Significance Index: 181.8100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0941
    Cell Significance Index: 144.7900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0807
    Cell Significance Index: 59.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0623
    Cell Significance Index: 84.7700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0578
    Cell Significance Index: 106.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0239
    Cell Significance Index: 2.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0176
    Cell Significance Index: 2.0800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0030
    Cell Significance Index: 0.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0019
    Cell Significance Index: -1.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0034
    Cell Significance Index: -0.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0093
    Cell Significance Index: -5.9300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0112
    Cell Significance Index: -0.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0141
    Cell Significance Index: -0.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0216
    Cell Significance Index: -16.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0243
    Cell Significance Index: -15.1500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0262
    Cell Significance Index: -3.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0367
    Cell Significance Index: -16.6700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0488
    Cell Significance Index: -2.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0543
    Cell Significance Index: -30.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0731
    Cell Significance Index: -7.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0941
    Cell Significance Index: -6.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0943
    Cell Significance Index: -19.8700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1267
    Cell Significance Index: -3.5400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1470
    Cell Significance Index: -2.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1538
    Cell Significance Index: -17.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1580
    Cell Significance Index: -45.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1762
    Cell Significance Index: -8.2800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1794
    Cell Significance Index: -1.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2004
    Cell Significance Index: -5.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2070
    Cell Significance Index: -30.0900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2114
    Cell Significance Index: -16.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2401
    Cell Significance Index: -9.0900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2419
    Cell Significance Index: -3.3000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2919
    Cell Significance Index: -33.3200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3315
    Cell Significance Index: -7.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3548
    Cell Significance Index: -27.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3901
    Cell Significance Index: -40.6200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4277
    Cell Significance Index: -13.7000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5243
    Cell Significance Index: -15.0300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5678
    Cell Significance Index: -6.4500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5966
    Cell Significance Index: -17.5200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.6156
    Cell Significance Index: -7.6400
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.6289
    Cell Significance Index: -5.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6818
    Cell Significance Index: -14.5200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6897
    Cell Significance Index: -17.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7635
    Cell Significance Index: -46.8100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.8726
    Cell Significance Index: -12.2400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.9252
    Cell Significance Index: -5.8100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.9253
    Cell Significance Index: -20.2600
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.9294
    Cell Significance Index: -10.5000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9874
    Cell Significance Index: -25.3800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.0001
    Cell Significance Index: -9.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **GTPase Activity:** ARL3 is a GTPase, which means it hydrolyzes GTP to GDP, regulating its activity and facilitating various cellular processes. 2. **Cargo Trafficking:** ARL3 is involved in the trafficking of proteins and lipids between the Golgi apparatus and the plasma membrane, ensuring proper cellular function. 3. **Cilia Formation and Maintenance:** ARL3 plays a crucial role in cilia formation and maintenance, particularly in the photoreceptor cells of the retina and the epithelial cells of the tracheobronchial tree. 4. **Signaling Pathways:** ARL3 is involved in various signaling pathways, including the Smoothened signaling pathway, which regulates cell growth and differentiation. **Pathways and Functions:** 1. **Cargo Trafficking to the Periciliary Membrane:** ARL3 regulates the trafficking of proteins and lipids to the periciliary membrane, essential for maintaining the structure and function of cilia. 2. **Cilium Assembly:** ARL3 is involved in the assembly of cilia, ensuring proper ciliary structure and function. 3. **Intraciliary Transport:** ARL3 regulates the transport of proteins and lipids within cilia, maintaining ciliary homeostasis. 4. **Smoothened Signaling Pathway:** ARL3 interacts with the Smoothened protein, regulating the activity of the Smoothened signaling pathway, which controls cell growth and differentiation. 5. **Microtubule Binding:** ARL3 binds to microtubules, regulating their dynamics and organization within the cell. **Clinical Significance:** Dysregulation of ARL3 has been implicated in various diseases, including: 1. **Ciliary Dyskinesia:** ARL3 mutations have been associated with ciliary dyskinesia, a condition characterized by impaired ciliary function and respiratory and reproductive tract dysfunction. 2. **Retinal Degeneration:** ARL3 mutations have been linked to retinal degeneration, a condition characterized by progressive loss of vision. 3. **Neurodegenerative Diseases:** ARL3 has been implicated in neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and Parkinson's disease. 4. **Gastrointestinal Disorders:** ARL3 has been associated with gastrointestinal disorders, such as primary ciliary dyskinesia and chronic rhinosinusitis. In conclusion, ARL3 is a critical gene involved in various cellular processes, including cargo trafficking, cilia formation, and signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the importance of ARL3 in maintaining cellular homeostasis. Further research is needed to fully understand the role of ARL3 in human disease and to develop therapeutic strategies for the treatment of ARL3-related disorders.

Genular Protein ID: 1448765199

Symbol: ARL3_HUMAN

Name: ADP-ribosylation factor-like protein 3

UniProtKB Accession Codes:

P36405 B2R6C7 Q53X83 Q5JSM2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 6 Ensembl 1 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8034651

Title: ADP-ribosylation factor (ARF)-like 3, a new member of the ARF family of GTP-binding proteins cloned from human and rat tissues.

PubMed ID: 8034651

DOI: 10.1016/s0021-9258(17)32257-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10831612

Title: ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin.

PubMed ID: 10831612

DOI: 10.1083/jcb.149.5.1087

PubMed ID: 11303027

Title: ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins.

PubMed ID: 11303027

DOI: 10.1074/jbc.m102359200

PubMed ID: 12417528

Title: Localization in the human retina of the X-linked retinitis pigmentosa protein RP2, its homologue cofactor C and the RP2 interacting protein Arl3.

PubMed ID: 12417528

DOI: 10.1093/hmg/11.24.3065

PubMed ID: 11847227

Title: Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C.

PubMed ID: 11847227

DOI: 10.1074/jbc.m200128200

PubMed ID: 15077113

Title: Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p.

PubMed ID: 15077113

DOI: 10.1038/ncb1120

PubMed ID: 16525022

Title: Arl2 and Arl3 regulate different microtubule-dependent processes.

PubMed ID: 16525022

DOI: 10.1091/mbc.e05-10-0929

PubMed ID: 16472755

Title: Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3.

PubMed ID: 16472755

DOI: 10.1016/j.str.2005.11.008

PubMed ID: 18588884

Title: Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex.

PubMed ID: 18588884

DOI: 10.1016/j.febslet.2008.05.053

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22085962

Title: An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium.

PubMed ID: 22085962

DOI: 10.1101/gad.173443.111

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26964041

Title: De novo occurrence of a variant in ARL3 and apparent autosomal dominant transmission of retinitis pigmentosa.

PubMed ID: 26964041

DOI: 10.1371/journal.pone.0150944

PubMed ID: 30269812

Title: ARL3 Mutations Cause Joubert Syndrome by Disrupting Ciliary Protein Composition.

PubMed ID: 30269812

DOI: 10.1016/j.ajhg.2018.08.015

Sequence Information:

  • Length: 182
  • Mass: 20456
  • Checksum: E5C1ACAD0BD55537
  • Sequence:
    • MGLLSILRKL KSAPDQEVRI LLLGLDNAGK TTLLKQLASE DISHITPTQG FNIKSVQSQG 
FKLNVWDIGG QRKIRPYWKN YFENTDILIY VIDSADRKRF EETGQELAEL LEEEKLSCVP 
VLIFANKQDL LTAAPASEIA EGLNLHTIRD RVWQIQSCSA LTGEGVQDGM NWVCKNVNAK 
KK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.