Details for: ARL3

Gene ID: 403

Symbol: ARL3

Ensembl ID: ENSG00000138175

Description: ARF like GTPase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: T cell (CL0000084)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: mast cell (CL0000097)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: club cell (CL0000158)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: platelet (CL0000233)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: macrophage (CL0000235)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: B cell (CL0000236)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: neuron (CL0000540)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: monocyte (CL0000576)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: enterocyte (CL0000584)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: basal cell (CL0000646)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: kidney granular cell (CL0000648)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: podocyte (CL0000653)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: pericyte (CL0000669)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: neutrophil (CL0000775)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: memory B cell (CL0000787)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: plasmablast (CL0000980)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: malignant cell (CL0001064)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: ionocyte (CL0005006)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: macula densa epithelial cell (CL1000850)
    Fold Change: N/A
    Cell Significance Index: 0.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **GTPase Activity:** ARL3 is a GTPase, which means it hydrolyzes GTP to GDP, regulating its activity and facilitating various cellular processes. 2. **Cargo Trafficking:** ARL3 is involved in the trafficking of proteins and lipids between the Golgi apparatus and the plasma membrane, ensuring proper cellular function. 3. **Cilia Formation and Maintenance:** ARL3 plays a crucial role in cilia formation and maintenance, particularly in the photoreceptor cells of the retina and the epithelial cells of the tracheobronchial tree. 4. **Signaling Pathways:** ARL3 is involved in various signaling pathways, including the Smoothened signaling pathway, which regulates cell growth and differentiation. **Pathways and Functions:** 1. **Cargo Trafficking to the Periciliary Membrane:** ARL3 regulates the trafficking of proteins and lipids to the periciliary membrane, essential for maintaining the structure and function of cilia. 2. **Cilium Assembly:** ARL3 is involved in the assembly of cilia, ensuring proper ciliary structure and function. 3. **Intraciliary Transport:** ARL3 regulates the transport of proteins and lipids within cilia, maintaining ciliary homeostasis. 4. **Smoothened Signaling Pathway:** ARL3 interacts with the Smoothened protein, regulating the activity of the Smoothened signaling pathway, which controls cell growth and differentiation. 5. **Microtubule Binding:** ARL3 binds to microtubules, regulating their dynamics and organization within the cell. **Clinical Significance:** Dysregulation of ARL3 has been implicated in various diseases, including: 1. **Ciliary Dyskinesia:** ARL3 mutations have been associated with ciliary dyskinesia, a condition characterized by impaired ciliary function and respiratory and reproductive tract dysfunction. 2. **Retinal Degeneration:** ARL3 mutations have been linked to retinal degeneration, a condition characterized by progressive loss of vision. 3. **Neurodegenerative Diseases:** ARL3 has been implicated in neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and Parkinson's disease. 4. **Gastrointestinal Disorders:** ARL3 has been associated with gastrointestinal disorders, such as primary ciliary dyskinesia and chronic rhinosinusitis. In conclusion, ARL3 is a critical gene involved in various cellular processes, including cargo trafficking, cilia formation, and signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the importance of ARL3 in maintaining cellular homeostasis. Further research is needed to fully understand the role of ARL3 in human disease and to develop therapeutic strategies for the treatment of ARL3-related disorders.

Genular Protein ID: 1448765199

Symbol: ARL3_HUMAN

Name: ADP-ribosylation factor-like protein 3

UniProtKB Accession Codes:

P36405 B2R6C7 Q53X83 Q5JSM2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 6 Ensembl 1 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8034651

Title: ADP-ribosylation factor (ARF)-like 3, a new member of the ARF family of GTP-binding proteins cloned from human and rat tissues.

PubMed ID: 8034651

DOI: 10.1016/s0021-9258(17)32257-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10831612

Title: ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin.

PubMed ID: 10831612

DOI: 10.1083/jcb.149.5.1087

PubMed ID: 11303027

Title: ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins.

PubMed ID: 11303027

DOI: 10.1074/jbc.m102359200

PubMed ID: 12417528

Title: Localization in the human retina of the X-linked retinitis pigmentosa protein RP2, its homologue cofactor C and the RP2 interacting protein Arl3.

PubMed ID: 12417528

DOI: 10.1093/hmg/11.24.3065

PubMed ID: 11847227

Title: Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C.

PubMed ID: 11847227

DOI: 10.1074/jbc.m200128200

PubMed ID: 15077113

Title: Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p.

PubMed ID: 15077113

DOI: 10.1038/ncb1120

PubMed ID: 16525022

Title: Arl2 and Arl3 regulate different microtubule-dependent processes.

PubMed ID: 16525022

DOI: 10.1091/mbc.e05-10-0929

PubMed ID: 16472755

Title: Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3.

PubMed ID: 16472755

DOI: 10.1016/j.str.2005.11.008

PubMed ID: 18588884

Title: Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex.

PubMed ID: 18588884

DOI: 10.1016/j.febslet.2008.05.053

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22085962

Title: An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium.

PubMed ID: 22085962

DOI: 10.1101/gad.173443.111

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26964041

Title: De novo occurrence of a variant in ARL3 and apparent autosomal dominant transmission of retinitis pigmentosa.

PubMed ID: 26964041

DOI: 10.1371/journal.pone.0150944

PubMed ID: 30269812

Title: ARL3 Mutations Cause Joubert Syndrome by Disrupting Ciliary Protein Composition.

PubMed ID: 30269812

DOI: 10.1016/j.ajhg.2018.08.015

Sequence Information:

  • Length: 182
  • Mass: 20456
  • Checksum: E5C1ACAD0BD55537
  • Sequence:
    • MGLLSILRKL KSAPDQEVRI LLLGLDNAGK TTLLKQLASE DISHITPTQG FNIKSVQSQG 
FKLNVWDIGG QRKIRPYWKN YFENTDILIY VIDSADRKRF EETGQELAEL LEEEKLSCVP 
VLIFANKQDL LTAAPASEIA EGLNLHTIRD RVWQIQSCSA LTGEGVQDGM NWVCKNVNAK 
KK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.