ARL3 | ENSG00000138175 | NCBI 403

Details for: ARL3

Gene ID: 403

Symbol: ARL3

Ensembl ID: ENSG00000138175

Description: ADP ribosylation factor like GTPase 3

Associated with

Cargo trafficking to the periciliary membrane
(R-HSA-5620920)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Trafficking of myristoylated proteins to the cilium
(R-HSA-5624138)
Centrosome
(GO:0005813)
Cilium
(GO:0005929)
Cilium assembly
(GO:0060271)
Cytoplasm
(GO:0005737)
Cytoplasmic microtubule
(GO:0005881)
Extracellular exosome
(GO:0070062)
Gdp binding
(GO:0019003)
Golgi apparatus
(GO:0005794)
Golgi membrane
(GO:0000139)
Golgi to plasma membrane transport
(GO:0006893)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Intraciliary transport
(GO:0042073)
Kidney development
(GO:0001822)
Magnesium ion binding
(GO:0000287)
Microtubule binding
(GO:0008017)
Microtubule cytoskeleton
(GO:0015630)
Midbody
(GO:0030496)
Mitotic cytokinesis
(GO:0000281)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Photoreceptor cell development
(GO:0042461)
Photoreceptor connecting cilium
(GO:0032391)
Post-golgi vesicle-mediated transport
(GO:0006892)
Protein binding
(GO:0005515)
Protein localization to ciliary membrane
(GO:1903441)
Protein localization to cilium
(GO:0061512)
Protein transport
(GO:0015031)
Small gtpase-mediated signal transduction
(GO:0007264)
Smoothened signaling pathway
(GO:0007224)
Spindle microtubule
(GO:0005876)

Other Information

Proteins

ADP-ribosylation factor-like protein 3

Genular Protein ID: 1448765199

Symbol: ARL3_HUMAN

Name: ADP-ribosylation factor-like protein 3

UniProtKB Accession Codes:

P36405 B2R6C7 Q53X83 Q5JSM2

Database IDs:

Citations:

PubMed ID: 8034651

Title: ADP-ribosylation factor (ARF)-like 3, a new member of the ARF family of GTP-binding proteins cloned from human and rat tissues.

PubMed ID: 8034651

DOI: 10.1016/s0021-9258(17)32257-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10831612

Title: ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin.

PubMed ID: 10831612

DOI: 10.1083/jcb.149.5.1087

PubMed ID: 11303027

Title: ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins.

PubMed ID: 11303027

DOI: 10.1074/jbc.m102359200

PubMed ID: 12417528

Title: Localization in the human retina of the X-linked retinitis pigmentosa protein RP2, its homologue cofactor C and the RP2 interacting protein Arl3.

PubMed ID: 12417528

DOI: 10.1093/hmg/11.24.3065

PubMed ID: 11847227

Title: Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C.

PubMed ID: 11847227

DOI: 10.1074/jbc.m200128200

PubMed ID: 15077113

Title: Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p.

PubMed ID: 15077113

DOI: 10.1038/ncb1120

PubMed ID: 16525022

Title: Arl2 and Arl3 regulate different microtubule-dependent processes.

PubMed ID: 16525022

DOI: 10.1091/mbc.e05-10-0929

PubMed ID: 16472755

Title: Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3.

PubMed ID: 16472755

DOI: 10.1016/j.str.2005.11.008

PubMed ID: 18588884

Title: Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex.

PubMed ID: 18588884

DOI: 10.1016/j.febslet.2008.05.053

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22085962

Title: An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium.

PubMed ID: 22085962

DOI: 10.1101/gad.173443.111

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26964041

Title: De novo occurrence of a variant in ARL3 and apparent autosomal dominant transmission of retinitis pigmentosa.

PubMed ID: 26964041

DOI: 10.1371/journal.pone.0150944

PubMed ID: 30269812

Title: ARL3 Mutations Cause Joubert Syndrome by Disrupting Ciliary Protein Composition.

PubMed ID: 30269812

DOI: 10.1016/j.ajhg.2018.08.015

Sequence Information:

Length: 182
Mass: 20456
Checksum: E5C1ACAD0BD55537
Sequence:

MGLLSILRKL KSAPDQEVRI LLLGLDNAGK TTLLKQLASE DISHITPTQG FNIKSVQSQG 
FKLNVWDIGG QRKIRPYWKN YFENTDILIY VIDSADRKRF EETGQELAEL LEEEKLSCVP 
VLIFANKQDL LTAAPASEIA EGLNLHTIRD RVWQIQSCSA LTGEGVQDGM NWVCKNVNAK 
KK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ARL3

Associated with

Other Information

ADP-ribosylation factor (ARF)-like 3, a new member of the ARF family of GTP-binding proteins cloned from human and rat tissues. PubMed ID: 8034651

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin. PubMed ID: 10831612

ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins. PubMed ID: 11303027

Localization in the human retina of the X-linked retinitis pigmentosa protein RP2, its homologue cofactor C and the RP2 interacting protein Arl3. PubMed ID: 12417528

Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C. PubMed ID: 11847227

Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p. PubMed ID: 15077113

Arl2 and Arl3 regulate different microtubule-dependent processes. PubMed ID: 16525022

Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3. PubMed ID: 16472755

Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex. PubMed ID: 18588884

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium. PubMed ID: 22085962

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

De novo occurrence of a variant in ARL3 and apparent autosomal dominant transmission of retinitis pigmentosa. PubMed ID: 26964041

ARL3 Mutations Cause Joubert Syndrome by Disrupting Ciliary Protein Composition. PubMed ID: 30269812