Details for: ARL3

Gene ID: 403

Symbol: ARL3

Ensembl ID: ENSG00000138175

Description: ADP ribosylation factor like GTPase 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.03
    Marker Score: 8641
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.55
    Marker Score: 760
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.53
    Marker Score: 21977
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.31
    Marker Score: 79958
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.31
    Marker Score: 9615
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.2
    Marker Score: 7553
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.18
    Marker Score: 4559.5
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.04
    Marker Score: 4139
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2
    Marker Score: 3796
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.93
    Marker Score: 2164
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.9
    Marker Score: 1265
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.88
    Marker Score: 8125
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.87
    Marker Score: 976
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.85
    Marker Score: 6868
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.85
    Marker Score: 2236
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.81
    Marker Score: 3079
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.8
    Marker Score: 1908.5
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.76
    Marker Score: 3307
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.74
    Marker Score: 1638
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.73
    Marker Score: 2492
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.72
    Marker Score: 19369
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.71
    Marker Score: 1805
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.71
    Marker Score: 881
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.67
    Marker Score: 1787
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.64
    Marker Score: 1547
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.6
    Marker Score: 6192
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.6
    Marker Score: 933
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.57
    Marker Score: 15819.5
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.56
    Marker Score: 739
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.53
    Marker Score: 3870
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.53
    Marker Score: 9093.5
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.52
    Marker Score: 32524
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.52
    Marker Score: 512
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.52
    Marker Score: 4135
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.51
    Marker Score: 555.5
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.5
    Marker Score: 939
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.49
    Marker Score: 1587
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.49
    Marker Score: 349
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.49
    Marker Score: 3498
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.48
    Marker Score: 2177
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.47
    Marker Score: 6113
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.47
    Marker Score: 54296
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.46
    Marker Score: 587
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.45
    Marker Score: 3882
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.45
    Marker Score: 1989
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.45
    Marker Score: 2562
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.44
    Marker Score: 2356
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.43
    Marker Score: 2203
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.43
    Marker Score: 412
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.42
    Marker Score: 18711
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.41
    Marker Score: 5446
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.41
    Marker Score: 4992
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.4
    Marker Score: 1698
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.4
    Marker Score: 1943.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.4
    Marker Score: 9107
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.4
    Marker Score: 918
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.39
    Marker Score: 655.5
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.39
    Marker Score: 1740
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.37
    Marker Score: 389
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.36
    Marker Score: 5554.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.36
    Marker Score: 11702
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.36
    Marker Score: 83729
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.36
    Marker Score: 14048
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.35
    Marker Score: 427
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.35
    Marker Score: 802
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.35
    Marker Score: 12826
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.34
    Marker Score: 51014
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.34
    Marker Score: 26610
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.33
    Marker Score: 734
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.33
    Marker Score: 2210
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.33
    Marker Score: 19873
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.33
    Marker Score: 756
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.32
    Marker Score: 298
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.32
    Marker Score: 574
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.3
    Marker Score: 5018
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.3
    Marker Score: 491
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.3
    Marker Score: 1398
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.29
    Marker Score: 365
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.29
    Marker Score: 9588
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.29
    Marker Score: 915
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.29
    Marker Score: 1660
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.27
    Marker Score: 11964
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.27
    Marker Score: 1290
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.26
    Marker Score: 3307
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.26
    Marker Score: 1204
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.26
    Marker Score: 1941
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.24
    Marker Score: 317
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.23
    Marker Score: 9457
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.22
    Marker Score: 601
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.21
    Marker Score: 450
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.2
    Marker Score: 943
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.19
    Marker Score: 2812
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.19
    Marker Score: 4987
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.19
    Marker Score: 749
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.18
    Marker Score: 232
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.18
    Marker Score: 842
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.17
    Marker Score: 625
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.17
    Marker Score: 1578
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.17
    Marker Score: 337
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.15
    Marker Score: 370

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Other Information

**Key characteristics** - ARL3 is a protein that is involved in the trafficking of myristoylated proteins to the cilium. - The protein is expressed in a variety of cell types, including retinal rod cells, eye photoreceptor cells, and ciliated columnar cells. - The protein is involved in the regulation of cilium assembly and function. - ARL3 is a key regulator of the development of the kidney. **Pathways and functions** - ARL3 is involved in the cargo trafficking to the periciliary membrane. - The protein is also involved in the cilium assembly process. - It is also involved in the Gdp binding pathway, Golgi to plasma membrane transport, and Gtpase activity. **Clinical significance** - Mutations in the ARL3 gene have been linked to a number of human diseases, including retinal disorders and ciliopathies. - These diseases are characterized by the misfficking of myristoylated proteins to the cilium, which can lead to a variety of symptoms, including photoreceptor cell dysfunction and cilium dysfunction. **Additional information** - The ARL3 gene is located on chromosome 17p13.2. - The protein is a glycoprotein with a molecular weight of approximately 70 kDa. - The protein is a member of the ADP-ribosylation factor like GTPase family of proteins. - The protein is regulated by a variety of factors, including the Gdp binding protein and the Smoothened signaling pathway.

Genular Protein ID: 1448765199

Symbol: ARL3_HUMAN

Name: ADP-ribosylation factor-like protein 3

UniProtKB Accession Codes:

P36405 B2R6C7 Q53X83 Q5JSM2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 6 EPD 1 Ensembl 1 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8034651

Title: ADP-ribosylation factor (ARF)-like 3, a new member of the ARF family of GTP-binding proteins cloned from human and rat tissues.

PubMed ID: 8034651

DOI: 10.1016/s0021-9258(17)32257-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10831612

Title: ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin.

PubMed ID: 10831612

DOI: 10.1083/jcb.149.5.1087

PubMed ID: 11303027

Title: ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins.

PubMed ID: 11303027

DOI: 10.1074/jbc.m102359200

PubMed ID: 12417528

Title: Localization in the human retina of the X-linked retinitis pigmentosa protein RP2, its homologue cofactor C and the RP2 interacting protein Arl3.

PubMed ID: 12417528

DOI: 10.1093/hmg/11.24.3065

PubMed ID: 11847227

Title: Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C.

PubMed ID: 11847227

DOI: 10.1074/jbc.m200128200

PubMed ID: 15077113

Title: Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p.

PubMed ID: 15077113

DOI: 10.1038/ncb1120

PubMed ID: 16525022

Title: Arl2 and Arl3 regulate different microtubule-dependent processes.

PubMed ID: 16525022

DOI: 10.1091/mbc.e05-10-0929

PubMed ID: 16472755

Title: Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3.

PubMed ID: 16472755

DOI: 10.1016/j.str.2005.11.008

PubMed ID: 18588884

Title: Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex.

PubMed ID: 18588884

DOI: 10.1016/j.febslet.2008.05.053

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22085962

Title: An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium.

PubMed ID: 22085962

DOI: 10.1101/gad.173443.111

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26964041

Title: De novo occurrence of a variant in ARL3 and apparent autosomal dominant transmission of retinitis pigmentosa.

PubMed ID: 26964041

DOI: 10.1371/journal.pone.0150944

PubMed ID: 30269812

Title: ARL3 Mutations Cause Joubert Syndrome by Disrupting Ciliary Protein Composition.

PubMed ID: 30269812

DOI: 10.1016/j.ajhg.2018.08.015

Sequence Information:

  • Length: 182
  • Mass: 20456
  • Checksum: E5C1ACAD0BD55537
  • Sequence:
    • MGLLSILRKL KSAPDQEVRI LLLGLDNAGK TTLLKQLASE DISHITPTQG FNIKSVQSQG 
FKLNVWDIGG QRKIRPYWKN YFENTDILIY VIDSADRKRF EETGQELAEL LEEEKLSCVP 
VLIFANKQDL LTAAPASEIA EGLNLHTIRD RVWQIQSCSA LTGEGVQDGM NWVCKNVNAK 
KK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.