Details for: CL1000850

Cell ID: CL1000850

Cell Name: macula densa epithelial cell

Marker Score Threshold: 466
(Derived using integrated single-cell and genomic data)

Description: Any epithelial cell of distal tubule that is part of some macula densa.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.49
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.39
    Ensembl ID: ENSG00000166710
  • Gene Symbol: FTH1 (ENSG00000167996)
    Fold Change: 2.39
    Ensembl ID: ENSG00000167996
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 2.39
    Ensembl ID: ENSG00000156508
  • Gene Symbol: FTL (ENSG00000087086)
    Fold Change: 2.38
    Ensembl ID: ENSG00000087086
  • Gene Symbol: FAU (ENSG00000149806)
    Fold Change: 2.3
    Ensembl ID: ENSG00000149806
  • Gene Symbol: GAPDH (ENSG00000111640)
    Fold Change: 2.24
    Ensembl ID: ENSG00000111640
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 2.13
    Ensembl ID: ENSG00000108654
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.08
    Ensembl ID: ENSG00000184009
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.05
    Ensembl ID: ENSG00000131143
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.04
    Ensembl ID: ENSG00000169100
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 2.04
    Ensembl ID: ENSG00000167658
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.02
    Ensembl ID: ENSG00000172757
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 1.99
    Ensembl ID: ENSG00000127184
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 1.99
    Ensembl ID: ENSG00000104529
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 1.96
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.88
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.87
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.76
    Ensembl ID: ENSG00000124172
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 1.76
    Ensembl ID: ENSG00000164919
  • Gene Symbol: EIF4A2 (ENSG00000156976)
    Fold Change: 1.76
    Ensembl ID: ENSG00000156976
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 1.76
    Ensembl ID: ENSG00000114942
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.75
    Ensembl ID: ENSG00000135390
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.75
    Ensembl ID: ENSG00000133639
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.66
    Ensembl ID: ENSG00000126267
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.64
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.64
    Ensembl ID: ENSG00000070831
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 1.64
    Ensembl ID: ENSG00000112695
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.6
    Ensembl ID: ENSG00000143933
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.59
    Ensembl ID: ENSG00000135940
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.57
    Ensembl ID: ENSG00000135404
  • Gene Symbol: FUS (ENSG00000089280)
    Fold Change: 1.55
    Ensembl ID: ENSG00000089280
  • Gene Symbol: EIF4G2 (ENSG00000110321)
    Fold Change: 1.53
    Ensembl ID: ENSG00000110321
  • Gene Symbol: ENO1 (ENSG00000074800)
    Fold Change: 1.53
    Ensembl ID: ENSG00000074800
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 1.52
    Ensembl ID: ENSG00000111775
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.51
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.51
    Ensembl ID: ENSG00000179218
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.5
    Ensembl ID: ENSG00000067082
  • Gene Symbol: DUSP1 (ENSG00000120129)
    Fold Change: 1.49
    Ensembl ID: ENSG00000120129
  • Gene Symbol: FOS (ENSG00000170345)
    Fold Change: 1.47
    Ensembl ID: ENSG00000170345
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.46
    Ensembl ID: ENSG00000169020
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.46
    Ensembl ID: ENSG00000122545
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 1.46
    Ensembl ID: ENSG00000176340
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.45
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.41
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.38
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.35
    Ensembl ID: ENSG00000110955
  • Gene Symbol: EIF4B (ENSG00000063046)
    Fold Change: 1.35
    Ensembl ID: ENSG00000063046
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.34
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.34
    Ensembl ID: ENSG00000154518
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.34
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CYBA (ENSG00000051523)
    Fold Change: 1.34
    Ensembl ID: ENSG00000051523
  • Gene Symbol: EIF5 (ENSG00000100664)
    Fold Change: 1.34
    Ensembl ID: ENSG00000100664
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.34
    Ensembl ID: ENSG00000213719
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.32
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.31
    Ensembl ID: ENSG00000099624
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.3
    Ensembl ID: ENSG00000172270
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 1.29
    Ensembl ID: ENSG00000131174
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 1.28
    Ensembl ID: ENSG00000160213
  • Gene Symbol: DBI (ENSG00000155368)
    Fold Change: 1.27
    Ensembl ID: ENSG00000155368
  • Gene Symbol: DAD1 (ENSG00000129562)
    Fold Change: 1.25
    Ensembl ID: ENSG00000129562
  • Gene Symbol: DDX3X (ENSG00000215301)
    Fold Change: 1.25
    Ensembl ID: ENSG00000215301
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.25
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.24
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.23
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.23
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.22
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 1.2
    Ensembl ID: ENSG00000113712
  • Gene Symbol: TSC22D3 (ENSG00000157514)
    Fold Change: 1.2
    Ensembl ID: ENSG00000157514
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.19
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.19
    Ensembl ID: ENSG00000128272
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.18
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.17
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ERH (ENSG00000100632)
    Fold Change: 1.17
    Ensembl ID: ENSG00000100632
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.16
    Ensembl ID: ENSG00000122705
  • Gene Symbol: GDI2 (ENSG00000057608)
    Fold Change: 1.15
    Ensembl ID: ENSG00000057608
  • Gene Symbol: EIF1AX (ENSG00000173674)
    Fold Change: 1.14
    Ensembl ID: ENSG00000173674
  • Gene Symbol: XRCC6 (ENSG00000196419)
    Fold Change: 1.13
    Ensembl ID: ENSG00000196419
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.12
    Ensembl ID: ENSG00000013441
  • Gene Symbol: EIF5A (ENSG00000132507)
    Fold Change: 1.11
    Ensembl ID: ENSG00000132507
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.1
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ENSA (ENSG00000143420)
    Fold Change: 1.1
    Ensembl ID: ENSG00000143420
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.1
    Ensembl ID: ENSG00000241837
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.1
    Ensembl ID: ENSG00000161203
  • Gene Symbol: ELF1 (ENSG00000120690)
    Fold Change: 1.1
    Ensembl ID: ENSG00000120690
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.09
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 1.09
    Ensembl ID: ENSG00000101439
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.09
    Ensembl ID: ENSG00000164111
  • Gene Symbol: BPTF (ENSG00000171634)
    Fold Change: 1.08
    Ensembl ID: ENSG00000171634
  • Gene Symbol: FKBP1A (ENSG00000088832)
    Fold Change: 1.08
    Ensembl ID: ENSG00000088832
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.07
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.07
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.06
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.06
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.06
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.05
    Ensembl ID: ENSG00000182718
  • Gene Symbol: EWSR1 (ENSG00000182944)
    Fold Change: 1.04
    Ensembl ID: ENSG00000182944
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.02
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1
    Ensembl ID: ENSG00000163399
Hovered Details

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Hovered Details

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**Key Characteristics** The macula densa epithelial cell is characterized by the following key features: 1. **Location**: The cell is located in the distal tubule of the kidney, where it plays a crucial role in regulating ion transport and blood pressure. 2. **Gene Expression**: The cell expresses specific genes, including ACTB, which is involved in actin cytoskeleton organization and cell signaling. 3. **Signaling Pathways**: The cell is involved in various signaling pathways, including those involved in cell signaling, protein localization, and cytoskeleton organization. 4. **Ion Transport**: The cell is responsible for regulating ion transport in the distal tubule, including the reabsorption of sodium and water. 5. **Response to Blood Pressure Changes**: The cell responds to changes in blood pressure by altering its ion transport activity and signaling pathways. **Clinical Significance** The macula densa epithelial cell plays a crucial role in regulating blood pressure and ion transport in the kidney. Dysregulation of this cell's function can lead to various clinical conditions, including: 1. **Hypertension**: Abnormal ion transport and signaling pathways in the macula densa epithelial cell can contribute to the development of hypertension. 2. **Kidney Disease**: Damage to the macula densa epithelial cell can lead to kidney disease, including chronic kidney disease and acute kidney injury. 3. **Fluid Balance**: The cell's ability to regulate ion transport and water reabsorption is critical for maintaining fluid balance in the body. 4. **Blood Pressure Regulation**: The macula densa epithelial cell plays a key role in regulating blood pressure by sensing changes in blood pressure and responding accordingly. In summary, the macula densa epithelial cell is a critical component of the kidney's function, and dysregulation of its function can lead to various clinical conditions. Further research is needed to understand the mechanisms underlying the cell's function and to develop new therapeutic strategies for treating related diseases.