Details for: KCNJ16

Gene ID: 3773

Symbol: KCNJ16

Ensembl ID: ENSG00000153822

Description: potassium inwardly rectifying channel subfamily J member 16

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 3.71
    Marker Score: 2856
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 3.67
    Marker Score: 3889
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.19
    Marker Score: 8554
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.16
    Marker Score: 7973
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.82
    Marker Score: 10003
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.52
    Marker Score: 3565
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.17
    Marker Score: 2185
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 2.1
    Marker Score: 761
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1168
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.42
    Marker Score: 1419
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.42
    Marker Score: 1112
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 868
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.3
    Marker Score: 3063
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 853
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.25
    Marker Score: 294
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.23
    Marker Score: 2322
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4806.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.14
    Marker Score: 1189
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.1
    Marker Score: 1049
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 795
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.03
    Marker Score: 427
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.01
    Marker Score: 530
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71815
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48040
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.99
    Marker Score: 1913
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.97
    Marker Score: 988
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.95
    Marker Score: 435
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5345
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.91
    Marker Score: 1504
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.89
    Marker Score: 1820
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5283
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.82
    Marker Score: 1555
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.8
    Marker Score: 984
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.78
    Marker Score: 519
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 702
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.76
    Marker Score: 11856
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.67
    Marker Score: 211
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.65
    Marker Score: 132
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.63
    Marker Score: 678
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.62
    Marker Score: 361
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.62
    Marker Score: 200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.62
    Marker Score: 536
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.61
    Marker Score: 194
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.57
    Marker Score: 490.5
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.56
    Marker Score: 258
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 234
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.56
    Marker Score: 206
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.55
    Marker Score: 314
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.53
    Marker Score: 252
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.51
    Marker Score: 364
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.5
    Marker Score: 4318
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.49
    Marker Score: 128
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.49
    Marker Score: 306
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.46
    Marker Score: 188
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.44
    Marker Score: 495
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.44
    Marker Score: 248
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.43
    Marker Score: 84
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.42
    Marker Score: 9059
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.42
    Marker Score: 280
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.42
    Marker Score: 781
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.4
    Marker Score: 191
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.4
    Marker Score: 239
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.38
    Marker Score: 400
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.36
    Marker Score: 161
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.34
    Marker Score: 526.5
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.33
    Marker Score: 145
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.33
    Marker Score: 807
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.32
    Marker Score: 192
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.3
    Marker Score: 390
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3
    Marker Score: 192
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.28
    Marker Score: 269
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.28
    Marker Score: 125
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.28
    Marker Score: 189.5
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.27
    Marker Score: 268
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.27
    Marker Score: 142
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.27
    Marker Score: 259.5
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 91
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.26
    Marker Score: 172
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.26
    Marker Score: 121
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.26
    Marker Score: 68
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.25
    Marker Score: 2117
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.25
    Marker Score: 858
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.25
    Marker Score: 86
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.24
    Marker Score: 172
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.23
    Marker Score: 132
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75

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Other Information

**Key characteristics:** * KCNJ16 is a transmembrane protein with a predicted molecular weight of approximately 130 kDa. * It is expressed in high levels in the kidney, particularly in renal principal cells, kidney distal convoluted tubule epithelial cells, kidney loop of Henle thick ascending limb epithelial cells, and blood vessel endothelial cells. * KCNJ16 is a ligand for the GABAB receptors, a family of G protein-coupled receptors that are involved in various cellular processes, including potassium channel regulation. * It is also a target for the G protein-coupled receptor alpha-adrenoceptor (GPCR-alpha). **Pathways and functions:** * KCNJ16 is involved in multiple cellular processes, including potassium channel regulation, G protein-coupled receptor signaling, and calcium signaling. * It is a key regulator of potassium homeostasis in the kidney, where it helps to maintain the resting membrane potential of renal cells and regulate the activity of other potassium channels. * In the central nervous system (CNS), KCNJ16 is expressed in neurons and modulates neuronal excitability. * It is also involved in regulating the activity of postsynaptic signal transmission at the neuromuscular junction. **Clinical significance:** * Mutations in KCNJ16 have been linked to several human diseases, including nephrogenic diabetes insipidus, a genetic disorder characterized by impaired kidney function. * KCNJ16 mutations can also cause epilepsy, stroke, and other neurological disorders. * Understanding the role of KCNJ16 in health and disease has potential implications for the development of new therapeutic strategies for these conditions.

Genular Protein ID: 1871153574

Symbol: KCJ16_HUMAN

Name: Inward rectifier potassium channel 16

UniProtKB Accession Codes:

Q9NPI9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 5 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 3 RefSeq 10 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 11060447

Title: The human inward rectifier K(+) channel subunit kir5.1 (KCNJ16) maps to chromosome 17q25 and is expressed in kidney and pancreas.

PubMed ID: 11060447

DOI: 10.1159/000015662

PubMed ID: 11240146

Title: Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits.

PubMed ID: 11240146

DOI: 10.1016/s0014-5793(01)02202-5

PubMed ID: 24561201

Title: Mislocalization of K+ channels causes the renal salt wasting in EAST/SeSAME syndrome.

PubMed ID: 24561201

DOI: 10.1016/j.febslet.2014.02.024

PubMed ID: 33811157

Title: Defects in KCNJ16 cause a novel tubulopathy with hypokalemia, salt wasting, disturbed acid-base homeostasis, and sensorineural deafness.

PubMed ID: 33811157

DOI: 10.1681/asn.2020111587

Sequence Information:

  • Length: 418
  • Mass: 47949
  • Checksum: 1E241B4C15CBD264
  • Sequence:
    • MSYYGSSYHI INADAKYPGY PPEHIIAEKR RARRRLLHKD GSCNVYFKHI FGEWGSYVVD 
IFTTLVDTKW RHMFVIFSLS YILSWLIFGS VFWLIAFHHG DLLNDPDITP CVDNVHSFTG 
AFLFSLETQT TIGYGYRCVT EECSVAVLMV ILQSILSCII NTFIIGAALA KMATARKRAQ 
TIRFSYFALI GMRDGKLCLM WRIGDFRPNH VVEGTVRAQL LRYTEDSEGR MTMAFKDLKL 
VNDQIILVTP VTIVHEIDHE SPLYALDRKA VAKDNFEILV TFIYTGDSTG TSHQSRSSYV 
PREILWGHRF NDVLEVKRKY YKVNCLQFEG SVEVYAPFCS AKQLDWKDQQ LHIEKAPPVR 
ESCTSDTKAR RRSFSAVAIV SSCENPEETT TSATHEYRET PYQKALLTLN RISVESQM

Genular Protein ID: 1827272592

Symbol: A8K434_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K434

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 2 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 PANTHER 2 PIRSF 1 PIRSR 1 PRINTS 2 PeptideAtlas 1 Pfam 4 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 2

Sequence Information:

  • Length: 418
  • Mass: 47915
  • Checksum: 1344162175C6B264
  • Sequence:
    • MSYYGSSYHI INADAKYPGY PPEHIIAEKR RARRRLLHKD GSCNVYFKHI FGEWGSYVVD 
IFTTLVDTKW RHMFVIFSLS YILSWLIFGS VFWLIAFHHG DLLNDPDITP CVDNVHSFTG 
AFLFSLETQT TIGYGYRCVT EECSVAVLMV ILQSILSCII NTFIIGAALA KMATARKRAQ 
TIRFSYFALI GMRDGKLCLM WRIGDFRPNH VVEGTVRAQL LRYTEDSEGR MTMAFKDLKL 
VNDQIILVTP VTIVHEIDHE SPLYALDRKA VAKDNFEILV TFIYTGDSTG TSHQSRSSYV 
PREILWGHRF NDVLEVKRKY YKVNCLQFEG SVEVYAPLCS AKQLDWKDQQ LHIEKAPPVR 
ESCTSDTKAR RRSFSAVAIV SSCENPEETT TSATHEYRET PYQKALLTLN RISVESQM

Genular Protein ID: 2145198085

Symbol: Q8N538_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8N538

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 PANTHER 2 PIRSF 1 PIRSR 1 PRINTS 2 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 418
  • Mass: 47963
  • Checksum: 1C22013E86D2FACC
  • Sequence:
    • MSYYGSSYHI INADAKYPGY PPEHIIAEKR RARRRLLHKD GSCNVYFKHI FGEWGSYVVD 
IFTTLVDTKW RHMFVIFSLS YILSWLIFGS VFWLIAFHHG DLLNDPDITP CVDNVHSFTG 
AFLFSLETQT TIGYGYRCVT EECSVAVLMV ILQSILSCII NTFIIGAALA KMATARKRAQ 
TIRFSYFALI GMRDGKLCLM WRIGDFRPNH VVEGTVRAQL LRYTEDSEGR MTMAFKDLKL 
VNDQIILVTP ITIVHEIDHE SPLYALDRKA VAKDNFEILV TFIYTGDSTG TSHQSRSSYV 
PREILWGHRF NDVLEVKRKY YKVNCLQFEG SVEVYAPFCS AKQLDWKDQQ LHIEKAPPVR 
ESCTSDTKAR RRSFSAVAIV SSCENPEETT TSATHEYRET PYQKALLTLN RISVESQM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.