Details for: RORA

Gene ID: 6095

Symbol: RORA

Ensembl ID: ENSG00000069667

Description: RAR related orphan receptor A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 827.4764
    Cell Significance Index: -128.7100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 518.6416
    Cell Significance Index: -131.5500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 270.2264
    Cell Significance Index: -127.5800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 246.3957
    Cell Significance Index: -100.1000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 105.8757
    Cell Significance Index: -130.5400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 105.3373
    Cell Significance Index: -100.5700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 61.2815
    Cell Significance Index: -134.1200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 43.7350
    Cell Significance Index: -134.3300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 43.2460
    Cell Significance Index: -115.8500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 33.4106
    Cell Significance Index: -131.8400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 16.4035
    Cell Significance Index: 320.1500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 14.2085
    Cell Significance Index: 96.2700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 13.8692
    Cell Significance Index: 303.6900
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 10.3286
    Cell Significance Index: 144.4300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 7.7423
    Cell Significance Index: 132.6800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 7.4295
    Cell Significance Index: 125.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 7.2252
    Cell Significance Index: 405.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 6.9077
    Cell Significance Index: 177.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 6.4368
    Cell Significance Index: 284.7200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 6.4071
    Cell Significance Index: 12063.8900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 6.3657
    Cell Significance Index: 155.3200
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 6.1722
    Cell Significance Index: 99.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 5.9349
    Cell Significance Index: 224.7400
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 4.8411
    Cell Significance Index: 73.6500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 4.6320
    Cell Significance Index: 7130.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 4.3800
    Cell Significance Index: 1571.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 4.3499
    Cell Significance Index: 2762.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.6410
    Cell Significance Index: 6714.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.3570
    Cell Significance Index: 666.2100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.9008
    Cell Significance Index: 2006.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.6793
    Cell Significance Index: 180.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.6268
    Cell Significance Index: 73.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.6076
    Cell Significance Index: 1183.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.1531
    Cell Significance Index: 2927.6000
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 2.1235
    Cell Significance Index: 22.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.8151
    Cell Significance Index: 189.0000
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.8025
    Cell Significance Index: 16.0000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1849
    Cell Significance Index: 90.9300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.1703
    Cell Significance Index: 24.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9850
    Cell Significance Index: 28.3800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.9380
    Cell Significance Index: 13.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8849
    Cell Significance Index: 103.1200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.7860
    Cell Significance Index: 22.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7276
    Cell Significance Index: 38.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.6033
    Cell Significance Index: 21.2000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.5140
    Cell Significance Index: 6.4100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4652
    Cell Significance Index: 420.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4501
    Cell Significance Index: 90.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1626
    Cell Significance Index: 19.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1178
    Cell Significance Index: 21.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0899
    Cell Significance Index: 12.3400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0556
    Cell Significance Index: 24.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0358
    Cell Significance Index: -0.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0425
    Cell Significance Index: -6.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0911
    Cell Significance Index: -67.5000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0955
    Cell Significance Index: -18.1700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0985
    Cell Significance Index: -61.5100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.1084
    Cell Significance Index: -59.2000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1166
    Cell Significance Index: -18.9700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.1278
    Cell Significance Index: -93.6900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1669
    Cell Significance Index: -126.3500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1694
    Cell Significance Index: -2.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1832
    Cell Significance Index: -103.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2180
    Cell Significance Index: -37.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3104
    Cell Significance Index: -14.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3816
    Cell Significance Index: -109.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4171
    Cell Significance Index: -87.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.4465
    Cell Significance Index: -44.1700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5493
    Cell Significance Index: -13.7300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5744
    Cell Significance Index: -7.2500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.6044
    Cell Significance Index: -65.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.6235
    Cell Significance Index: -63.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.6581
    Cell Significance Index: -85.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.7949
    Cell Significance Index: -36.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7979
    Cell Significance Index: -50.2900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.9412
    Cell Significance Index: -11.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.9453
    Cell Significance Index: -121.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.9583
    Cell Significance Index: -109.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.9803
    Cell Significance Index: -115.6100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.0118
    Cell Significance Index: -29.0100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.0572
    Cell Significance Index: -120.6800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -1.1119
    Cell Significance Index: -14.4200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -1.3218
    Cell Significance Index: -98.5100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.3490
    Cell Significance Index: -28.8400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.3619
    Cell Significance Index: -107.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3629
    Cell Significance Index: -83.5600
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -1.3724
    Cell Significance Index: -15.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.4439
    Cell Significance Index: -19.7000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.4720
    Cell Significance Index: -88.3700
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -1.5029
    Cell Significance Index: -18.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.5453
    Cell Significance Index: -72.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.5610
    Cell Significance Index: -107.9500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.7592
    Cell Significance Index: -21.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -1.7892
    Cell Significance Index: -126.5400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.8355
    Cell Significance Index: -95.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.8459
    Cell Significance Index: -119.0900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.9026
    Cell Significance Index: -99.1100
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -1.9515
    Cell Significance Index: -12.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.9715
    Cell Significance Index: -121.1800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.9941
    Cell Significance Index: -15.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RORA is a transcription factor that belongs to the nuclear receptor superfamily, which includes other receptors such as PPARα, PPARγ, and RXR. RORA is characterized by its ability to bind to specific DNA sequences, known as response elements, and regulate gene expression by recruiting other transcription factors and coactivators. RORA is also known for its ability to interact with other transcription factors, such as PPARα and PPARγ, to modulate their activity. **Pathways and Functions:** RORA is involved in various biological pathways, including: 1. **Circadian Clock Regulation:** RORA plays a crucial role in regulating the circadian clock by controlling the expression of genes involved in the clock mechanism, such as PER2 and BMAL1. 2. **Immune Regulation:** RORA modulates the activity of immune cells, such as T cells and macrophages, by regulating the expression of genes involved in immune responses, such as cytokines and chemokines. 3. **Metabolic Homeostasis:** RORA regulates lipid metabolism by controlling the expression of genes involved in fatty acid synthesis and degradation, such as PPARα and PPARγ. 4. **Cholesterol Homeostasis:** RORA modulates cholesterol homeostasis by regulating the expression of genes involved in cholesterol synthesis and uptake, such as HMG-CoA reductase and LDLR. 5. **Stress Response:** RORA regulates the expression of genes involved in stress responses, such as heat shock proteins and chaperones. **Clinical Significance:** RORA has been implicated in various diseases, including: 1. **Metabolic Disorders:** RORA has been linked to metabolic disorders, such as obesity and type 2 diabetes, due to its role in regulating lipid metabolism and glucose homeostasis. 2. **Immune-Mediated Diseases:** RORA has been implicated in immune-mediated diseases, such as rheumatoid arthritis and multiple sclerosis, due to its role in regulating immune responses. 3. **Circadian Disorders:** RORA has been linked to circadian disorders, such as delayed sleep phase syndrome and jet lag, due to its role in regulating the circadian clock. 4. **Neurological Disorders:** RORA has been implicated in neurological disorders, such as Parkinson's disease and Alzheimer's disease, due to its role in regulating neuronal function and survival. In conclusion, RORA is a transcription factor that plays a crucial role in various biological processes, including immune regulation, circadian clock, and metabolic homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of RORA in maintaining overall health and well-being. **References:** * [Insert references to recent studies on RORA and its role in different diseases] Note: This is a general summary of the gene RORA, and it is not intended to be a comprehensive review of the literature.

Genular Protein ID: 2344009623

Symbol: RORA_HUMAN

Name: Nuclear receptor ROR-alpha

UniProtKB Accession Codes:

P35398 P35397 P35399 P45445 Q495X4 Q96H83

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 18 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 47 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 4 PRINTS 3 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 7 RefSeq 4 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7926749

Title: Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors.

PubMed ID: 7926749

DOI: 10.1101/gad.8.5.538

PubMed ID: 7916608

Title: Identification of nuclear receptor mRNAs by RT-PCR amplification of conserved zinc-finger motif sequences.

PubMed ID: 7916608

DOI: 10.1006/bbrc.1993.1976

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9328355

Title: Transcriptional activation and repression by RORalpha, an orphan nuclear receptor required for cerebellar development.

PubMed ID: 9328355

DOI: 10.1210/mend.11.11.0002

PubMed ID: 10478845

Title: Coactivators for the orphan nuclear receptor RORalpha.

PubMed ID: 10478845

DOI: 10.1210/mend.13.9.0343

PubMed ID: 9862959

Title: Exogenous expression of a dominant negative RORalpha1 vector in muscle cells impairs differentiation: RORalpha1 directly interacts with p300 and myoD.

PubMed ID: 9862959

DOI: 10.1093/nar/27.2.411

PubMed ID: 11554739

Title: Identification of a novel peroxisome proliferator-activated receptor (PPAR) gamma promoter in man and transactivation by the nuclear receptor RORalpha1.

PubMed ID: 11554739

DOI: 10.1006/bbrc.2001.5602

PubMed ID: 11252722

Title: The orphan nuclear receptor ROR alpha is a negative regulator of the inflammatory response.

PubMed ID: 11252722

DOI: 10.1093/embo-reports/kve007

PubMed ID: 11053433

Title: Transcriptional regulation of apolipoprotein C-III gene expression by the orphan nuclear receptor RORalpha.

PubMed ID: 11053433

DOI: 10.1074/jbc.m004982200

PubMed ID: 14570920

Title: The co-repressor hairless protects RORalpha orphan nuclear receptor from proteasome-mediated degradation.

PubMed ID: 14570920

DOI: 10.1074/jbc.m308152200

PubMed ID: 14742449

Title: Hypoxia-induced activation of the retinoic acid receptor-related orphan receptor alpha4 gene by an interaction between hypoxia-inducible factor-1 and Sp1.

PubMed ID: 14742449

DOI: 10.1074/jbc.m313186200

PubMed ID: 15790933

Title: Transcriptional regulation of apolipoprotein A5 gene expression by the nuclear receptor RORalpha.

PubMed ID: 15790933

DOI: 10.1161/01.atv.0000163841.85333.83

PubMed ID: 15781255

Title: Identification of the human ApoAV gene as a novel RORalpha target gene.

PubMed ID: 15781255

DOI: 10.1016/j.bbrc.2005.02.151

PubMed ID: 16462772

Title: RORA, a large common fragile site gene, is involved in cellular stress response.

PubMed ID: 16462772

DOI: 10.1038/sj.onc.1209314

PubMed ID: 17512500

Title: Extracellular signal-regulated kinase-2 phosphorylates RORalpha4 in vitro.

PubMed ID: 17512500

DOI: 10.1016/j.bbrc.2007.05.016

PubMed ID: 18658046

Title: Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling.

PubMed ID: 18658046

DOI: 10.1161/atvbaha.108.171546

PubMed ID: 18354202

Title: Isoform-specific inhibition of ROR alpha-mediated transcriptional activation by human FOXP3.

PubMed ID: 18354202

DOI: 10.4049/jimmunol.180.7.4785

PubMed ID: 18005000

Title: Phosphorylation and transcriptional activity regulation of retinoid-related orphan receptor alpha 1 by protein kinases C.

PubMed ID: 18005000

DOI: 10.1111/j.1471-4159.2007.05074.x

PubMed ID: 19041634

Title: SUMOylation of RORalpha potentiates transcriptional activation function.

PubMed ID: 19041634

DOI: 10.1016/j.bbrc.2008.11.072

PubMed ID: 19381306

Title: Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism.

PubMed ID: 19381306

DOI: 10.1621/nrs.07003

PubMed ID: 19965867

Title: Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands.

PubMed ID: 19965867

DOI: 10.1074/jbc.m109.080614

PubMed ID: 21628546

Title: Modulation of clock gene expression by the transcriptional coregulator receptor interacting protein 140 (RIP140).

PubMed ID: 21628546

DOI: 10.1177/0748730411401579

PubMed ID: 21499262

Title: Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand.

PubMed ID: 21499262

DOI: 10.1038/nature10075

PubMed ID: 22170608

Title: Cryptochromes mediate rhythmic repression of the glucocorticoid receptor.

PubMed ID: 22170608

DOI: 10.1038/nature10700

PubMed ID: 23063525

Title: EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex.

PubMed ID: 23063525

DOI: 10.1016/j.molcel.2012.09.004

PubMed ID: 22789990

Title: Action of RORs and their ligands in (patho)physiology.

PubMed ID: 22789990

DOI: 10.1016/j.tem.2012.05.012

PubMed ID: 29656859

Title: Dual molecular effects of dominant RORA mutations cause two variants of syndromic intellectual disability with either autism or cerebellar ataxia.

PubMed ID: 29656859

DOI: 10.1016/j.ajhg.2018.02.021

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 12467577

Title: X-ray structure of the hRORalpha LBD at 1.63 A: structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha.

PubMed ID: 12467577

DOI: 10.1016/s0969-2126(02)00912-7

PubMed ID: 14722075

Title: Crystal structure of the human RORalpha Ligand binding domain in complex with cholesterol sulfate at 2.2 A.

PubMed ID: 14722075

DOI: 10.1074/jbc.m400302200

Sequence Information:

  • Length: 523
  • Mass: 58975
  • Checksum: 0FA43BBCE6E28DC7
  • Sequence:
    • MESAPAAPDP AASEPGSSGA DAAAGSRETP LNQESARKSE PPAPVRRQSY SSTSRGISVT 
KKTHTSQIEI IPCKICGDKS SGIHYGVITC EGCKGFFRRS QQSNATYSCP RQKNCLIDRT 
SRNRCQHCRL QKCLAVGMSR DAVKFGRMSK KQRDSLYAEV QKHRMQQQQR DHQQQPGEAE 
PLTPTYNISA NGLTELHDDL SNYIDGHTPE GSKADSAVSS FYLDIQPSPD QSGLDINGIK 
PEPICDYTPA SGFFPYCSFT NGETSPTVSM AELEHLAQNI SKSHLETCQY LREELQQITW 
QTFLQEEIEN YQNKQREVMW QLCAIKITEA IQYVVEFAKR IDGFMELCQN DQIVLLKAGS 
LEVVFIRMCR AFDSQNNTVY FDGKYASPDV FKSLGCEDFI SFVFEFGKSL CSMHLTEDEI 
ALFSAFVLMS ADRSWLQEKV KIEKLQQKIQ LALQHVLQKN HREDGILTKL ICKVSTLRAL 
CGRHTEKLMA FKAIYPDIVR LHFPPLYKEL FTSEFEPAMQ IDG

Genular Protein ID: 1987799638

Symbol: A0A0C4DG53_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0C4DG53

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 7 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 5 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

Sequence Information:

  • Length: 468
  • Mass: 53540
  • Checksum: 906C317B11AB3C2D
  • Sequence:
    • MMYFVIAAMK AQIEIIPCKI CGDKSSGIHY GVITCEGCKG FFRRSQQSNA TYSCPRQKNC 
LIDRTSRNRC QHCRLQKCLA VGMSRDAVKF GRMSKKQRDS LYAEVQKHRM QQQQRDHQQQ 
PGEAEPLTPT YNISANGLTE LHDDLSNYID GHTPEGSKAD SAVSSFYLDI QPSPDQSGLD 
INGIKPEPIC DYTPASGFFP YCSFTNGETS PTVSMAELEH LAQNISKSHL ETCQYLREEL 
QQITWQTFLQ EEIENYQNKQ REVMWQLCAI KITEAIQYVV EFAKRIDGFM ELCQNDQIVL 
LKAGSLEVVF IRMCRAFDSQ NNTVYFDGKY ASPDVFKSLG CEDFISFVFE FGKSLCSMHL 
TEDEIALFSA FVLMSADRSW LQEKVKIEKL QQKIQLALQH VLQKNHREDG ILTKLICKVS 
TLRALCGRHT EKLMAFKAIY PDIVRLHFPP LYKELFTSEF EPAMQIDG

Genular Protein ID: 1436332595

Symbol: A0A0C4DFP5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0C4DFP5

Database IDs:

ARBA 10 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 GO 5 Gene3D 2 GeneTree 1 HGNC 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 5 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

Sequence Information:

  • Length: 548
  • Mass: 62251
  • Checksum: 505F1369DEFEB3A6
  • Sequence:
    • MNEGAPGDSD LETEARVPWS IMGHCLRTGQ ARMSATPTPA GEGARSSSTC SSLSRLFWSQ 
LEHINWDGAT AKNFINLREF FSFLLPALRK AQIEIIPCKI CGDKSSGIHY GVITCEGCKG 
FFRRSQQSNA TYSCPRQKNC LIDRTSRNRC QHCRLQKCLA VGMSRDAVKF GRMSKKQRDS 
LYAEVQKHRM QQQQRDHQQQ PGEAEPLTPT YNISANGLTE LHDDLSNYID GHTPEGSKAD 
SAVSSFYLDI QPSPDQSGLD INGIKPEPIC DYTPASGFFP YCSFTNGETS PTVSMAELEH 
LAQNISKSHL ETCQYLREEL QQITWQTFLQ EEIENYQNKQ REVMWQLCAI KITEAIQYVV 
EFAKRIDGFM ELCQNDQIVL LKAGSLEVVF IRMCRAFDSQ NNTVYFDGKY ASPDVFKSLG 
CEDFISFVFE FGKSLCSMHL TEDEIALFSA FVLMSADRSW LQEKVKIEKL QQKIQLALQH 
VLQKNHREDG ILTKLICKVS TLRALCGRHT EKLMAFKAIY PDIVRLHFPP LYKELFTSEF 
EPAMQIDG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.