Details for: FKBP2

Gene ID: 2286

Symbol: FKBP2

Ensembl ID: ENSG00000173486

Description: FKBP prolyl isomerase 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 4.31
    Marker Score: 3667
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.38
    Marker Score: 9067
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.19
    Marker Score: 1099
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.16
    Marker Score: 2471.5
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 3.06
    Marker Score: 1221
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.01
    Marker Score: 7597
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.95
    Marker Score: 4894
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.92
    Marker Score: 101106
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.86
    Marker Score: 4595
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.81
    Marker Score: 17921
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.81
    Marker Score: 2505
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.76
    Marker Score: 13235
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.69
    Marker Score: 1003
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.63
    Marker Score: 3176
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.62
    Marker Score: 11281.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.61
    Marker Score: 16989
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.59
    Marker Score: 4112
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.57
    Marker Score: 5839
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.56
    Marker Score: 2457
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.54
    Marker Score: 9802.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.54
    Marker Score: 3595
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.53
    Marker Score: 7955
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.52
    Marker Score: 8956
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.52
    Marker Score: 1241.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.5
    Marker Score: 6109.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.5
    Marker Score: 28151
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.49
    Marker Score: 1451
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.48
    Marker Score: 21343
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.45
    Marker Score: 2482
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 2.41
    Marker Score: 662
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.41
    Marker Score: 2560
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.4
    Marker Score: 20888
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.4
    Marker Score: 18711
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.37
    Marker Score: 4461
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.35
    Marker Score: 984
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.33
    Marker Score: 1660
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.32
    Marker Score: 17297
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.32
    Marker Score: 1203
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.3
    Marker Score: 3551
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.3
    Marker Score: 728
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.3
    Marker Score: 3301
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.3
    Marker Score: 1182
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.28
    Marker Score: 1800
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.27
    Marker Score: 1213
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 2.27
    Marker Score: 992
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.27
    Marker Score: 4616
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.27
    Marker Score: 1076
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.25
    Marker Score: 13326
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.23
    Marker Score: 2599
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 2.22
    Marker Score: 812
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.2
    Marker Score: 2867
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.2
    Marker Score: 4010
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 2.18
    Marker Score: 1514
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.17
    Marker Score: 1450
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.17
    Marker Score: 8535
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.11
    Marker Score: 4405
  • Cell Name: PP cell (CL0000696)
    Fold Change: 2.09
    Marker Score: 471
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.08
    Marker Score: 2514
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.07
    Marker Score: 5410
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.05
    Marker Score: 2304
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.05
    Marker Score: 1935
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.04
    Marker Score: 7548
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.02
    Marker Score: 4803
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.01
    Marker Score: 569
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2
    Marker Score: 13024
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.98
    Marker Score: 5400
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.97
    Marker Score: 3228.5
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.97
    Marker Score: 2119.5
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.95
    Marker Score: 656
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.95
    Marker Score: 3894
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.94
    Marker Score: 19550.5
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.94
    Marker Score: 480
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.94
    Marker Score: 49603
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.91
    Marker Score: 1348
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.89
    Marker Score: 455
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.88
    Marker Score: 1769
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.87
    Marker Score: 755
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.87
    Marker Score: 873.5
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.87
    Marker Score: 811
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.85
    Marker Score: 2117
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.85
    Marker Score: 695
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.84
    Marker Score: 413
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.83
    Marker Score: 518
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.82
    Marker Score: 1818
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.81
    Marker Score: 900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.8
    Marker Score: 3057
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.79
    Marker Score: 983
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.78
    Marker Score: 23491
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.77
    Marker Score: 416
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.77
    Marker Score: 4888
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.77
    Marker Score: 1114
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.75
    Marker Score: 608
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.74
    Marker Score: 3312
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.74
    Marker Score: 370
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.74
    Marker Score: 1847
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.73
    Marker Score: 2297
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.71
    Marker Score: 15030
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.71
    Marker Score: 1051
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 1.7
    Marker Score: 465
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.7
    Marker Score: 432

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Other Information

**Key characteristics:** * It is a chaperone protein with a molecular weight of approximately 130 kDa. * It is expressed in a wide range of cell types, including plasma cells, kidney cells, and epithelial cells. * It is a key regulator of ER protein folding and is involved in the maintenance of protein quality control. **Pathways and functions:** * The FKBP2 protein is involved in the Chaperone-mediated Protein Folding (CMPF) pathway, which is a highly conserved protein folding pathway in eukaryotes. * It helps to fold and refold secretory and membrane proteins by catalyzing the isomerization of proline residues to their corresponding serine or threonine residues. * It is involved in the folding and trafficking of proteins involved in various cellular processes, including secretion, protein-protein interactions, and membrane trafficking. * It is also involved in the regulation of inflammation and cell signaling pathways. **Clinical significance:** * Mutations in FKBP2 have been linked to several human diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). * FKBP2 mutations can lead to the accumulation of misfolded or unfolded proteins, which can disrupt protein function and contribute to disease pathogenesis. * Targeting FKBP2 has emerged as a potential therapeutic strategy for diseases associated with protein misfolding. **Conclusion:** FKBP2 is a critical chaperone protein that plays a crucial role in the folding and stability of proteins in the endoplasmic reticulum. Its mutations have significant implications for human health, underscoring its importance in maintaining cellular function and preventing disease.

Genular Protein ID: 3879071654

Symbol: FKBP2_HUMAN

Name: Peptidyl-prolyl cis-trans isomerase FKBP2

UniProtKB Accession Codes:

P26885 Q5BJH9 Q9BTS7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 4 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OpenTargets 1 PANTHER 2 PDB 3 PDBsum 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 4 Rhea 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1713687

Title: Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13.

PubMed ID: 1713687

DOI: 10.1073/pnas.88.15.6677

PubMed ID: 1281998

Title: Chromosomal band assignments of the genes encoding human FKBP12 and FKBP13.

PubMed ID: 1281998

DOI: 10.1016/0006-291x(92)92276-4

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12606707

Title: Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506.

PubMed ID: 12606707

DOI: 10.1073/pnas.2628047100

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 142
  • Mass: 15649
  • Checksum: 01024F869BA7B5DA
  • Sequence:
    • MRLSWFRVLT VLSICLSAVA TATGAEGKRK LQIGVKKRVD HCPIKSRKGD VLHMHYTGKL 
EDGTEFDSSL PQNQPFVFSL GTGQVIKGWD QGLLGMCEGE KRKLVIPSEL GYGERGAPPK 
IPGGATLVFE VELLKIERRT EL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.