Details for: FKBP2

Gene ID: 2286

Symbol: FKBP2

Ensembl ID: ENSG00000173486

Description: FKBP prolyl isomerase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 411.0702
    Cell Significance Index: -63.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 235.4093
    Cell Significance Index: -59.7100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 170.5799
    Cell Significance Index: -70.2700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 151.2319
    Cell Significance Index: -71.4000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 149.7574
    Cell Significance Index: -60.8400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 135.4044
    Cell Significance Index: -69.6500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 106.9264
    Cell Significance Index: -71.7500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 64.8552
    Cell Significance Index: -61.9200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 56.1334
    Cell Significance Index: -69.2100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.8191
    Cell Significance Index: -70.3200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.9956
    Cell Significance Index: -42.8500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.3380
    Cell Significance Index: -47.1100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.7311
    Cell Significance Index: 29.7900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 3.4385
    Cell Significance Index: 374.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.7967
    Cell Significance Index: 1527.3400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.5145
    Cell Significance Index: 187.4000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.4180
    Cell Significance Index: 64.6800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.0615
    Cell Significance Index: 123.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.9810
    Cell Significance Index: 569.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.8850
    Cell Significance Index: 98.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.5675
    Cell Significance Index: 202.5100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.4630
    Cell Significance Index: 38.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.4153
    Cell Significance Index: 73.7200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1462
    Cell Significance Index: 506.7600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0094
    Cell Significance Index: 164.1800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.9469
    Cell Significance Index: 32.9100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8880
    Cell Significance Index: 62.8000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8537
    Cell Significance Index: 17.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.7574
    Cell Significance Index: 129.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6994
    Cell Significance Index: 31.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6591
    Cell Significance Index: 17.9400
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.6299
    Cell Significance Index: 1.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6071
    Cell Significance Index: 77.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6027
    Cell Significance Index: 59.6300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.4671
    Cell Significance Index: 342.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.4212
    Cell Significance Index: 318.8500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4023
    Cell Significance Index: 18.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3685
    Cell Significance Index: 50.6100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3360
    Cell Significance Index: 63.9400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2985
    Cell Significance Index: 206.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2977
    Cell Significance Index: 8.3200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2974
    Cell Significance Index: 19.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2973
    Cell Significance Index: 35.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1920
    Cell Significance Index: 8.9500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1192
    Cell Significance Index: 7.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1068
    Cell Significance Index: 21.2000
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.0815
    Cell Significance Index: 1.7000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0757
    Cell Significance Index: 2.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0731
    Cell Significance Index: 13.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0496
    Cell Significance Index: 0.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0136
    Cell Significance Index: -10.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0159
    Cell Significance Index: -1.6200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0201
    Cell Significance Index: -0.5900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0333
    Cell Significance Index: -62.7900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0458
    Cell Significance Index: -0.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0514
    Cell Significance Index: -94.7200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0530
    Cell Significance Index: -33.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0615
    Cell Significance Index: -94.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0619
    Cell Significance Index: -34.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0642
    Cell Significance Index: -12.8700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0701
    Cell Significance Index: -95.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0986
    Cell Significance Index: -62.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1074
    Cell Significance Index: -22.6300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1624
    Cell Significance Index: -19.9700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1641
    Cell Significance Index: -74.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1858
    Cell Significance Index: -66.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1860
    Cell Significance Index: -21.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2557
    Cell Significance Index: -29.3000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2729
    Cell Significance Index: -3.1000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3146
    Cell Significance Index: -3.4200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3348
    Cell Significance Index: -9.6500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3601
    Cell Significance Index: -24.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4110
    Cell Significance Index: -21.3500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4169
    Cell Significance Index: -10.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4250
    Cell Significance Index: -33.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4633
    Cell Significance Index: -14.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4745
    Cell Significance Index: -68.9800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5439
    Cell Significance Index: -6.9600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5616
    Cell Significance Index: -6.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6060
    Cell Significance Index: -37.2500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6089
    Cell Significance Index: -69.5100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6618
    Cell Significance Index: -11.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6913
    Cell Significance Index: -71.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.9199
    Cell Significance Index: -70.6000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.0415
    Cell Significance Index: -22.1800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.0498
    Cell Significance Index: -15.7300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.0574
    Cell Significance Index: -18.1200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.1037
    Cell Significance Index: -29.5800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1696
    Cell Significance Index: -71.7100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.1765
    Cell Significance Index: -79.1100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.2806
    Cell Significance Index: -37.7200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.3168
    Cell Significance Index: -10.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.3273
    Cell Significance Index: -74.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.4729
    Cell Significance Index: -31.9100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.5534
    Cell Significance Index: -39.9300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.5674
    Cell Significance Index: -28.9700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.5696
    Cell Significance Index: -57.6200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.6027
    Cell Significance Index: -31.2800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.6602
    Cell Significance Index: -47.5900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.6730
    Cell Significance Index: -74.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FKBP2 shares structural and functional similarities with other peptidyl-prolyl cis-trans isomerases. Its primary function is to catalyze the isomerization of peptidyl-prolyl bonds, a critical step in protein folding. This process enables the proper assembly and stabilization of proteins, which is essential for various cellular functions. FKBP2 is also known to interact with various proteins, including FK506, which highlights its role in immune regulation. **Pathways and Functions** FKBP2 is involved in several key pathways, including: 1. **Chaperone-mediated protein folding**: FKBP2 plays a crucial role in protein folding by facilitating the isomerization of peptidyl-prolyl bonds. This process is essential for the proper assembly and stabilization of proteins. 2. **Endoplasmic reticulum (ER) function**: FKBP2 is localized to the ER, where it interacts with other proteins involved in protein folding and quality control. 3. **FK506 binding**: FKBP2 binds to FK506, a potent immunosuppressive agent, which highlights its role in immune regulation. 4. **Peptidyl-prolyl cis-trans isomerase activity**: FKBP2 catalyzes the isomerization of peptidyl-prolyl bonds, a critical step in protein folding. **Clinical Significance** FKBP2 has significant implications in various clinical contexts: 1. **Immunosuppression**: FKBP2's interaction with FK506 highlights its role in immune regulation. FK506, a widely used immunosuppressive agent, binds to FKBP2, which in turn inhibits calcineurin, a key regulator of T-cell activation. 2. **Cancer**: Dysregulation of FKBP2 has been implicated in various cancers, including breast and lung cancer. Overexpression of FKBP2 has been associated with tumor progression and poor prognosis. 3. **Kidney disease**: FKBP2 is expressed in kidney cells, where it plays a role in protein folding and quality control. Dysregulation of FKBP2 has been implicated in kidney disease, including diabetic nephropathy and acute kidney injury. In conclusion, FKBP2 is a critical component of protein folding and immune regulation, with significant implications in various clinical contexts. Its dysregulation has been implicated in various diseases, including cancer and kidney disease. Further research is necessary to fully understand the role of FKBP2 in human health and disease.

Genular Protein ID: 3879071654

Symbol: FKBP2_HUMAN

Name: Peptidyl-prolyl cis-trans isomerase FKBP2

UniProtKB Accession Codes:

P26885 Q5BJH9 Q9BTS7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 4 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OpenTargets 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 4 Rhea 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1713687

Title: Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13.

PubMed ID: 1713687

DOI: 10.1073/pnas.88.15.6677

PubMed ID: 1281998

Title: Chromosomal band assignments of the genes encoding human FKBP12 and FKBP13.

PubMed ID: 1281998

DOI: 10.1016/0006-291x(92)92276-4

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12606707

Title: Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506.

PubMed ID: 12606707

DOI: 10.1073/pnas.2628047100

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 142
  • Mass: 15649
  • Checksum: 01024F869BA7B5DA
  • Sequence:
    • MRLSWFRVLT VLSICLSAVA TATGAEGKRK LQIGVKKRVD HCPIKSRKGD VLHMHYTGKL 
EDGTEFDSSL PQNQPFVFSL GTGQVIKGWD QGLLGMCEGE KRKLVIPSEL GYGERGAPPK 
IPGGATLVFE VELLKIERRT EL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.