Details for: CRYL1

Gene ID: 51084

Symbol: CRYL1

Ensembl ID: ENSG00000165475

Description: crystallin lambda 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 244.4305
    Cell Significance Index: -38.0200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 132.2723
    Cell Significance Index: -33.5500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 89.5502
    Cell Significance Index: -36.8900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 83.2724
    Cell Significance Index: -33.8300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 74.2245
    Cell Significance Index: -38.1800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 59.3274
    Cell Significance Index: -39.8100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 35.6431
    Cell Significance Index: -34.0300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.3799
    Cell Significance Index: -38.6900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.2500
    Cell Significance Index: -35.5000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.2222
    Cell Significance Index: -37.5400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.8567
    Cell Significance Index: -38.9000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.5019
    Cell Significance Index: -14.2300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 3.6299
    Cell Significance Index: 61.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.1565
    Cell Significance Index: 46.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8398
    Cell Significance Index: 369.0600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.6544
    Cell Significance Index: 1493.7800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1903
    Cell Significance Index: 236.2200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.9443
    Cell Significance Index: 14.1500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9209
    Cell Significance Index: 55.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9015
    Cell Significance Index: 42.0300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8730
    Cell Significance Index: 33.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8539
    Cell Significance Index: 37.7700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.7615
    Cell Significance Index: 6.0800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7074
    Cell Significance Index: 48.9200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6797
    Cell Significance Index: 243.7900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.6320
    Cell Significance Index: 10.1400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5569
    Cell Significance Index: 385.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5423
    Cell Significance Index: 296.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4646
    Cell Significance Index: 21.0600
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.4564
    Cell Significance Index: 1.7500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.3853
    Cell Significance Index: 6.4800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3757
    Cell Significance Index: 67.7300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3700
    Cell Significance Index: 60.1700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.3066
    Cell Significance Index: 2.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2596
    Cell Significance Index: 44.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2191
    Cell Significance Index: 21.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2078
    Cell Significance Index: 91.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1539
    Cell Significance Index: 11.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1535
    Cell Significance Index: 10.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1453
    Cell Significance Index: 106.5100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1449
    Cell Significance Index: 272.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1175
    Cell Significance Index: 14.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1019
    Cell Significance Index: 13.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0888
    Cell Significance Index: 11.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0811
    Cell Significance Index: 15.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0619
    Cell Significance Index: 114.2000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.0585
    Cell Significance Index: 4.6300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0528
    Cell Significance Index: 0.7800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0503
    Cell Significance Index: 77.4600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0470
    Cell Significance Index: 29.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0354
    Cell Significance Index: 48.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0077
    Cell Significance Index: 0.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0091
    Cell Significance Index: -6.7700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0094
    Cell Significance Index: -0.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0143
    Cell Significance Index: -1.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0192
    Cell Significance Index: -8.7300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0241
    Cell Significance Index: -15.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0273
    Cell Significance Index: -3.9800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0347
    Cell Significance Index: -1.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0387
    Cell Significance Index: -29.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0419
    Cell Significance Index: -23.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0599
    Cell Significance Index: -7.7400
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0719
    Cell Significance Index: -0.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0891
    Cell Significance Index: -10.2100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0971
    Cell Significance Index: -7.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1038
    Cell Significance Index: -21.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1119
    Cell Significance Index: -6.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1170
    Cell Significance Index: -33.6600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1516
    Cell Significance Index: -3.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1810
    Cell Significance Index: -2.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1866
    Cell Significance Index: -21.7500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2045
    Cell Significance Index: -4.2800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2094
    Cell Significance Index: -6.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2292
    Cell Significance Index: -6.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2356
    Cell Significance Index: -14.8500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2391
    Cell Significance Index: -16.9100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2577
    Cell Significance Index: -15.8400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2676
    Cell Significance Index: -13.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2718
    Cell Significance Index: -12.7800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2840
    Cell Significance Index: -14.3500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2852
    Cell Significance Index: -7.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2890
    Cell Significance Index: -34.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2930
    Cell Significance Index: -30.5100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3386
    Cell Significance Index: -38.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3433
    Cell Significance Index: -22.1500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4115
    Cell Significance Index: -4.2600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4470
    Cell Significance Index: -12.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4812
    Cell Significance Index: -29.5000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.5128
    Cell Significance Index: -8.4500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5294
    Cell Significance Index: -14.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6266
    Cell Significance Index: -32.9000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6330
    Cell Significance Index: -20.1600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6342
    Cell Significance Index: -13.4600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.6559
    Cell Significance Index: -6.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.6561
    Cell Significance Index: -17.5200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.6574
    Cell Significance Index: -12.8300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6839
    Cell Significance Index: -11.7200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6883
    Cell Significance Index: -18.1000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7058
    Cell Significance Index: -19.2100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7122
    Cell Significance Index: -24.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Crystallin family member**: CRYL1 is a member of the crystallin family, which is composed of alpha, beta, gamma, delta, epsilon, and lambda crystallins. These proteins are responsible for maintaining the transparency and refractive index of the lens in the eye. 2. **Cellular expression**: CRYL1 is expressed in various cell types, including hematopoietic cells, stem cells, epithelial cells, and erythroblasts. 3. **Protein homodimerization**: CRYL1 forms homodimers, which are stable complexes composed of two identical protein subunits. 4. **NAD+ binding**: CRYL1 binds to NAD+, a coenzyme involved in various cellular processes, including energy metabolism and DNA repair. **Pathways and Functions** 1. **Cytoskeletal regulation**: CRYL1 participates in the regulation of the cytoskeleton, which is essential for maintaining cellular structure and function. 2. **Cell differentiation**: CRYL1 may contribute to the regulation of cellular differentiation, particularly in hematopoietic cells and stem cells. 3. **Apoptosis regulation**: CRYL1 has been implicated in the regulation of apoptosis, a process of programmed cell death that is crucial for maintaining tissue homeostasis. 4. **Energy metabolism**: CRYL1 interacts with NAD+, which is involved in energy metabolism and DNA repair. **Clinical Significance** 1. **Eye disorders**: Mutations in the CRYL1 gene have been associated with certain eye disorders, such as cataracts and glaucoma. 2. **Hematological disorders**: Alterations in CRYL1 expression have been observed in hematological disorders, such as leukemia and lymphoma. 3. **Cancer**: CRYL1 may play a role in the development and progression of certain cancers, including breast and lung cancer. 4. **Neurological disorders**: CRYL1 has been implicated in the regulation of cellular processes that contribute to the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the CRYL1 gene plays a complex role in various cellular processes, including cytoskeletal regulation, cell differentiation, apoptosis regulation, and energy metabolism. Further research is needed to fully elucidate the functions of CRYL1 and its role in various diseases.

Genular Protein ID: 1010317790

Symbol: CRYL1_HUMAN

Name: Lambda-crystallin homolog

UniProtKB Accession Codes:

Q9Y2S2 A0PJ43 B3KN92 Q0VDI1 Q7Z4Z9 Q9P0G7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 9 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 12 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 2 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12527201

Title: Human CRYL1, a novel enzyme-crystallin overexpressed in liver and kidney and downregulated in 58% of liver cancer tissues from 60 Chinese patients, and four new homologs from other mammalians.

PubMed ID: 12527201

DOI: 10.1016/s0378-1119(02)01095-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15809331

Title: Structural and functional characterization of rabbit and human L-gulonate 3-dehydrogenase.

PubMed ID: 15809331

DOI: 10.1093/jb/mvi033

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 319
  • Mass: 35419
  • Checksum: C8DCF74DDE2FDE21
  • Sequence:
    • MASSAAGCVV IVGSGVIGRS WAMLFASGGF QVKLYDIEQQ QIRNALENIR KEMKLLEQAG 
SLKGSLSVEE QLSLISGCPN IQEAVEGAMH IQECVPEDLE LKKKIFAQLD SIIDDRVILS 
SSTSCLMPSK LFAGLVHVKQ CIVAHPVNPP YYIPLVELVP HPETAPTTVD RTHALMKKIG 
QCPMRVQKEV AGFVLNRLQY AIISEAWRLV EEGIVSPSDL DLVMSEGLGM RYAFIGPLET 
MHLNAEGMLS YCDRYSEGIK HVLQTFGPIP EFSRATAEKV NQDMCMKVPD DPEHLAARRQ 
WRDECLMRLA KLKSQVQPQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.