Details for: PCCA
Gene ID: 5095
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PCCA
Ensembl ID: ENSG00000175198
Description: propionyl-CoA carboxylase subunit alpha
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 37.9rCSI 47.15%PRS 18.58
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CSI 37.74rCSI 48.46%PRS 29.63
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CSI 30.27rCSI 49.58%PRS 24.63
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CSI 28.32rCSI 47.54%PRS 19.71
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CSI 26.57rCSI 28.48%PRS 29.29
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CSI 25.26rCSI 61.38%PRS 19.21
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CSI 24.59rCSI 44.02%PRS 29.62
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CSI 23.49rCSI 28.06%PRS 19.58
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CSI 23.1rCSI 51.04%PRS 22.81
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CSI 23.06rCSI 22.23%PRS 23.99
-
CSI 21rCSI 65.67%PRS 22.42
-
CSI 20.83rCSI 28.5%PRS 30.07
-
CSI 20.22rCSI 23.44%PRS 60.45
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CSI 18.74rCSI 58.58%PRS 20.67
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CSI 18.51rCSI 29.53%PRS 26.86
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CSI 18.36rCSI 18.79%PRS 50.06
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CSI 18.3rCSI 32.07%PRS 25.21
-
CSI 17.95rCSI 64.58%PRS 18.76
-
CSI 17.47rCSI 45.38%PRS 37.4
-
CSI 17.45rCSI 28.06%PRS 21.43
-
CSI 17.28rCSI 29.89%PRS 24.37
-
CSI 17.14rCSI 34.42%PRS 23.73
-
CSI 16.81rCSI 14.92%PRS 31.16
-
CSI 16.68rCSI 23.17%PRS 31.62
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CSI 16.51rCSI 62.41%PRS 20.52
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CSI 15.99rCSI 36.9%PRS 25.82
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CSI 14.71rCSI 11.63%PRS 22.04
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CSI 14.7rCSI 16.97%PRS 27.42
-
CSI 14.65rCSI 18.89%PRS 20.43
-
CSI 14.43rCSI 36.59%PRS 24.45
-
CSI 13.04rCSI 19.67%PRS 32.42
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CSI 12.98rCSI 32.12%PRS 29.63
-
CSI 12.3rCSI 19.92%PRS 30.92
-
CSI 11.98rCSI 10.53%PRS 23.24
-
CSI 11.84rCSI 31.63%PRS 26.55
-
CSI 11.81rCSI 37.78%PRS 28.25
-
CSI 11.29rCSI 8.37%PRS 27.04
-
CSI 11.28rCSI 25.8%PRS 30.9
-
CSI 11.21rCSI 66.01%PRS 20.79
-
CSI 10.94rCSI 15.5%PRS 29.19
-
CSI 10.69rCSI 35.42%PRS 34.31
-
CSI 10.69rCSI 36.21%PRS 28.91
-
CSI 10.26rCSI 26.75%PRS 30.41
-
CSI 10.13rCSI 37.94%PRS 26.65
-
CSI 10.09rCSI 21.36%PRS 53.8
-
CSI 10.09rCSI 50.8%PRS 47.73
-
CSI 10.01rCSI 20.31%PRS 18.26
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CSI 10rCSI 23.85%PRS 34.41
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CSI 9.92rCSI 21.84%PRS 22.46
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CSI 9.21rCSI 16.27%PRS 19.11
-
CSI 9.11rCSI 20.43%PRS 20.28
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CSI 9.03rCSI 13.81%PRS 47.33
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CSI 8.81rCSI 19.39%PRS 35.08
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CSI 8.68rCSI 11.14%PRS 29.97
-
CSI 8.56rCSI 9.37%PRS 34.79
-
CSI 8.41rCSI 7.83%PRS 31.34
-
CSI 8.34rCSI 17.31%PRS 30.67
-
CSI 8.3rCSI 51.84%PRS 25.68
-
CSI 8.29rCSI 33.36%PRS 47.19
-
CSI 8.22rCSI 46.46%PRS 20.7
-
CSI 8.17rCSI 15.3%PRS 23.66
-
CSI 8.02rCSI 26.11%PRS 35.19
-
CSI 7.82rCSI 11.22%PRS 24.92
-
CSI 7.79rCSI 15.47%PRS 31.91
-
CSI 7.79rCSI 57.27%PRS 21.7
-
CSI 7.79rCSI 13.73%PRS 30.56
-
CSI 7.4rCSI 11.37%PRS 37.54
-
CSI 7.35rCSI 11.2%PRS 29.09
-
CSI 7.32rCSI 17.6%PRS 42.67
-
CSI 7.13rCSI 16.28%PRS 26.98
-
CSI 7.08rCSI 28.03%PRS 37.06
-
CSI 7.06rCSI 18.8%PRS 26.68
-
CSI 6.98rCSI 12.54%PRS 26.42
-
CSI 6.88rCSI 10.12%PRS 29.15
-
CSI 6.69rCSI 19.02%PRS 33.13
-
CSI 6.65rCSI 10.95%PRS 36.15
-
CSI 6.63rCSI 19.67%PRS 41.57
-
CSI 6.52rCSI 19.24%PRS 30.43
-
CSI 6.49rCSI 31.08%PRS 28.94
-
CSI 6.39rCSI 6.69%PRS 29.38
-
CSI 6.33rCSI 4.75%PRS 66.75
-
CSI 6.32rCSI 10.09%PRS 34.3
-
CSI 6.22rCSI 31.88%PRS 34.1
-
CSI 6.11rCSI 6.37%PRS 32
-
CSI 6.07rCSI 11.03%PRS 27.2
-
CSI 6.04rCSI 6.02%PRS 26.92
-
CSI 5.99rCSI 13.37%PRS 36.59
-
CSI 5.82rCSI 19.51%PRS 23.35
-
CSI 5.62rCSI 32.39%PRS 35.75
-
CSI 5.61rCSI 7.19%PRS 35.87
-
CSI 5.53rCSI 13.51%PRS 29.57
-
CSI 5.39rCSI 21.74%PRS 30.18
-
CSI 5.39rCSI 28.32%PRS 33.13
-
CSI 5.34rCSI 38.14%PRS 42.59
-
CSI 5.33rCSI 26.48%PRS 32.85
-
CSI 5.29rCSI 42.99%PRS 28.87
-
CSI 5.12rCSI 20.87%PRS 31.3
-
CSI 4.99rCSI 11.37%PRS 31.23
-
CSI 4.94rCSI 5.81%PRS 35.07
-
CSI 4.91rCSI 11.72%PRS 43.05
-
CSI 0.2rCSI 2.2%PRS 60.6%
-
CSI 0.3rCSI 0.5%PRS 29.7%
-
CSI 0.6rCSI 1.4%PRS 29.9%
-
CSI 0.6rCSI 4.4%PRS 51.7%
-
CSI 0.8rCSI 6.0%PRS 73.5%
-
CSI 0.8rCSI 3.6%PRS 27.6%
-
CSI 0.8rCSI 2.3%PRS 35.3%
-
CSI 0.9rCSI 3.3%PRS 52.0%
-
CSI 0.9rCSI 2.4%PRS 47.4%
-
CSI 0.9rCSI 2.4%PRS 54.3%
-
CSI 1.0rCSI 1.8%PRS 32.6%
-
CSI 1.0rCSI 1.2%PRS 28.0%
-
CSI 1.0rCSI 1.2%PRS 37.4%
-
CSI 1.0rCSI 6.5%PRS 41.1%
-
CSI 1.1rCSI 12.1%PRS 31.2%
-
CSI 1.1rCSI 5.9%PRS 43.4%
-
CSI 1.2rCSI 1.2%PRS 33.3%
-
CSI 1.3rCSI 1.5%PRS 49.6%
-
CSI 1.3rCSI 9.0%PRS 29.8%
-
CSI 1.3rCSI 30.0%PRS 53.7%
-
CSI 1.3rCSI 6.8%PRS 47.5%
-
CSI 1.3rCSI 11.0%PRS 31.1%
-
CSI 1.3rCSI 2.5%PRS 39.6%
-
CSI 1.4rCSI 5.4%PRS 28.2%
-
CSI 1.4rCSI 7.1%PRS 41.3%
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CSI 1.5rCSI 2.7%PRS 46.1%
-
CSI 1.5rCSI 1.8%PRS 30.3%
-
CSI 1.5rCSI 9.7%PRS 55.6%
-
CSI 1.6rCSI 2.5%PRS 32.0%
-
CSI 1.6rCSI 1.9%PRS 23.7%
-
CSI 1.6rCSI 18.4%PRS 61.1%
-
CSI 1.7rCSI 24.2%PRS 72.2%
-
CSI 1.7rCSI 4.8%PRS 45.8%
-
CSI 1.7rCSI 4.5%PRS 28.9%
-
CSI 1.8rCSI 29.1%PRS 32.9%
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CSI 2.0rCSI 3.1%PRS 40.0%
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CSI 2.0rCSI 1.7%PRS 32.4%
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CSI 2.2rCSI 5.6%PRS 36.7%
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CSI 2.2rCSI 3.2%PRS 40.6%
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CSI 2.3rCSI 2.2%PRS 33.5%
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CSI 2.3rCSI 10.7%PRS 52.5%
-
CSI 2.3rCSI 2.1%PRS 37.3%
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CSI 2.3rCSI 6.3%PRS 39.8%
-
CSI 2.4rCSI 2.5%PRS 36.6%
-
CSI 2.4rCSI 10.6%PRS 29.6%
-
CSI 2.5rCSI 1.9%PRS 45.4%
-
CSI 2.5rCSI 6.4%PRS 38.3%
-
CSI 2.6rCSI 3.3%PRS 35.9%
-
CSI 2.7rCSI 20.6%PRS 31.8%
-
CSI 2.7rCSI 12.0%PRS 30.2%
-
CSI 2.7rCSI 8.9%PRS 23.0%
-
CSI 2.7rCSI 8.7%PRS 32.0%
-
CSI 2.7rCSI 6.4%PRS 41.4%
-
CSI 2.8rCSI 7.2%PRS 31.6%
-
CSI 2.8rCSI 20.9%PRS 30.6%
-
CSI 2.8rCSI 2.6%PRS 32.5%
-
CSI 2.8rCSI 18.7%PRS 31.9%
-
CSI 2.9rCSI 11.2%PRS 12.8%
-
CSI 2.9rCSI 17.0%PRS 31.5%
-
CSI 2.9rCSI 70.8%PRS 19.8%
-
CSI 2.9rCSI 4.0%PRS 17.2%
-
CSI 3.0rCSI 71.4%PRS 19.0%
-
CSI 3.0rCSI 9.2%PRS 43.3%
-
CSI 3.0rCSI 3.8%PRS 33.6%
-
CSI 3.0rCSI 26.2%PRS 37.5%
-
CSI 3.1rCSI 11.9%PRS 40.7%
-
CSI 3.1rCSI 6.7%PRS 40.6%
-
CSI 3.1rCSI 8.1%PRS 42.0%
-
CSI 3.2rCSI 14.2%PRS 22.1%
-
CSI 3.2rCSI 33.7%PRS 35.6%
-
CSI 3.2rCSI 29.5%PRS 56.6%
-
CSI 3.2rCSI 7.0%PRS 24.4%
-
CSI 3.2rCSI 65.5%PRS 27.8%
-
CSI 3.2rCSI 9.3%PRS 25.1%
-
CSI 3.3rCSI 28.3%PRS 20.6%
-
CSI 3.3rCSI 6.5%PRS 60.6%
-
CSI 3.3rCSI 7.3%PRS 45.2%
-
CSI 3.4rCSI 34.9%PRS 31.2%
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CSI 3.4rCSI 69.2%PRS 26.6%
-
CSI 3.6rCSI 8.5%PRS 49.0%
-
CSI 3.6rCSI 14.7%PRS 42.9%
-
CSI 3.6rCSI 26.0%PRS 30.3%
-
CSI 3.7rCSI 4.9%PRS 33.4%
-
CSI 3.7rCSI 32.4%PRS 22.8%
-
CSI 3.7rCSI 5.8%PRS 42.4%
-
CSI 3.8rCSI 18.2%PRS 35.3%
-
CSI 3.8rCSI 6.0%PRS 26.6%
-
CSI 3.8rCSI 7.9%PRS 29.2%
-
CSI 3.9rCSI 5.3%PRS 43.7%
-
CSI 3.9rCSI 24.4%PRS 22.0%
-
CSI 3.9rCSI 21.6%PRS 39.4%
-
CSI 4.0rCSI 56.7%PRS 26.1%
-
CSI 4.0rCSI 18.8%PRS 31.8%
-
CSI 4.1rCSI 3.2%PRS 29.8%
-
CSI 4.2rCSI 28.6%PRS 31.3%
-
CSI 4.3rCSI 6.6%PRS 31.8%
-
CSI 4.4rCSI 5.5%PRS 41.8%
-
CSI 4.4rCSI 15.0%PRS 26.6%
-
CSI 4.4rCSI 7.1%PRS 24.4%
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CSI 4.5rCSI 6.5%PRS 33.5%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3323447151
Symbol: PCCA_HUMAN
Name: Propanoyl-CoA:carbon dioxide ligase subunit alpha
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11592820
Title: Structure of the PCCA gene and distribution of mutations causing propionic acidemia.
PubMed ID: 11592820
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15057823
Title: The DNA sequence and analysis of human chromosome 13.
PubMed ID: 15057823
DOI: 10.1038/nature02379
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2740237
Title: Human mitochondrial propionyl-CoA carboxylase: localization of the N-terminus of the pro- and mature alpha chains in the deduced primary sequence of a full-length cDNA.
PubMed ID: 2740237
PubMed ID: 16023992
Title: Mitochondrial targeting signals and mature peptides of 3-methylcrotonyl-CoA carboxylase.
PubMed ID: 16023992
PubMed ID: 8434582
Title: Cloning of functional alpha propionyl CoA carboxylase and correction of enzyme deficiency in pccA fibroblasts.
PubMed ID: 8434582
PubMed ID: 3460076
Title: Isolation of cDNA clones coding for the alpha and beta chains of human propionyl-CoA carboxylase: chromosomal assignments and DNA polymorphisms associated with PCCA and PCCB genes.
PubMed ID: 3460076
PubMed ID: 3555348
Title: Sequence homology around the biotin-binding site of human propionyl-CoA carboxylase and pyruvate carboxylase.
PubMed ID: 3555348
PubMed ID: 6765947
Title: Isolation and characterization of propionyl-CoA carboxylase from normal human liver. Evidence for a protomeric tetramer of nonidentical subunits.
PubMed ID: 6765947
PubMed ID: 7753853
Title: Isolation of a cDNA encoding human holocarboxylase synthetase by functional complementation of a biotin auxotroph of Escherichia coli.
PubMed ID: 7753853
PubMed ID: 20725044
Title: Crystal structure of the alpha(6)beta(6) holoenzyme of propionyl-coenzyme A carboxylase.
PubMed ID: 20725044
DOI: 10.1038/nature09302
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23438705
Title: Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases.
PubMed ID: 23438705
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 20443544
Title: Structural impact of human and Escherichia coli biotin carboxyl carrier proteins on biotin attachment.
PubMed ID: 20443544
DOI: 10.1021/bi901612y
PubMed ID: 10502773
Title: Overview of mutations in the PCCA and PCCB genes causing propionic acidemia.
PubMed ID: 10502773
DOI: 10.1002/(sici)1098-1004(199910)14:4<275::aid-humu1>3.0.co;2-n
PubMed ID: 10101253
Title: Genetic heterogeneity in propionic acidemia patients with alpha-subunit defects: identification of five novel mutations, one of them causing instability of the protein.
PubMed ID: 10101253
PubMed ID: 12559849
Title: Propionic acidemia: identification of twenty-four novel mutations in Europe and North America.
PubMed ID: 12559849
PubMed ID: 15059621
Title: Mutation spectrum of the PCCA and PCCB genes in Japanese patients with propionic acidemia.
PubMed ID: 15059621
PubMed ID: 10329019
Title: Coding sequence mutations in the alpha subunit of propionyl-CoA carboxylase in patients with propionic acidemia.
PubMed ID: 10329019
Sequence Information:
- Length: 728
- Mass: 80059
- Checksum: 065F64186A0B8CCC
- Sequence:
MAGFWVGTAP LVAAGRRGRW PPQQLMLSAA LRTLKHVLYY SRQCLMVSRN LGSVGYDPNE KTFDKILVAN RGEIACRVIR TCKKMGIKTV AIHSDVDASS VHVKMADEAV CVGPAPTSKS YLNMDAIMEA IKKTRAQAVH PGYGFLSENK EFARCLAAED VVFIGPDTHA IQAMGDKIES KLLAKKAEVN TIPGFDGVVK DAEEAVRIAR EIGYPVMIKA SAGGGGKGMR IAWDDEETRD GFRLSSQEAA SSFGDDRLLI EKFIDNPRHI EIQVLGDKHG NALWLNEREC SIQRRNQKVV EEAPSIFLDA ETRRAMGEQA VALARAVKYS SAGTVEFLVD SKKNFYFLEM NTRLQVEHPV TECITGLDLV QEMIRVAKGY PLRHKQADIR INGWAVECRV YAEDPYKSFG LPSIGRLSQY QEPLHLPGVR VDSGIQPGSD ISIYYDPMIS KLITYGSDRT EALKRMADAL DNYVIRGVTH NIALLREVII NSRFVKGDIS TKFLSDVYPD GFKGHMLTKS EKNQLLAIAS SLFVAFQLRA QHFQENSRMP VIKPDIANWE LSVKLHDKVH TVVASNNGSV FSVEVDGSKL NVTSTWNLAS PLLSVSVDGT QRTVQCLSRE AGGNMSIQFL GTVYKVNILT RLAAELNKFM LEKVTEDTSS VLRSPMPGVV VAVSVKPGDA VAEGQEICVI EAMKMQNSMT AGKTGTVKSV HCQAGDTVGE GDLLVELE