Details for: HSPA9

Gene ID: 3313

Symbol: HSPA9

Ensembl ID: ENSG00000113013

Description: heat shock protein family A (Hsp70) member 9

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.14
    Marker Score: 106983
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.94
    Marker Score: 52162
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.85
    Marker Score: 3043
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.72
    Marker Score: 2315
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.44
    Marker Score: 11978.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.4
    Marker Score: 998
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.36
    Marker Score: 1344
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.31
    Marker Score: 5654
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.31
    Marker Score: 6197
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.14
    Marker Score: 2231
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.13
    Marker Score: 3137
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.01
    Marker Score: 2354
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.98
    Marker Score: 7787
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.98
    Marker Score: 1550
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.94
    Marker Score: 4049
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.94
    Marker Score: 2039
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.93
    Marker Score: 5421
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.93
    Marker Score: 3198
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.91
    Marker Score: 1208
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.91
    Marker Score: 2028
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.91
    Marker Score: 456
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.89
    Marker Score: 4777
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.89
    Marker Score: 2444
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.89
    Marker Score: 7915
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.89
    Marker Score: 21949
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.87
    Marker Score: 1273.5
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.86
    Marker Score: 7183
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.86
    Marker Score: 758
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.86
    Marker Score: 2564
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.86
    Marker Score: 3047
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.85
    Marker Score: 2456
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.84
    Marker Score: 2220
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.84
    Marker Score: 3256
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.84
    Marker Score: 6522
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.83
    Marker Score: 13599
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.82
    Marker Score: 1063
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.82
    Marker Score: 15720
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.82
    Marker Score: 4144
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.81
    Marker Score: 1209.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.8
    Marker Score: 948
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.8
    Marker Score: 725
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.79
    Marker Score: 7739
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.79
    Marker Score: 1896
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.79
    Marker Score: 446
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.79
    Marker Score: 894
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.79
    Marker Score: 7322
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.79
    Marker Score: 3038
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.78
    Marker Score: 1915
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.78
    Marker Score: 446
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.75
    Marker Score: 384
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.75
    Marker Score: 1275
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.75
    Marker Score: 505
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.75
    Marker Score: 609
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.75
    Marker Score: 6465
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.75
    Marker Score: 1899
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.74
    Marker Score: 1316
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.74
    Marker Score: 1625
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.72
    Marker Score: 4093
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.72
    Marker Score: 836
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.72
    Marker Score: 741
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.72
    Marker Score: 1824
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.71
    Marker Score: 500
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.7
    Marker Score: 421
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.69
    Marker Score: 1701
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.69
    Marker Score: 2683
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.68
    Marker Score: 533
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.68
    Marker Score: 2384
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.67
    Marker Score: 1043
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.67
    Marker Score: 832
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.67
    Marker Score: 1532
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.67
    Marker Score: 18781
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.66
    Marker Score: 1126
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.66
    Marker Score: 2229
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.65
    Marker Score: 17071
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.65
    Marker Score: 475
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.64
    Marker Score: 2867
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.64
    Marker Score: 2628
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.63
    Marker Score: 798
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.63
    Marker Score: 2043
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.63
    Marker Score: 760
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.63
    Marker Score: 746
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.62
    Marker Score: 2334
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.62
    Marker Score: 6935
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.62
    Marker Score: 501
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.61
    Marker Score: 4391
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.61
    Marker Score: 1076
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.61
    Marker Score: 515
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.6
    Marker Score: 15888
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.6
    Marker Score: 2866
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.6
    Marker Score: 407
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.6
    Marker Score: 1349
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.6
    Marker Score: 1663
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.6
    Marker Score: 1336
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.6
    Marker Score: 10379
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.59
    Marker Score: 2257
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 1.59
    Marker Score: 1026
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.59
    Marker Score: 3230
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 1.58
    Marker Score: 720
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.58
    Marker Score: 1848
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.58
    Marker Score: 1196

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Other Information

**Key characteristics:** - HSPA9 is a large protein with a molecular weight of approximately 90 kDa. - It is expressed in high levels in various cell types, including fibroblasts, myoepithelial cells, and immune cells. - HSPA9 is a chaperone protein that helps to protect other proteins from damage by binding to unfolded or misfolded proteins. - It is also involved in the regulation of the heat shock response. **Pathways and functions:** - HSPA9 is involved in cellular responses to stimuli, cellular responses to stress, and heat stress response. - It is a key regulator of the heat shock response, which is a protective mechanism that is triggered when the body is exposed to high temperatures or other forms of stress. - HSPA9 helps to prevent the aggregation of misfolded proteins and to chaperone them to their proper destinations. - It also helps to regulate the expression of other heat shock proteins. **Clinical significance:** - Mutations in the HSPA9 gene have been linked to an increased risk of certain chronic diseases, including cancer and cardiovascular disease. - HSPA9 is a potential target for therapeutic intervention in these diseases. **Additional points:** - HSPA9 is also involved in mitochondrial biogenesis, protein degradation, and organelle biogenesis. - It is a key regulator of the immune system, where it plays a role in the regulation of interleukin-12 signaling. - It is a promising target for the treatment of inflammatory diseases.

Genular Protein ID: 3781151190

Symbol: GRP75_HUMAN

Name: 75 kDa glucose-regulated protein

UniProtKB Accession Codes:

P38646 B2RCM1 P30036 P31932 Q1HB43 Q53H23 Q6GU03 Q9BWB7 Q9UC56

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 31 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HAMAP 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 5 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 4 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7684501

Title: Cloning of the gene encoding peptide-binding protein 74 shows that it is a new member of the heat shock protein 70 family.

PubMed ID: 7684501

DOI: 10.1128/mcb.13.6.3598-3610.1993

PubMed ID: 7829505

Title: Cloning and subcellular localization of human mitochondrial hsp70.

PubMed ID: 7829505

DOI: 10.1074/jbc.270.4.1705

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9150948

Title: A two-dimensional gel database of human colon carcinoma proteins.

PubMed ID: 9150948

DOI: 10.1002/elps.1150180344

PubMed ID: 7498169

Title: Analysis of proteins from human breast epithelial cells using two-dimensional gel electrophoresis.

PubMed ID: 7498169

DOI: 10.1002/elps.11501601202

PubMed ID: 1286669

Title: Human liver protein map: a reference database established by microsequencing and gel comparison.

PubMed ID: 1286669

DOI: 10.1002/elps.11501301201

PubMed ID: 8313870

Title: Human liver protein map: update 1993.

PubMed ID: 8313870

DOI: 10.1002/elps.11501401181

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17331979

Title: Mitochondrial frataxin interacts with ISD11 of the NFS1/ISCU complex and multiple mitochondrial chaperones.

PubMed ID: 17331979

DOI: 10.1093/hmg/ddm038

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20668094

Title: Characterization of the human HSC20, an unusual DnaJ type III protein, involved in iron-sulfur cluster biogenesis.

PubMed ID: 20668094

DOI: 10.1093/hmg/ddq301

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21123823

Title: Knockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in mice.

PubMed ID: 21123823

DOI: 10.1182/blood-2010-06-293167

PubMed ID: 21908771

Title: The first identification of lysine malonylation substrates and its regulatory enzyme.

PubMed ID: 21908771

DOI: 10.1074/mcp.m111.012658

PubMed ID: 22114354

Title: MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization.

PubMed ID: 22114354

DOI: 10.1091/mbc.e11-09-0774

PubMed ID: 22002106

Title: Systematic analysis of protein pools, isoforms, and modifications affecting turnover and subcellular localization.

PubMed ID: 22002106

DOI: 10.1074/mcp.m111.013680

PubMed ID: 23501103

Title: Tespa1 is a novel component of mitochondria-associated endoplasmic reticulum membranes and affects mitochondrial calcium flux.

PubMed ID: 23501103

DOI: 10.1016/j.bbrc.2013.02.099

PubMed ID: 23541579

Title: Extracellular heat shock protein A9 is a novel interaction partner of podoplanin in oral squamous cell carcinoma cells.

PubMed ID: 23541579

DOI: 10.1016/j.bbrc.2013.03.057

PubMed ID: 23462535

Title: Structural and stability studies of the human mtHsp70-escort protein 1: An essential mortalin co-chaperone.

PubMed ID: 23462535

DOI: 10.1016/j.ijbiomac.2013.02.009

PubMed ID: 23940031

Title: Human mitochondrial chaperone (mtHSP70) and cysteine desulfurase (NFS1) bind preferentially to the disordered conformation, whereas co-chaperone (HSC20) binds to the structured conformation of the iron-sulfur cluster scaffold protein (ISCU).

PubMed ID: 23940031

DOI: 10.1074/jbc.m113.482042

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24625977

Title: Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.

PubMed ID: 24625977

DOI: 10.1038/cddis.2014.100

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 26491070

Title: Congenital sideroblastic anemia due to mutations in the mitochondrial HSP70 homologue HSPA9.

PubMed ID: 26491070

DOI: 10.1182/blood-2015-09-659854

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26598328

Title: Mutations in the heat-shock protein A9 (HSPA9) gene cause the EVEN-PLUS syndrome of congenital malformations and skeletal dysplasia.

PubMed ID: 26598328

DOI: 10.1038/srep17154

PubMed ID: 26634371

Title: Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.

PubMed ID: 26634371

DOI: 10.1007/s12192-015-0661-5

PubMed ID: 26702583

Title: Mitochondrial Hspa9/Mortalin regulates erythroid differentiation via iron-sulfur cluster assembly.

PubMed ID: 26702583

DOI: 10.1016/j.mito.2015.12.005

Sequence Information:

  • Length: 679
  • Mass: 73680
  • Checksum: 90969A8D06757753
  • Sequence:
    • MISASRAAAA RLVGAAASRG PTAARHQDSW NGLSHEAFRL VSRRDYASEA IKGAVVGIDL 
GTTNSCVAVM EGKQAKVLEN AEGARTTPSV VAFTADGERL VGMPAKRQAV TNPNNTFYAT 
KRLIGRRYDD PEVQKDIKNV PFKIVRASNG DAWVEAHGKL YSPSQIGAFV LMKMKETAEN 
YLGHTAKNAV ITVPAYFNDS QRQATKDAGQ ISGLNVLRVI NEPTAAALAY GLDKSEDKVI 
AVYDLGGGTF DISILEIQKG VFEVKSTNGD TFLGGEDFDQ ALLRHIVKEF KRETGVDLTK 
DNMALQRVRE AAEKAKCELS SSVQTDINLP YLTMDSSGPK HLNMKLTRAQ FEGIVTDLIR 
RTIAPCQKAM QDAEVSKSDI GEVILVGGMT RMPKVQQTVQ DLFGRAPSKA VNPDEAVAIG 
AAIQGGVLAG DVTDVLLLDV TPLSLGIETL GGVFTKLINR NTTIPTKKSQ VFSTAADGQT 
QVEIKVCQGE REMAGDNKLL GQFTLIGIPP APRGVPQIEV TFDIDANGIV HVSAKDKGTG 
REQQIVIQSS GGLSKDDIEN MVKNAEKYAE EDRRKKERVE AVNMAEGIIH DTETKMEEFK 
DQLPADECNK LKEEISKMRE LLARKDSETG ENIRQAASSL QQASLKLFEM AYKKMASERE 
GSGSSGTGEQ KEDQKEEKQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.