Details for: ERBB4

Gene ID: 2066

Symbol: ERBB4

Ensembl ID: ENSG00000178568

Description: erb-b2 receptor tyrosine kinase 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 30.3255
    Cell Significance Index: -66.3700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 18.3383
    Cell Significance Index: 439.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 16.1460
    Cell Significance Index: 992.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 8.1908
    Cell Significance Index: 2937.8900
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 7.0169
    Cell Significance Index: 98.1200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 5.2779
    Cell Significance Index: 199.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 5.1930
    Cell Significance Index: 398.5000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 3.9824
    Cell Significance Index: 2754.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.9757
    Cell Significance Index: 6120.4900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 3.2232
    Cell Significance Index: 41.8000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.0898
    Cell Significance Index: 136.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 3.0093
    Cell Significance Index: 4091.8600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 2.1398
    Cell Significance Index: 36.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.6209
    Cell Significance Index: 2989.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.3785
    Cell Significance Index: 77.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.3148
    Cell Significance Index: 2475.6000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.8887
    Cell Significance Index: 13.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7715
    Cell Significance Index: 154.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2997
    Cell Significance Index: 136.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0528
    Cell Significance Index: 33.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0485
    Cell Significance Index: 8.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0361
    Cell Significance Index: -26.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1152
    Cell Significance Index: -2.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1315
    Cell Significance Index: -97.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1550
    Cell Significance Index: -19.0600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2172
    Cell Significance Index: -135.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.2232
    Cell Significance Index: -121.8700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.2268
    Cell Significance Index: -171.6600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2992
    Cell Significance Index: -168.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3052
    Cell Significance Index: -14.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.3556
    Cell Significance Index: -157.2200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4538
    Cell Significance Index: -9.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4769
    Cell Significance Index: -137.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5474
    Cell Significance Index: -79.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.6477
    Cell Significance Index: -136.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.6707
    Cell Significance Index: -133.1000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7350
    Cell Significance Index: -15.6000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.7912
    Cell Significance Index: -11.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.9813
    Cell Significance Index: -167.5600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.1718
    Cell Significance Index: -122.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -1.1953
    Cell Significance Index: -154.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -1.2172
    Cell Significance Index: -167.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.2574
    Cell Significance Index: -144.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -1.2816
    Cell Significance Index: -149.3600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -1.3079
    Cell Significance Index: -167.6600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -1.3793
    Cell Significance Index: -140.9000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -1.3852
    Cell Significance Index: -17.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -1.4834
    Cell Significance Index: -110.5600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.5769
    Cell Significance Index: -180.0000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -1.7629
    Cell Significance Index: -22.6100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.9166
    Cell Significance Index: -128.8800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.9688
    Cell Significance Index: -155.9300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -2.3181
    Cell Significance Index: -108.9500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -2.3759
    Cell Significance Index: -41.0800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -2.4918
    Cell Significance Index: -29.0700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -2.5957
    Cell Significance Index: -112.8700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -2.6927
    Cell Significance Index: -140.2600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -2.7680
    Cell Significance Index: -31.6800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -2.8128
    Cell Significance Index: -68.6300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -2.8345
    Cell Significance Index: -61.2400
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: -2.8572
    Cell Significance Index: -23.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -2.8654
    Cell Significance Index: -148.8500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -2.9358
    Cell Significance Index: -58.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -2.9798
    Cell Significance Index: -156.4500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -3.0789
    Cell Significance Index: -36.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -3.0941
    Cell Significance Index: -86.4700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -3.4599
    Cell Significance Index: -109.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -3.4894
    Cell Significance Index: -158.1700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -3.5461
    Cell Significance Index: -74.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -3.5709
    Cell Significance Index: -113.7300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -3.7055
    Cell Significance Index: -39.7300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -3.7071
    Cell Significance Index: -121.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -3.7330
    Cell Significance Index: -235.2800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -3.9013
    Cell Significance Index: -136.6700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -4.4176
    Cell Significance Index: -40.6800
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -4.5485
    Cell Significance Index: -40.9900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -4.6540
    Cell Significance Index: -137.0800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -4.6559
    Cell Significance Index: -161.7900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -4.8194
    Cell Significance Index: -64.9900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -4.8598
    Cell Significance Index: -96.9100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -4.8996
    Cell Significance Index: -179.8600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -4.9482
    Cell Significance Index: -97.3900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -4.9529
    Cell Significance Index: -114.4300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -5.1129
    Cell Significance Index: -145.9100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -5.1228
    Cell Significance Index: -109.5000
  • Cell Name: neuron (CL0000540)
    Fold Change: -5.1692
    Cell Significance Index: -49.0000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -5.3271
    Cell Significance Index: -132.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -5.4846
    Cell Significance Index: -192.7200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -5.5027
    Cell Significance Index: -157.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -5.6791
    Cell Significance Index: -151.6400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -5.7318
    Cell Significance Index: -138.8400
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -5.8620
    Cell Significance Index: -73.8200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -5.8635
    Cell Significance Index: -119.3100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -5.9131
    Cell Significance Index: -129.4800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -6.0780
    Cell Significance Index: -159.8200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -6.1547
    Cell Significance Index: -153.4800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -6.3036
    Cell Significance Index: -101.7100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -6.3226
    Cell Significance Index: -169.1300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -6.3656
    Cell Significance Index: -162.6200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -6.4210
    Cell Significance Index: -174.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ERBB4 is a transmembrane receptor tyrosine kinase with a single extracellular ligand-binding domain and four intracellular tyrosine kinase domains. It is activated by binding to its ligands, such as neuregulin-1 (NRG1), which induces autophosphorylation of tyrosine residues and activates downstream signaling pathways. ERBB4 is highly expressed in the nervous system, particularly in neurons and glial cells, and is also found in various other tissues, including the mammary gland, heart, and skeletal muscle. **Pathways and Functions** ERBB4 signaling pathways are involved in various cellular processes, including: 1. **Neurodevelopment and Neurogenesis**: ERBB4 plays a crucial role in the development and maintenance of the nervous system, particularly in the formation of synapses and the regulation of neuronal differentiation and migration. 2. **Cell Proliferation and Survival**: ERBB4 signaling promotes cell proliferation and survival by activating downstream pathways, such as the PI3K/AKT and MAPK/ERK cascades. 3. **Cancer Progression**: Aberrant expression or mutations of ERBB4 have been implicated in various cancers, including breast cancer, lung cancer, and glioblastoma, where it promotes tumor growth and metastasis. 4. **Heart Development and Function**: ERBB4 is involved in the development and maintenance of the heart, particularly in the regulation of cardiac muscle cell proliferation and differentiation. **Clinical Significance** ERBB4 dysregulation has been implicated in various diseases, including: 1. **Breast Cancer**: Overexpression of ERBB4 has been associated with poor prognosis and increased risk of recurrence in breast cancer patients. 2. **Lung Cancer**: ERBB4 amplification or overexpression has been observed in lung cancer, particularly in non-small cell lung cancer (NSCLC). 3. **Neurodegenerative Disorders**: ERBB4 mutations have been associated with neurodegenerative disorders, such as Alzheimer's disease and frontotemporal dementia. 4. **Heart Disease**: ERBB4 dysregulation has been implicated in heart failure and cardiac arrhythmias. In conclusion, ERBB4 is a critical regulator of cellular processes, including neurodevelopment, cell proliferation, and cancer progression. Its dysregulation has been implicated in various diseases, highlighting the importance of ERBB4 as a therapeutic target for the treatment of cancer and neurodegenerative disorders.

Genular Protein ID: 2606548003

Symbol: ERBB4_HUMAN

Name: Receptor tyrosine-protein kinase erbB-4

UniProtKB Accession Codes:

Q15303 B7ZLD7 B7ZLE2 B7ZLE3 Q2M1W1 Q59EW4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EC 2 ELM 1 EMBL 6 EMDB 4 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 63 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 15 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 14 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 20 RefSeq 4 Rhea 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8383326

Title: Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family.

PubMed ID: 8383326

DOI: 10.1073/pnas.90.5.1746

PubMed ID: 9334263

Title: A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester.

PubMed ID: 9334263

DOI: 10.1074/jbc.272.42.26761

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7689552

Title: Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor.

PubMed ID: 7689552

DOI: 10.1016/s0021-9258(17)46636-1

PubMed ID: 7902537

Title: Heregulin induces tyrosine phosphorylation of HER4/p180erbB4.

PubMed ID: 7902537

DOI: 10.1038/366473a0

PubMed ID: 8617750

Title: HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers.

PubMed ID: 8617750

DOI: 10.1074/jbc.271.9.4813

PubMed ID: 8570211

Title: Betacellulin activates the epidermal growth factor receptor and erbB-4, and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulin-beta.

PubMed ID: 8570211

PubMed ID: 9135143

Title: Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation.

PubMed ID: 9135143

DOI: 10.1093/emboj/16.6.1268

PubMed ID: 9168115

Title: Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases.

PubMed ID: 9168115

DOI: 10.1038/387512a0

PubMed ID: 9419975

Title: Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4.

PubMed ID: 9419975

DOI: 10.1038/sj.onc.1201458

PubMed ID: 9275162

Title: Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4.

PubMed ID: 9275162

DOI: 10.1073/pnas.94.18.9562

PubMed ID: 9516479

Title: Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3.

PubMed ID: 9516479

DOI: 10.1074/jbc.273.13.7717

PubMed ID: 10358079

Title: ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases.

PubMed ID: 10358079

DOI: 10.1074/jbc.274.24.17209

PubMed ID: 10353604

Title: Characterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinase.

PubMed ID: 10353604

DOI: 10.1038/sj.onc.1202612

PubMed ID: 10348342

Title: Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase.

PubMed ID: 10348342

DOI: 10.1038/sj.onc.1202631

PubMed ID: 10722704

Title: A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis.

PubMed ID: 10722704

DOI: 10.1074/jbc.275.12.8641

PubMed ID: 10744726

Title: Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4.

PubMed ID: 10744726

DOI: 10.1074/jbc.275.14.10379

PubMed ID: 10867024

Title: Ligand discrimination in signaling through an ErbB4 receptor homodimer.

PubMed ID: 10867024

DOI: 10.1074/jbc.c901015199

PubMed ID: 10725395

Title: The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses.

PubMed ID: 10725395

DOI: 10.1073/pnas.97.7.3596

PubMed ID: 11178955

Title: BIBX1382BS, but not AG1478 or PD153035, inhibits the ErbB kinases at different concentrations in intact cells.

PubMed ID: 11178955

DOI: 10.1006/bbrc.2001.4302

PubMed ID: 11390655

Title: Her4 mediates ligand-dependent antiproliferative and differentiation responses in human breast cancer cells.

PubMed ID: 11390655

DOI: 10.1128/mcb.21.13.4265-4275.2001

PubMed ID: 12807903

Title: WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus.

PubMed ID: 12807903

DOI: 10.1074/jbc.m305597200

PubMed ID: 12939402

Title: Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein.

PubMed ID: 12939402

PubMed ID: 15534001

Title: The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone.

PubMed ID: 15534001

DOI: 10.1083/jcb.200403155

PubMed ID: 16061658

Title: WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function.

PubMed ID: 16061658

DOI: 10.1158/0008-5472.can-05-1150

PubMed ID: 15746097

Title: Presenilin-dependent gamma-secretase processing regulates multiple ERBB4/HER4 activities.

PubMed ID: 15746097

DOI: 10.1074/jbc.m412457200

PubMed ID: 16778220

Title: The ERBB4/HER4 intracellular domain 4ICD is a BH3-only protein promoting apoptosis of breast cancer cells.

PubMed ID: 16778220

DOI: 10.1158/0008-5472.can-05-2368

PubMed ID: 16815842

Title: ErbB-4 s80 intracellular domain abrogates ETO2-dependent transcriptional repression.

PubMed ID: 16815842

DOI: 10.1074/jbc.m603998200

PubMed ID: 16251361

Title: Proteolytic cleavage and phosphorylation of a tumor-associated ErbB4 isoform promote ligand-independent survival and cancer cell growth.

PubMed ID: 16251361

DOI: 10.1091/mbc.e05-05-0402

PubMed ID: 16837552

Title: The intracellular domain of ErbB4 induces differentiation of mammary epithelial cells.

PubMed ID: 16837552

DOI: 10.1091/mbc.e06-02-0101

PubMed ID: 17120616

Title: Phosphorylation of ErbB4 on tyrosine 1056 is critical for ErbB4 coupling to inhibition of colony formation by human mammary cell lines.

PubMed ID: 17120616

DOI: 10.3727/000000006783981134

PubMed ID: 17638867

Title: HER4 D-box sequences regulate mitotic progression and degradation of the nuclear HER4 cleavage product s80HER4.

PubMed ID: 17638867

DOI: 10.1158/0008-5472.can-06-4145

PubMed ID: 16978839

Title: Neuregulin-1 only induces trans-phosphorylation between ErbB receptor heterodimer partners.

PubMed ID: 16978839

DOI: 10.1016/j.cellsig.2006.07.020

PubMed ID: 17486069

Title: Differential nuclear localization and kinase activity of alternative ErbB4 intracellular domains.

PubMed ID: 17486069

DOI: 10.1038/sj.onc.1210501

PubMed ID: 18721752

Title: System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties.

PubMed ID: 18721752

DOI: 10.1016/j.chembiol.2008.07.006

PubMed ID: 19193720

Title: Nedd4 mediates ErbB4 JM-a/CYT-1 ICD ubiquitination and degradation in MDCK II cells.

PubMed ID: 19193720

DOI: 10.1096/fj.08-121947

PubMed ID: 19098003

Title: Somatic mutations of ErbB4: selective loss-of-function phenotype affecting signal transduction pathways in cancer.

PubMed ID: 19098003

DOI: 10.1074/jbc.m805438200

PubMed ID: 19561640

Title: WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer.

PubMed ID: 19561640

DOI: 10.1038/onc.2009.162

PubMed ID: 20858735

Title: Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways.

PubMed ID: 20858735

DOI: 10.1158/1541-7786.mcr-10-0042

PubMed ID: 21439954

Title: Small tyrosine kinase inhibitors interrupt EGFR signaling by interacting with erbB3 and erbB4 in glioblastoma cell lines.

PubMed ID: 21439954

DOI: 10.1016/j.yexcr.2011.03.015

PubMed ID: 14504474

Title: ErbB4 signaling during breast and neural development: novel genetic models reveal unique ErbB4 activities.

PubMed ID: 14504474

PubMed ID: 15944951

Title: The diverse signaling network of EGFR, HER2, HER3 and HER4 tyrosine kinase receptors and the consequences for therapeutic approaches.

PubMed ID: 15944951

DOI: 10.14670/hh-20.1005

PubMed ID: 18437540

Title: ErbB4/HER4: role in mammary gland development, differentiation and growth inhibition.

PubMed ID: 18437540

DOI: 10.1007/s10911-008-9080-x

PubMed ID: 18473151

Title: HER4 intracellular domain (4ICD) activity in the developing mammary gland and breast cancer.

PubMed ID: 18473151

DOI: 10.1007/s10911-008-9076-6

PubMed ID: 18454307

Title: Role of ErbB4 in breast cancer.

PubMed ID: 18454307

DOI: 10.1007/s10911-008-9079-3

PubMed ID: 20933198

Title: Neuregulin-1/ErbB signaling and chronic heart failure.

PubMed ID: 20933198

DOI: 10.1016/s1054-3589(10)59002-1

PubMed ID: 21811097

Title: Function of ERBB4 is determined by alternative splicing.

PubMed ID: 21811097

DOI: 10.4161/cc.10.16.17194

PubMed ID: 16203964

Title: The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand.

PubMed ID: 16203964

DOI: 10.1073/pnas.0507591102

PubMed ID: 18287036

Title: 6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases.

PubMed ID: 18287036

DOI: 10.1073/pnas.0708281105

PubMed ID: 18334220

Title: Mechanism of activation and inhibition of the HER4/ErbB4 kinase.

PubMed ID: 18334220

DOI: 10.1016/j.str.2007.12.016

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 24119685

Title: ERBB4 mutations that disrupt the neuregulin-ErbB4 pathway cause amyotrophic lateral sclerosis type 19.

PubMed ID: 24119685

DOI: 10.1016/j.ajhg.2013.09.008

Sequence Information:

  • Length: 1308
  • Mass: 146808
  • Checksum: 5E4AE80985D88761
  • Sequence:
    • MKPATGLWVW VSLLVAAGTV QPSDSQSVCA GTENKLSSLS DLEQQYRALR KYYENCEVVM 
GNLEITSIEH NRDLSFLRSV REVTGYVLVA LNQFRYLPLE NLRIIRGTKL YEDRYALAIF 
LNYRKDGNFG LQELGLKNLT EILNGGVYVD QNKFLCYADT IHWQDIVRNP WPSNLTLVST 
NGSSGCGRCH KSCTGRCWGP TENHCQTLTR TVCAEQCDGR CYGPYVSDCC HRECAGGCSG 
PKDTDCFACM NFNDSGACVT QCPQTFVYNP TTFQLEHNFN AKYTYGAFCV KKCPHNFVVD 
SSSCVRACPS SKMEVEENGI KMCKPCTDIC PKACDGIGTG SLMSAQTVDS SNIDKFINCT 
KINGNLIFLV TGIHGDPYNA IEAIDPEKLN VFRTVREITG FLNIQSWPPN MTDFSVFSNL 
VTIGGRVLYS GLSLLILKQQ GITSLQFQSL KEISAGNIYI TDNSNLCYYH TINWTTLFST 
INQRIVIRDN RKAENCTAEG MVCNHLCSSD GCWGPGPDQC LSCRRFSRGR ICIESCNLYD 
GEFREFENGS ICVECDPQCE KMEDGLLTCH GPGPDNCTKC SHFKDGPNCV EKCPDGLQGA 
NSFIFKYADP DRECHPCHPN CTQGCNGPTS HDCIYYPWTG HSTLPQHART PLIAAGVIGG 
LFILVIVGLT FAVYVRRKSI KKKRALRRFL ETELVEPLTP SGTAPNQAQL RILKETELKR 
VKVLGSGAFG TVYKGIWVPE GETVKIPVAI KILNETTGPK ANVEFMDEAL IMASMDHPHL 
VRLLGVCLSP TIQLVTQLMP HGCLLEYVHE HKDNIGSQLL LNWCVQIAKG MMYLEERRLV 
HRDLAARNVL VKSPNHVKIT DFGLARLLEG DEKEYNADGG KMPIKWMALE CIHYRKFTHQ 
SDVWSYGVTI WELMTFGGKP YDGIPTREIP DLLEKGERLP QPPICTIDVY MVMVKCWMID 
ADSRPKFKEL AAEFSRMARD PQRYLVIQGD DRMKLPSPND SKFFQNLLDE EDLEDMMDAE 
EYLVPQAFNI PPPIYTSRAR IDSNRSEIGH SPPPAYTPMS GNQFVYRDGG FAAEQGVSVP 
YRAPTSTIPE APVAQGATAE IFDDSCCNGT LRKPVAPHVQ EDSSTQRYSA DPTVFAPERS 
PRGELDEEGY MTPMRDKPKQ EYLNPVEENP FVSRRKNGDL QALDNPEYHN ASNGPPKAED 
EYVNEPLYLN TFANTLGKAE YLKNNILSMP EKAKKAFDNP DYWNHSLPPR STLQHPDYLQ 
EYSTKYFYKQ NGRIRPIVAE NPEYLSEFSL KPGTVLPPPP YRHRNTVV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.