Details for: ERBB4

Gene ID: 2066

Symbol: ERBB4

Ensembl ID: ENSG00000178568

Description: erb-b2 receptor tyrosine kinase 4

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 14.36
    Marker Score: 48,148
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 11.78
    Marker Score: 61,823
  • Cell Name: granule cell (CL0000120)
    Fold Change: 11.72
    Marker Score: 88,348
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 10.86
    Marker Score: 58,351
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 9.67
    Marker Score: 22,230
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 6.63
    Marker Score: 4,363
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 5.67
    Marker Score: 2,724
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 5.07
    Marker Score: 4,383
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 4.82
    Marker Score: 3,668
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 4.7
    Marker Score: 21,749
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 4.55
    Marker Score: 18,981
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 4.53
    Marker Score: 2,538
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 4.44
    Marker Score: 99,257
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 4.26
    Marker Score: 5,156
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.97
    Marker Score: 5,336
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 3.95
    Marker Score: 3,047
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 3.94
    Marker Score: 9,428
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 3.9
    Marker Score: 2,263
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 3.74
    Marker Score: 13,307
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 3.62
    Marker Score: 1,905
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.27
    Marker Score: 69,697
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.09
    Marker Score: 5,629
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.88
    Marker Score: 22,064
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.86
    Marker Score: 42,820
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.85
    Marker Score: 11,934
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.83
    Marker Score: 5,353
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.82
    Marker Score: 2,446
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.81
    Marker Score: 1,641
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.79
    Marker Score: 7,466
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.75
    Marker Score: 104,412
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.67
    Marker Score: 5,860
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.62
    Marker Score: 10,856
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.59
    Marker Score: 10,799
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.57
    Marker Score: 1,783
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 2.55
    Marker Score: 925
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.46
    Marker Score: 90,664
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.43
    Marker Score: 3,003
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.36
    Marker Score: 9,127
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 2.26
    Marker Score: 30,075
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.26
    Marker Score: 2,154
  • Cell Name: podocyte (CL0000653)
    Fold Change: 2.21
    Marker Score: 817
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.19
    Marker Score: 4,210
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 2.14
    Marker Score: 1,759
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.13
    Marker Score: 42,271
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.07
    Marker Score: 21,389
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.06
    Marker Score: 7,319
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.05
    Marker Score: 543
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.94
    Marker Score: 4,859
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.94
    Marker Score: 2,229
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.86
    Marker Score: 590
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.84
    Marker Score: 2,604
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.83
    Marker Score: 29,309
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.81
    Marker Score: 3,043
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.79
    Marker Score: 3,645
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.74
    Marker Score: 4,976
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.71
    Marker Score: 1,841
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.7
    Marker Score: 1,020
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.69
    Marker Score: 396
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.67
    Marker Score: 1,766
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.62
    Marker Score: 968
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.59
    Marker Score: 15,073
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.52
    Marker Score: 1,540
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.5
    Marker Score: 432
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.49
    Marker Score: 6,055
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.46
    Marker Score: 1,337
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.44
    Marker Score: 165,063
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.43
    Marker Score: 453
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.43
    Marker Score: 12,269
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 865
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.35
    Marker Score: 4,650
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.34
    Marker Score: 20,964
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.32
    Marker Score: 507
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.3
    Marker Score: 470
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.28
    Marker Score: 856
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.25
    Marker Score: 11,751
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.23
    Marker Score: 389
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.23
    Marker Score: 497
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.22
    Marker Score: 499
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.21
    Marker Score: 7,275
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.21
    Marker Score: 40,833
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.19
    Marker Score: 1,254
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.19
    Marker Score: 72,933
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.18
    Marker Score: 370
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.17
    Marker Score: 2,014
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.15
    Marker Score: 6,810
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.13
    Marker Score: 2,664
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.11
    Marker Score: 985
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.1
    Marker Score: 383
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.09
    Marker Score: 319
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.09
    Marker Score: 1,928
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.05
    Marker Score: 1,622
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.04
    Marker Score: 566
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,737
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.03
    Marker Score: 522
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.01
    Marker Score: 1,121
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1
    Marker Score: 202
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 1
    Marker Score: 259
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,760
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,986
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1
    Marker Score: 1,294

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ERBB4 is a transmembrane receptor tyrosine kinase with a single extracellular ligand-binding domain and four intracellular tyrosine kinase domains. It is activated by binding to its ligands, such as neuregulin-1 (NRG1), which induces autophosphorylation of tyrosine residues and activates downstream signaling pathways. ERBB4 is highly expressed in the nervous system, particularly in neurons and glial cells, and is also found in various other tissues, including the mammary gland, heart, and skeletal muscle. **Pathways and Functions** ERBB4 signaling pathways are involved in various cellular processes, including: 1. **Neurodevelopment and Neurogenesis**: ERBB4 plays a crucial role in the development and maintenance of the nervous system, particularly in the formation of synapses and the regulation of neuronal differentiation and migration. 2. **Cell Proliferation and Survival**: ERBB4 signaling promotes cell proliferation and survival by activating downstream pathways, such as the PI3K/AKT and MAPK/ERK cascades. 3. **Cancer Progression**: Aberrant expression or mutations of ERBB4 have been implicated in various cancers, including breast cancer, lung cancer, and glioblastoma, where it promotes tumor growth and metastasis. 4. **Heart Development and Function**: ERBB4 is involved in the development and maintenance of the heart, particularly in the regulation of cardiac muscle cell proliferation and differentiation. **Clinical Significance** ERBB4 dysregulation has been implicated in various diseases, including: 1. **Breast Cancer**: Overexpression of ERBB4 has been associated with poor prognosis and increased risk of recurrence in breast cancer patients. 2. **Lung Cancer**: ERBB4 amplification or overexpression has been observed in lung cancer, particularly in non-small cell lung cancer (NSCLC). 3. **Neurodegenerative Disorders**: ERBB4 mutations have been associated with neurodegenerative disorders, such as Alzheimer's disease and frontotemporal dementia. 4. **Heart Disease**: ERBB4 dysregulation has been implicated in heart failure and cardiac arrhythmias. In conclusion, ERBB4 is a critical regulator of cellular processes, including neurodevelopment, cell proliferation, and cancer progression. Its dysregulation has been implicated in various diseases, highlighting the importance of ERBB4 as a therapeutic target for the treatment of cancer and neurodegenerative disorders.

Genular Protein ID: 2606548003

Symbol: ERBB4_HUMAN

Name: Receptor tyrosine-protein kinase erbB-4

UniProtKB Accession Codes:

Q15303 B7ZLD7 B7ZLE2 B7ZLE3 Q2M1W1 Q59EW4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EC 2 ELM 1 EMBL 6 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 62 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 14 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 10 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 20 RefSeq 4 Rhea 3 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8383326

Title: Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family.

PubMed ID: 8383326

DOI: 10.1073/pnas.90.5.1746

PubMed ID: 9334263

Title: A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester.

PubMed ID: 9334263

DOI: 10.1074/jbc.272.42.26761

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7689552

Title: Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor.

PubMed ID: 7689552

DOI: 10.1016/s0021-9258(17)46636-1

PubMed ID: 7902537

Title: Heregulin induces tyrosine phosphorylation of HER4/p180erbB4.

PubMed ID: 7902537

DOI: 10.1038/366473a0

PubMed ID: 8617750

Title: HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers.

PubMed ID: 8617750

DOI: 10.1074/jbc.271.9.4813

PubMed ID: 8570211

Title: Betacellulin activates the epidermal growth factor receptor and erbB-4, and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulin-beta.

PubMed ID: 8570211

PubMed ID: 9135143

Title: Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation.

PubMed ID: 9135143

DOI: 10.1093/emboj/16.6.1268

PubMed ID: 9168115

Title: Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases.

PubMed ID: 9168115

DOI: 10.1038/387512a0

PubMed ID: 9419975

Title: Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4.

PubMed ID: 9419975

DOI: 10.1038/sj.onc.1201458

PubMed ID: 9275162

Title: Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4.

PubMed ID: 9275162

DOI: 10.1073/pnas.94.18.9562

PubMed ID: 9516479

Title: Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3.

PubMed ID: 9516479

DOI: 10.1074/jbc.273.13.7717

PubMed ID: 10358079

Title: ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases.

PubMed ID: 10358079

DOI: 10.1074/jbc.274.24.17209

PubMed ID: 10353604

Title: Characterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinase.

PubMed ID: 10353604

DOI: 10.1038/sj.onc.1202612

PubMed ID: 10348342

Title: Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase.

PubMed ID: 10348342

DOI: 10.1038/sj.onc.1202631

PubMed ID: 10722704

Title: A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis.

PubMed ID: 10722704

DOI: 10.1074/jbc.275.12.8641

PubMed ID: 10744726

Title: Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4.

PubMed ID: 10744726

DOI: 10.1074/jbc.275.14.10379

PubMed ID: 10867024

Title: Ligand discrimination in signaling through an ErbB4 receptor homodimer.

PubMed ID: 10867024

DOI: 10.1074/jbc.c901015199

PubMed ID: 10725395

Title: The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses.

PubMed ID: 10725395

DOI: 10.1073/pnas.97.7.3596

PubMed ID: 11178955

Title: BIBX1382BS, but not AG1478 or PD153035, inhibits the ErbB kinases at different concentrations in intact cells.

PubMed ID: 11178955

DOI: 10.1006/bbrc.2001.4302

PubMed ID: 11390655

Title: Her4 mediates ligand-dependent antiproliferative and differentiation responses in human breast cancer cells.

PubMed ID: 11390655

DOI: 10.1128/mcb.21.13.4265-4275.2001

PubMed ID: 12807903

Title: WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus.

PubMed ID: 12807903

DOI: 10.1074/jbc.m305597200

PubMed ID: 12939402

Title: Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein.

PubMed ID: 12939402

PubMed ID: 15534001

Title: The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone.

PubMed ID: 15534001

DOI: 10.1083/jcb.200403155

PubMed ID: 16061658

Title: WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function.

PubMed ID: 16061658

DOI: 10.1158/0008-5472.can-05-1150

PubMed ID: 15746097

Title: Presenilin-dependent gamma-secretase processing regulates multiple ERBB4/HER4 activities.

PubMed ID: 15746097

DOI: 10.1074/jbc.m412457200

PubMed ID: 16778220

Title: The ERBB4/HER4 intracellular domain 4ICD is a BH3-only protein promoting apoptosis of breast cancer cells.

PubMed ID: 16778220

DOI: 10.1158/0008-5472.can-05-2368

PubMed ID: 16815842

Title: ErbB-4 s80 intracellular domain abrogates ETO2-dependent transcriptional repression.

PubMed ID: 16815842

DOI: 10.1074/jbc.m603998200

PubMed ID: 16251361

Title: Proteolytic cleavage and phosphorylation of a tumor-associated ErbB4 isoform promote ligand-independent survival and cancer cell growth.

PubMed ID: 16251361

DOI: 10.1091/mbc.e05-05-0402

PubMed ID: 16837552

Title: The intracellular domain of ErbB4 induces differentiation of mammary epithelial cells.

PubMed ID: 16837552

DOI: 10.1091/mbc.e06-02-0101

PubMed ID: 17120616

Title: Phosphorylation of ErbB4 on tyrosine 1056 is critical for ErbB4 coupling to inhibition of colony formation by human mammary cell lines.

PubMed ID: 17120616

DOI: 10.3727/000000006783981134

PubMed ID: 17638867

Title: HER4 D-box sequences regulate mitotic progression and degradation of the nuclear HER4 cleavage product s80HER4.

PubMed ID: 17638867

DOI: 10.1158/0008-5472.can-06-4145

PubMed ID: 16978839

Title: Neuregulin-1 only induces trans-phosphorylation between ErbB receptor heterodimer partners.

PubMed ID: 16978839

DOI: 10.1016/j.cellsig.2006.07.020

PubMed ID: 17486069

Title: Differential nuclear localization and kinase activity of alternative ErbB4 intracellular domains.

PubMed ID: 17486069

DOI: 10.1038/sj.onc.1210501

PubMed ID: 18721752

Title: System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties.

PubMed ID: 18721752

DOI: 10.1016/j.chembiol.2008.07.006

PubMed ID: 19193720

Title: Nedd4 mediates ErbB4 JM-a/CYT-1 ICD ubiquitination and degradation in MDCK II cells.

PubMed ID: 19193720

DOI: 10.1096/fj.08-121947

PubMed ID: 19098003

Title: Somatic mutations of ErbB4: selective loss-of-function phenotype affecting signal transduction pathways in cancer.

PubMed ID: 19098003

DOI: 10.1074/jbc.m805438200

PubMed ID: 19561640

Title: WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer.

PubMed ID: 19561640

DOI: 10.1038/onc.2009.162

PubMed ID: 20858735

Title: Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways.

PubMed ID: 20858735

DOI: 10.1158/1541-7786.mcr-10-0042

PubMed ID: 21439954

Title: Small tyrosine kinase inhibitors interrupt EGFR signaling by interacting with erbB3 and erbB4 in glioblastoma cell lines.

PubMed ID: 21439954

DOI: 10.1016/j.yexcr.2011.03.015

PubMed ID: 14504474

Title: ErbB4 signaling during breast and neural development: novel genetic models reveal unique ErbB4 activities.

PubMed ID: 14504474

PubMed ID: 15944951

Title: The diverse signaling network of EGFR, HER2, HER3 and HER4 tyrosine kinase receptors and the consequences for therapeutic approaches.

PubMed ID: 15944951

DOI: 10.14670/hh-20.1005

PubMed ID: 18437540

Title: ErbB4/HER4: role in mammary gland development, differentiation and growth inhibition.

PubMed ID: 18437540

DOI: 10.1007/s10911-008-9080-x

PubMed ID: 18473151

Title: HER4 intracellular domain (4ICD) activity in the developing mammary gland and breast cancer.

PubMed ID: 18473151

DOI: 10.1007/s10911-008-9076-6

PubMed ID: 18454307

Title: Role of ErbB4 in breast cancer.

PubMed ID: 18454307

DOI: 10.1007/s10911-008-9079-3

PubMed ID: 20933198

Title: Neuregulin-1/ErbB signaling and chronic heart failure.

PubMed ID: 20933198

DOI: 10.1016/s1054-3589(10)59002-1

PubMed ID: 21811097

Title: Function of ERBB4 is determined by alternative splicing.

PubMed ID: 21811097

DOI: 10.4161/cc.10.16.17194

PubMed ID: 16203964

Title: The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand.

PubMed ID: 16203964

DOI: 10.1073/pnas.0507591102

PubMed ID: 18287036

Title: 6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases.

PubMed ID: 18287036

DOI: 10.1073/pnas.0708281105

PubMed ID: 18334220

Title: Mechanism of activation and inhibition of the HER4/ErbB4 kinase.

PubMed ID: 18334220

DOI: 10.1016/j.str.2007.12.016

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 24119685

Title: ERBB4 mutations that disrupt the neuregulin-ErbB4 pathway cause amyotrophic lateral sclerosis type 19.

PubMed ID: 24119685

DOI: 10.1016/j.ajhg.2013.09.008

Sequence Information:

  • Length: 1308
  • Mass: 146808
  • Checksum: 5E4AE80985D88761
  • Sequence:
    • MKPATGLWVW VSLLVAAGTV QPSDSQSVCA GTENKLSSLS DLEQQYRALR KYYENCEVVM 
GNLEITSIEH NRDLSFLRSV REVTGYVLVA LNQFRYLPLE NLRIIRGTKL YEDRYALAIF 
LNYRKDGNFG LQELGLKNLT EILNGGVYVD QNKFLCYADT IHWQDIVRNP WPSNLTLVST 
NGSSGCGRCH KSCTGRCWGP TENHCQTLTR TVCAEQCDGR CYGPYVSDCC HRECAGGCSG 
PKDTDCFACM NFNDSGACVT QCPQTFVYNP TTFQLEHNFN AKYTYGAFCV KKCPHNFVVD 
SSSCVRACPS SKMEVEENGI KMCKPCTDIC PKACDGIGTG SLMSAQTVDS SNIDKFINCT 
KINGNLIFLV TGIHGDPYNA IEAIDPEKLN VFRTVREITG FLNIQSWPPN MTDFSVFSNL 
VTIGGRVLYS GLSLLILKQQ GITSLQFQSL KEISAGNIYI TDNSNLCYYH TINWTTLFST 
INQRIVIRDN RKAENCTAEG MVCNHLCSSD GCWGPGPDQC LSCRRFSRGR ICIESCNLYD 
GEFREFENGS ICVECDPQCE KMEDGLLTCH GPGPDNCTKC SHFKDGPNCV EKCPDGLQGA 
NSFIFKYADP DRECHPCHPN CTQGCNGPTS HDCIYYPWTG HSTLPQHART PLIAAGVIGG 
LFILVIVGLT FAVYVRRKSI KKKRALRRFL ETELVEPLTP SGTAPNQAQL RILKETELKR 
VKVLGSGAFG TVYKGIWVPE GETVKIPVAI KILNETTGPK ANVEFMDEAL IMASMDHPHL 
VRLLGVCLSP TIQLVTQLMP HGCLLEYVHE HKDNIGSQLL LNWCVQIAKG MMYLEERRLV 
HRDLAARNVL VKSPNHVKIT DFGLARLLEG DEKEYNADGG KMPIKWMALE CIHYRKFTHQ 
SDVWSYGVTI WELMTFGGKP YDGIPTREIP DLLEKGERLP QPPICTIDVY MVMVKCWMID 
ADSRPKFKEL AAEFSRMARD PQRYLVIQGD DRMKLPSPND SKFFQNLLDE EDLEDMMDAE 
EYLVPQAFNI PPPIYTSRAR IDSNRSEIGH SPPPAYTPMS GNQFVYRDGG FAAEQGVSVP 
YRAPTSTIPE APVAQGATAE IFDDSCCNGT LRKPVAPHVQ EDSSTQRYSA DPTVFAPERS 
PRGELDEEGY MTPMRDKPKQ EYLNPVEENP FVSRRKNGDL QALDNPEYHN ASNGPPKAED 
EYVNEPLYLN TFANTLGKAE YLKNNILSMP EKAKKAFDNP DYWNHSLPPR STLQHPDYLQ 
EYSTKYFYKQ NGRIRPIVAE NPEYLSEFSL KPGTVLPPPP YRHRNTVV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.