Details for: SULT1C2

Gene ID: 6819

Symbol: SULT1C2

Ensembl ID: ENSG00000198203

Description: sulfotransferase family 1C member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 26.4939
    Cell Significance Index: -6.7200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 17.4780
    Cell Significance Index: -7.2000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 17.1320
    Cell Significance Index: -6.9600
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 5.3252
    Cell Significance Index: 20.3900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.7512
    Cell Significance Index: -7.3700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.5706
    Cell Significance Index: 42.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.5419
    Cell Significance Index: 55.0700
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.2466
    Cell Significance Index: 19.1000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.6640
    Cell Significance Index: 17.6800
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.6193
    Cell Significance Index: 5.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.4446
    Cell Significance Index: 209.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4251
    Cell Significance Index: 282.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2490
    Cell Significance Index: 35.9900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.8648
    Cell Significance Index: 6.9100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7545
    Cell Significance Index: 39.3000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.6784
    Cell Significance Index: 11.4100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6209
    Cell Significance Index: 118.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5847
    Cell Significance Index: 35.1000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2996
    Cell Significance Index: 6.2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2736
    Cell Significance Index: 29.7600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2508
    Cell Significance Index: 11.3700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2329
    Cell Significance Index: 4.9600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.2211
    Cell Significance Index: 25.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2169
    Cell Significance Index: 408.3700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.2158
    Cell Significance Index: 1.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1931
    Cell Significance Index: 10.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1735
    Cell Significance Index: 127.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1568
    Cell Significance Index: 15.5200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1447
    Cell Significance Index: 10.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1383
    Cell Significance Index: 124.8900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1253
    Cell Significance Index: 79.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0890
    Cell Significance Index: 14.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0720
    Cell Significance Index: 1.8000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0705
    Cell Significance Index: 44.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0543
    Cell Significance Index: 29.6700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 0.0449
    Cell Significance Index: 0.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0424
    Cell Significance Index: 1.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0349
    Cell Significance Index: 6.2900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.0326
    Cell Significance Index: 2.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0280
    Cell Significance Index: 3.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0156
    Cell Significance Index: 1.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0094
    Cell Significance Index: 1.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0004
    Cell Significance Index: -0.6900
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0021
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0035
    Cell Significance Index: -2.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0035
    Cell Significance Index: -4.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0038
    Cell Significance Index: -2.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0040
    Cell Significance Index: -2.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0062
    Cell Significance Index: -1.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0062
    Cell Significance Index: -2.7500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0074
    Cell Significance Index: -1.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0075
    Cell Significance Index: -0.7700
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0078
    Cell Significance Index: -0.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0109
    Cell Significance Index: -3.9100
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0112
    Cell Significance Index: -0.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0114
    Cell Significance Index: -5.1900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0119
    Cell Significance Index: -0.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0122
    Cell Significance Index: -1.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0141
    Cell Significance Index: -2.4100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0159
    Cell Significance Index: -0.1700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0248
    Cell Significance Index: -1.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0295
    Cell Significance Index: -3.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0307
    Cell Significance Index: -3.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0417
    Cell Significance Index: -5.7300
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0433
    Cell Significance Index: -0.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0510
    Cell Significance Index: -5.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0548
    Cell Significance Index: -7.0800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0556
    Cell Significance Index: -1.4300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0570
    Cell Significance Index: -2.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0576
    Cell Significance Index: -1.6100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0628
    Cell Significance Index: -7.4100
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.0666
    Cell Significance Index: -0.6900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0689
    Cell Significance Index: -1.0000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0737
    Cell Significance Index: -1.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0771
    Cell Significance Index: -2.4700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0854
    Cell Significance Index: -5.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0912
    Cell Significance Index: -6.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0934
    Cell Significance Index: -6.9600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0980
    Cell Significance Index: -0.9700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1023
    Cell Significance Index: -1.4200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1102
    Cell Significance Index: -7.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1135
    Cell Significance Index: -3.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1136
    Cell Significance Index: -6.9800
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.1176
    Cell Significance Index: -0.5600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1210
    Cell Significance Index: -1.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1219
    Cell Significance Index: -6.8400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1286
    Cell Significance Index: -1.9900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1307
    Cell Significance Index: -2.2400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1401
    Cell Significance Index: -4.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1413
    Cell Significance Index: -4.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1428
    Cell Significance Index: -7.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1431
    Cell Significance Index: -6.7300
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1465
    Cell Significance Index: -0.9600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1479
    Cell Significance Index: -6.5400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1486
    Cell Significance Index: -6.4600
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.1513
    Cell Significance Index: -1.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1515
    Cell Significance Index: -7.0700
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.1521
    Cell Significance Index: -1.6100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1558
    Cell Significance Index: -3.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Sulfotransferase activity:** SULT1C2 is a sulfotransferase enzyme, which means it has the ability to catalyze the transfer of a sulfate group to specific substrates. 2. **High expression in renal tissues:** SULT1C2 is predominantly expressed in renal alpha-intercalated cells, foveolar cells of the stomach, and other epithelial cells, suggesting its critical role in kidney function and detoxification processes. 3. **Wide substrate specificity:** SULT1C2 has been shown to sulfate a variety of substrates, including steroids, bile acids, and other small molecules, highlighting its versatility and importance in various metabolic pathways. 4. **Phase II conjugation:** As a member of the sulfotransferase family, SULT1C2 participates in phase II conjugation reactions, which involve the conjugation of a sulfate group to a substrate, making it more water-soluble and easier to excrete. **Pathways and Functions:** 1. **Amine metabolic process:** SULT1C2 is involved in the sulfation of amines, which is an essential step in the degradation of various xenobiotics and endogenous compounds. 2. **Aryl sulfotransferase activity:** This enzyme is capable of sulfating aryl compounds, which is critical for the metabolism and detoxification of aromatic compounds. 3. **Biological oxidations:** SULT1C2 participates in the sulfation of various substrates, which is an essential step in the biological oxidation of these compounds. 4. **Cytoplasmic and cytosolic sulfonation:** This enzyme is localized in the cytoplasm and cytosol, where it plays a key role in the sulfonation of small molecules and the regulation of metabolic pathways. **Clinical Significance:** 1. **Detoxification and metabolism:** SULT1C2 plays a crucial role in the detoxification and metabolism of various xenobiotics and endogenous compounds, making it an essential enzyme in maintaining overall health. 2. **Kidney function:** The high expression of SULT1C2 in renal tissues highlights its importance in kidney function and the regulation of electrolyte and water balance. 3. **Cancer and metabolic disorders:** Alterations in SULT1C2 expression and activity have been linked to various cancers and metabolic disorders, suggesting its potential as a biomarker and therapeutic target. 4. **Pharmacokinetics and pharmacodynamics:** Understanding the role of SULT1C2 in the sulfation of various substrates can provide valuable insights into the pharmacokinetics and pharmacodynamics of drugs, leading to the development of more effective and targeted treatments. In conclusion, SULT1C2 is a vital enzyme that plays a critical role in maintaining the delicate balance of metabolic processes within the body. Its high expression in various tissues, wide substrate specificity, and involvement in phase II conjugation reactions make it an essential enzyme in the detoxification and metabolism of various compounds. Further research on SULT1C2 is necessary to fully elucidate its functions and clinical significance, which can lead to the development of new therapeutic strategies and the improvement of overall health outcomes.

Genular Protein ID: 322561497

Symbol: ST1C2_HUMAN

Name: Sulfotransferase 1C2

UniProtKB Accession Codes:

O00338 B2R813 Q53SG4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 11 ChEMBL 1 DNASU 1 DisGeNET 1 DrugBank 7 EC 1 EMBL 24 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9169148

Title: Human sulfotransferase SULT1C1: cDNA cloning, tissue-specific expression, and chromosomal localization.

PubMed ID: 9169148

DOI: 10.1006/geno.1997.4683

PubMed ID: 9635888

Title: Molecular characterization of ST1C1-related human sulfotransferase.

PubMed ID: 9635888

DOI: 10.1093/carcin/19.5.951

PubMed ID: 9852044

Title: Molecular cloning, expression, and characterization of novel human SULT1C sulfotransferases that catalyze the sulfonation of N-hydroxy-2-acetylaminofluorene.

PubMed ID: 9852044

DOI: 10.1074/jbc.273.51.33929

PubMed ID: 10481272

Title: Molecular cloning, expression, localisation and functional characterisation of a rabbit SULT1C2 sulfotransferase.

PubMed ID: 10481272

DOI: 10.1016/s1357-2725(99)00038-2

PubMed ID: 10783263

Title: Human sulfotransferases SULT1C1 and SULT1C2: cDNA characterization, gene cloning, and chromosomal localization.

PubMed ID: 10783263

DOI: 10.1006/geno.2000.6150

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16804942

Title: Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP).

PubMed ID: 16804942

DOI: 10.1002/prot.21048

Sequence Information:

  • Length: 296
  • Mass: 34880
  • Checksum: 3DC01C8A8ED61EFD
  • Sequence:
    • MALTSDLGKQ IKLKEVEGTL LQPATVDNWS QIQSFEAKPD DLLICTYPKA GTTWIQEIVD 
MIEQNGDVEK CQRAIIQHRH PFIEWARPPQ PSGVEKAKAM PSPRILKTHL STQLLPPSFW 
ENNCKFLYVA RNAKDCMVSY YHFQRMNHML PDPGTWEEYF ETFINGKVVW GSWFDHVKGW 
WEMKDRHQIL FLFYEDIKRD PKHEIRKVMQ FMGKKVDETV LDKIVQETSF EKMKENPMTN 
RSTVSKSILD QSISSFMRKG TVGDWKNHFT VAQNERFDEI YRRKMEGTSI NFCMEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.