Details for: TFCP2L1

Gene ID: 29842

Symbol: TFCP2L1

Ensembl ID: ENSG00000115112

Description: transcription factor CP2 like 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 46.0435
    Cell Significance Index: -18.9700
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 44.7064
    Cell Significance Index: 31.9500
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 16.1101
    Cell Significance Index: 36.3200
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 12.7648
    Cell Significance Index: 71.0500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.5517
    Cell Significance Index: -20.2300
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 6.9352
    Cell Significance Index: 26.5600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 4.1110
    Cell Significance Index: 186.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.3019
    Cell Significance Index: 64.3300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.2343
    Cell Significance Index: -4.8900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2687
    Cell Significance Index: 17.3100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1932
    Cell Significance Index: 31.8600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1558
    Cell Significance Index: 25.0400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.1439
    Cell Significance Index: 17.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1351
    Cell Significance Index: 184.6100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1178
    Cell Significance Index: 121.5900
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 1.0652
    Cell Significance Index: 10.6600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9103
    Cell Significance Index: 54.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8446
    Cell Significance Index: 39.3800
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.8134
    Cell Significance Index: 8.3900
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.6813
    Cell Significance Index: 7.9200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.6173
    Cell Significance Index: 5.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5868
    Cell Significance Index: 40.5800
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.5193
    Cell Significance Index: 10.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5002
    Cell Significance Index: 23.5100
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.4052
    Cell Significance Index: 2.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3842
    Cell Significance Index: 19.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3719
    Cell Significance Index: 10.7200
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.3551
    Cell Significance Index: 2.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2491
    Cell Significance Index: 24.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2177
    Cell Significance Index: 159.6400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1887
    Cell Significance Index: 24.3800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1782
    Cell Significance Index: 78.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1756
    Cell Significance Index: 4.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1407
    Cell Significance Index: 25.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1357
    Cell Significance Index: 25.8300
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.1197
    Cell Significance Index: 1.1400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.1067
    Cell Significance Index: 8.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0928
    Cell Significance Index: 50.6900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0687
    Cell Significance Index: 7.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0633
    Cell Significance Index: 119.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0595
    Cell Significance Index: 2.0900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0576
    Cell Significance Index: 1.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0520
    Cell Significance Index: 6.4000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0497
    Cell Significance Index: 31.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0009
    Cell Significance Index: 0.5900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0012
    Cell Significance Index: -0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0028
    Cell Significance Index: -5.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0032
    Cell Significance Index: -2.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0092
    Cell Significance Index: -1.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0147
    Cell Significance Index: -10.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0181
    Cell Significance Index: -10.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0210
    Cell Significance Index: -2.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0213
    Cell Significance Index: -32.7900
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0222
    Cell Significance Index: -0.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0252
    Cell Significance Index: -34.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0437
    Cell Significance Index: -19.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0445
    Cell Significance Index: -15.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0515
    Cell Significance Index: -6.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0535
    Cell Significance Index: -15.3900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0535
    Cell Significance Index: -1.1100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0606
    Cell Significance Index: -12.7700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0704
    Cell Significance Index: -4.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0775
    Cell Significance Index: -15.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0785
    Cell Significance Index: -15.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0944
    Cell Significance Index: -10.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1094
    Cell Significance Index: -15.9000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1137
    Cell Significance Index: -5.7500
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.1323
    Cell Significance Index: -1.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1387
    Cell Significance Index: -10.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1419
    Cell Significance Index: -19.4800
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1443
    Cell Significance Index: -1.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1631
    Cell Significance Index: -19.2300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1738
    Cell Significance Index: -7.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1932
    Cell Significance Index: -20.1200
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.1947
    Cell Significance Index: -1.4700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2297
    Cell Significance Index: -14.0800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2414
    Cell Significance Index: -3.7400
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.2655
    Cell Significance Index: -2.4200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2759
    Cell Significance Index: -3.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2928
    Cell Significance Index: -19.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3038
    Cell Significance Index: -23.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3122
    Cell Significance Index: -19.6800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3243
    Cell Significance Index: -16.8900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3517
    Cell Significance Index: -5.3000
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.3589
    Cell Significance Index: -3.8900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3794
    Cell Significance Index: -23.3200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4032
    Cell Significance Index: -14.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4134
    Cell Significance Index: -13.2400
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.4184
    Cell Significance Index: -2.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4288
    Cell Significance Index: -24.0600
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.4679
    Cell Significance Index: -5.8100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4685
    Cell Significance Index: -13.8000
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.4878
    Cell Significance Index: -4.4100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4959
    Cell Significance Index: -8.3400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4982
    Cell Significance Index: -5.6600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.4993
    Cell Significance Index: -6.4300
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.5074
    Cell Significance Index: -5.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5150
    Cell Significance Index: -22.7800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5170
    Cell Significance Index: -13.2900
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: -0.5213
    Cell Significance Index: -5.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TFCP2L1 is a transcription factor that belongs to the CP2 family, which is characterized by its ability to regulate transcription by interacting with RNA polymerase II. The gene is significantly expressed in various cell types, including epithelial cells, kidney cells, and salivary gland cells. TFCP2L1 exhibits sequence-specific double-stranded DNA binding capabilities, allowing it to regulate transcription in specific genomic regions. **Pathways and Functions:** TFCP2L1 is involved in several cellular pathways, including: 1. **Cell morphogenesis**: TFCP2L1 regulates cell shape and morphology by controlling the expression of genes involved in cell adhesion and migration. 2. **Epithelial cell maturation**: The gene is essential for the development and maturation of epithelial cells, which form the lining of various organs and glands. 3. **Regulation of transcription by RNA polymerase II**: TFCP2L1 interacts with RNA polymerase II to regulate the expression of genes involved in cell growth, differentiation, and survival. 4. **Chromatin organization**: The gene is involved in the regulation of chromatin structure and function, which is critical for gene expression and cellular differentiation. **Clinical Significance:** TFCP2L1 has been implicated in various diseases, including: 1. **Kidney disorders**: Alterations in TFCP2L1 expression have been associated with kidney diseases, such as chronic kidney disease and kidney failure. 2. **Salivary gland disorders**: The gene has been linked to salivary gland disorders, including sialadenitis and salivary gland cancer. 3. **Epithelial cancers**: TFCP2L1 has been identified as a potential oncogene, with its expression altered in various epithelial cancers, including lung, breast, and colon cancer. In conclusion, TFCP2L1 is a critical regulator of cellular processes, including cell morphogenesis, epithelial cell maturation, and transcription regulation. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its role in human health and disease. **Implications for Immunology:** While TFCP2L1 is primarily associated with epithelial cells and kidney cells, its role in the immune system is less well understood. However, the gene's involvement in regulating transcription and chromatin organization suggests that it may play a role in modulating immune responses, particularly in the context of epithelial barrier function and tissue repair. Further research is needed to elucidate the immunological significance of TFCP2L1 and its potential implications in immune-related diseases. **Future Directions:** Future studies should focus on: 1. **Elucidating the molecular mechanisms** underlying TFCP2L1's role in cellular processes and disease. 2. **Investigating the gene's expression** in different tissues and cell types to better understand its regulatory functions. 3. **Developing therapeutic strategies** targeting TFCP2L1 to treat diseases associated with its dysregulation. By exploring the complexities of TFCP2L1, we can gain a deeper understanding of the gene's role in human health and disease, ultimately leading to the development of innovative therapeutic approaches.

Genular Protein ID: 2546170293

Symbol: TF2L1_HUMAN

Name: Transcription factor CP2-like protein 1

UniProtKB Accession Codes:

Q9NZI6 Q4ZG43

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10644752

Title: Cloning of factors related to HIV-inducible LBP proteins that regulate steroidogenic factor-1-independent human placental transcription of the cholesterol side-chain cleavage enzyme, P450scc.

PubMed ID: 10644752

DOI: 10.1074/jbc.275.4.2852

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 25215486

Title: Resetting transcription factor control circuitry toward ground-state pluripotency in human.

PubMed ID: 25215486

DOI: 10.1016/j.cell.2014.08.029

PubMed ID: 26906118

Title: Functional analysis of CP2-like domain and SAM-like domain in TFCP2L1, novel pluripotency factor of embryonic stem cells.

PubMed ID: 26906118

DOI: 10.1007/s12010-016-2021-z

Sequence Information:

  • Length: 479
  • Mass: 54627
  • Checksum: C2D0B56D0705AE75
  • Sequence:
    • MLFWHTQPEH YNQHNSGSYL RDVLALPIFK QEEPQLSPEN EARLPPLQYV LCAATSPAVK 
LHEETLTYLN QGQSYEIRLL ENRKLGDFQD LNTKYVKSII RVVFHDRRLQ YTEHQQLEGW 
RWSRPGDRIL DIDIPLSVGI LDPRASPTQL NAVEFLWDPA KRASAFIQVH CISTEFTPRK 
HGGEKGVPFR VQIDTFKQNE NGEYTEHLHS ASCQIKVFKP KGADRKQKTD REKMEKRTAQ 
EKEKYQPSYE TTILTECSPW PDVAYQVNSA PSPSYNGSPN SFGLGEGNAS PTHPVEALPV 
GSDHLLPSAS IQDAQQWLHR NRFSQFCRLF ASFSGADLLK MSRDDLVQIC GPADGIRLFN 
AIKGRNVRPK MTIYVCQELE QNRVPLQQKR DGSGDSNLSV YHAIFLEELT TLELIEKIAN 
LYSISPQHIH RVYRQGPTGI HVVVSNEMVQ NFQDESCFVL STIKAESNDG YHIILKCGL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.