Details for: MAN1A2
Gene ID: 10905
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: MAN1A2
Ensembl ID: ENSG00000198162
Description: mannosidase alpha class 1A member 2
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 68.95rCSI 82.36%PRS 12.59
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CSI 63.49rCSI 78.98%PRS 11.96
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CSI 46.09rCSI 59.41%PRS 13.38
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CSI 38.81rCSI 65.14%PRS 12.79
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CSI 36.98rCSI 45.75%PRS 18.95
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CSI 34.41rCSI 55.35%PRS 13.94
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CSI 33.84rCSI 82.24%PRS 12.51
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CSI 32.6rCSI 57.57%PRS 12.68
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CSI 27.04rCSI 58.65%PRS 15.64
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CSI 25.74rCSI 61.56%PRS 14.36
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CSI 23.64rCSI 73.87%PRS 13.62
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CSI 23.55rCSI 73.66%PRS 14.67
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CSI 23.04rCSI 82.93%PRS 12.01
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CSI 21.67rCSI 81.91%PRS 13.19
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CSI 19.28rCSI 51.35%PRS 18.78
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CSI 13.88rCSI 35.88%PRS 20.14
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CSI 13.43rCSI 17.96%PRS 27.89
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CSI 12.24rCSI 72.08%PRS 13.39
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CSI 11.88rCSI 18.25%PRS 29.29
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CSI 11.87rCSI 34.19%PRS 39.28
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CSI 10.88rCSI 23.83%PRS 28.87
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CSI 10.86rCSI 19.45%PRS 20.03
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CSI 10.54rCSI 27.49%PRS 32.73
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CSI 10.52rCSI 8.27%PRS 26.19
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CSI 10.23rCSI 26.57%PRS 27.58
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CSI 9.34rCSI 68.68%PRS 12.99
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CSI 8.82rCSI 12.48%PRS 30.01
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CSI 8.63rCSI 51.74%PRS 37.32
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CSI 8.61rCSI 10.33%PRS 21.05
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CSI 8.23rCSI 13.08%PRS 18.23
-
CSI 8.2rCSI 18.12%PRS 15.41
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CSI 8.12rCSI 7.2%PRS 21.81
-
CSI 7.83rCSI 5.44%PRS 26.01
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CSI 7.79rCSI 13.47%PRS 16.54
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CSI 7.58rCSI 14.23%PRS 41.55
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CSI 7.57rCSI 10.34%PRS 24.1
-
CSI 7.29rCSI 11.63%PRS 18.44
-
CSI 6.89rCSI 59.4%PRS 11.35
-
CSI 6.83rCSI 5.85%PRS 34.91
-
CSI 6.8rCSI 14.96%PRS 32.67
-
CSI 6.56rCSI 13.02%PRS 22.63
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CSI 6.39rCSI 12.96%PRS 11.22
-
CSI 6.34rCSI 4.71%PRS 31.83
-
CSI 6.34rCSI 23.74%PRS 18.23
-
CSI 6.23rCSI 20.05%PRS 22.45
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CSI 5.96rCSI 20.42%PRS 18.85
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CSI 5.89rCSI 17.49%PRS 30.21
-
CSI 5.86rCSI 9.06%PRS 20.21
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CSI 5.83rCSI 19.16%PRS 14.18
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CSI 5.8rCSI 22.44%PRS 41.54
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CSI 5.67rCSI 12.97%PRS 21.06
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CSI 5.51rCSI 9.66%PRS 16.51
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CSI 5.4rCSI 7.48%PRS 30.26
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CSI 5.38rCSI 29.42%PRS 33.13
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CSI 5.33rCSI 7.84%PRS 19.9
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CSI 5.26rCSI 6.75%PRS 20.92
-
CSI 5.17rCSI 5.97%PRS 18.81
-
CSI 5.16rCSI 3.43%PRS 25.87
-
CSI 5.14rCSI 4.16%PRS 33.39
-
CSI 5.08rCSI 11.73%PRS 17.37
-
CSI 5.07rCSI 10.19%PRS 15.95
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CSI 4.99rCSI 6.66%PRS 40.74
-
CSI 4.9rCSI 3.44%PRS 48.99
-
CSI 4.81rCSI 22.22%PRS 44.13
-
CSI 4.81rCSI 4.63%PRS 22.42
-
CSI 4.8rCSI 12.17%PRS 16.4
-
CSI 4.75rCSI 4.98%PRS 20.22
-
CSI 4.73rCSI 6.57%PRS 21.96
-
CSI 4.72rCSI 7.74%PRS 16.59
-
CSI 4.71rCSI 5.46%PRS 31.13
-
CSI 4.62rCSI 6.78%PRS 28.38
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CSI 4.5rCSI 6.45%PRS 16.73
-
CSI 4.46rCSI 4.11%PRS 22.56
-
CSI 4.42rCSI 29.36%PRS 23.4
-
CSI 4.21rCSI 6.26%PRS 25.46
-
CSI 4.18rCSI 4.36%PRS 22.2
-
CSI 4.15rCSI 3.16%PRS 28.63
-
CSI 4.15rCSI 13.45%PRS 25.95
-
CSI 4.14rCSI 6.06%PRS 22.94
-
CSI 4.14rCSI 16.86%PRS 30.74
-
CSI 4.12rCSI 6.29%PRS 21.81
-
CSI 4.08rCSI 2.93%PRS 29.85
-
CSI 4.03rCSI 5.48%PRS 32.66
-
CSI 4.01rCSI 5.8%PRS 32.73
-
CSI 3.99rCSI 9.75%PRS 21.18
-
CSI 3.99rCSI 3.3%PRS 22.01
-
CSI 3.89rCSI 3.98%PRS 39.44
-
CSI 3.86rCSI 4.96%PRS 20.79
-
CSI 3.85rCSI 5.05%PRS 69.33
-
CSI 3.76rCSI 3.7%PRS 23.33
-
CSI 3.76rCSI 59.33%PRS 20.22
-
CSI 3.73rCSI 6.05%PRS 21.83
-
CSI 3.67rCSI 8.75%PRS 24.62
-
CSI 3.66rCSI 8.59%PRS 30.95
-
CSI 3.63rCSI 4.85%PRS 23.69
-
CSI 3.61rCSI 9.51%PRS 41.64
-
CSI 3.59rCSI 3.27%PRS 32.97
-
CSI 3.59rCSI 7.38%PRS 21.25
-
CSI 3.58rCSI 3.69%PRS 34.89
-
CSI 3.55rCSI 2.75%PRS 20.81
-
CSI -1.5rCSI -1.1%PRS 23.1%
-
CSI -1.4rCSI -2.0%PRS 29.1%
-
CSI -0.4rCSI -3.8%PRS 15.7%
-
CSI 0.0rCSI 0.1%PRS 52.3%
-
CSI 0.1rCSI 0.4%PRS 31.8%
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CSI 0.2rCSI 0.9%PRS 31.9%
-
CSI 0.2rCSI 1.7%PRS 37.8%
-
CSI 0.2rCSI 1.0%PRS 20.1%
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CSI 0.3rCSI 2.6%PRS 53.7%
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CSI 0.3rCSI 1.4%PRS 41.6%
-
CSI 0.3rCSI 0.8%PRS 33.8%
-
CSI 0.3rCSI 4.6%PRS 50.5%
-
CSI 0.3rCSI 1.1%PRS 35.0%
-
CSI 0.4rCSI 1.5%PRS 39.1%
-
CSI 0.4rCSI 2.1%PRS 46.8%
-
CSI 0.4rCSI 0.8%PRS 34.2%
-
CSI 0.4rCSI 4.2%PRS 25.8%
-
CSI 0.4rCSI 0.6%PRS 27.8%
-
CSI 0.4rCSI 2.0%PRS 48.3%
-
CSI 0.4rCSI 0.6%PRS 34.8%
-
CSI 0.4rCSI 1.1%PRS 24.4%
-
CSI 0.4rCSI 0.5%PRS 25.1%
-
CSI 0.4rCSI 4.3%PRS 49.5%
-
CSI 0.4rCSI 1.3%PRS 34.0%
-
CSI 0.4rCSI 1.6%PRS 36.6%
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CSI 0.4rCSI 3.2%PRS 22.7%
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CSI 0.4rCSI 1.1%PRS 21.7%
-
CSI 0.5rCSI 0.4%PRS 19.6%
-
CSI 0.5rCSI 2.4%PRS 23.7%
-
CSI 0.5rCSI 3.2%PRS 16.8%
-
CSI 0.5rCSI 1.0%PRS 36.2%
-
CSI 0.5rCSI 3.9%PRS 39.2%
-
CSI 0.6rCSI 0.9%PRS 21.7%
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CSI 0.6rCSI 2.9%PRS 36.7%
-
CSI 0.6rCSI 3.4%PRS 23.5%
-
CSI 0.6rCSI 4.1%PRS 22.9%
-
CSI 0.6rCSI 1.0%PRS 41.5%
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CSI 0.6rCSI 1.6%PRS 28.5%
-
CSI 0.6rCSI 1.3%PRS 41.4%
-
CSI 0.6rCSI 1.6%PRS 56.1%
-
CSI 0.6rCSI 1.3%PRS 33.0%
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CSI 0.6rCSI 5.4%PRS 23.7%
-
CSI 0.7rCSI 1.2%PRS 32.9%
-
CSI 0.7rCSI 1.6%PRS 32.1%
-
CSI 0.7rCSI 7.2%PRS 40.7%
-
CSI 0.7rCSI 0.7%PRS 25.5%
-
CSI 0.7rCSI 4.5%PRS 45.4%
-
CSI 0.7rCSI 0.7%PRS 25.4%
-
CSI 0.7rCSI 1.0%PRS 30.9%
-
CSI 0.7rCSI 3.0%PRS 44.5%
-
CSI 0.7rCSI 1.4%PRS 27.4%
-
CSI 0.8rCSI 2.9%PRS 35.4%
-
CSI 0.8rCSI 2.9%PRS 20.9%
-
CSI 0.8rCSI 4.9%PRS 33.1%
-
CSI 0.8rCSI 1.8%PRS 41.9%
-
CSI 0.8rCSI 3.7%PRS 42.5%
-
CSI 0.8rCSI 0.7%PRS 27.2%
-
CSI 0.8rCSI 1.1%PRS 19.0%
-
CSI 0.8rCSI 1.0%PRS 26.0%
-
CSI 0.8rCSI 4.2%PRS 25.8%
-
CSI 0.9rCSI 1.7%PRS 50.5%
-
CSI 0.9rCSI 2.2%PRS 26.6%
-
CSI 0.9rCSI 4.9%PRS 12.4%
-
CSI 0.9rCSI 2.5%PRS 16.6%
-
CSI 0.9rCSI 12.6%PRS 70.3%
-
CSI 0.9rCSI 4.0%PRS 71.3%
-
CSI 0.9rCSI 2.5%PRS 28.1%
-
CSI 1.0rCSI 1.1%PRS 24.9%
-
CSI 1.0rCSI 4.5%PRS 46.2%
-
CSI 1.0rCSI 16.6%PRS 65.1%
-
CSI 1.0rCSI 1.3%PRS 28.1%
-
CSI 1.0rCSI 1.5%PRS 24.3%
-
CSI 1.1rCSI 0.8%PRS 23.1%
-
CSI 1.1rCSI 3.1%PRS 37.8%
-
CSI 1.1rCSI 1.2%PRS 23.0%
-
CSI 1.1rCSI 1.5%PRS 21.4%
-
CSI 1.1rCSI 1.7%PRS 19.9%
-
CSI 1.1rCSI 3.2%PRS 32.4%
-
CSI 1.1rCSI 2.5%PRS 20.0%
-
CSI 1.1rCSI 1.0%PRS 20.5%
-
CSI 1.1rCSI 2.0%PRS 21.1%
-
CSI 1.2rCSI 1.4%PRS 37.4%
-
CSI 1.2rCSI 2.8%PRS 31.7%
-
CSI 1.2rCSI 1.9%PRS 24.7%
-
CSI 1.2rCSI 9.6%PRS 23.8%
-
CSI 1.2rCSI 3.2%PRS 27.9%
-
CSI 1.3rCSI 2.5%PRS 22.2%
-
CSI 1.3rCSI 1.9%PRS 33.6%
-
CSI 1.3rCSI 1.5%PRS 29.8%
-
CSI 1.3rCSI 5.2%PRS 29.0%
-
CSI 1.3rCSI 4.3%PRS 30.4%
-
CSI 1.3rCSI 2.8%PRS 42.7%
-
CSI 1.4rCSI 5.6%PRS 21.9%
-
CSI 1.4rCSI 3.1%PRS 25.3%
-
CSI 1.4rCSI 2.1%PRS 24.6%
-
CSI 1.4rCSI 7.1%PRS 29.2%
-
CSI 1.4rCSI 1.5%PRS 19.9%
-
CSI 1.5rCSI 2.3%PRS 32.0%
-
CSI 1.5rCSI 5.4%PRS 37.1%
-
CSI 1.5rCSI 6.0%PRS 19.7%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Comma-separated if multiple.
Comma-separated if multiple.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.
Genular Protein ID: 3855776411
Symbol: MA1A2_HUMAN
Name: Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9592125
Title: Molecular cloning, chromosomal mapping and tissue-specific expression of a novel human alpha-1,2-mannosidase gene involved in N-glycan maturation.
PubMed ID: 9592125
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
Sequence Information:
- Length: 641
- Mass: 73004
- Checksum: 19DA691A9C4B0ED3
- Sequence:
MTTPALLPLS GRRIPPLNLG PPSFPHHRAT LRLSEKFILL LILSAFITLC FGAFFFLPDS SKHKRFDLGL EDVLIPHVDA GKGAKNPGVF LIHGPDEHRH REEEERLRNK IRADHEKALE EAKEKLRKSR EEIRAEIQTE KNKVVQEMKI KENKPLPPVP IPNLVGIRGG DPEDNDIREK REKIKEMMKH AWDNYRTYGW GHNELRPIAR KGHSPNIFGS SQMGATIVDA LDTLYIMGLH DEFLDGQRWI EDNLDFSVNS EVSVFEVNIR FIGGLLAAYY LSGEEIFKIK AVQLAEKLLP AFNTPTGIPW AMVNLKSGVG RNWGWASAGS SILAEFGTLH MEFIHLSYLT GDLTYYKKVM HIRKLLQKMD RPNGLYPNYL NPRTGRWGQY HTSVGGLGDS FYEYLLKAWL MSDKTDHEAR KMYDDAIEAI EKHLIKKSRG GLTFIGEWKN GHLEKKMGHL ACFAGGMFAL GADGSRADKA GHYLELGAEI ARTCHESYDR TALKLGPESF KFDGAVEAVA VRQAEKYYIL RPEVIETYWY LWRFTHDPRY RQWGWEAALA IEKYCRVNGG FSGVKDVYSS TPTHDDVQQS FFLAETLKYL YLLFSGDDLL PLDHWVFNTE AHPLPVLHLA NTTLSGNPAV R