Details for: ACSL4

Gene ID: 2182

Symbol: ACSL4

Ensembl ID: ENSG00000068366

Description: acyl-CoA synthetase long chain family member 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 267.6071
    Cell Significance Index: -41.6300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 165.6262
    Cell Significance Index: -42.0100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 97.3052
    Cell Significance Index: -45.9400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 91.8630
    Cell Significance Index: -37.3200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 83.0506
    Cell Significance Index: -42.7200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 39.9793
    Cell Significance Index: -38.1700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.8269
    Cell Significance Index: -42.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.0553
    Cell Significance Index: -43.0100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.9616
    Cell Significance Index: -43.2600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.0613
    Cell Significance Index: -22.0200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.8747
    Cell Significance Index: 768.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7951
    Cell Significance Index: 360.0900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.7344
    Cell Significance Index: 48.4700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.4789
    Cell Significance Index: 24.3700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.3155
    Cell Significance Index: 37.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.2235
    Cell Significance Index: 32.7900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1757
    Cell Significance Index: 127.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1322
    Cell Significance Index: 406.1100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.9588
    Cell Significance Index: 27.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.9411
    Cell Significance Index: 49.0200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.9028
    Cell Significance Index: 17.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.8946
    Cell Significance Index: 50.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8363
    Cell Significance Index: 56.2300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7140
    Cell Significance Index: 493.8300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6882
    Cell Significance Index: 52.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6822
    Cell Significance Index: 48.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6781
    Cell Significance Index: 41.6800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6049
    Cell Significance Index: 5.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5397
    Cell Significance Index: 66.3700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.4893
    Cell Significance Index: 3.0400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4881
    Cell Significance Index: 29.3000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4824
    Cell Significance Index: 47.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4307
    Cell Significance Index: 77.6500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2982
    Cell Significance Index: 6.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2962
    Cell Significance Index: 130.9600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2572
    Cell Significance Index: 17.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2319
    Cell Significance Index: 126.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1911
    Cell Significance Index: 31.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1298
    Cell Significance Index: 17.8300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1196
    Cell Significance Index: 22.7700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1149
    Cell Significance Index: 2.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1146
    Cell Significance Index: 5.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1142
    Cell Significance Index: 4.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1132
    Cell Significance Index: 213.1200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1015
    Cell Significance Index: 0.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0951
    Cell Significance Index: 43.1800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0839
    Cell Significance Index: 61.5300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0784
    Cell Significance Index: 1.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0466
    Cell Significance Index: 29.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0358
    Cell Significance Index: 27.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0162
    Cell Significance Index: 29.9400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0053
    Cell Significance Index: 8.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0056
    Cell Significance Index: -0.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0143
    Cell Significance Index: -0.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0145
    Cell Significance Index: -19.7600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0206
    Cell Significance Index: -12.8400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0228
    Cell Significance Index: -16.8700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0387
    Cell Significance Index: -5.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0436
    Cell Significance Index: -7.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0525
    Cell Significance Index: -29.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0689
    Cell Significance Index: -8.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0774
    Cell Significance Index: -2.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0838
    Cell Significance Index: -3.8000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0953
    Cell Significance Index: -3.3500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0973
    Cell Significance Index: -1.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0985
    Cell Significance Index: -11.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1128
    Cell Significance Index: -11.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1246
    Cell Significance Index: -35.8400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1285
    Cell Significance Index: -2.3800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1355
    Cell Significance Index: -28.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1503
    Cell Significance Index: -17.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1577
    Cell Significance Index: -20.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1642
    Cell Significance Index: -4.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1707
    Cell Significance Index: -11.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1764
    Cell Significance Index: -11.1200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1908
    Cell Significance Index: -3.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1915
    Cell Significance Index: -9.0000
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.2121
    Cell Significance Index: -2.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2220
    Cell Significance Index: -5.5500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2420
    Cell Significance Index: -4.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2607
    Cell Significance Index: -6.8600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2694
    Cell Significance Index: -30.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2739
    Cell Significance Index: -35.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2769
    Cell Significance Index: -14.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2876
    Cell Significance Index: -29.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3237
    Cell Significance Index: -25.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3785
    Cell Significance Index: -8.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3924
    Cell Significance Index: -10.6800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4149
    Cell Significance Index: -5.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4451
    Cell Significance Index: -23.3700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4763
    Cell Significance Index: -10.1100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5619
    Cell Significance Index: -8.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5673
    Cell Significance Index: -42.2800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6486
    Cell Significance Index: -17.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6942
    Cell Significance Index: -22.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6963
    Cell Significance Index: -22.3000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.7045
    Cell Significance Index: -20.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7183
    Cell Significance Index: -44.0400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7468
    Cell Significance Index: -24.4500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7485
    Cell Significance Index: -14.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ACSL4 is a member of the acyl-CoA synthetase long chain family, which is a group of enzymes that catalyze the formation of acyl-CoA esters from fatty acids and CoA. The ACSL4 enzyme is a long-chain acyl-CoA synthetase, which means it is involved in the synthesis of long-chain fatty acyl-CoAs. The enzyme has a high affinity for long-chain fatty acids and is able to catalyze the formation of acyl-CoA esters in the presence of ATP. One of the key characteristics of ACSL4 is its ability to regulate insulin secretion. The enzyme is involved in the production of long-chain fatty acyl-CoAs, which are then transported to the pancreas where they are converted into insulin. This process is crucial for the regulation of glucose metabolism and energy homeostasis. **Pathways and Functions** ACSL4 is involved in several cellular pathways, including: 1. **Fatty acid metabolic process**: ACSL4 is involved in the synthesis and degradation of fatty acids, which is a critical process for energy metabolism. 2. **Insulin secretion regulation**: ACSL4 is involved in the regulation of insulin secretion, which is crucial for glucose metabolism and energy homeostasis. 3. **Long-chain fatty acid-coa ligase activity**: ACSL4 is involved in the synthesis of long-chain fatty acyl-CoAs, which are then transported to the pancreas where they are converted into insulin. 4. **Free fatty acids regulate insulin secretion**: ACSL4 is involved in the regulation of insulin secretion by free fatty acids, which are produced by the breakdown of triglycerides. **Clinical Significance** Dysregulation of ACSL4 has been implicated in several diseases, including: 1. **Type 2 diabetes**: ACSL4 has been shown to play a critical role in the regulation of insulin secretion, and dysregulation of the enzyme has been implicated in the development of type 2 diabetes. 2. **Metabolic syndrome**: ACSL4 has been shown to be involved in the regulation of fatty acid metabolism, and dysregulation of the enzyme has been implicated in the development of metabolic syndrome. 3. **Neurological disorders**: ACSL4 has been shown to be involved in the regulation of fatty acid metabolism in neurons, and dysregulation of the enzyme has been implicated in the development of neurological disorders such as Alzheimer's disease and Parkinson's disease. In conclusion, ACSL4 plays a critical role in the regulation of fatty acid metabolism and insulin secretion, and dysregulation of the enzyme has been implicated in several diseases. Further research is needed to fully understand the mechanisms by which ACSL4 regulates fatty acid metabolism and insulin secretion, and to explore the potential therapeutic applications of this enzyme.

Genular Protein ID: 1060402651

Symbol: ACSL4_HUMAN

Name: Long-chain acyl-CoA synthetase 4

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9598324

Title: Cloning, expression, and chromosomal localization of human long-chain fatty acid-CoA ligase 4 (FACL4).

PubMed ID: 9598324

DOI: 10.1006/geno.1998.5268

PubMed ID: 9480748

Title: FACL4, a new gene encoding long-chain acyl-CoA synthetase 4, is deleted in a family with Alport syndrome, elliptocytosis, and mental retardation.

PubMed ID: 9480748

DOI: 10.1006/geno.1997.5104

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21242590

Title: Long-chain acyl-CoA synthetase 4 modulates prostaglandin E(2) release from human arterial smooth muscle cells.

PubMed ID: 21242590

DOI: 10.1194/jlr.m013292

PubMed ID: 22633490

Title: The Sjogren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway.

PubMed ID: 22633490

DOI: 10.1016/j.molcel.2012.04.033

PubMed ID: 24269233

Title: Identification of acyl-CoA synthetases involved in the mammalian sphingosine 1-phosphate metabolic pathway.

PubMed ID: 24269233

DOI: 10.1016/j.bbrc.2013.11.036

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 11889465

Title: FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation.

PubMed ID: 11889465

DOI: 10.1038/ng857

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 29961568

Title: De Novo Truncating Mutations in WASF1 Cause Intellectual Disability with Seizures.

PubMed ID: 29961568

DOI: 10.1016/j.ajhg.2018.06.001

Sequence Information:

  • Length: 711
  • Mass: 79188
  • Checksum: 6483CD17FE78FE73
  • Sequence:
  • MKLKLNVLTI ILLPVHLLIT IYSALIFIPW YFLTNAKKKN AMAKRIKAKP TSDKPGSPYR 
    SVTHFDSLAV IDIPGADTLD KLFDHAVSKF GKKDSLGTRE ILSEENEMQP NGKVFKKLIL 
    GNYKWMNYLE VNRRVNNFGS GLTALGLKPK NTIAIFCETR AEWMIAAQTC FKYNFPLVTL 
    YATLGKEAVV HGLNESEASY LITSVELLES KLKTALLDIS CVKHIIYVDN KAINKAEYPE 
    GFEIHSMQSV EELGSNPENL GIPPSRPTPS DMAIVMYTSG STGRPKGVMM HHSNLIAGMT 
    GQCERIPGLG PKDTYIGYLP LAHVLELTAE ISCFTYGCRI GYSSPLTLSD QSSKIKKGSK 
    GDCTVLKPTL MAAVPEIMDR IYKNVMSKVQ EMNYIQKTLF KIGYDYKLEQ IKKGYDAPLC 
    NLLLFKKVKA LLGGNVRMML SGGAPLSPQT HRFMNVCFCC PIGQGYGLTE SCGAGTVTEV 
    TDYTTGRVGA PLICCEIKLK DWQEGGYTIN DKPNPRGEIV IGGQNISMGY FKNEEKTAED 
    YSVDENGQRW FCTGDIGEFH PDGCLQIIDR KKDLVKLQAG EYVSLGKVEA ALKNCPLIDN 
    ICAFAKSDQS YVISFVVPNQ KRLTLLAQQK GVEGTWVDIC NNPAMEAEIL KEIREAANAM 
    KLERFEIPIK VRLSPEPWTP ETGLVTDAFK LKRKELRNHY LKDIERMYGG K

Genular Protein ID: 4071079676

Symbol: Q8TAF6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 670
  • Mass: 74422
  • Checksum: 0C282E80DAB599F1
  • Sequence:
  • MAKRIKAKPT SDKPGSPYRS VTHFDSLAVI DIPGADTLDK LFDHAVSKFG KKDSLGTREI 
    LSEENEMQPN GKVFKKLILG NYKWMNYLEV NRRVNNFGSG LTALGLKPKN TIAIFCETRA 
    EWMIAAQTCF KYNFPLVTLY ATLGKEAVVH GLNESEASYL ITSVELLESK LKTALLDISC 
    VKHIIYVDNK AINKAEYPEG FEIHSMQSVE ELGSNPENLG IPPSRPTPSD MAIVMYTSGS 
    TGRPKGVMMH HSNLIAGMTG QCERIPGLGP KDTYIGYLPL AHVLELTAEI SCFTYGCRIG 
    YSSPLTLSDQ SSKIKKGSKG DCTVLKPTLM AAVPEIMDRI YKNVMSKVQE MNYIQKTLFK 
    IGYDYKLEQI KKGYDAPLCN LLLFKKVKAL LGGNVRMMLS GGGPLSPQTH RFMNVCFCCP 
    IGQGYGLTES CGAGTVTEVT DYTTGRVGAP LICCEIKLKD WQEGGYTIND KPNPRGEIVI 
    GGQNISMGYF KNEEKTAEDY SVDENGQRWF CTGDIGEFHP DGCLQIIDRK KDLVKLQAGE 
    YVSLGKVEAA LKNCPLIDNI CAFAKSDQSY VISFVVPNQK RLTLLAQQKG VEGTWVDICN 
    NPAMEAEILK EIREAANAMK LERFEIPIKV RLSPEPWTPE TGLVTDAFKL KRKELRNHYL 
    KDIERMYGGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.