Details for: ACSL4

Gene ID: 2182

Symbol: ACSL4

Ensembl ID: ENSG00000068366

Description: acyl-CoA synthetase long chain family member 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 9.65
    Marker Score: 31606
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.94
    Marker Score: 3113
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.14
    Marker Score: 1343.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.13
    Marker Score: 5699.5
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.93
    Marker Score: 34241
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.82
    Marker Score: 865
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.81
    Marker Score: 7351
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.79
    Marker Score: 935
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.76
    Marker Score: 789
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.75
    Marker Score: 18044.5
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.75
    Marker Score: 28027
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.75
    Marker Score: 64390
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.73
    Marker Score: 4255
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.72
    Marker Score: 58587.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.69
    Marker Score: 11024
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.67
    Marker Score: 954
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.66
    Marker Score: 3196
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.64
    Marker Score: 101096
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.64
    Marker Score: 15390
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.63
    Marker Score: 12531
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.63
    Marker Score: 6740.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.63
    Marker Score: 32335
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.62
    Marker Score: 24227.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.62
    Marker Score: 61513.5
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.6
    Marker Score: 3520
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.6
    Marker Score: 54120
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.58
    Marker Score: 355
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.57
    Marker Score: 6061
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.55
    Marker Score: 14741
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.53
    Marker Score: 13154
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.48
    Marker Score: 1497
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.47
    Marker Score: 1664.5
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.46
    Marker Score: 6772.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.46
    Marker Score: 2066
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167426
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.46
    Marker Score: 2246
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.44
    Marker Score: 2320
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.34
    Marker Score: 1034
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.32
    Marker Score: 656
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.31
    Marker Score: 731
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.31
    Marker Score: 7757
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.29
    Marker Score: 1482
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.25
    Marker Score: 609
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.25
    Marker Score: 3160
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.22
    Marker Score: 729
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.2
    Marker Score: 1283
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.19
    Marker Score: 591.5
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.18
    Marker Score: 4937.5
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.16
    Marker Score: 1103
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.13
    Marker Score: 1222
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.12
    Marker Score: 9817
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.11
    Marker Score: 1274
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.1
    Marker Score: 415
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.1
    Marker Score: 397
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.08
    Marker Score: 936
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.08
    Marker Score: 601
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.07
    Marker Score: 2552
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.06
    Marker Score: 5215
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.04
    Marker Score: 2506
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.02
    Marker Score: 690
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.02
    Marker Score: 3615
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.01
    Marker Score: 352
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1
    Marker Score: 315
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71666
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47891
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.99
    Marker Score: 988
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30386
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.97
    Marker Score: 1204.5
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.97
    Marker Score: 655
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.96
    Marker Score: 2401
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.96
    Marker Score: 399
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.95
    Marker Score: 400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.95
    Marker Score: 490
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.95
    Marker Score: 3189.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.95
    Marker Score: 53177.5
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.94
    Marker Score: 5742
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2398
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.94
    Marker Score: 1838
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.94
    Marker Score: 23995.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 477
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.93
    Marker Score: 342
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.92
    Marker Score: 3831
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.92
    Marker Score: 1333
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2704
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.89
    Marker Score: 516
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.88
    Marker Score: 10221.5
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.88
    Marker Score: 218
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.87
    Marker Score: 238
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.87
    Marker Score: 318
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.87
    Marker Score: 218
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.87
    Marker Score: 228
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.87
    Marker Score: 253
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.86
    Marker Score: 332
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.86
    Marker Score: 765
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.86
    Marker Score: 207
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.86
    Marker Score: 1322
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.86
    Marker Score: 786

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * The ACSL4 gene is located on chromosome 15q21.1. * It is a large gene, encoding a protein of 1,312 amino acids. * The protein is expressed in a variety of cell types, including hepatocytes, kidney cells, and immune cells. **Pathways and functions:** * ACSL4 is involved in multiple pathways related to fatty acid metabolism. * It is a key enzyme in the synthesis of very long-chain fatty acids (VLCFAs), which are an important source of energy for cells. * ACSL4 also plays a role in the regulation of insulin secretion. * It is involved in the integration of energy metabolism, as it is a key enzyme in the production of very long-chain fatty acids from other fatty acids. * ACSL4 is also involved in the regulation of insulin secretion by modulating the release of insulin from the beta-cell of the pancreas. **Clinical significance:** * Mutations in the ACSL4 gene have been linked to several human diseases, including obesity, diabetes, and metabolic syndrome. * These mutations can lead to the accumulation of VLCFAs in the blood, which can contribute to insulin resistance and other metabolic abnormalities. * Targeting ACSL4 has been investigated as a therapeutic strategy for these diseases.

Genular Protein ID: 1060402651

Symbol: ACSL4_HUMAN

Name: Long-chain acyl-CoA synthetase 4

UniProtKB Accession Codes:

O60488 D3DUY2 O60848 O60849 Q5JWV8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 67 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 2 EMBL 9 EPD 1 Ensembl 8 ExpressionAtlas 1 GO 26 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 8 Rhea 22 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 3 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9598324

Title: Cloning, expression, and chromosomal localization of human long-chain fatty acid-CoA ligase 4 (FACL4).

PubMed ID: 9598324

DOI: 10.1006/geno.1998.5268

PubMed ID: 9480748

Title: FACL4, a new gene encoding long-chain acyl-CoA synthetase 4, is deleted in a family with Alport syndrome, elliptocytosis, and mental retardation.

PubMed ID: 9480748

DOI: 10.1006/geno.1997.5104

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21242590

Title: Long-chain acyl-CoA synthetase 4 modulates prostaglandin E(2) release from human arterial smooth muscle cells.

PubMed ID: 21242590

DOI: 10.1194/jlr.m013292

PubMed ID: 22633490

Title: The Sjogren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway.

PubMed ID: 22633490

DOI: 10.1016/j.molcel.2012.04.033

PubMed ID: 24269233

Title: Identification of acyl-CoA synthetases involved in the mammalian sphingosine 1-phosphate metabolic pathway.

PubMed ID: 24269233

DOI: 10.1016/j.bbrc.2013.11.036

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 11889465

Title: FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation.

PubMed ID: 11889465

DOI: 10.1038/ng857

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 29961568

Title: De Novo Truncating Mutations in WASF1 Cause Intellectual Disability with Seizures.

PubMed ID: 29961568

DOI: 10.1016/j.ajhg.2018.06.001

Sequence Information:

  • Length: 711
  • Mass: 79188
  • Checksum: 6483CD17FE78FE73
  • Sequence:
    • MKLKLNVLTI ILLPVHLLIT IYSALIFIPW YFLTNAKKKN AMAKRIKAKP TSDKPGSPYR 
SVTHFDSLAV IDIPGADTLD KLFDHAVSKF GKKDSLGTRE ILSEENEMQP NGKVFKKLIL 
GNYKWMNYLE VNRRVNNFGS GLTALGLKPK NTIAIFCETR AEWMIAAQTC FKYNFPLVTL 
YATLGKEAVV HGLNESEASY LITSVELLES KLKTALLDIS CVKHIIYVDN KAINKAEYPE 
GFEIHSMQSV EELGSNPENL GIPPSRPTPS DMAIVMYTSG STGRPKGVMM HHSNLIAGMT 
GQCERIPGLG PKDTYIGYLP LAHVLELTAE ISCFTYGCRI GYSSPLTLSD QSSKIKKGSK 
GDCTVLKPTL MAAVPEIMDR IYKNVMSKVQ EMNYIQKTLF KIGYDYKLEQ IKKGYDAPLC 
NLLLFKKVKA LLGGNVRMML SGGAPLSPQT HRFMNVCFCC PIGQGYGLTE SCGAGTVTEV 
TDYTTGRVGA PLICCEIKLK DWQEGGYTIN DKPNPRGEIV IGGQNISMGY FKNEEKTAED 
YSVDENGQRW FCTGDIGEFH PDGCLQIIDR KKDLVKLQAG EYVSLGKVEA ALKNCPLIDN 
ICAFAKSDQS YVISFVVPNQ KRLTLLAQQK GVEGTWVDIC NNPAMEAEIL KEIREAANAM 
KLERFEIPIK VRLSPEPWTP ETGLVTDAFK LKRKELRNHY LKDIERMYGG K

Genular Protein ID: 4071079676

Symbol: Q8TAF6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8TAF6

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 6 ChiTaRS 1 DNASU 1 EC 1 EMBL 4 GO 1 Gene3D 2 GenomeRNAi 1 IntAct 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 2 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 670
  • Mass: 74422
  • Checksum: 0C282E80DAB599F1
  • Sequence:
    • MAKRIKAKPT SDKPGSPYRS VTHFDSLAVI DIPGADTLDK LFDHAVSKFG KKDSLGTREI 
LSEENEMQPN GKVFKKLILG NYKWMNYLEV NRRVNNFGSG LTALGLKPKN TIAIFCETRA 
EWMIAAQTCF KYNFPLVTLY ATLGKEAVVH GLNESEASYL ITSVELLESK LKTALLDISC 
VKHIIYVDNK AINKAEYPEG FEIHSMQSVE ELGSNPENLG IPPSRPTPSD MAIVMYTSGS 
TGRPKGVMMH HSNLIAGMTG QCERIPGLGP KDTYIGYLPL AHVLELTAEI SCFTYGCRIG 
YSSPLTLSDQ SSKIKKGSKG DCTVLKPTLM AAVPEIMDRI YKNVMSKVQE MNYIQKTLFK 
IGYDYKLEQI KKGYDAPLCN LLLFKKVKAL LGGNVRMMLS GGGPLSPQTH RFMNVCFCCP 
IGQGYGLTES CGAGTVTEVT DYTTGRVGAP LICCEIKLKD WQEGGYTIND KPNPRGEIVI 
GGQNISMGYF KNEEKTAEDY SVDENGQRWF CTGDIGEFHP DGCLQIIDRK KDLVKLQAGE 
YVSLGKVEAA LKNCPLIDNI CAFAKSDQSY VISFVVPNQK RLTLLAQQKG VEGTWVDICN 
NPAMEAEILK EIREAANAMK LERFEIPIKV RLSPEPWTPE TGLVTDAFKL KRKELRNHYL 
KDIERMYGGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.