Details for: ACSL4
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 267.6071
Cell Significance Index: -41.6300 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 165.6262
Cell Significance Index: -42.0100 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 97.3052
Cell Significance Index: -45.9400 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 91.8630
Cell Significance Index: -37.3200 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 83.0506
Cell Significance Index: -42.7200 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 39.9793
Cell Significance Index: -38.1700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 34.8269
Cell Significance Index: -42.9400 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 16.0553
Cell Significance Index: -43.0100 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 10.9616
Cell Significance Index: -43.2600 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 10.0613
Cell Significance Index: -22.0200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 3.8747
Cell Significance Index: 768.9400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.7951
Cell Significance Index: 360.0900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.7344
Cell Significance Index: 48.4700 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 1.4789
Cell Significance Index: 24.3700 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.3155
Cell Significance Index: 37.7100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.2235
Cell Significance Index: 32.7900 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.1757
Cell Significance Index: 127.8800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.1322
Cell Significance Index: 406.1100 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.9588
Cell Significance Index: 27.3600 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.9411
Cell Significance Index: 49.0200 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.9028
Cell Significance Index: 17.6200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.8946
Cell Significance Index: 50.2000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.8363
Cell Significance Index: 56.2300 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.7140
Cell Significance Index: 493.8300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.6882
Cell Significance Index: 52.8200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.6822
Cell Significance Index: 48.2500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.6781
Cell Significance Index: 41.6800 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.6049
Cell Significance Index: 5.5700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.5397
Cell Significance Index: 66.3700 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.4893
Cell Significance Index: 3.0400 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.4881
Cell Significance Index: 29.3000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4824
Cell Significance Index: 47.7200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.4307
Cell Significance Index: 77.6500 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.2982
Cell Significance Index: 6.5300 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2962
Cell Significance Index: 130.9600 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2572
Cell Significance Index: 17.7900 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2319
Cell Significance Index: 126.6500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1911
Cell Significance Index: 31.0800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1298
Cell Significance Index: 17.8300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1196
Cell Significance Index: 22.7700 - Cell Name: peg cell (CL4033014)
Fold Change: 0.1149
Cell Significance Index: 2.6600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.1146
Cell Significance Index: 5.0700 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.1142
Cell Significance Index: 4.3300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1132
Cell Significance Index: 213.1200 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.1015
Cell Significance Index: 0.8300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0951
Cell Significance Index: 43.1800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0839
Cell Significance Index: 61.5300 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.0784
Cell Significance Index: 1.8800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0466
Cell Significance Index: 29.6100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0358
Cell Significance Index: 27.1200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0162
Cell Significance Index: 29.9400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0053
Cell Significance Index: 8.1500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0056
Cell Significance Index: -0.1500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0143
Cell Significance Index: -0.3100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0145
Cell Significance Index: -19.7600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0206
Cell Significance Index: -12.8400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0228
Cell Significance Index: -16.8700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0387
Cell Significance Index: -5.6200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0436
Cell Significance Index: -7.4500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0525
Cell Significance Index: -29.5900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0689
Cell Significance Index: -8.1300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0774
Cell Significance Index: -2.2300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0838
Cell Significance Index: -3.8000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0953
Cell Significance Index: -3.3500 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.0973
Cell Significance Index: -1.4000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0985
Cell Significance Index: -11.2900 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1128
Cell Significance Index: -11.5200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1246
Cell Significance Index: -35.8400 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.1285
Cell Significance Index: -2.3800 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1355
Cell Significance Index: -28.5400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1503
Cell Significance Index: -17.5200 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.1577
Cell Significance Index: -20.2100 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1642
Cell Significance Index: -4.2200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1707
Cell Significance Index: -11.0200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1764
Cell Significance Index: -11.1200 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1908
Cell Significance Index: -3.2700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1915
Cell Significance Index: -9.0000 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: -0.2121
Cell Significance Index: -2.1400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.2220
Cell Significance Index: -5.5500 - Cell Name: hepatoblast (CL0005026)
Fold Change: -0.2420
Cell Significance Index: -4.0700 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2607
Cell Significance Index: -6.8600 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2694
Cell Significance Index: -30.7500 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.2739
Cell Significance Index: -35.3800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2769
Cell Significance Index: -14.3900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2876
Cell Significance Index: -29.9500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3237
Cell Significance Index: -25.6400 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3785
Cell Significance Index: -8.0600 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.3924
Cell Significance Index: -10.6800 - Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.4149
Cell Significance Index: -5.8200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4451
Cell Significance Index: -23.3700 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.4763
Cell Significance Index: -10.1100 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.5619
Cell Significance Index: -8.3000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.5673
Cell Significance Index: -42.2800 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.6486
Cell Significance Index: -17.3500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.6942
Cell Significance Index: -22.1100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.6963
Cell Significance Index: -22.3000 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.7045
Cell Significance Index: -20.6900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.7183
Cell Significance Index: -44.0400 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.7468
Cell Significance Index: -24.4500 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.7485
Cell Significance Index: -14.8000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1060402651
Symbol: ACSL4_HUMAN
Name: Long-chain acyl-CoA synthetase 4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9598324
Title: Cloning, expression, and chromosomal localization of human long-chain fatty acid-CoA ligase 4 (FACL4).
PubMed ID: 9598324
PubMed ID: 9480748
Title: FACL4, a new gene encoding long-chain acyl-CoA synthetase 4, is deleted in a family with Alport syndrome, elliptocytosis, and mental retardation.
PubMed ID: 9480748
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21242590
Title: Long-chain acyl-CoA synthetase 4 modulates prostaglandin E(2) release from human arterial smooth muscle cells.
PubMed ID: 21242590
DOI: 10.1194/jlr.m013292
PubMed ID: 22633490
Title: The Sjogren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway.
PubMed ID: 22633490
PubMed ID: 24269233
Title: Identification of acyl-CoA synthetases involved in the mammalian sphingosine 1-phosphate metabolic pathway.
PubMed ID: 24269233
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 11889465
Title: FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation.
PubMed ID: 11889465
DOI: 10.1038/ng857
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
PubMed ID: 29961568
Title: De Novo Truncating Mutations in WASF1 Cause Intellectual Disability with Seizures.
PubMed ID: 29961568
Sequence Information:
- Length: 711
- Mass: 79188
- Checksum: 6483CD17FE78FE73
- Sequence:
MKLKLNVLTI ILLPVHLLIT IYSALIFIPW YFLTNAKKKN AMAKRIKAKP TSDKPGSPYR SVTHFDSLAV IDIPGADTLD KLFDHAVSKF GKKDSLGTRE ILSEENEMQP NGKVFKKLIL GNYKWMNYLE VNRRVNNFGS GLTALGLKPK NTIAIFCETR AEWMIAAQTC FKYNFPLVTL YATLGKEAVV HGLNESEASY LITSVELLES KLKTALLDIS CVKHIIYVDN KAINKAEYPE GFEIHSMQSV EELGSNPENL GIPPSRPTPS DMAIVMYTSG STGRPKGVMM HHSNLIAGMT GQCERIPGLG PKDTYIGYLP LAHVLELTAE ISCFTYGCRI GYSSPLTLSD QSSKIKKGSK GDCTVLKPTL MAAVPEIMDR IYKNVMSKVQ EMNYIQKTLF KIGYDYKLEQ IKKGYDAPLC NLLLFKKVKA LLGGNVRMML SGGAPLSPQT HRFMNVCFCC PIGQGYGLTE SCGAGTVTEV TDYTTGRVGA PLICCEIKLK DWQEGGYTIN DKPNPRGEIV IGGQNISMGY FKNEEKTAED YSVDENGQRW FCTGDIGEFH PDGCLQIIDR KKDLVKLQAG EYVSLGKVEA ALKNCPLIDN ICAFAKSDQS YVISFVVPNQ KRLTLLAQQK GVEGTWVDIC NNPAMEAEIL KEIREAANAM KLERFEIPIK VRLSPEPWTP ETGLVTDAFK LKRKELRNHY LKDIERMYGG K
Genular Protein ID: 4071079676
Symbol: Q8TAF6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 670
- Mass: 74422
- Checksum: 0C282E80DAB599F1
- Sequence:
MAKRIKAKPT SDKPGSPYRS VTHFDSLAVI DIPGADTLDK LFDHAVSKFG KKDSLGTREI LSEENEMQPN GKVFKKLILG NYKWMNYLEV NRRVNNFGSG LTALGLKPKN TIAIFCETRA EWMIAAQTCF KYNFPLVTLY ATLGKEAVVH GLNESEASYL ITSVELLESK LKTALLDISC VKHIIYVDNK AINKAEYPEG FEIHSMQSVE ELGSNPENLG IPPSRPTPSD MAIVMYTSGS TGRPKGVMMH HSNLIAGMTG QCERIPGLGP KDTYIGYLPL AHVLELTAEI SCFTYGCRIG YSSPLTLSDQ SSKIKKGSKG DCTVLKPTLM AAVPEIMDRI YKNVMSKVQE MNYIQKTLFK IGYDYKLEQI KKGYDAPLCN LLLFKKVKAL LGGNVRMMLS GGGPLSPQTH RFMNVCFCCP IGQGYGLTES CGAGTVTEVT DYTTGRVGAP LICCEIKLKD WQEGGYTIND KPNPRGEIVI GGQNISMGYF KNEEKTAEDY SVDENGQRWF CTGDIGEFHP DGCLQIIDRK KDLVKLQAGE YVSLGKVEAA LKNCPLIDNI CAFAKSDQSY VISFVVPNQK RLTLLAQQKG VEGTWVDICN NPAMEAEILK EIREAANAMK LERFEIPIKV RLSPEPWTPE TGLVTDAFKL KRKELRNHYL KDIERMYGGK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.