Details for: TAX1BP1
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 103.48rCSI 91%PRS 9.71
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CSI 88.61rCSI 100%PRS 9.8
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CSI 76.7rCSI 59.09%PRS 12.16
-
CSI 75.24rCSI 75.09%PRS 11.43
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CSI 58.63rCSI 100%PRS 14.26
-
CSI 56.96rCSI 54.84%PRS 13.87
-
CSI 55.52rCSI 82.53%PRS 16.31
-
CSI 45.13rCSI 68.93%PRS 13.4
-
CSI 44.16rCSI 54.93%PRS 14.13
-
CSI 42.66rCSI 76.65%PRS 11.2
-
CSI 41.27rCSI 56.43%PRS 21.76
-
CSI 38.29rCSI 50.89%PRS 14.64
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CSI 36.08rCSI 82.24%PRS 13.96
-
CSI 34.74rCSI 67.57%PRS 13.67
-
CSI 34.69rCSI 50.75%PRS 14.15
-
CSI 33.36rCSI 54.06%PRS 13.63
-
CSI 33.05rCSI 78.45%PRS 16.94
-
CSI 31.88rCSI 49.26%PRS 12.54
-
CSI 30.05rCSI 66.39%PRS 9.65
-
CSI 28.82rCSI 28.35%PRS 14.57
-
CSI 27.88rCSI 67.76%PRS 7.66
-
CSI 25.73rCSI 21.57%PRS 16.02
-
CSI 25.56rCSI 26.78%PRS 14.32
-
CSI 25.14rCSI 55.07%PRS 17.84
-
CSI 24.53rCSI 70.65%PRS 25.88
-
CSI 23.69rCSI 85.24%PRS 7.3
-
CSI 23.13rCSI 66.96%PRS 15.19
-
CSI 22.35rCSI 27.65%PRS 11.75
-
CSI 21.61rCSI 22.64%PRS 12.48
-
CSI 21.35rCSI 66.72%PRS 8.42
-
CSI 21.2rCSI 34.09%PRS 8.63
-
CSI 19.98rCSI 43.99%PRS 20.53
-
CSI 19.93rCSI 98.25%PRS 18.17
-
CSI 19.79rCSI 43.2%PRS 26.84
-
CSI 19.51rCSI 15.12%PRS 12.77
-
CSI 19.42rCSI 18.72%PRS 9.29
-
CSI 19.18rCSI 54.86%PRS 23.73
-
CSI 18.8rCSI 50.68%PRS 17.23
-
CSI 18.74rCSI 34.05%PRS 20.49
-
CSI 18.41rCSI 34.75%PRS 16.64
-
CSI 18.36rCSI 26.46%PRS 21.48
-
CSI 17.07rCSI 19.8%PRS 19.78
-
CSI 16.95rCSI 28.44%PRS 7.88
-
CSI 16.38rCSI 57.47%PRS 24.13
-
CSI 15.75rCSI 43.28%PRS 22.04
-
CSI 15.69rCSI 36.55%PRS 27.97
-
CSI 15.68rCSI 43.93%PRS 20.69
-
CSI 14.99rCSI 15.93%PRS 23.65
-
CSI 14.42rCSI 48.77%PRS 22.36
-
CSI 14.12rCSI 22.73%PRS 10.31
-
CSI 14.1rCSI 74.14%PRS 15.36
-
CSI 13.92rCSI 22.92%PRS 15.6
-
CSI 13.7rCSI 54.54%PRS 23.57
-
CSI 13.17rCSI 17.6%PRS 17.75
-
CSI 13.08rCSI 9.89%PRS 18.5
-
CSI 13.02rCSI 68.36%PRS 23.63
-
CSI 12.91rCSI 76.02%PRS 8.23
-
CSI 12.8rCSI 18.75%PRS 15.61
-
CSI 12.57rCSI 29.88%PRS 20.11
-
CSI 12.23rCSI 15.21%PRS 7.32
-
CSI 12.19rCSI 56.32%PRS 27.55
-
CSI 11.98rCSI 23.89%PRS 22.25
-
CSI 11.53rCSI 17.72%PRS 18.99
-
CSI 11.06rCSI 34.58%PRS 9.02
-
CSI 11.02rCSI 11.23%PRS 19.14
-
CSI 10.18rCSI 19.44%PRS 31.16
-
CSI 10.14rCSI 16.34%PRS 21.33
-
CSI 10.13rCSI 26.33%PRS 17.65
-
CSI 10.13rCSI 44.49%PRS 24.93
-
CSI 10.06rCSI 15.17%PRS 13.23
-
CSI 9.81rCSI 33.59%PRS 11.81
-
CSI 9.52rCSI 22.86%PRS 24.17
-
CSI 9.45rCSI 35.73%PRS 8.03
-
CSI 9.27rCSI 50.5%PRS 32.87
-
CSI 8.95rCSI 41.74%PRS 31.7
-
CSI 8.55rCSI 22.77%PRS 10.5
-
CSI 8.43rCSI 5.68%PRS 16.11
-
CSI 8.42rCSI 17.93%PRS 21.56
-
CSI 8.34rCSI 48.51%PRS 20.1
-
CSI 8.25rCSI 21.73%PRS 26.16
-
CSI 8.11rCSI 9.13%PRS 21.48
-
CSI 7.99rCSI 23.11%PRS 29.69
-
CSI 7.74rCSI 17.13%PRS 12.46
-
CSI 7.62rCSI 24.46%PRS 19.58
-
CSI 7.54rCSI 5.01%PRS 15.96
-
CSI 7.45rCSI 6.84%PRS 15.35
-
CSI 7.34rCSI 11.22%PRS 15.34
-
CSI 7.27rCSI 48.28%PRS 13.57
-
CSI 7.2rCSI 54.07%PRS 24.53
-
CSI 6.9rCSI 27.56%PRS 29.19
-
CSI 6.75rCSI 5.84%PRS 14.93
-
CSI 6.56rCSI 71.36%PRS 25.73
-
CSI 6.54rCSI 7.01%PRS 12.33
-
CSI 6.45rCSI 4.51%PRS 14.05
-
CSI 6.41rCSI 4.46%PRS 15.71
-
CSI 6.4rCSI 5.68%PRS 13.4
-
CSI 6.39rCSI 34.38%PRS 24.08
-
CSI 6.3rCSI 4.67%PRS 11.86
-
CSI 6.29rCSI 7.9%PRS 17.06
-
CSI 6.28rCSI 5.52%PRS 15.05
-
CSI -5.1rCSI -5.2%PRS 24.8%
-
CSI -4.8rCSI -4.7%PRS 21.1%
-
CSI -4.3rCSI -7.6%PRS 12.8%
-
CSI -4.2rCSI -10.7%PRS 13.6%
-
CSI -3.5rCSI -2.9%PRS 14.1%
-
CSI -3.2rCSI -13.1%PRS 27.3%
-
CSI -2.6rCSI -2.3%PRS 17.8%
-
CSI -2.1rCSI -5.9%PRS 12.4%
-
CSI -1.7rCSI -8.3%PRS 9.0%
-
CSI -1.4rCSI -3.2%PRS 20.8%
-
CSI -1.3rCSI -3.9%PRS 32.8%
-
CSI -1.3rCSI -5.8%PRS 35.6%
-
CSI -1.2rCSI -6.8%PRS 5.7%
-
CSI -1.2rCSI -3.8%PRS 9.6%
-
CSI -1.2rCSI -2.0%PRS 9.8%
-
CSI -1.0rCSI -4.4%PRS 13.0%
-
CSI -0.8rCSI -1.2%PRS 13.4%
-
CSI -0.8rCSI -3.6%PRS 16.9%
-
CSI -0.7rCSI -1.7%PRS 12.9%
-
CSI -0.6rCSI -10.0%PRS 49.5%
-
CSI -0.6rCSI -1.2%PRS 9.9%
-
CSI -0.3rCSI -0.8%PRS 14.8%
-
CSI -0.3rCSI -0.7%PRS 8.2%
-
CSI -0.3rCSI -2.0%PRS 10.4%
-
CSI -0.3rCSI -0.7%PRS 20.1%
-
CSI -0.3rCSI -7.1%PRS 57.0%
-
CSI -0.3rCSI -0.4%PRS 15.4%
-
CSI -0.2rCSI -0.5%PRS 16.0%
-
CSI -0.2rCSI -0.1%PRS 27.6%
-
CSI -0.1rCSI -0.1%PRS 17.7%
-
CSI -0.1rCSI -0.3%PRS 19.6%
-
CSI 0.0rCSI 0.1%PRS 18.6%
-
CSI 0.0rCSI 0.1%PRS 19.5%
-
CSI 0.1rCSI 1.5%PRS 56.2%
-
CSI 0.1rCSI 2.3%PRS 44.3%
-
CSI 0.1rCSI 0.7%PRS 26.1%
-
CSI 0.1rCSI 0.7%PRS 50.8%
-
CSI 0.1rCSI 0.3%PRS 7.4%
-
CSI 0.1rCSI 0.4%PRS 13.2%
-
CSI 0.1rCSI 1.9%PRS 42.5%
-
CSI 0.1rCSI 0.2%PRS 23.4%
-
CSI 0.2rCSI 0.6%PRS 7.0%
-
CSI 0.2rCSI 0.5%PRS 22.0%
-
CSI 0.2rCSI 0.5%PRS 51.7%
-
CSI 0.2rCSI 2.3%PRS 49.4%
-
CSI 0.2rCSI 1.3%PRS 42.0%
-
CSI 0.2rCSI 0.6%PRS 18.7%
-
CSI 0.3rCSI 4.7%PRS 65.0%
-
CSI 0.3rCSI 1.1%PRS 57.8%
-
CSI 0.3rCSI 1.0%PRS 27.6%
-
CSI 0.3rCSI 1.4%PRS 24.0%
-
CSI 0.3rCSI 4.7%PRS 59.8%
-
CSI 0.3rCSI 1.7%PRS 17.7%
-
CSI 0.3rCSI 1.2%PRS 21.9%
-
CSI 0.3rCSI 2.0%PRS 42.7%
-
CSI 0.3rCSI 0.4%PRS 23.0%
-
CSI 0.4rCSI 1.4%PRS 13.5%
-
CSI 0.4rCSI 0.5%PRS 12.3%
-
CSI 0.4rCSI 0.5%PRS 13.6%
-
CSI 0.4rCSI 1.3%PRS 50.4%
-
CSI 0.4rCSI 2.4%PRS 35.7%
-
CSI 0.4rCSI 0.9%PRS 63.3%
-
CSI 0.4rCSI 0.7%PRS 11.5%
-
CSI 0.5rCSI 5.0%PRS 24.2%
-
CSI 0.5rCSI 4.0%PRS 62.0%
-
CSI 0.5rCSI 2.1%PRS 45.8%
-
CSI 0.5rCSI 1.0%PRS 30.8%
-
CSI 0.5rCSI 0.7%PRS 21.1%
-
CSI 0.5rCSI 0.6%PRS 13.2%
-
CSI 0.5rCSI 1.7%PRS 9.2%
-
CSI 0.5rCSI 1.0%PRS 13.6%
-
CSI 0.5rCSI 2.6%PRS 17.5%
-
CSI 0.5rCSI 1.3%PRS 38.4%
-
CSI 0.5rCSI 1.1%PRS 39.2%
-
CSI 0.5rCSI 1.1%PRS 27.0%
-
CSI 0.5rCSI 5.3%PRS 37.6%
-
CSI 0.6rCSI 4.5%PRS 51.4%
-
CSI 0.6rCSI 0.6%PRS 14.1%
-
CSI 0.6rCSI 1.2%PRS 7.5%
-
CSI 0.6rCSI 2.6%PRS 36.5%
-
CSI 0.6rCSI 2.2%PRS 23.0%
-
CSI 0.6rCSI 1.0%PRS 17.3%
-
CSI 0.6rCSI 9.2%PRS 33.5%
-
CSI 0.6rCSI 1.5%PRS 31.7%
-
CSI 0.6rCSI 0.4%PRS 18.5%
-
CSI 0.6rCSI 9.5%PRS 41.2%
-
CSI 0.6rCSI 0.5%PRS 23.7%
-
CSI 0.7rCSI 3.7%PRS 25.0%
-
CSI 0.7rCSI 4.9%PRS 12.8%
-
CSI 0.7rCSI 1.9%PRS 21.1%
-
CSI 0.7rCSI 1.0%PRS 32.1%
-
CSI 0.7rCSI 1.5%PRS 20.3%
-
CSI 0.7rCSI 1.1%PRS 12.5%
-
CSI 0.8rCSI 4.3%PRS 20.6%
-
CSI 0.8rCSI 1.2%PRS 11.5%
-
CSI 0.8rCSI 3.4%PRS 5.6%
-
CSI 0.8rCSI 11.4%PRS 63.1%
-
CSI 0.8rCSI 4.5%PRS 26.9%
-
CSI 0.8rCSI 1.6%PRS 5.8%
-
CSI 0.8rCSI 1.0%PRS 18.9%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2048259026
Symbol: TAXB1_HUMAN
Name: Tax1-binding protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10435631
Title: The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases.
PubMed ID: 10435631
PubMed ID: 10920205
Title: T6BP, a TRAF6-interacting protein involved in IL-1 signaling.
PubMed ID: 10920205
PubMed ID: 11230166
Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
PubMed ID: 11230166
DOI: 10.1101/gr.gr1547r
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12853948
PubMed ID: 12690205
Title: Human chromosome 7: DNA sequence and biology.
PubMed ID: 12690205
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14697242
Title: Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins.
PubMed ID: 14697242
PubMed ID: 14530271
PubMed ID: 17703191
Title: Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling.
PubMed ID: 17703191
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21885437
Title: ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling.
PubMed ID: 21885437
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 27062441
Title: A novel mode of ubiquitin recognition by the ubiquitin-binding zinc finger domain of WRNIP1.
PubMed ID: 27062441
DOI: 10.1111/febs.13734
PubMed ID: 27736772
Title: TAX1BP1 Restrains Virus-Induced Apoptosis by Facilitating Itch-Mediated Degradation of the Mitochondrial Adaptor MAVS.
PubMed ID: 27736772
DOI: 10.1128/mcb.00422-16
PubMed ID: 28898289
Title: TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses.
PubMed ID: 28898289
PubMed ID: 30909570
Title: Autophagy Promotes Infectious Particle Production of Mopeia and Lassa Viruses.
PubMed ID: 30909570
DOI: 10.3390/v11030293
PubMed ID: 33226137
Title: Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.
PubMed ID: 33226137
PubMed ID: 34471133
Title: Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation.
PubMed ID: 34471133
PubMed ID: 34431698
Title: Depletion of TAX1BP1 Amplifies Innate Immune Responses during Respiratory Syncytial Virus Infection.
PubMed ID: 34431698
DOI: 10.1128/jvi.00912-21
PubMed ID: 24239949
Title: The structure of TAX1BP1 UBZ1+2 provides insight into target specificity and adaptability.
PubMed ID: 24239949
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
PubMed ID: 21765415
Title: The kinase IKKalpha inhibits activation of the transcription factor NF-kappaB by phosphorylating the regulatory molecule TAX1BP1.
PubMed ID: 21765415
DOI: 10.1038/ni.2066
PubMed ID: 31371777
Title: Structure of Myosin VI/Tom1 complex reveals a cargo recognition mode of Myosin VI for tethering.
PubMed ID: 31371777
PubMed ID: 26451915
Title: The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI Are Required for Clearance of Salmonella Typhimurium by Autophagy.
PubMed ID: 26451915
PubMed ID: 29940186
Title: Mechanistic Insights into Recognitions of Ubiquitin and Myosin VI by Autophagy Receptor TAX1BP1.
PubMed ID: 29940186
PubMed ID: 30459273
Title: Mechanistic insights into the interactions of NAP1 with the SKICH domains of NDP52 and TAX1BP1.
PubMed ID: 30459273
Sequence Information:
- Length: 789
- Mass: 90877
- Checksum: DE8460DAA6712125
- Sequence:
MTSFQEVPLQ TSNFAHVIFQ NVAKSYLPNA HLECHYTLTP YIHPHPKDWV GIFKVGWSTA RDYYTFLWSP MPEHYVEGST VNCVLAFQGY YLPNDDGEFY QFCYVTHKGE IRGASTPFQF RASSPVEELL TMEDEGNSDM LVVTTKAGLL ELKIEKTMKE KEELLKLIAV LEKETAQLRE QVGRMERELN HEKERCDQLQ AEQKGLTEVT QSLKMENEEF KKRFSDATSK AHQLEEDIVS VTHKAIEKET ELDSLKDKLK KAQHEREQLE CQLKTEKDEK ELYKVHLKNT EIENTKLMSE VQTLKNLDGN KESVITHFKE EIGRLQLCLA EKENLQRTFL LTTSSKEDTC FLKEQLRKAE EQVQATRQEV VFLAKELSDA VNVRDRTMAD LHTARLENEK VKKQLADAVA ELKLNAMKKD QDKTDTLEHE LRREVEDLKL RLQMAADHYK EKFKECQRLQ KQINKLSDQS ANNNNVFTKK TGNQQKVNDA SVNTDPATSA STVDVKPSPS AAEADFDIVT KGQVCEMTKE IADKTEKYNK CKQLLQDEKA KCNKYADELA KMELKWKEQV KIAENVKLEL AEVQDNYKEL KRSLENPAER KMEGQNSQSP QCFKTCSEQN GYVLTLSNAQ PVLQYGNPYA SQETRDGADG AFYPDEIQRP PVRVPSWGLE DNVVCSQPAR NFSRPDGLED SEDSKEDENV PTAPDPPSQH LRGHGTGFCF DSSFDVHKKC PLCELMFPPN YDQSKFEEHV ESHWKVCPMC SEQFPPDYDQ QVFERHVQTH FDQNVLNFD
Genular Protein ID: 752904585
Symbol: B4DSG5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 747
- Mass: 86158
- Checksum: 93EEDFF296B0A57D
- Sequence:
MTSFQEVPLQ TSNFAHVIFQ NVAKSYLPNA HLECHYTLTP YIHPHPKDWV GIFKVGWSTA RDYYTFLWSP MPEHYVEGST VNCVLAFQGY YLPNDDGEFY QFCYVTHKGE IRGASTPFQF RASSPVEELL TMEDEGNSDM LVVTTKAGLL ELKIEKTMKE KEELLKLIAV LEKETAQLRE QVGRMERELN HEKERCDQLQ AEQKGLTEVT QSLKMENEEF KKGFSDATSK AHQLEEDIVS VTHKAIEKET ELDSLKDKLK KAQHEREQLE CQLKTEKDEK ELYKVHLKNT EIENTKLMSE VQTLKNLDGN KESVITHFKE EIGRLQLCLA EKENLQRTFL LTTSSKEDTC FLKEQLRKAE EQVQATRQEV VFLAKELSDA VNVRDRTMAD LHTARLENEK VKKQLADAVA ELKLNAMKKD QDKTDTLEHE LRREVEDLKL RLQMAADHYK EKFKECQRLQ KQINKLSDQS ANNNNVFTKK TGNQQKVNDA SVNTDPATSA STVDVKPSPS AAEADFDIVT KGQVCEMTKE IADKTEKYNK CKQLLQDEKA KCNKYADELA KMELKWKEQV KIAENVKLEL AEVQDNYKEL KRSLENPAER KMEDGADGAF YPDEIQRPPV RVPSWGLEDN VVCSQPARNF SRPDGLEDSE DSKEDENVPT APDPPSQHLR GHGTGFCFDS SFDVHKKCPL CELMFPPNYD QSKFEEHVES HWKVCPMCSE QFPPDYDQQV FERHVQTHFD QNVLNFD