TAX1BP1 | ENSG00000106052 | NCBI 8887

Details for: TAX1BP1

Gene ID: 8887

Symbol: TAX1BP1

Ensembl ID: ENSG00000106052

Description: Tax1 binding protein 1

Associated with

Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-HSA-168928)
Death receptor signaling
(R-HSA-73887)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Negative regulators of ddx58/ifih1 signaling
(R-HSA-936440)
Regulation of tnfr1 signaling
(R-HSA-5357905)
Signal transduction
(R-HSA-162582)
Tnf signaling
(R-HSA-75893)
Apoptotic process
(GO:0006915)
Autophagosome
(GO:0005776)
Autophagy
(GO:0006914)
Cytoplasmic vesicle
(GO:0031410)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Innate immune response
(GO:0045087)
Kinase binding
(GO:0019900)
Metal ion binding
(GO:0046872)
Mitochondrion
(GO:0005739)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cytoplasmic pattern recognition receptor signaling pathway
(GO:0039532)
Negative regulation of nf-kappab transcription factor activity
(GO:0032088)
Negative regulation of toll-like receptor 4 signaling pathway
(GO:0034144)
Phagophore assembly site
(GO:0000407)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Protein localization to phagocytic vesicle
(GO:1905161)

Other Information

Proteins

Tax1-binding protein 1
B4DSG5_HUMAN

Genular Protein ID: 2048259026

Symbol: TAXB1_HUMAN

Name: Tax1-binding protein 1

UniProtKB Accession Codes:

Q86VP1 A4D196 B4DKU7 E7ENV2 O60398 O95770 Q13311 Q9BQG5 Q9UI88

Database IDs:

Citations:

PubMed ID: 10435631

Title: The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases.

PubMed ID: 10435631

DOI: 10.1038/sj.onc.1202787

PubMed ID: 10920205

Title: T6BP, a TRAF6-interacting protein involved in IL-1 signaling.

PubMed ID: 10920205

DOI: 10.1073/pnas.170279097

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14697242

Title: Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins.

PubMed ID: 14697242

DOI: 10.1016/j.bbrc.2003.12.001

PubMed ID: 14530271

Title: Protein profile of tax-associated complexes.

PubMed ID: 14530271

DOI: 10.1074/jbc.m310069200

PubMed ID: 17703191

Title: Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling.

PubMed ID: 17703191

DOI: 10.1038/sj.emboj.7601823

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21885437

Title: ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling.

PubMed ID: 21885437

DOI: 10.1074/jbc.m111.283762

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27062441

Title: A novel mode of ubiquitin recognition by the ubiquitin-binding zinc finger domain of WRNIP1.

PubMed ID: 27062441

DOI: 10.1111/febs.13734

PubMed ID: 27736772

Title: TAX1BP1 Restrains Virus-Induced Apoptosis by Facilitating Itch-Mediated Degradation of the Mitochondrial Adaptor MAVS.

PubMed ID: 27736772

DOI: 10.1128/mcb.00422-16

PubMed ID: 30909570

Title: Autophagy Promotes Infectious Particle Production of Mopeia and Lassa Viruses.

PubMed ID: 30909570

DOI: 10.3390/v11030293

PubMed ID: 33226137

Title: Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.

PubMed ID: 33226137

DOI: 10.15252/embj.2020104948

PubMed ID: 34471133

Title: Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation.

PubMed ID: 34471133

DOI: 10.1038/s41467-021-25572-w

PubMed ID: 34431698

Title: Depletion of TAX1BP1 Amplifies Innate Immune Responses during Respiratory Syncytial Virus Infection.

PubMed ID: 34431698

DOI: 10.1128/jvi.00912-21

PubMed ID: 24239949

Title: The structure of TAX1BP1 UBZ1+2 provides insight into target specificity and adaptability.

PubMed ID: 24239949

DOI: 10.1016/j.jmb.2013.11.006

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 21765415

Title: The kinase IKKalpha inhibits activation of the transcription factor NF-kappaB by phosphorylating the regulatory molecule TAX1BP1.

PubMed ID: 21765415

DOI: 10.1038/ni.2066

PubMed ID: 31371777

Title: Structure of Myosin VI/Tom1 complex reveals a cargo recognition mode of Myosin VI for tethering.

PubMed ID: 31371777

DOI: 10.1038/s41467-019-11481-6

PubMed ID: 26451915

Title: The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI Are Required for Clearance of Salmonella Typhimurium by Autophagy.

PubMed ID: 26451915

DOI: 10.1371/journal.ppat.1005174

PubMed ID: 29940186

Title: Mechanistic Insights into Recognitions of Ubiquitin and Myosin VI by Autophagy Receptor TAX1BP1.

PubMed ID: 29940186

DOI: 10.1016/j.jmb.2018.06.030

PubMed ID: 30459273

Title: Mechanistic insights into the interactions of NAP1 with the SKICH domains of NDP52 and TAX1BP1.

PubMed ID: 30459273

DOI: 10.1073/pnas.1811421115

Sequence Information:

Length: 789
Mass: 90877
Checksum: DE8460DAA6712125
Sequence:

MTSFQEVPLQ TSNFAHVIFQ NVAKSYLPNA HLECHYTLTP YIHPHPKDWV GIFKVGWSTA 
RDYYTFLWSP MPEHYVEGST VNCVLAFQGY YLPNDDGEFY QFCYVTHKGE IRGASTPFQF 
RASSPVEELL TMEDEGNSDM LVVTTKAGLL ELKIEKTMKE KEELLKLIAV LEKETAQLRE 
QVGRMERELN HEKERCDQLQ AEQKGLTEVT QSLKMENEEF KKRFSDATSK AHQLEEDIVS 
VTHKAIEKET ELDSLKDKLK KAQHEREQLE CQLKTEKDEK ELYKVHLKNT EIENTKLMSE 
VQTLKNLDGN KESVITHFKE EIGRLQLCLA EKENLQRTFL LTTSSKEDTC FLKEQLRKAE 
EQVQATRQEV VFLAKELSDA VNVRDRTMAD LHTARLENEK VKKQLADAVA ELKLNAMKKD 
QDKTDTLEHE LRREVEDLKL RLQMAADHYK EKFKECQRLQ KQINKLSDQS ANNNNVFTKK 
TGNQQKVNDA SVNTDPATSA STVDVKPSPS AAEADFDIVT KGQVCEMTKE IADKTEKYNK 
CKQLLQDEKA KCNKYADELA KMELKWKEQV KIAENVKLEL AEVQDNYKEL KRSLENPAER 
KMEGQNSQSP QCFKTCSEQN GYVLTLSNAQ PVLQYGNPYA SQETRDGADG AFYPDEIQRP 
PVRVPSWGLE DNVVCSQPAR NFSRPDGLED SEDSKEDENV PTAPDPPSQH LRGHGTGFCF 
DSSFDVHKKC PLCELMFPPN YDQSKFEEHV ESHWKVCPMC SEQFPPDYDQ QVFERHVQTH 
FDQNVLNFD

Genular Protein ID: 752904585

Symbol: B4DSG5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DSG5

Database IDs:

Sequence Information:

Length: 747
Mass: 86158
Checksum: 93EEDFF296B0A57D
Sequence:

MTSFQEVPLQ TSNFAHVIFQ NVAKSYLPNA HLECHYTLTP YIHPHPKDWV GIFKVGWSTA 
RDYYTFLWSP MPEHYVEGST VNCVLAFQGY YLPNDDGEFY QFCYVTHKGE IRGASTPFQF 
RASSPVEELL TMEDEGNSDM LVVTTKAGLL ELKIEKTMKE KEELLKLIAV LEKETAQLRE 
QVGRMERELN HEKERCDQLQ AEQKGLTEVT QSLKMENEEF KKGFSDATSK AHQLEEDIVS 
VTHKAIEKET ELDSLKDKLK KAQHEREQLE CQLKTEKDEK ELYKVHLKNT EIENTKLMSE 
VQTLKNLDGN KESVITHFKE EIGRLQLCLA EKENLQRTFL LTTSSKEDTC FLKEQLRKAE 
EQVQATRQEV VFLAKELSDA VNVRDRTMAD LHTARLENEK VKKQLADAVA ELKLNAMKKD 
QDKTDTLEHE LRREVEDLKL RLQMAADHYK EKFKECQRLQ KQINKLSDQS ANNNNVFTKK 
TGNQQKVNDA SVNTDPATSA STVDVKPSPS AAEADFDIVT KGQVCEMTKE IADKTEKYNK 
CKQLLQDEKA KCNKYADELA KMELKWKEQV KIAENVKLEL AEVQDNYKEL KRSLENPAER 
KMEDGADGAF YPDEIQRPPV RVPSWGLEDN VVCSQPARNF SRPDGLEDSE DSKEDENVPT 
APDPPSQHLR GHGTGFCFDS SFDVHKKCPL CELMFPPNYD QSKFEEHVES HWKVCPMCSE 
QFPPDYDQQV FERHVQTHFD QNVLNFD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TAX1BP1

Associated with

Other Information

The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. PubMed ID: 10435631

T6BP, a TRAF6-interacting protein involved in IL-1 signaling. PubMed ID: 10920205

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. PubMed ID: 11230166

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of human chromosome 7. PubMed ID: 12853948

Human chromosome 7: DNA sequence and biology. PubMed ID: 12690205

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins. PubMed ID: 14697242

Protein profile of tax-associated complexes. PubMed ID: 14530271

Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling. PubMed ID: 17703191

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling. PubMed ID: 21885437

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

A novel mode of ubiquitin recognition by the ubiquitin-binding zinc finger domain of WRNIP1. PubMed ID: 27062441

TAX1BP1 Restrains Virus-Induced Apoptosis by Facilitating Itch-Mediated Degradation of the Mitochondrial Adaptor MAVS. PubMed ID: 27736772

Autophagy Promotes Infectious Particle Production of Mopeia and Lassa Viruses. PubMed ID: 30909570

Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy. PubMed ID: 33226137

Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation. PubMed ID: 34471133

Depletion of TAX1BP1 Amplifies Innate Immune Responses during Respiratory Syncytial Virus Infection. PubMed ID: 34431698

The structure of TAX1BP1 UBZ1+2 provides insight into target specificity and adaptability. PubMed ID: 24239949

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

The kinase IKKalpha inhibits activation of the transcription factor NF-kappaB by phosphorylating the regulatory molecule TAX1BP1. PubMed ID: 21765415

Structure of Myosin VI/Tom1 complex reveals a cargo recognition mode of Myosin VI for tethering. PubMed ID: 31371777

The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI Are Required for Clearance of Salmonella Typhimurium by Autophagy. PubMed ID: 26451915

Mechanistic Insights into Recognitions of Ubiquitin and Myosin VI by Autophagy Receptor TAX1BP1. PubMed ID: 29940186

Mechanistic insights into the interactions of NAP1 with the SKICH domains of NDP52 and TAX1BP1. PubMed ID: 30459273