Details for: BEX3

Gene ID: 27018

Symbol: BEX3

Ensembl ID: ENSG00000166681

Description: brain expressed X-linked 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 213.7650
    Cell Significance Index: -88.0600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 185.9263
    Cell Significance Index: -87.7800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 176.2308
    Cell Significance Index: -71.6000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 161.6493
    Cell Significance Index: -83.1500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 131.7989
    Cell Significance Index: -88.4400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 75.2087
    Cell Significance Index: -71.8100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 31.3193
    Cell Significance Index: -83.9000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 18.8575
    Cell Significance Index: -57.9200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 16.1474
    Cell Significance Index: 128.9300
  • Cell Name: theca cell (CL0000503)
    Fold Change: 15.7889
    Cell Significance Index: 92.7600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 14.0146
    Cell Significance Index: 179.4800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 11.5825
    Cell Significance Index: 304.5600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 9.3891
    Cell Significance Index: 196.5300
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 9.1939
    Cell Significance Index: 44.7200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 8.3765
    Cell Significance Index: 291.0800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 8.3283
    Cell Significance Index: 90.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 7.1721
    Cell Significance Index: 376.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.9906
    Cell Significance Index: 135.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.8583
    Cell Significance Index: 667.1800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 4.3975
    Cell Significance Index: 63.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.3365
    Cell Significance Index: 173.7900
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 3.1778
    Cell Significance Index: 19.6600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.0340
    Cell Significance Index: 388.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.9398
    Cell Significance Index: 1605.4700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.5537
    Cell Significance Index: 59.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.4435
    Cell Significance Index: 300.4500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.4227
    Cell Significance Index: 22.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.3039
    Cell Significance Index: 415.3200
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.2814
    Cell Significance Index: 12.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.7828
    Cell Significance Index: 109.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.7366
    Cell Significance Index: 129.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7275
    Cell Significance Index: 346.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6782
    Cell Significance Index: 87.1800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.5838
    Cell Significance Index: 95.0800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.5627
    Cell Significance Index: 41.8000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.4894
    Cell Significance Index: 11.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.3463
    Cell Significance Index: 62.7700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.2966
    Cell Significance Index: 573.2500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.2223
    Cell Significance Index: 157.9100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1039
    Cell Significance Index: 219.0800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.7992
    Cell Significance Index: 17.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7759
    Cell Significance Index: 278.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6705
    Cell Significance Index: 47.4200
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.5064
    Cell Significance Index: 2.9900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.4525
    Cell Significance Index: 331.8000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.3626
    Cell Significance Index: 28.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2990
    Cell Significance Index: 226.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2667
    Cell Significance Index: 50.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2626
    Cell Significance Index: 17.6600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2156
    Cell Significance Index: 5.1700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2019
    Cell Significance Index: 3.4600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1882
    Cell Significance Index: 354.3200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1646
    Cell Significance Index: 2.7600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0771
    Cell Significance Index: 2.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0548
    Cell Significance Index: 9.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0528
    Cell Significance Index: 33.5400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0225
    Cell Significance Index: 1.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0205
    Cell Significance Index: 0.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0049
    Cell Significance Index: 7.5300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0037
    Cell Significance Index: 6.7500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0043
    Cell Significance Index: -0.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0086
    Cell Significance Index: -0.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0120
    Cell Significance Index: -16.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0143
    Cell Significance Index: -0.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0286
    Cell Significance Index: -2.8300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0423
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0605
    Cell Significance Index: -44.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0850
    Cell Significance Index: -38.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1000
    Cell Significance Index: -10.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1172
    Cell Significance Index: -66.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1296
    Cell Significance Index: -3.7400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1444
    Cell Significance Index: -4.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1756
    Cell Significance Index: -109.6500
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: -0.2265
    Cell Significance Index: -1.1300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2347
    Cell Significance Index: -1.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2480
    Cell Significance Index: -71.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2834
    Cell Significance Index: -6.1400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2993
    Cell Significance Index: -12.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3105
    Cell Significance Index: -45.1400
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.3224
    Cell Significance Index: -1.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3453
    Cell Significance Index: -39.5600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3481
    Cell Significance Index: -40.5700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3717
    Cell Significance Index: -17.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4229
    Cell Significance Index: -19.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4268
    Cell Significance Index: -89.9000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4553
    Cell Significance Index: -53.6900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.4757
    Cell Significance Index: -5.9000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5557
    Cell Significance Index: -15.9300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5664
    Cell Significance Index: -14.4700
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.6211
    Cell Significance Index: -3.9000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6697
    Cell Significance Index: -51.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7587
    Cell Significance Index: -79.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.0123
    Cell Significance Index: -63.8000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.0288
    Cell Significance Index: -45.5100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0899
    Cell Significance Index: -66.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.1106
    Cell Significance Index: -35.5700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.2932
    Cell Significance Index: -48.9700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.3090
    Cell Significance Index: -23.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.3138
    Cell Significance Index: -84.7600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.4297
    Cell Significance Index: -42.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Tissue-Specific Expression:** BEX3 is predominantly expressed in brain-expressed X-linked genes, with notable expression in glycinergic neurons, thyroid follicular cells, skeletal muscle satellite cells, and embryonic stem cells. 2. **Cell Death Signaling:** BEX3 is involved in regulating cell death signaling via the Nrage, Nrif, and Nade pathways, modulating the activity of cysteine-type endopeptidases and interacting with death receptors. 3. **Protein Binding and Regulation:** BEX3 interacts with various proteins, including nerve growth factor receptors, and regulates protein ubiquitination, inhibiting the negative regulation of protein degradation. 4. **Metal Ion Binding:** BEX3 exhibits metal ion-binding properties, which may influence its interactions with other proteins and signaling molecules. **Pathways and Functions:** 1. **Extrinsic Apoptotic Signaling Pathway:** BEX3 modulates the extrinsic apoptotic signaling pathway via death receptors, influencing the activity of cysteine-type endopeptidases involved in the apoptotic process. 2. **Nrage, Nrif, and Nade Pathways:** BEX3 interacts with these pathways, regulating cell death signaling and modulating the activity of cysteine-type endopeptidases. 3. **Protein Ubiquitination:** BEX3 regulates protein ubiquitination, inhibiting the negative regulation of protein degradation and influencing protein turnover. 4. **Signal Transduction:** BEX3 interacts with signaling receptors, including nerve growth factor receptors, and modulates signal transduction pathways. **Clinical Significance:** 1. **Apoptosis Dysregulation:** Dysregulation of BEX3 has been implicated in various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases, characterized by apoptosis dysregulation. 2. **Thyroid Disease:** BEX3 expression is altered in thyroid follicular cells, suggesting its potential role in thyroid disease, such as thyroid cancer and hypothyroidism. 3. **Neurological Disorders:** BEX3's involvement in glycinergic neurons and its regulation of apoptosis signaling pathways makes it a potential candidate for investigating neurological disorders, such as amyotrophic lateral sclerosis (ALS) and Parkinson's disease. 4. **Cancer Therapy:** BEX3's role in modulating apoptosis signaling pathways makes it a potential target for cancer therapy, particularly in the development of novel anti-cancer agents. In conclusion, BEX3 is a multifunctional gene that plays a critical role in regulating cell death signaling, protein ubiquitination, and signal transduction pathways. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying BEX3's functions and its clinical significance.

Genular Protein ID: 1215437672

Symbol: BEX3_HUMAN

Name: Nerve growth factor receptor-associated protein 1

UniProtKB Accession Codes:

Q00994 B2RD17 D3DXA3 Q5JQT4 Q5JQT5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 4 GO 12 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 3 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2171551

Title: Characterization of three abundant mRNAs from human ovarian granulosa cells.

PubMed ID: 2171551

DOI: 10.1089/dna.1990.9.479

PubMed ID: 10764727

Title: NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR.

PubMed ID: 10764727

DOI: 10.1074/jbc.c000140200

PubMed ID: 15958283

Title: Characterization of the Bex gene family in humans, mice, and rats.

PubMed ID: 15958283

DOI: 10.1016/j.gene.2005.05.012

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 111
  • Mass: 12959
  • Checksum: 29AA0573282C933E
  • Sequence:
    • MANIHQENEE MEQPMQNGEE DRPLGGGEGH QPAGNRRGQA RRLAPNFRWA IPNRQINDGM 
GGDGDDMEIF MEEMREIRRK LRELQLRNCL RILMGELSNH HDHHDEFCLM P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.